AutismKB 2.0

Annotation Detail for MST4


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Basic Information Top
Gene Symbol:MST4 ( MASK )
Gene Full Name: -
Band: Xq26.2
Quick LinksEntrez ID:51765; OMIM: 300547; Uniprot ID:MST4_HUMAN; ENSEMBL ID: ENSG00000134602; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200061LKB1 signaling events
No data
Pathway IDPathway Name
500270Apoptotic cleavage of cellular proteins
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of MST4 mRNAdecreases expression 16514628
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MST4 mRNAdecreases expression 20018196
D004317 Doxorubicin MST4 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of MST4 mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of MST4 mRNAdecreases expression 16514628
D020849 Raloxifene Raloxifene results in decreased expression of MST4 mRNAdecreases expression 16514628
D014747 Vinblastine MST4 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 4.6917418594
MESH:D000230 Adenocarcinoma Estradiol 4.6911473722
MESH:D000419 Albuminuria Doxorubicin 12.5821441931
MESH:D000419 Albuminuria Raloxifene 12.5817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D001284 Atrophy fulvestrant 5.1811514358
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0719526202 15634643 15939500 16595493 16322301 16115903 16264153 15993339 18695136 15692762 17426702 11325840 15136595 16826403 15567936 16096432 18382427 17983394 15994142 15668708 18234424 18628466 16935488 17369602
MESH:D001943 Breast Neoplasms Estradiol 2.0712948864 14630087 17289903 16675129 17018787 17261762 19861407 18497071
MESH:D001943 Breast Neoplasms fulvestrant 2.0718984771
MESH:D001943 Breast Neoplasms Raloxifene 2.0716837676 17893378 17952589 15572757 15758505 16912660 15775269 17261762 17595753 17242785 17049068 17440819
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2416234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2416924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.331485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.331485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3417572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017329180 15811867 16364871 17007740 17928571 17924179 18627295 17382496 15505089 16455267 16731534 15792986 17308081 16242529 17351982 16612575 16952015 17974986 16651473 16109756 15476868 17131338 16278810 16269455 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0217334414 16243910
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2618566989
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9818259882 18802399
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9818802399
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.8519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.8515920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5017416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D004487 Edema Raloxifene 3.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.3215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 13.6219148513
MESH:D016889 Endometrial Neoplasms Doxorubicin 13.6217359293
MESH:D016889 Endometrial Neoplasms Estradiol 13.6219148513 11473722 18566989
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Raloxifene 3.9017473493
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 8.4616244371 16879835 16144979 16244372 16330681 16495754 17888722 14766674 12587719 18006777 18674790 17875725 16707910
MESH:D006331 Heart Diseases Raloxifene 8.4611110106
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D006689 Hodgkin Disease Doxorubicin 8.6315147373 18501091 17606976
MESH:D006689 Hodgkin Disease Vinblastine 8.6318501091 18180244
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006973 Hypertension Raloxifene 2.9517577099 15787275
MESH:D007248 Infertility, Male fulvestrant 3.9211514358
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007674 Kidney Diseases Doxorubicin 6.6816775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 6.6815618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6614716833 14659978
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1717085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.156189445 17418594
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.6815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6816891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008545 Melanoma Doxorubicin 3.9116827129
MESH:D008545 Melanoma Vinblastine 3.9116432458 12374674 17761969 15577320 16248763 18332650 18505091 18176117 16809738 15577323
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009203 Myocardial Infarction Doxorubicin 3.0419429709 15857846
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009401 Nephrosis Doxorubicin 5.1316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2516889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 3.9816427766 11399458
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D009503 Neutropenia Vinblastine 4.8717378895
MESH:D010024 Osteoporosis Raloxifene 3.5517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 17893378 15579764 15758505
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6015749863 16888761 15897917 16868541 18437689 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6016536755 15731164 16220300
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D012509 Sarcoma Doxorubicin 4.2515675481 17203757 18313854 15625365 17710206 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0615692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9316767912 17203757 15625365
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5816010429 17909728
MESH:D013978 Tibial Fractures Estradiol 15.2419048282
MESH:D013978 Tibial Fractures Raloxifene 15.2419048282
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.6917653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6917572228
MESH:D014625 Vaginal Neoplasms Vinblastine 5.4015577323
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817334414 17638931 16364871 17678736
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
Pathway ID Pathway Name
REACT:578 Apoptosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394664
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07853 - [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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