AutismKB 2.0

Annotation Detail for ZAK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ZAK ( AZK,MLK7,MLT,MLTK,MRK,mlklak,pk )
Gene Full Name: -
Band: 2q24.2
Quick LinksEntrez ID:51776; OMIM: 609479; Uniprot ID:MLTK_HUMAN; ENSEMBL ID: ENSG00000091436; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04530Tight junction
No data
Pathway IDPathway Name
200143Signaling mediated by p38-gamma and p38-delta
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000841 Anisomycin quinoline analog inhibits the reaction [ZAK protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 15737997
D000841 Anisomycin ZAK protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]increases activity|increases phosphorylation|increases reaction 15737997
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of ZAK mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ZAK mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZAK mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of ZAK mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil affects the expression of ZAK mRNAaffects expression 16584549
C030110 oxaliplatin oxaliplatin results in decreased expression of ZAK mRNAdecreases expression 16510598
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZAK mRNAaffects binding|decreases expression|increases activity 19710929
C037219 quinoline quinoline analog inhibits the reaction [ZAK protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 15737997
C037219 quinoline quinoline analog results in decreased activity of ZAK proteindecreases activity 15737997
D020849 Raloxifene Raloxifene results in decreased expression of ZAK mRNAdecreases expression 19429434
D013629 Tamoxifen Tamoxifen results in decreased expression of ZAK mRNAdecreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000419 Albuminuria Raloxifene 4.7617308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000740 Anemia Fluorouracil 3.8417963324 15504547 16511603
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001930 Brain Injuries Raloxifene 4.6516580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.0019217205 16595493 15136595 18357371 18608205 16557594 16110121
MESH:D001943 Breast Neoplasms Raloxifene 2.0016912660 17893378 16837676 17049068 17440819 17952589 15758505 17261762 17242785 15775269 17595753 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 2.0017242785 18629630 18997820 16202921 18351453 19066611 20135344 19200415 20005174 19487384 16273361 21138602 18821012 19288272 18425577 20544844 11161223 15668708 19289846 19142967 18984771 21152245 19103187 19189212 19059307 15565566 20065188 19189210 19221464 16818667 20859285 19011961 17261762 18855134 20390343 19115204 19244106 16873071 19410462 17049068 19084267 18815881 17440819 19155303 17893378
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.9417088986 17045692 17971768 16799960 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular quinoline 4.94598648
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.9416924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7618986760 16757204 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.9417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5415775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D003072 Cognition Disorders Raloxifene 4.7915800139
MESH:D003110 Colonic Neoplasms Fluorouracil 4.2517016597 17725105 17172411 18772588 15001691 16510598 17169374 17287894 17018589 16340194
MESH:D003110 Colonic Neoplasms oxaliplatin 4.2516024531 16004971 16510598
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9718383874 17695437 16303861 17016601 15148649 16282729 18509181 18802399 16331619 18288408 17454858 20501625 15289873 16524972 17255274 18448328 18949393 17094418 14970324 17401013 16391804 17594712
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9717695437 17255274 18448328 18509181 17594712 17401013
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.4517308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.4519279558
MESH:D004487 Edema pirinixic acid 7.3612083418
MESH:D004487 Edema Raloxifene 7.3615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1320544844 16202921 17893378 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4216337965 15173087 16785472 16481741 17638652
MESH:D005234 Fatty Liver Cyclosporine 19.9819224547
MESH:D005234 Fatty Liver pirinixic acid 19.9819236843 20131406
MESH:D005234 Fatty Liver Raloxifene 19.9817473493
MESH:D005234 Fatty Liver Tamoxifen 19.9819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006331 Heart Diseases Raloxifene 3.6311110106
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006390 Hemangioendothelioma quinoline 6.12598648
MESH:D006394 Hemangiosarcoma quinoline 5.13598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1718467677 19176532 19772884 16221962
MESH:D006930 Hyperalgesia oxaliplatin 4.4617418472
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.4610903974
MESH:D006973 Hypertension Raloxifene 5.4617577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.4219457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 13.1212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 13.1216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.1218625569
MESH:D007889 Leiomyoma Raloxifene 4.6516973256
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1021137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 11.1015113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 11.1020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.1016684651
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2017365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5217053015 6695378 18520028 18816296 20464547 18569708 20064080 20135361 20869020
MESH:D008175 Lung Neoplasms Fluorouracil 3.5215246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.5218625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7111731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2318303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8918986760 16757204
MESH:D009101 Multiple Myeloma Raloxifene 3.5316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009232 Myxoma Raloxifene 5.7716343187
MESH:D009362 Neoplasm Metastasis quinoline 6.44598648
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6011141357
MESH:D009369 Neoplasms Fluorouracil 8.6018239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 8.6017405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Raloxifene 3.4717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3817823083 17893378 15758505 15579764
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7119003803 16929163 16500647 15113037
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0710923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0618626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0616220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0717365031 15814490 17975199 17322281
MESH:D011693 Purpura Raloxifene 5.7715770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1416160472 18286688 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013088 Spermatocele Tamoxifen 4.5116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.452093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4516424979 19084572 17522103 18396642 17172411 16951190 19015929 17498489 15786421 18567086
MESH:D020521 Stroke Raloxifene 3.9316837676
MESH:D013978 Tibial Fractures Raloxifene 5.4319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6417053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.6417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.6417572228 8653321 16712894
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.4316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7716343187
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved