AutismKB 2.0

Annotation Detail for PEG3


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Basic Information Top
Gene Symbol:PEG3 ( DKFZp781A095,KIAA0287,PW1,ZNF904,ZSCAN24 )
Gene Full Name: paternally expressed 3
Band: 19q13.4
Quick LinksEntrez ID:5178; OMIM: 601483; Uniprot ID:PEG3_HUMAN; ENSEMBL ID: ENSG00000198300; HGNC ID: 8826
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PEG3 mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PEG3 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PEG3 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of PEG3 mRNAdecreases expression 18042831
C008493 methylselenic acid methylselenic acid affects the expression of PEG3 mRNAaffects expression 14617803
C041786 palm oil palm oil results in decreased expression of PEG3 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEG3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PEG3 mRNAincreases expression 20059764
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PEG3 mRNA]increases expression|increases reaction 20059764
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PEG3 mRNAincreases expression 19933214
18691609
D014635 Valproic Acid Valproic Acid results in increased expression of PEG3 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin results in decreased expression of PEG3 mRNAdecreases expression 18042343
D015032 Zinc Zinc results in decreased expression of PEG3 mRNAdecreases expression 16870260
C016837 zinc chloride zinc chloride results in decreased expression of PEG3 mRNAdecreases expression 16870260
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8314514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000169 Acrodermatitis Zinc 5.5617202136 16889938 17190629
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000544 Alzheimer Disease Zinc 2.7716580781 16325427 16410023 17119284
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D001008 Anxiety Disorders Valproic Acid 9.1517497229
MESH:D001008 Anxiety Disorders vinclozolin 9.1519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001249 Asthma Zinc 2.9817085522
MESH:D001321 Autistic Disorder Valproic Acid 2.0016609825 18316065 18396377 20603192 18775368 19460635 17688650 15238991 18177632 19232924 17157402 17507914 18940202 18558336 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.2515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.258888407
MESH:D001930 Brain Injuries Zinc 4.8317109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.8020435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9210355542 15721981 18705752 15673190 16011737 16227642 16192424 16050911 16097048 15700767 16124888 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.8916543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Zinc 3.7316936243
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 16354765 15668235 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9016575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Zinc 3.9019302082
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3817522070 15998439 21278145 15027814 16177239 7120509 11566570 7179309 19336974 10915739 15968718 10092053 19085960 6884620 2869522 3732212 4309450 3786805 9327722 6623471 7440962 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.381733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7216530937
MESH:D004938 Esophageal Neoplasms Zinc 4.7216543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7215959796 61145 12795759 19224547 12631006 17595544 16239168 16045604
MESH:D005234 Fatty Liver Dietary Fats 19.7218296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 19.7219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 19.7214986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2618558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 15.6018705752
MESH:D005355 Fibrosis Dietary Fats 15.6018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6020067830
MESH:D005756 Gastritis Zinc 4.9717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006130 Growth Disorders Zinc 4.0317217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.3620558911
MESH:D006333 Heart Failure Zinc 7.3617162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8317276780
MESH:D006529 Hepatomegaly pirinixic acid 8.7319176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 15340226 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.4818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Zinc 3.3816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5316518626
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8221278145 11903743 17174718 16239168 17334410 17157831 11408273 16943688 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4515370692 14724832 18006644 18263696 12609069 18210741 17714472 16027843 17708605 15893842 14716496 12546737 16638106 15650968 15925388 15876570 17944888 15673190 18481824 18429990 17698563 10355542 14748882 12958196 18376398 12667390 17481882 15996030 16033810 20821823 12389079 12632514 17805973 12898905 18412020 15730626 18054572 12445421 17900296 12741479 18277467 17721639 15057751 18418968 14620537 11481614 17823541 16248980 15818738 18339082 18705752 18187930 18395095 15362042 12445418 18279442 14716833 17565644 15338365 12586293 12666154 17766677 17922224 18395914 18166357 16011737 14512876 17557913 12649538 13678700 18472332 16116963 18472094 18156304 18420326 18205269 17869086 15123356 16015684 15052691 17761835 18317297 15931870 17976157 16097048 17525996 18251166 12632512 16136751 16192424 17631135 15959796 17640975
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016964402 17285989 16246199 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9819294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.9815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2118816296 20869020 6695378 17053015 18569708 18520028 20464547 20064080 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2119555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.3612773700
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.208888407 16359493
MESH:D009765 Obesity Dietary Fats 4.5217217161 19632207 21332399 11836018 20132043 18674790 18457598 20518802 16723640
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.1811399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.1820603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.1818220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6817292933
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6816205645
MESH:D011471 Prostatic Neoplasms Zinc 2.6816517595 16606632 16700911 12429649
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration Zinc 4.2116584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.811511512 16876388 11044598 17978042 14763951 11738929 3137016 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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