AutismKB 2.0

Annotation Detail for ATP5G3


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Basic Information Top
Gene Symbol:ATP5G3 ( MGC125738,P3 )
Gene Full Name: ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
Band: 2q31.1
Quick LinksEntrez ID:518; OMIM: 602736; Uniprot ID:AT5G3_HUMAN; ENSEMBL ID: ENSG00000154518; HGNC ID: 843
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATP5G3 mRNAaffects expression 21346803
C099555 CD 437 CD 437 results in decreased expression of ATP5G3 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in decreased expression of ATP5G3 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5G3 mRNAaffects cotreatment|decreases expression 18313992
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ATP5G3 mRNAaffects cotreatment|increases expression 17183730
C059514 resveratrol resveratrol results in increased expression of ATP5G3 mRNAincreases expression 17112576
D012402 Rotenone Rotenone results in increased expression of ATP5G3 mRNAincreases expression 18191903
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATP5G3 mRNAincreases expression 20399798
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ATP5G3 mRNAaffects cotreatment|increases expression 17183730
D015215 Zidovudine Zidovudine results in increased expression of ATP5G3 mRNAincreases expression 16894629
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5G3 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1114514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D058186 Acute Kidney Injury resveratrol 4.0216538975
MESH:D000236 Adenoma resveratrol 3.4115688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000544 Alzheimer Disease resveratrol 2.6016183991 16162502
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001169 Arthritis, Experimental resveratrol 3.6017115116
MESH:D050197 Atherosclerosis resveratrol 3.3716873680 17967414
MESH:D001321 Autistic Disorder Valproic Acid 1.9918396377 18985861 17157402 17507914 17688650 18558336 19232924 15238991 19460635 18316065 18775368 18940202 18177632 20603192 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D002545 Brain Ischemia resveratrol 4.5217600658
MESH:D001943 Breast Neoplasms resveratrol 2.1217651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.2316705839
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.2316227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8316675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7516227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.5915458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 16354765 15340226 8697196 15668235
MESH:D003092 Colitis resveratrol 4.3416474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4816338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.528888407 16575769 17688650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9116873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.1116286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4619641884 1733752
MESH:D004362 Drug Toxicity Lamivudine 14.6215040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.6211462148
MESH:D004362 Drug Toxicity Zidovudine 14.6215040536
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema resveratrol 7.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.2217872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0617923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 14.2519224547
MESH:D005234 Fatty Liver Valproic Acid 14.2519224547 14986274
MESH:D005234 Fatty Liver Zidovudine 14.2518299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006509 Hepatitis B Lamivudine 5.2717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2716476009 15631357 12044531 15309715 15274664
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006561 Herpes Simplex resveratrol 4.4216876885
MESH:D015658 HIV Infections Lamivudine 7.3317530837 11141242 20032539 9296927
MESH:D015658 HIV Infections Zidovudine 7.3311141242 20032539 17358032 11698656 11363243
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 8697196 18606429 16959395 16354765
MESH:D006937 Hypercholesterolemia resveratrol 4.1817188708
MESH:D006949 Hyperlipidemias resveratrol 4.2116873680
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4617488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8617600658
MESH:D007249 Inflammation resveratrol 5.3416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.8116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.3316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.3312371664
MESH:D007680 Kidney Neoplasms Zidovudine 13.3312579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5820370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6816087638
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.787678174
MESH:D008113 Liver Neoplasms resveratrol 7.7820405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.076135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5619555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 2.5618800350
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.218985016 11606380
MESH:D008545 Melanoma resveratrol 2.3917992120
MESH:D008659 Metabolic Diseases resveratrol 4.5517112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009101 Multiple Myeloma resveratrol 3.5816490592 17935668 17049120 14749477 17164350 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1117962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction resveratrol 3.0916317513 16525036 16456233 17188708 17015251 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.4717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D009205 Myocarditis resveratrol 5.0017322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009374 Neoplasms, Experimental resveratrol 4.218985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 4.0118619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9517652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5817929310
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4417513867
MESH:D010051 Ovarian Neoplasms CD 437 3.3617474084
MESH:D010300 Parkinson Disease Rotenone 3.0318619942 15451049 16412576 19232380 18191903 11445065 16140633 11535288 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 4.2415574749 15795934 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 17.7316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.7311399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.7320603192
MESH:D011471 Prostatic Neoplasms resveratrol 3.6116731767 17804756 17718901 17636462 17675339 15767336
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8516325855
MESH:D015427 Reperfusion Injury resveratrol 3.3516314181 17058453 15827377 16317513 17520802
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.779296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.3215475178 16876388 11738929 14763951 17978042 1511512 11044598 3137016
MESH:D012878 Skin Neoplasms resveratrol 5.968985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9616192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6416321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014062 Tongue Neoplasms resveratrol 4.3716227395
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.6116049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.6116720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2617473185
MESH:D014594 Uterine Neoplasms resveratrol 4.3317044934
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5217488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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