AutismKB 2.0

Annotation Detail for PER1


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Basic Information Top
Gene Symbol:PER1 ( MGC88021,PER,RIGUI,hPER )
Gene Full Name: period homolog 1 (Drosophila)
Band: 17p13.1
Quick LinksEntrez ID:5187; OMIM: 602260; Uniprot ID:PER1_HUMAN; ENSEMBL ID: ENSG00000179094; HGNC ID: 8845
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
Pathway IDPathway Name
200068Circadian rhythm pathway
Pathway IDPathway Name
P00015Circadian clock system
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
NEUROLOGICAL
delayed sleep phase syndrome
Autism
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PER1 mRNAincreases expression 20826375
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PER1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PER1 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in increased expression of PER1 mRNAincreases expression 17069763
D000638 Amiodarone Amiodarone results in increased expression of PER1 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PER1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of PER1 mRNAdecreases expression 19654921
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PER1 mRNAincreases expression 18687144
D019324 beta-Naphthoflavone beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to PER1 promoter]affects binding|decreases reaction 20106950
D019324 beta-Naphthoflavone beta-Naphthoflavone promotes the reaction [AHR protein binds to PER1 promoter]affects binding|increases reaction 20106950
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of PER1 mRNAdecreases expression 20106950
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of PER1 proteindecreases expression 20106950
C006780 bisphenol A bisphenol A results in increased expression of PER1 mRNAincreases expression 20826375
D003907 Dexamethasone Dexamethasone results in increased expression of PER1 mRNAincreases expression 15679045
D003907 Dexamethasone Dexamethasone results in increased expression of PER1 proteinincreases expression 15679045
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNAaffects cotreatment|increases expression 16054899
D004958 Estradiol Estradiol results in increased expression of PER1 mRNAincreases expression 20826375
D004958 Estradiol Estradiol results in increased expression of PER1 mRNAincreases expression 17761890
D004958 Estradiol Estradiol results in increased expression of PER1 proteinincreases expression 17761890
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of PER1 mRNA]decreases reaction|increases expression 17761890
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PER1 mRNAincreases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of PER1 mRNAdecreases expression 18329632
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of PER1 mRNA]decreases reaction|increases expression 17761890
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNAaffects cotreatment|increases expression 16054899
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in increased expression of PER1 mRNA]decreases reaction|increases expression 17761890
D009638 Norepinephrine Norepinephrine results in increased expression of PER1 mRNAincreases expression 12729908
D010126 Ozone Ozone results in increased expression of PER1 mRNAincreases expression 19555225
D010269 Paraquat Paraquat results in increased expression of PER1 mRNAincreases expression 12595580
D010634 Phenobarbital Phenobarbital results in decreased expression of PER1 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of PER1 mRNAincreases expression 19270015
D010656 Phenylephrine U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]decreases reaction|increases expression 12729908
C006253 pirinixic acid pirinixic acid results in increased expression of PER1 mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in increased expression of PER1 mRNAincreases expression 18037150
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in increased expression of PER1 mRNA]decreases reaction|increases expression 17761890
D011374 Progesterone Progesterone results in increased expression of PER1 mRNAincreases expression 17761890
D011374 Progesterone Progesterone results in increased expression of PER1 proteinincreases expression 17761890
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNAaffects cotreatment|increases expression 16054899
D013749 Tetrachlorodibenzodioxin PER1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]affects reaction|increases expression 19038280
D013749 Tetrachlorodibenzodioxin PER1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]affects reaction|increases expression 19038280
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PER1 mRNAdecreases expression 20106950
16556773
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PER1 proteindecreases expression 20106950
D019284 Thapsigargin Thapsigargin results in increased expression of PER1 mRNAincreases expression 12729908
D014212 Tretinoin Tretinoin results in increased expression of PER1 mRNAincreases expression 17069763
C010809 tulobuterol tulobuterol results in increased expression of PER1 mRNAincreases expression 17364588
C113580 U 0126 U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]decreases reaction|increases expression 12729908
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.376195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.2017694057
MESH:D055371 Acute Lung Injury pirinixic acid 2.8618653653
MESH:D000230 Adenocarcinoma Estradiol 6.6211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6214692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.6217638652
MESH:D000236 Adenoma beta-Naphthoflavone 3.1719389873
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.6617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.6616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.6616835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9317306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4911874814
MESH:D000505 Alopecia Tretinoin 3.4015955085
MESH:D000544 Alzheimer Disease Ozone 4.2615513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.2619621015
MESH:D000740 Anemia Fluorouracil 7.8817963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8811748828
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.3418057881 20041841 18218290
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.3417460149
MESH:D020261 Arsenic Poisoning Arsenic 2.7916835338 18414634 16251483 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.2917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.2915885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.2916412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4316292516
MESH:D001249 Asthma Ozone 7.7717854713 16373670
MESH:D001249 Asthma Tretinoin 7.7716456186
MESH:D001249 Asthma tulobuterol 7.7715007912 15212190
MESH:D050197 Atherosclerosis Arsenic 3.0912928151 19371607
MESH:D001281 Atrial Fibrillation Amiodarone 3.7019698954 18651412
MESH:D001284 Atrophy fulvestrant 4.5811514358
MESH:D001321 Autistic Disorder marker/mechanism 17264841
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Norepinephrine 2.358570775
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 19.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.9019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.9012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.9016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001862 Bone Resorption bisphenol A 3.6111985600
MESH:D001919 Bradycardia Phenylephrine 4.2615306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 3.9815845082 15380490 15665606
MESH:D001943 Breast Neoplasms alitretinoin 4.4916344269
MESH:D001943 Breast Neoplasms bisphenol A 4.4917123778
MESH:D001943 Breast Neoplasms Estradiol 4.4917261762 17289903 16675129 12948864 14630087 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 4.4919217205 18608205 15136595 18357371 16557594 16595493 16110121
MESH:D001943 Breast Neoplasms fulvestrant 4.4918984771
MESH:D001943 Breast Neoplasms Progesterone 4.4915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4920435547
MESH:D001943 Breast Neoplasms Tretinoin 4.4916166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4616777450 15516495 19059883 18315731 14754758 18417511 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3116813970
MESH:D002100 Cachexia Ozone 4.4616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3816051944
MESH:D002277 Carcinoma Fluorouracil 7.4617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4415504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.3316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.333084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.3317306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.3317971768 18930000 16799960 16332177 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.3317173139 6705139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.331917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7117123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.1117687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.1117066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.1116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8418640142
MESH:D006332 Cardiomegaly Norepinephrine 10.7211179087
MESH:D006332 Cardiomegaly Phenylephrine 10.7211179087 17124262 11754973 15728586 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.7216120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8015710769 19225199
MESH:D002318 Cardiovascular Diseases Arsenic 3.2615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.0818022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8018974383
MESH:D002375 Catalepsy Norepinephrine 5.268216760
MESH:D002386 Cataract Acetaminophen 6.6810977129
MESH:D002386 Cataract Tretinoin 6.6817460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.984080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0615861022 16105132 17333356 16919318 17110522 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 7.0619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3715668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.379407595
MESH:D003092 Colitis Tretinoin 3.4317035595
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7415824018
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7416510598 16340194 17169374 18772588 17725105 17172411 17016597 17018589 15001691 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9917016601 16331619 17594712 18383874 16391804 18509181 17695437 16303861 18448328 16524972 16282729 17454858 18949393 15148649 18288408 14970324 15289873 20501625 17094418 17401013 17255274 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.6317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.639224671 10589399 8800419 16925845 9142499 17551590 14991402 9211117 9125849 9664655
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7418551238
MESH:D007644 Darier Disease Fluorouracil 4.5116733453
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1412438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0717446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.2512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D003967 Diarrhea Dexamethasone 3.447237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.2321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.2316485898 16109766 11743745 17906064 12392966 18071297 19370779 11461765 12958197 19085960 10663392 12153990 17562736 11287661 11739529 15968718 16393943 12705907 15619225 16781746 19164858 19739265 12594235 16177239 16227642 14986274 11529661 14725611 11834606 18713872 2444490 16081117 19420014 10915739 11421492 19416960 14550746 12540782 19923254 17522070 10774834
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.2315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004421 Dystonia Phenobarbital 3.751851702
MESH:D004485 Eczema Dexamethasone 4.1912438553
MESH:D004487 Edema Dexamethasone 14.4319703484
MESH:D004487 Edema pirinixic acid 14.4312083418
MESH:D004487 Edema rosiglitazone 14.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0016714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.1517692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.8119148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 6.8116569247
MESH:D004715 Endometriosis Mifepristone 13.9316134523
MESH:D004715 Endometriosis Progesterone 13.9316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.9310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.833659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.593922381 11558140
MESH:D004827 Epilepsy Norepinephrine 6.69821787
MESH:D004827 Epilepsy Phenobarbital 6.6920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.316401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.743659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3817638652 16337965 15173087 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1511564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1516938888 9664655
MESH:D005234 Fatty Liver Amiodarone 16.7514986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.7515345470
MESH:D005234 Fatty Liver pirinixic acid 16.7519236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 16.7519196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7120067830
MESH:D005355 Fibrosis Tretinoin 7.7117994277
MESH:D005534 Foot Diseases Arsenic 5.276392382
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005909 Glioblastoma Tretinoin 2.8317312396
MESH:D005910 Glioma Fluorouracil 2.7616145905
MESH:D005911 Gliosis Paraquat 4.8811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1715102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.0514991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006529 Hepatomegaly Amiodarone 18.4215265979
MESH:D006529 Hepatomegaly Phenobarbital 18.4216109766
MESH:D006529 Hepatomegaly pirinixic acid 18.4219772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.4216120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.768697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 11.8316870215
MESH:D006930 Hyperalgesia rosiglitazone 11.8312083418
MESH:D006930 Hyperalgesia Tretinoin 11.8316870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.628137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2117050553
MESH:D006973 Hypertension Arsenic 11.5316076760 9931084 11953799
MESH:D006973 Hypertension Dexamethasone 11.5317042910
MESH:D006973 Hypertension Phenylephrine 11.538949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.5318670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.3012791704 18502941
MESH:D006987 Hypesthesia Arsenic 5.2716093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416945680 16569931
MESH:D007022 Hypotension Norepinephrine 4.746740701
MESH:D007037 Hypothyroidism Amiodarone 4.2417991464 18020914
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.2717937319
MESH:D007248 Infertility, Male fulvestrant 10.2711514358
MESH:D007248 Infertility, Male Paraquat 10.274850670
MESH:D007249 Inflammation Dexamethasone 10.8111099482 8960868
MESH:D007249 Inflammation Progesterone 10.8115869954
MESH:D007249 Inflammation rosiglitazone 10.8112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.8112878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 16.1916393666
MESH:D007333 Insulin Resistance Estradiol 16.1916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.1916306350
MESH:D007333 Insulin Resistance rosiglitazone 16.1916306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4917994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1015992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D007642 Keratosis Arsenic 4.7116930632 12749816
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3616144296
MESH:D007674 Kidney Diseases Acetaminophen 5.3512587719 15629191
MESH:D007674 Kidney Diseases Estradiol 5.3515618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.1416705839
MESH:D007680 Kidney Neoplasms Estradiol 11.1415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.1416985049
MESH:D007938 Leukemia Tretinoin 2.6317143497
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.0316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive marker/mechanism 16999817
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.1617339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1616823087 17217047 19035177 17368321 17107899 17712046 19075265 19029980 16788101 19225113 17301526 12679006 17294898 9834237 16935935 15748426 16891316 16766008 17339181 16331271 19642359 17506722 17361223 16140955 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.119224671
MESH:D008064 Lipidoses Amiodarone 3.3117567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7421047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.2516718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2515474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.2515980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.0919014921 16611625 12587719 12969438 11587558 16610002 19784758 19460945
MESH:D008107 Liver Diseases Arsenic 6.0911134558
MESH:D008107 Liver Diseases Phenobarbital 6.0919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9916871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 16.5716368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 16.5721295105 19389873
MESH:D008113 Liver Neoplasms Fluorouracil 16.5717045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 16.5719482888 19073162 21047994 15975961 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 16.5720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.5716984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 8.8718164116
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.871399818 2563599 17172636 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.8712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3717391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 6.9712587719
MESH:D008171 Lung Diseases Ozone 6.978266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2018516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.3417365036
MESH:D055370 Lung Injury Ozone 8.3420417186
MESH:D008175 Lung Neoplasms alitretinoin 8.0816413115
MESH:D008175 Lung Neoplasms Arsenic 8.0819168569 17976673 17306315
MESH:D008175 Lung Neoplasms Dexamethasone 8.0815824018 11195469
MESH:D008175 Lung Neoplasms Fluorouracil 8.0815246190
MESH:D008175 Lung Neoplasms Ozone 8.087614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5115086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.0411408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.0417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.0416827153
MESH:D020149 Manganese Poisoning Estradiol 4.2019453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0718303189 16166281 16966607
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1517261469
MESH:D008679 Metaplasia Ozone 4.8210496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4216757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 3.3115744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009181 Mycoses Amiodarone 4.6217974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.019809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D017202 Myocardial Ischemia Arsenic 8.2715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1116810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 13.1115642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2017484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5818551238
MESH:D009369 Neoplasms alitretinoin 10.7516946489
MESH:D009369 Neoplasms Fluorouracil 10.7518600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 10.7517405874
MESH:D009369 Neoplasms Tretinoin 10.7516946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009410 Nerve Degeneration Paraquat 3.5116893418
MESH:D009421 Nervous System Malformations bisphenol A 21.2416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.2411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.2414600291
MESH:D009421 Nervous System Malformations Tretinoin 21.249125849
MESH:D009436 Neural Tube Defects Arsenic 6.8216620997
MESH:D009436 Neural Tube Defects Tretinoin 6.829142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6518514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.1217056641
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2516436463
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1912819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.0817016548
MESH:D010049 Ovarian Diseases bisphenol A 4.7111985600
MESH:D010051 Ovarian Neoplasms Arsenic 17.6917306315
MESH:D010051 Ovarian Neoplasms Estradiol 17.6919401270
MESH:D010051 Ovarian Neoplasms Mifepristone 17.6916525653
MESH:D010051 Ovarian Neoplasms Progesterone 17.6917393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 17.6916936753
MESH:D010051 Ovarian Neoplasms U 0126 17.6916211241
MESH:D010146 Pain Acetaminophen 5.8516870215
MESH:D010146 Pain Tretinoin 5.8516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.0416500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.0416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010300 Parkinson Disease Paraquat 2.7111445065 15824117 11181820 16510128 15451049 11124998 12911755 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1616190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7116905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.8616369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6210923243
MESH:D011014 Pneumonia Ozone 10.1318381685 18929643 18007984
MESH:D011014 Pneumonia Paraquat 10.1312504350
MESH:D017499 Porokeratosis alitretinoin 5.7216144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.392563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3921297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.5810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5811399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7220887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1516140617
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1516740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1518626508 19082440
MESH:D011507 Proteinuria Arsenic 8.4221343184
MESH:D011507 Proteinuria Tretinoin 8.4216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2112752131
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5110548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 8.7212490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.7217365031 17975199 15814490 17322281
MESH:D011658 Pulmonary Fibrosis Paraquat 8.7217997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7816160472 18286688 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.4118379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.4111700416
MESH:D012135 Respiratory Sounds Paraquat 3.7811874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration Paraquat 3.6616458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8416116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3018551238
MESH:D012640 Seizures Phenobarbital 5.303137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.546407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8018724381
MESH:D012852 Sinusitis Phenylephrine 4.427327846
MESH:D012871 Skin Diseases Arsenic 2.6816702368 17548696 17453740 15952646 16353154 19834688 6392382 17050553 17938729 16759981 18709164
MESH:D012878 Skin Neoplasms Arsenic 8.7017976673 16251483 17029826 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7016192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0015862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 4.0415472012
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4415786421 17522103 19015929 16424979 18396642 17498489 16951190 18567086 19084572 17172411
MESH:D013274 Stomach Neoplasms Tretinoin 2.4417261132
MESH:D013276 Stomach Ulcer Amiodarone 6.6518087811
MESH:D013276 Stomach Ulcer Dexamethasone 6.6515138204
MESH:D019966 Substance-Related Disorders bisphenol A 3.7116684133 16045194
MESH:D013610 Tachycardia Amiodarone 10.2211238279
MESH:D013610 Tachycardia Norepinephrine 10.223261545
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Amiodarone 11.1019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.1012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.501399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.5016026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.5918020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0316280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.0316051514
MESH:D016171 Torsades de Pointes Amiodarone 3.9111989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.8416049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 4.8417976673 19429237 15987713 17306315 11144890 18640142 19322015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0410091137
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.6516803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.6516129372
MESH:D014591 Uterine Diseases bisphenol A 4.7214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3316752155
MESH:D014605 Uveitis Dexamethasone 4.531336536
MESH:D014652 Vascular Diseases Arsenic 4.4617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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