AutismKB 2.0

Annotation Detail for PET112L


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Basic Information Top
Gene Symbol:PET112L ( PET112 )
Gene Full Name: PET112-like (yeast)
Band: 4q27-q28
Quick LinksEntrez ID:5188; OMIM: 603645; Uniprot ID:GATB_HUMAN; ENSEMBL ID: ENSG00000059691; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5921L-glutamine biosynthesis II (tRNA-dependent)
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PET112 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PET112 mRNAaffects expression 17562736
C006253 pirinixic acid pirinixic acid results in increased expression of PET112 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.6718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0516393943 18071297 19420014 19739265 19085960 18713872 15968718 11287661 16081117 19416960 16485898 10663392 16177239 17522070 2444490 12153990 19923254 11834606 19370779 14725611 17562736 17906064 15619225 12705907 10774834 12958197 12392966 14986274 11739529 16227642 19164858 16781746 11743745 11461765 14550746 10915739 12594235 11421492 16109766 11529661 12540782
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D005234 Fatty Liver pirinixic acid 3.2519236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6419772884 19176532 18467677 16221962
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3616705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.7119014921 16611625 19784758 11587558 19460945 12587719 12969438 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9415890375 16377806 20007298
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.6018551238
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8812819281 16049721
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.8118551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.4216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 5.0610091137
MESH:D014581 Urticaria Acetaminophen 3.5010982225
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Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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