Annotation Detail for PEX7
Basic Information
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| Pathway ID | Pathway Name |
|---|
| hsa04146 | Peroxisome |
| Desease ID | Desease Name |
|---|
| H00075 | Refsum disease |
| H00207 | Rhizomelic chondrodysplasia punctata |
| Peroxisomal diseases |
| Genetic disorders |
| Desease Name |
|---|
| Rhizomelic chondrodysplasia punctata, type 1 |
| Refsum disease |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of PEX7 mRNA | affects expression | 21346803
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of PEX7 mRNA | affects expression | 17562736
|
| D016572 |
Cyclosporine |
Cyclosporine results in decreased expression of PEX7 mRNA | decreases expression | 20106945
|
| D012643 |
Selenium |
[Selenium co-treated with Vitamin E] results in increased expression of PEX7 mRNA | affects cotreatment|increases expression | 19244175
|
| D014810 |
Vitamin E |
[Selenium co-treated with Vitamin E] results in increased expression of PEX7 mRNA | affects cotreatment|increases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.45 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.41 | 16050911 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
2.95 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.95 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.77 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
2.76 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
3.17 | 19486331 |
| MESH:D018902 |
Chondrodysplasia Punctata, Rhizomelic |
marker/mechanism |
|
| |
| MESH:D003092 |
Colitis |
|
Selenium |
4.26 | 17936198 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.92 | 19769572 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
4.50 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
6.70 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
6.70 | 12958197 19085960 12540782 19416960 19420014 12705907 19923254 11529661 18713872 11461765 19164858 16109766 10663392 15968718 14550746 11743745 2444490 19739265 14986274 10915739 16227642 16781746 19370779 18071297 17562736 11287661 15619225 17522070 12594235 11421492 16485898 11739529 11834606 14725611 10774834 16177239 12392966 16081117 16393943 17906064 12153990 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Selenium |
6.70 | 15131321 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.71 | 19426721 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.32 | 9068938 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
3.23 | 19224547 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.62 | 12639820 12168785 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.29 | 16983495 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.76 | 8708960 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.15 | 16080930 |
| MESH:D006333 |
Heart Failure |
|
Selenium |
3.27 | 17162251 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
4.96 | 15720958 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.80 | 16490937 16863852 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.58 | 14716179 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.99 | 16870215 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.20 | 10903974 |
| MESH:D007251 |
Influenza, Human |
|
Selenium |
13.09 | 16624496 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
13.09 | 16624496 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.05 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
11.09 | 12587719 15629191 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
11.09 | 10903974 8314463 18776723 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
11.09 | 12488133 |
| MESH:D007676 |
Kidney Failure, Chronic |
|
Selenium |
4.26 | 16518626 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.30 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
8.30 | 12371664 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
1.90 | 16169303 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.69 | 19460945 11587558 19014921 12587719 19784758 16610002 16611625 12969438 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.58 | 17185352 16871587 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.40 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
1.90 | 11062179 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Selenium |
2.97 | 15318939 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.05 | 19513568 |
| MESH:D008654 |
Mesothelioma |
|
Selenium |
2.90 | 15107826 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.40 | 16801185 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
4.40 | 18551238 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.05 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.61 | 19348381 18481113 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.18 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
3.78 | 12819281 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.69 | 16870215 |
| MESH:D010954 |
Plasmacytoma |
|
Selenium |
5.50 | 15087411 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.55 | 12371664 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.25 | 15084515 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.32 | 16882103 |
| MESH:D012035 |
Refsum Disease |
marker/mechanism |
|
| |
| OMIM:266500 |
REFSUM DISEASE, ADULT |
marker/mechanism |
|
| |
| MESH:C531651 |
Rhizomelic chondrodysplasia punctata, type 1 |
marker/mechanism |
|
| |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
2.76 | 18551238 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.51 | 18709164 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.81 | 16517955 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
2.39 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
4.86 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.38 | 10982225 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.59 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.05 | 17120751 |
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