AutismKB 2.0

Annotation Detail for PEX14


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Basic Information Top
Gene Symbol:PEX14 ( MGC12767,NAPP2,Pex14p,dJ734G22.2 )
Gene Full Name: peroxisomal biogenesis factor 14
Band: 1p36.22
Quick LinksEntrez ID:5195; OMIM: 601791; Uniprot ID:PEX14_HUMAN; ENSEMBL ID: ENSG00000142655; HGNC ID: 8856
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00205Zellweger syndrome spectrum
Peroxisomal diseases
Genetic disorders
No data
No data
Desease Name
Optic disc size (rim)
Desease Name
Zellweger syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PEX14 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PEX14 mRNAdecreases expression 19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEX14 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEX14 mRNAaffects cotreatment|affects expression 17602206
D008628 Mercury Mercury results in increased expression of PEX14 mRNAincreases expression 16823088
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEX14 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PEX14 mRNAincreases expression 17426115
18301758
D012643 Selenium Selenium results in increased expression of PEX14 mRNAincreases expression 19244175
C009250 sevoflurane sevoflurane affects the expression of PEX14 mRNAaffects expression 15967596
C017947 sodium arsenite sodium arsenite results in decreased expression of PEX14 mRNAdecreases expression 16507463
D013853 Thioacetamide Thioacetamide results in increased expression of PEX14 mRNAincreases expression 16297948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9017162532 17620307 16434500 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1716712894 17306315
MESH:D001321 Autistic Disorder Mercury 2.7717497416
MESH:D001327 Autoimmune Diseases Mercury 5.0916634805
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7619483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 9.7619483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8316681979 19519916 17055752 19822196 19919837 17162532 18691550 17978847 10672840 18494052 10737359 16779866 20514400 20101231 17761372 20524982 18506893 17138121 18210153 16830150 19208518 16540662 18788625 19701751 16935385 20007298 16328049 19539802 20432363 20512989 18393292 20935162 18056438 18978308 18665156 16807293 16878318 16288022 20214788 18785209 18971187 21159647 16569478 11831363 19052882 19394651 20727157 17428255 3084413 19335982 16502159 16698587 19418558 3581430 19171122 17173139 19383236 20084675 19107877
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8316507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.8317997003
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4218572023
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5010334427
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.8921159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.8920056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.2519052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 10.2518291259
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.0016823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6219107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6215131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 6.6212963478
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005218 Fat Necrosis Thioacetamide 5.9916456712
MESH:D005234 Fatty Liver Diethylnitrosamine 8.2621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.2620131406 19236843
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7418665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.4116456712
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 19176532 18467677 19772884
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007251 Influenza, Human Selenium 4.4616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007674 Kidney Diseases Mercury 6.7717934191
MESH:D007674 Kidney Diseases sodium arsenite 6.7720008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007859 Learning Disorders sevoflurane 4.9919212262
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118522880 19638242 18407596 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5918380797 16511523 15288472 15288473 17292413 18263696 16343077 15075984 16126171 12531686 18032466 15334695 15316131 18615449 15716488 17050028 10677585 17127702 18295389 16098781 17355460 15095483 12085344 11481614 15158331 15465738 12891558 18416461 18458672 15362042 18606216 18395095 11172339 12679928 16097051 11682029 15078482 16489207 18031379 14739098 16248980 12175628 15474484 17629604 12557150
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4317034775
MESH:D008107 Liver Diseases Thioacetamide 4.4316337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.4715313186 12479984 15633222 17276928
MESH:D008113 Liver Neoplasms Clofibric Acid 11.2117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2120452335 10737359 19294768 19833225 18978307 20492335 21278145 20137499 18754104 20405173 19812893 19499222 19551842 12112319 18977376 20583210 19254457 16942905 18644402 19256749 20101389 19255062 19642983 9163691 20118626 19638242 18648771 19996281 2422723 21167192 20501860 20434301 15175105 12771043 2862719 19427195 19426721 19850985 21071580 21047994 19090486 19073162 19690152 15885732
MESH:D008113 Liver Neoplasms pirinixic acid 11.2120007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 11.2116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7318775883 18253720 17174075 18093689 18079962 18282651 19009564 19519916 9362446 19126423 18544905 18308698 19004024 17854601 2563599 16842330 16267830 21159647 19539802 3124819 17942915 18164116
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5420970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 2.5417306315 17077188 16712894 15276417 19931552
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008569 Memory Disorders sevoflurane 4.9519212262
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D009369 Neoplasms pirinixic acid 5.2017405874
MESH:D009369 Neoplasms sodium arsenite 5.2011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4815276417 17306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2716039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012878 Skin Neoplasms sodium arsenite 2.7719524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5617306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D015211 Zellweger Syndrome marker/mechanism
Pathway ID Pathway Name
KEGG:04146 Peroxisome
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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