AutismKB 2.0

Annotation Detail for ATP8B1


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Basic Information Top
Gene Symbol:ATP8B1 ( ATPIC,BRIC,FIC1,PFIC,PFIC1 )
Gene Full Name: ATPase, aminophospholipid transporter, class I, type 8B, member 1
Band: 18q21.31
Quick LinksEntrez ID:5205; OMIM: 602397; Uniprot ID:AT8B1_HUMAN; ENSEMBL ID: ENSG00000081923; HGNC ID: 3706
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
vitiligo
greenland familial cholestasis
PSYCH
Attention deficit hyperactivity disorder and conduct disorder
cholestasis
IMMUNE
METABOLIC
Desease Name
Vitiligo
Attention deficit hyperactivity disorder and conduct disorder
Desease Name
Cholestasis, benign recurrent intrahepatic
Cholestasis, progressive familial intrahepatic 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of ATP8B1 mRNAaffects expression 18648102
D000255 Adenosine Triphosphate ATP8B1 protein results in increased hydrolysis of Adenosine Triphosphateincreases hydrolysis 11584374
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ATP8B1 proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of ATP8B1 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ATP8B1 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ATP8B1 mRNAincreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATP8B1 mRNAdecreases expression 20018196
D002118 Calcium Calcium inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ATP8B1 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ATP8B1 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of ATP8B1 mRNAincreases expression 16002434
D005033 Ethylmaleimide Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D007213 Indomethacin Indomethacin results in decreased expression of ATP8B1 mRNAdecreases expression 16984733
D019810 Sodium Azide Sodium Azide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNAincreases expression 19407337
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of ATP8B1 mRNAdecreases expression 17681415
D010718 Phosphatidylserines ATP8B1 protein results in increased transport of Phosphatidylserinesincreases transport 11584374
D010718 Phosphatidylserines Calcium inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D010718 Phosphatidylserines Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D010718 Phosphatidylserines Sodium Azide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D010718 Phosphatidylserines Vanadates inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ATP8B1 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased expression of ATP8B1 mRNAdecreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of ATP8B1 mRNAaffects expression 17440010
D014638 Vanadates Vanadates inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]decreases reaction|increases transport 11584374
D014810 Vitamin E Vitamin E results in decreased expression of ATP8B1 mRNAdecreases expression 19244175
D015215 Zidovudine Zidovudine results in decreased expression of ATP8B1 mRNAdecreases expression 16894629
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.699612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4220127859 20464547
MESH:D000230 Adenocarcinoma Indomethacin 4.4216537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.773712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.776695378
MESH:D000236 Adenoma Indomethacin 10.7711497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3516434500
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2417225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6817627676 15579461
MESH:D001014 Aortic Aneurysm Indomethacin 4.7210231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.2819183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.2810388637
MESH:D018771 Arthralgia Indomethacin 5.042160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7911248219
MESH:D001477 Bartter Syndrome Indomethacin 4.8510684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0319483382
MESH:D001929 Brain Edema Indomethacin 4.9011481608
MESH:D002545 Brain Ischemia Indomethacin 4.2912524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 2.0011237771
MESH:D001943 Breast Neoplasms Indomethacin 2.0017401462
MESH:D002056 Burns Indomethacin 4.5710459503
MESH:D002100 Cachexia Indomethacin 4.8711239499 15625704 16537180 15141370
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.5016011737 10355542 16124888 15700767 16097048 15673190 18705752 15721981 3786805 16227642 16050911 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.5016050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.433581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.4321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.4318788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.4316391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2214736730 18791128 11352223
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.437296757
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.4317341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3920419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.3911237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.3915482327 12636206
MESH:D002386 Cataract Adenosine Triphosphate 4.5315003327
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.617505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.6120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6112371664
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.0712912871
MESH:D002764 Cholecystitis Indomethacin 5.0411181007
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 18.4918590720 7624871 19486331 15500046 18164287 15913567 16629650 12927374
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.4919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.4919486331
MESH:D002779 Cholestasis pirinixic acid 18.4919176532
MESH:C535930 Cholestasis, benign recurrent intrahepatic 1 marker/mechanism 18379143
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.7319407337 10220858
MESH:C535933 Cholestasis, progressive familial intrahepatic 1 marker/mechanism
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6215894690
MESH:D003110 Colonic Neoplasms Indomethacin 2.5711260862 15786552 15936596 15625704 15637740 15963497
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3518059344 12606626 11197048 17054584
MESH:D018352 Coronavirus Infections Indomethacin 5.5917302372
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6818759878 14531868 11298694 2524372 8970840 8156756 12868966 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.373621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6616285004
MESH:D003967 Diarrhea Indomethacin 3.677907874 7237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 8.7317522070 20133375 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.7316192314 18692083 9328219 9653073 6679447 9022650 8291058 7440962 18289764 11289319 1440618 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.733732212 10915739 19085960 21278145 3786805 7440962 7120509 2869522 9327722 11566570 16177239 6623471 4309450 7179309 16227642 15027814 15968718 15998439 19336974 10092053 17522070 6884620
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.7315131321
MESH:D004362 Drug Toxicity Zidovudine 3.9115040536
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0218043480 12774134 18446180 16133044 17190690 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.0117045617 10671773 17151854 11595431 17329845 17202747 11535926 11991626 16699067 11595415 17351913
MESH:C538011 Eales disease Vitamin E 4.579068938
MESH:D004487 Edema Indomethacin 10.9219703484 7907874 8273558 16100529 8985016 10653021 7990266
MESH:D004487 Edema perfluorooctanoic acid 10.9217259670 12083418
MESH:D004487 Edema pirinixic acid 10.9212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8115138306
MESH:D004715 Endometriosis Indomethacin 4.0315652904
MESH:D019446 Endotoxemia Indomethacin 4.3718509659
MESH:D004751 Enteritis Indomethacin 4.6210567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8517980183
MESH:D004802 Eosinophilia Indomethacin 3.9211298111
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.1216530937
MESH:D004938 Esophageal Neoplasms Indomethacin 10.1211005569
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.7916239168 61145 15959796 19224547 17595544 12631006 16045604 12795759
MESH:D005234 Fatty Liver Cyclosporine 17.7919224547
MESH:D005234 Fatty Liver pirinixic acid 17.7920131406 19236843
MESH:D005234 Fatty Liver Zidovudine 17.7918299183
MESH:D005334 Fever Indomethacin 4.0011852909 17627676 10431976
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.896705139
MESH:D005354 Fibrosarcoma Indomethacin 4.7610962813
MESH:D005355 Fibrosis Carbon Tetrachloride 14.1118705752
MESH:D005355 Fibrosis Cyclosporine 14.1112168785 12639820
MESH:D005355 Fibrosis Indomethacin 14.1117994277
MESH:D005499 Folliculitis Indomethacin 5.0411298111
MESH:D005756 Gastritis Indomethacin 4.6215046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D005909 Glioblastoma Indomethacin 3.4812870263
MESH:D005910 Glioma Indomethacin 3.1716487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1811849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.917505956
MESH:D006073 Gout Indomethacin 5.2211248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.6515482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4620471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.4616080930
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006402 Hematologic Diseases Zidovudine 4.5912579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4515633222
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 15.0518590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 15.056705139
MESH:D006505 Hepatitis Carbon Tetrachloride 15.0519900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5515135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 8.273609246
MESH:D006529 Hepatomegaly pirinixic acid 8.2716221962 18467677 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D015658 HIV Infections Zidovudine 3.4217358032 11363243 11141242 11698656 20032539
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6217440010
MESH:D019584 Hot Flashes Vitamin E 3.8414716179
MESH:D006930 Hyperalgesia Indomethacin 7.9112727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.9112083418
MESH:D034321 Hyperamylasemia Indomethacin 5.5917883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006940 Hyperemia Indomethacin 4.8712524144
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006949 Hyperlipidemias Indomethacin 4.0417546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8115034207
MESH:D006973 Hypertension Cyclosporine 2.0510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007077 Ileal Diseases Indomethacin 4.9018306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2210647630 16133968 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2416133044
MESH:D007249 Inflammation Indomethacin 5.347812673 3291741 12568917
MESH:D007249 Inflammation perfluorooctanoic acid 5.3412083418
MESH:D007251 Influenza, Human Vitamin E 4.0916624496
MESH:D007333 Insulin Resistance pirinixic acid 7.0316306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.0314714311
MESH:D007410 Intestinal Diseases Indomethacin 4.2017329856 18236018 11713966 17994277 15831440 11686837 10210152 15610444 11855677
MESH:D019586 Intracranial Hypertension Indomethacin 5.2415241188
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.899022650 8074119
MESH:D007579 Jejunal Diseases Indomethacin 4.9010574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 9.718314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 9.7117190690
MESH:D007674 Kidney Diseases Vitamin E 9.7112488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.8512371664
MESH:D007680 Kidney Neoplasms Zidovudine 11.8512579204
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9216316344
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8012228301 11703811 10320625
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2920370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8310785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6118360721
MESH:D007964 Leukocytosis Indomethacin 5.2416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5917980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.108812269
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5911479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7416221502 17157831 17174718 16943688 11408273 11903743 16239168 17334410 21278145
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8518395914 16136751 17714472 14748882 17766677 17761835 18412020 17481882 17631135 17557913 18376398 17869086 15818738 18472332 12741479 12649538 15123356 18472094 13678700 15673190 18187930 18277467 15362042 15925388 12958196 12546737 12632512 18210741 16192424 15730626 12586293 15931870 15996030 16248980 18205269 15338365 18339082 17805973 18251166 16638106 17525996 17708605 15893842 12632514 12445418 12898905 18166357 17922224 14716496 18481824 12667390 18156304 16027843 18279442 15052691 18317297 15959796 17976157 12389079 17900296 18420326 18429990 16116963 16011737 14620537 17944888 17823541 16033810 17640975 12609069 11481614 20821823 18263696 15057751 12666154 14512876 15650968 18418968 16097048 15370692 17565644 12445421 14716833 17721639 18395095 15876570 16015684 18054572 18006644 10355542 14724832 17698563 18705752
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.8518194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.8516169303
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 4.3617184895
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3617285989 16246199 16964402 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5716899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.7218177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.7220195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.7219294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.7218709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 13.7215890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.39598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.398603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3915583823 12014681
MESH:D008171 Lung Diseases Vitamin E 3.0916863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8917365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.4414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4418569708 20064080 18816296 6695378 20464547 18520028 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms Indomethacin 6.4416537180 11497255 11053908
MESH:D008175 Lung Neoplasms Vitamin E 6.4411062179
MESH:D008175 Lung Neoplasms Zidovudine 6.4418800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9314737004
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1316966607 18303189 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7117358032
MESH:D008881 Migraine Disorders Indomethacin 3.5811903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3216381670
MESH:D009062 Mouth Neoplasms Indomethacin 8.3212636206
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.753581430
MESH:D009362 Neoplasm Metastasis Indomethacin 5.7511053908 11239499 16537180
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6111141357
MESH:D009369 Neoplasms pirinixic acid 4.6117405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.0110663608 15625704
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1718481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.836679447
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.8312349958
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.829802331
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.046374098
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.304026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.893988306
MESH:D010003 Osteoarthritis Indomethacin 3.597009135
MESH:D010024 Osteoporosis Calcium 3.7017882678
MESH:D010146 Pain Indomethacin 3.3617440234 13679232 3291741 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.5512538197 18702446
MESH:D010195 Pancreatitis Indomethacin 3.8017883296 15028970
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.357296757
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5911903285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 5.7320133375
MESH:D010437 Peptic Ulcer Indomethacin 5.0211148446
MESH:D010518 Periodontitis Indomethacin 4.7817225004
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.346228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7610923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.1112371664
MESH:D047928 Premature Birth Indomethacin 5.0017000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.2717132714
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6515572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1112479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1118760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1115084515
MESH:D011507 Proteinuria Indomethacin 4.0411849393
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9817365031 17975199 17322281 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.283692021
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3119755658 10029692
MESH:D013272 Stomach Diseases Indomethacin 4.2910192188 16184426 16280098 17160473 16113693 17207306 18209964 15472012 10486359 17638125 10215738 15038085 18545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4320155912 2093021
MESH:D013274 Stomach Neoplasms Indomethacin 3.4315609394
MESH:D013274 Stomach Neoplasms Zidovudine 3.4317696246
MESH:D013276 Stomach Ulcer Indomethacin 3.4717627676 11906479 15255614 10750652 12500499 16150113 11729361 1323529 18299717 10423059 16397915 17918041 12467913 18543354 11595415 17135157 12077510 16169175 18431645 18209962 18087811 17654042 16755016 16631530 15104355 12787963 14567935 17977527 18181030 17657623 12498302 18726076 18237397 18193104 16252198 10878458 11145282 17895592 15138204 11595431 11523592 16934674
MESH:D020521 Stroke Vitamin E 3.4116517955
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.6420133375
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.013712494 6582329 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms Indomethacin 7.0111352223 14736730 18791128
MESH:D014456 Ulcer Indomethacin 4.7610574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.808074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8017053015
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6312579204
MESH:D014839 Vomiting Indomethacin 4.6211897121
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA265
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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