AutismKB 2.0

Annotation Detail for PFKFB3


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Basic Information Top
Gene Symbol:PFKFB3 ( FLJ37326,IPFK2,PFK2 )
Gene Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Band: 10p15.1
Quick LinksEntrez ID:5209; OMIM: 605319; Uniprot ID:F263_HUMAN; ENSEMBL ID: ENSG00000170525; HGNC ID: 8874
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of PFKFB3 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of PFKFB3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PFKFB3 mRNAincreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PFKFB3 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of PFKFB3 mRNAdecreases expression 16835338
D001241 Aspirin Aspirin results in decreased expression of PFKFB3 mRNAdecreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PFKFB3 mRNAincreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PFKFB3 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of PFKFB3 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNAaffects cotreatment|decreases expression 16931933
D004041 Dietary Fats Dietary Fats results in decreased expression of PFKFB3 mRNAdecreases expression 18042831
18457598
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PFKFB3 mRNAincreases expression 20360939
D004958 Estradiol Estradiol results in decreased expression of PFKFB3 mRNAdecreases expression 20106945
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNAaffects cotreatment|decreases expression 16931933
C119620 kenpaullone kenpaullone results in decreased expression of PFKFB3 mRNAdecreases expression 17993264
C041786 palm oil palm oil results in decreased expression of PFKFB3 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of PFKFB3 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of PFKFB3 mRNAincreases expression 17426115
C025299 polyphenols polyphenols results in decreased expression of PFKFB3 mRNAdecreases expression 16293270
D011374 Progesterone Progesterone results in decreased expression of PFKFB3decreases expression 17510236
D011794 Quercetin Quercetin results in increased expression of PFKFB3 mRNAincreases expression 19729006
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNAaffects cotreatment|increases expression 19059307
C010327 salinomycin salinomycin results in decreased expression of PFKFB3 mRNAdecreases expression 19682730
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNAaffects cotreatment|decreases expression 16931933
C009250 sevoflurane sevoflurane affects the expression of PFKFB3 mRNAaffects expression 15967596
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PFKFB3 mRNAdecreases expression 17884332
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PFKFB3 mRNAdecreases expression 19933214
D014638 Vanadates Vanadates results in increased expression of PFKFB3 mRNAincreases expression 15297373
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNAaffects cotreatment|decreases expression 16931933
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of PFKFB3 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.7418287403
MESH:D000138 Acidosis Zinc Sulfate 9.747265320
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.579612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.8818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0511473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.136695378
MESH:D000236 Adenoma Diethylnitrosamine 6.1310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.6818056438 19052882 17162532 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.6817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.6816835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9517306315
MESH:D000419 Albuminuria Raloxifene 4.3417308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0017084956
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D000860 Anoxia Zinc Sulfate 4.767265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.7916251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 3.6315238619
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.4820485159 12372130
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7115336622
MESH:D050197 Atherosclerosis Arsenic 3.1019371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.1519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 10.1115665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 10.1116580743
MESH:D001932 Brain Neoplasms Aspirin 4.1915481559
MESH:D001943 Breast Neoplasms Aspirin 7.9915161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.9917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 7.9920435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.9917474063
MESH:D001943 Breast Neoplasms Estradiol 7.9912948864 17261762 18497071 19861407 17289903 14630087 17018787 16675129
MESH:D001943 Breast Neoplasms Progesterone 7.9916175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 7.9918628248
MESH:D001943 Breast Neoplasms Raloxifene 7.9917440819 17261762 17242785 17952589 17049068 16912660 16837676 15572757 17595753 15758505 15775269 17893378
MESH:D001943 Breast Neoplasms salinomycin 7.9919682730
MESH:D001943 Breast Neoplasms Tamoxifen 7.9918984771 19189212 18629630 18815881 18351453 21152245 18855134 21138602 16202921 19103187 15668708 19221464 16818667 16273361 19142967 19410462 19115204 17893378 19066611 19200415 20065188 16873071 19289846 19244106 18425577 19288272 11161223 20390343 15565566 17261762 19155303 19059307 18997820 17242785 20005174 17440819 20544844 17049068 20135344 19189210 19011961 19487384 18821012 20859285 19084267
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.9920435547
MESH:D002105 Cadmium Poisoning Quercetin 5.2816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4515504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2519066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.393084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.3916507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.3918506893 17173139 16569478 18785209 17055752 20101231 3084413 16288022 18210153 18056438 18393292 3581430 16540662 17138121 18788625 19335982 16935385 20512989 20727157 18494052 19701751 19822196 20214788 17428255 16830150 20432363 20514400 18665156 19539802 20084675 19919837 19171122 10672840 19107877 18978308 18971187 16878318 19418558 16328049 19394651 16502159 19383236 19052882 20524982 19208518 17978847 11831363 17761372 16681979 19519916 20007298 18691550 21159647 10737359 20935162 16807293 17162532 16698587 16779866
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.3920935162 6705139 20007298 17173139 1701930
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.3919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3916924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7017234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.4518922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4520419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 14.6018640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 14.6017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 14.6017572228
MESH:D006332 Cardiomegaly Quercetin 6.3219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 6.9617938729 19152805 15738583
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.0916973168 18022660
MESH:D002386 Cataract Acetaminophen 2.4310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.5320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.5312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.5317174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.5318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5916835633
MESH:D002779 Cholestasis Cyclosporine 7.1219486331
MESH:D002779 Cholestasis pirinixic acid 7.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.998697196 15668235 16354765 12621046 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.3615800139
MESH:D003110 Colonic Neoplasms Aspirin 5.7412411196
MESH:D003110 Colonic Neoplasms polyphenols 5.7416293270
MESH:D003110 Colonic Neoplasms Quercetin 5.7416640504 19440933 19056647 17148506 17191121 11134977 15741050
MESH:D015179 Colorectal Neoplasms Aspirin 2.8817047198
MESH:D015179 Colorectal Neoplasms Quercetin 2.8818095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5219496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9917107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.7519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.7517308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.7519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3019416960 12153990 17522070 10915739 18071297 17562736 12705907 14550746 12958197 12540782 15619225 11529661 14725611 19923254 16227642 2444490 12392966 17906064 19420014 11743745 19085960 19164858 10774834 11739529 16781746 11287661 11834606 16485898 16109766 10663392 15968718 12594235 16081117 16393943 16177239 18713872 11421492 19739265 14986274 19370779 11461765
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3019107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 8.3019370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Lamivudine 12.7615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.7611462148
MESH:D004362 Drug Toxicity Zidovudine 12.7615040536
MESH:D050171 Dyslipidemias Dietary Fats 3.2718367378
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:D004487 Edema Aspirin 14.5517259670
MESH:D004487 Edema pirinixic acid 14.5512083418
MESH:D004487 Edema Raloxifene 14.5515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.9817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.9815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.9819031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.8219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.8220544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.179294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.613922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Cyclosporine 33.3619224547
MESH:D005234 Fatty Liver Dietary Fats 33.3617967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 33.3620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 33.3619236843 20131406
MESH:D005234 Fatty Liver Raloxifene 33.3617473493
MESH:D005234 Fatty Liver Tamoxifen 33.3619224547 14986274
MESH:D005234 Fatty Liver Zidovudine 33.3618299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9219069698
MESH:D005355 Fibrosis Cyclosporine 19.0312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 19.0318296743
MESH:D005355 Fibrosis Quercetin 19.0319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.0320067830
MESH:D005534 Foot Diseases Arsenic 5.296392382
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Aspirin 7.0412870263
MESH:D005909 Glioblastoma Quercetin 7.0419804834
MESH:D005910 Glioma Quercetin 2.9517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006261 Headache Aspirin 4.6915240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9911294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006402 Hematologic Diseases Zidovudine 4.4712579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006509 Hepatitis B Lamivudine 4.8617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.8612044531 16476009 15274664 15631357 15309715
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.7417063115
MESH:D006529 Hepatomegaly Phenobarbital 12.8916109766
MESH:D006529 Hepatomegaly pirinixic acid 12.8919176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.8915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D015658 HIV Infections Indinavir 14.3915388451 11141242 11363243
MESH:D015658 HIV Infections Lamivudine 14.3911141242 20032539 9296927 17530837
MESH:D015658 HIV Infections Saquinavir 14.3911141242 15388451
MESH:D015658 HIV Infections Zidovudine 14.3911363243 17358032 20032539 11141242 11698656
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7815340226 16959395 8697196 16354765 18606429
MESH:D012001 Hyperacusis Aspirin 5.5015240983
MESH:D006930 Hyperalgesia Acetaminophen 2.5016870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3621332399
MESH:D006943 Hyperglycemia pirinixic acid 8.4920558911
MESH:D006943 Hyperglycemia Quercetin 8.4911834736 18262572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2317050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.3721332399
MESH:D006973 Hypertension Arsenic 15.319931084 16076760 11953799
MESH:D006973 Hypertension Cyclosporine 15.3110903974
MESH:D006973 Hypertension Quercetin 15.3118356687
MESH:D006973 Hypertension Raloxifene 15.3115787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.3118850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.2916093927
MESH:D007022 Hypotension Zinc Sulfate 4.237265320
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007249 Inflammation Dietary Fats 18.1820412841
MESH:D007249 Inflammation Diethylnitrosamine 18.1818785209
MESH:D007249 Inflammation polyphenols 18.1816366677
MESH:D007249 Inflammation Progesterone 18.1815869954
MESH:D007249 Inflammation Tamoxifen 18.1819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.1812878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.2416624496
MESH:D007333 Insulin Resistance Dietary Fats 11.3118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.3116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.3116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007627 Keloid Quercetin 4.7017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007642 Keratosis Arsenic 4.7316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 13.1912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.1918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 13.1915618244
MESH:D007674 Kidney Diseases Quercetin 13.1916962696
MESH:D007680 Kidney Neoplasms Cyclosporine 16.0412371664
MESH:D007680 Kidney Neoplasms Estradiol 16.0415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.0418625569
MESH:D007680 Kidney Neoplasms Zidovudine 16.0412579204
MESH:D007859 Learning Disorders sevoflurane 4.5219212262
MESH:D007889 Leiomyoma Raloxifene 4.2516973256
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.0515237267
MESH:D007938 Leukemia Quercetin 3.0317468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.1820370541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.3817339181
MESH:D008064 Lipidoses Tamoxifen 2.9717567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 10.1918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.1919638242 20032147 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 10.1921047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.3512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3512878042
MESH:D008107 Liver Diseases Acetaminophen 11.7719014921 16611625 19460945 11587558 12969438 12587719 19784758 16610002
MESH:D008107 Liver Diseases Arsenic 11.7711134558
MESH:D008107 Liver Diseases Diethylnitrosamine 11.7717034775
MESH:D008107 Liver Diseases Phenobarbital 11.7719363144
MESH:D008107 Liver Diseases polyphenols 11.7716698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0117185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 24.1816368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.1821137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.1820137499 19996281 20434301 19642983 12112319 19254457 16942905 2862719 19073162 19638242 20118626 15175105 20492335 19294768 20583210 18648771 12771043 21167192 18978307 19499222 20452335 18977376 19256749 18754104 2422723 18644402 20405173 19690152 21278145 19426721 9163691 21071580 19833225 20101389 19427195 19255062 19812893 20501860 10737359 19551842 15885732 21047994 19090486 19850985
MESH:D008113 Liver Neoplasms Phenobarbital 24.1819812893 19482888 19073162 15975961 8742319 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 24.1815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 24.1818980244
MESH:D008113 Liver Neoplasms Tamoxifen 24.1816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.1816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.7918282651 19009564 21159647 18308698 17174075 19539802 17854601 16842330 19004024 16267830 2563599 9362446 18093689 19519916 3124819 18079962 18253720 18164116 17942915 18775883 18544905 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.7918308698 6150874 2563599 17172636 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.7919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7912151625
MESH:D008175 Lung Neoplasms Arsenic 10.1719168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.1718816296 17053015 18569708 20869020 20464547 20064080 18520028 20135361 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.1720970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Quercetin 10.1716280456
MESH:D008175 Lung Neoplasms Tamoxifen 10.1718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1719555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 10.1718800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.9416891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.9411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 12.9419682730
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.9416827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7619453300
MESH:D008545 Melanoma Tamoxifen 1.8519393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008569 Memory Disorders sevoflurane 4.5019212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5717358032
MESH:D008881 Migraine Disorders Aspirin 3.8815240983
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9916381670
MESH:D009101 Multiple Myeloma Raloxifene 3.2616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009164 Mycobacterium Infections Indinavir 5.1521442799
MESH:D009203 Myocardial Infarction Aspirin 8.9412692751
MESH:D009203 Myocardial Infarction pirinixic acid 8.9419151258
MESH:D009203 Myocardial Infarction Quercetin 8.9419595682
MESH:D017202 Myocardial Ischemia Arsenic 8.3215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0416810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.0419207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009325 Nausea Aspirin 4.9515240983
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.383581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4319410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.4811141357
MESH:D009369 Neoplasms pirinixic acid 7.4817405874
MESH:D009369 Neoplasms Quercetin 7.4815185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.6311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009436 Neural Tube Defects Arsenic 3.2916620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4820387270
MESH:D020078 Neurogenic Inflammation Arsenic 9.8817056641
MESH:D020078 Neurogenic Inflammation Quercetin 9.8817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8520387270
MESH:D009765 Obesity Dietary Fats 4.2017217161 18457598 20518802 18674790 21332399 20132043 16723640 11836018 19632207
MESH:D009765 Obesity pirinixic acid 4.2020558911
MESH:D010003 Osteoarthritis Aspirin 3.907009135
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D010024 Osteoporosis Raloxifene 3.2419059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.3819495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.3817823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 10.6217306315
MESH:D010051 Ovarian Neoplasms Estradiol 10.6219401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.6217393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 10.6219005980
MESH:D010146 Pain Acetaminophen 6.2416870215
MESH:D010146 Pain Aspirin 6.246363464 6995502
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1016540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1016965848
MESH:D010190 Pancreatic Neoplasms Quercetin 8.1016965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.2811156591
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9316093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.736392382 16905509 15371236
MESH:D020795 Photophobia Aspirin 5.5015240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 20.0712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 20.072563599
MESH:D011230 Precancerous Conditions Phenobarbital 20.072563599
MESH:D011230 Precancerous Conditions Quercetin 20.0719056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9311222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Quercetin 1.8817292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011507 Proteinuria Arsenic 3.7621343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.279296927
MESH:D012220 Rhinitis Aspirin 4.1512372130
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.2816862918
MESH:D012640 Seizures Phenobarbital 2.523137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.0112269725
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.6815952646 16759981 17050553 6392382 17453740 16702368 17938729 16353154 17548696 19834688 18709164
MESH:D012878 Skin Neoplasms Arsenic 8.7117029826 16251483 17976673 15504454 19538983 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7116192470
MESH:D013088 Spermatocele Tamoxifen 4.0316709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9915862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2718456281
MESH:D013274 Stomach Neoplasms Zidovudine 3.2717696246
MESH:D020521 Stroke Aspirin 8.3416403987
MESH:D020521 Stroke Raloxifene 8.3416837676
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9817997062
MESH:D013927 Thrombosis Aspirin 4.3017672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.537505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.531399818
MESH:D013978 Tibial Fractures Estradiol 12.8219048282
MESH:D013978 Tibial Fractures Raloxifene 12.8219048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.7019322015 18640142 11144890 15987713 17976673 19429237 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.7017053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 14.7016720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.7017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.7016712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 8.1010982225
MESH:D014581 Urticaria Aspirin 8.1020485159 10982225
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5012579204
MESH:D014652 Vascular Diseases Arsenic 4.4717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015430 Weight Gain Dietary Fats 3.5216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
REACT:474 Metabolism of carbohydrates
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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