AutismKB 2.0

Annotation Detail for PFKL


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Basic Information Top
Gene Symbol:PFKL ( DKFZp686G1648,DKFZp686L2097,FLJ30173,FLJ40909,PFK-B )
Gene Full Name: phosphofructokinase, liver
Band: 21q22.3
Quick LinksEntrez ID:5211; OMIM: 171860; Uniprot ID:K6PL_HUMAN; ENSEMBL ID: ENSG00000141959; HGNC ID: 8876
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCOLYSISglycolysis I
PWY-5484glycolysis II
ANAGLYCOLYSIS-PWYglycolysis III
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa01100Metabolic pathways
hsa00052Galactose metabolism
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Hemolytic anemia due to phosphofructokinase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PFKL mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PFKL mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PFKL mRNAaffects cotreatment|increases expression 18164116
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of PFKL mRNAincreases expression 15912405
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PFKL mRNAincreases expression 15003993
D003345 Corticosterone Corticosterone results in increased expression of PFKL mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of PFKL mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PFKL mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PFKL mRNAaffects cotreatment|increases expression 18164116
C045651 epigallocatechin gallate epigallocatechin gallate results in increased expression of PFKL mRNAincreases expression 16988119
D005485 Flutamide Flutamide analog results in decreased expression of PFKL mRNAdecreases expression 17702527
D005632 Fructose Fructose results in increased expression of PFKL mRNAincreases expression 18346472
D009151 Mustard Gas Mustard Gas affects the expression of PFKL mRNAaffects expression 15651846
C022838 nickel chloride nickel chloride results in increased expression of PFKL mRNAincreases expression 12839937
C041786 palm oil palm oil results in decreased expression of PFKL mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of PFKL mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of PFKL mRNAincreases expression 17426115
C031280 pyrazole pyrazole results in decreased expression of PFKL mRNAdecreases expression 17945193
D012402 Rotenone Rotenone results in decreased expression of PFKL mRNAdecreases expression 17702527
D012643 Selenium Selenium results in increased expression of PFKL mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of PFKL mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PFKL mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PFKL mRNAdecreases expression 15667827
D014810 Vitamin E Vitamin E results in increased expression of PFKL mRNAincreases expression 19244175
D015032 Zinc Zinc results in decreased expression of PFKL mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of PFKL mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.9818287403
MESH:D000138 Acidosis Zinc Sulfate 9.987265320
MESH:D000169 Acrodermatitis Zinc 5.2116889938 17202136 17190629
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000236 Adenoma beta-Naphthoflavone 6.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 6.526695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1617620307 18056438 17162532 19052882 19061943 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.1616835633
MESH:D000544 Alzheimer Disease Zinc 2.7216410023 16325427 16580781 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.7216916123
MESH:D000860 Anoxia Zinc Sulfate 4.837265320
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.7015238619
MESH:D001249 Asthma epigallocatechin gallate 7.7916516891
MESH:D001249 Asthma Mustard Gas 7.7910378619
MESH:D001249 Asthma Zinc 7.7917085522
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.8819761891
MESH:D001768 Blister Mustard Gas 4.9719167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001930 Brain Injuries Zinc 4.5017109824
MESH:D001943 Breast Neoplasms Dietary Fats 1.8420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7810378619 17687719
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9016705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9021159647 16698587 16502159 20935162 17978847 16540662 18506893 19418558 20727157 17162532 19919837 16830150 20214788 19107877 19701751 18494052 19822196 19383236 3581430 19519916 17173139 20524982 18210153 10672840 19335982 20084675 18393292 19394651 16935385 18691550 19171122 20101231 16288022 18665156 17138121 20512989 3084413 11831363 19539802 18785209 19052882 16681979 16328049 20514400 18788625 17055752 20007298 16807293 19208518 18971187 16779866 20432363 17761372 18978308 16569478 10737359 16878318 18056438 17428255
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.8516543248
MESH:D006332 Cardiomegaly Phenylephrine 6.5315728586 16170337 11179087 17287366 17124262 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5318850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Zinc 3.5316936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.406135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.4012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.4021159647 17174075 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis Cyclosporine 7.2919486331
MESH:D002779 Cholestasis pirinixic acid 7.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0316354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Selenium 3.5917936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D003327 Coronary Disease Fructose 4.3518504504
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7319769572
MESH:D019465 Craniofacial Abnormalities Zinc 3.7319302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003920 Diabetes Mellitus Zinc 4.0416479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.3418603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.9320387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 9.9316988119
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 9.9318603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.9317107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.4118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.4119107877
MESH:D056486 Drug-Induced Liver Injury pyrazole 11.4112499123
MESH:D056486 Drug-Induced Liver Injury Selenium 11.4115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:C538011 Eales disease Vitamin E 4.519068938
MESH:D004487 Edema Mustard Gas 10.4311402378 11428631 11428647 9260866
MESH:D004487 Edema pirinixic acid 10.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D004890 Erythema Mustard Gas 4.979357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms Zinc 2.8116543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Cyclosporine 22.8219224547
MESH:D005234 Fatty Liver Dietary Fats 22.8217967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 22.8220387270 21071580
MESH:D005234 Fatty Liver Fructose 22.8218395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 22.8219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005355 Fibrosis Cyclosporine 19.6312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.6318296743
MESH:D005355 Fibrosis Fructose 19.6318504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.6320067830
MESH:D005756 Gastritis Zinc 4.6117241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D018149 Glucose Intolerance Fructose 5.1419165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006130 Growth Disorders Zinc 3.8417217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2410048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.2416080930
MESH:D006333 Heart Failure pirinixic acid 11.1720558911
MESH:D006333 Heart Failure Selenium 11.1717162251
MESH:D006333 Heart Failure Zinc 11.1717162251
MESH:D006335 Heart Injuries Zinc 5.5817074742
MESH:D016481 Helicobacter Infections Zinc 4.3517241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006527 Hepatolenticular Degeneration Zinc 10.6917276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.6917063115
MESH:D006529 Hepatomegaly pirinixic acid 7.6319176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6315340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5517440010
MESH:D019584 Hot Flashes Vitamin E 3.7814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8516354765 15340226 16959395 8697196 18606429
MESH:D017588 Hyperandrogenism Flutamide 5.2715356085
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006946 Hyperinsulinism Fructose 4.7418563319 14757778 18360027 15752949 19008412
MESH:D006949 Hyperlipidemias Dietary Fats 8.9621332399
MESH:D006949 Hyperlipidemias Fructose 8.9615752949
MESH:D006973 Hypertension Cyclosporine 11.8310903974
MESH:D006973 Hypertension Fructose 11.8314573337 14568997 14633139 16843071 19008412
MESH:D006973 Hypertension Phenylephrine 11.838949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.8318670907 18850075
MESH:D015228 Hypertriglyceridemia Fructose 4.9119799862 19342510
MESH:D006984 Hypertrophy Phenylephrine 4.3812791704 18502941
MESH:D007022 Hypotension Zinc Sulfate 4.297265320
MESH:D007249 Inflammation Dietary Fats 11.1520412841
MESH:D007249 Inflammation Diethylnitrosamine 11.1518785209
MESH:D007249 Inflammation Mustard Gas 11.1511428631 11428647 11428620 11402378 9260866 9357497 16001271 17524151 8975870
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1512878042 12200463
MESH:D007251 Influenza, Human Selenium 10.3116624496
MESH:D007251 Influenza, Human Vitamin E 10.3116624496
MESH:D007333 Insulin Resistance Dietary Fats 11.7511836018 18457598
MESH:D007333 Insulin Resistance Fructose 11.7518981581 19008412 18563319 17133782 18057795 14573337 19586609 14757778 14633139 19799862 19342510
MESH:D007333 Insulin Resistance pirinixic acid 11.7516306350
MESH:D007511 Ischemia Zinc 4.4416584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 9.5218776723 8314463 10903974
MESH:D007674 Kidney Diseases Vitamin E 9.5212488133
MESH:D007674 Kidney Diseases Zinc 9.5216960431
MESH:D007676 Kidney Failure, Chronic Selenium 9.5116518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.5116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7612371664
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.1115237267
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2918407596 18522880 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 4.7917481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.7916169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0617034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.467678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.4621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.4620501860 18977376 20434301 19426721 19833225 18754104 19090486 21278145 19256749 19690152 20118626 12112319 19850985 19294768 19996281 18644402 19255062 15175105 2422723 19638242 15885732 19499222 20583210 12771043 18978307 20452335 20492335 16942905 10737359 19073162 19551842 19427195 2862719 19254457 19642983 21047994 20405173 20101389 9163691 18648771 21071580 19812893 21167192 20137499
MESH:D008113 Liver Neoplasms pirinixic acid 13.4616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.156135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.1518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.1519519916 18544905 2563599 16267830 19009564 19126423 18093689 18775883 18164116 18079962 21159647 19539802 17942915 3124819 16842330 18253720 19004024 17174075 9362446 18308698 18282651 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.1512151625
MESH:D008171 Lung Diseases Mustard Gas 7.1218161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.1216863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.6620512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 4.663148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6611884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.6611062179
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 9.4912807724
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.4915318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.4912773700
MESH:D008545 Melanoma epigallocatechin gallate 2.9611746506 17992120
MESH:D008654 Mesothelioma Selenium 2.7215107826
MESH:D024821 Metabolic Syndrome X Fructose 4.6618497449 17261469 19165636 16815490 17098227
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.3017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6718551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.499029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.8617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.7315790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009503 Neutropenia Mustard Gas 3.7916761898 7688884
MESH:D009765 Obesity Dietary Fats 7.2411836018 21332399 17217161 20132043 20518802 18457598 19632207 18674790 16723640
MESH:D009765 Obesity Fructose 7.2417707055 18585860
MESH:D009765 Obesity pirinixic acid 7.2420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2616049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3616540662
MESH:D010300 Parkinson Disease Rotenone 2.9111445065 19114014 11535288 18191903 15451049 18619942 16412576 19232380 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.9115927086 18197244 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D011041 Poisoning Mustard Gas 3.6215727166
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.8315356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.412563599
MESH:D011225 Pre-Eclampsia Zinc 4.0317114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Flutamide 2.873169114
MESH:D011471 Prostatic Neoplasms Vitamin E 2.8715084515
MESH:D011471 Prostatic Neoplasms Zinc 2.8716606632 16517595 12429649 16700911
MESH:D011537 Pruritus Mustard Gas 3.9018058305
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8617266442 17894541 17720292 10334151 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration Zinc 3.9816584753
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4118551238
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012871 Skin Diseases Mustard Gas 4.8612880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 4.8618709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.298532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2916192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D020521 Stroke Vitamin E 3.3716517955
MESH:D013733 Testicular Diseases pyrazole 4.626499806
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.847505956
MESH:D014062 Tongue Neoplasms Zinc 4.2316543248
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1310091137
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
KEGG:00052 Galactose metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00030 Pentose phosphate pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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