AutismKB 2.0

Annotation Detail for PFKP


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Basic Information Top
Gene Symbol:PFKP ( FLJ40226,PFK-C,PFKF )
Gene Full Name: phosphofructokinase, platelet
Band: 10p15.2
Quick LinksEntrez ID:5214; OMIM: 171840; Uniprot ID:K6PP_HUMAN; ENSEMBL ID: ENSG00000067057; HGNC ID: 8878
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCOLYSISglycolysis I
PWY-5484glycolysis II
ANAGLYCOLYSIS-PWYglycolysis III
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa01100Metabolic pathways
hsa00052Galactose metabolism
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PFKP mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PFKP mRNAincreases expression 15084756
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PFKP proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PFKP mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PFKP mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of PFKP mRNAincreases expression 12075121
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PFKP mRNAincreases expression 15003993
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PFKP mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PFKP mRNAaffects expression 17484886
D003024 Clozapine Clozapine results in increased expression of PFKP mRNAincreases expression 15860345
D016572 Cyclosporine Cyclosporine results in increased expression of PFKP mRNAincreases expression 20106945
D002945 Cisplatin PFKP protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in decreased expression of PFKP mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PFKP mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PFKP mRNAincreases expression 12075121
D019833 Genistein Genistein results in increased expression of PFKP mRNAincreases expression 12075121
D006220 Haloperidol Haloperidol results in increased expression of PFKP mRNAincreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in increased expression of PFKP mRNAincreases expression 16807920
C030110 oxaliplatin oxaliplatin results in decreased expression of PFKP mRNAdecreases expression 17762391
C041786 palm oil palm oil results in decreased expression of PFKP mRNAdecreases expression 18042831
D010852 Picrotoxin Picrotoxin results in decreased expression of PFKP mRNAdecreases expression 15170462
C006253 pirinixic acid pirinixic acid results in decreased expression of PFKP mRNAdecreases expression 17426115
D011794 Quercetin Quercetin results in increased expression of PFKP mRNAincreases expression 19729006
D014284 Triiodothyronine Triiodothyronine results in increased expression of PFKP mRNAincreases expression 15507505
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PFKP mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of PFKP mRNAdecreases expression 16604517
D014810 Vitamin E Vitamin E results in increased expression of PFKP mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7712690470 15814532 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7420127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 9.7411798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7414692618
MESH:D000230 Adenocarcinoma Genistein 9.7411473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.236695378
MESH:D000236 Adenoma Diethylnitrosamine 6.2310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.0516434500 19052882 18056438 17620307 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.0516835633
MESH:D000380 Agranulocytosis Clozapine 4.8512649775 16160616 14617031
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0517084956
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7715336622
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001327 Autoimmune Diseases Quercetin 4.2019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D001862 Bone Resorption bisphenol A 3.6711985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.6220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 5.6217123778
MESH:D001943 Breast Neoplasms Cisplatin 5.6218382427 19526202
MESH:D001943 Breast Neoplasms Dietary Fats 5.6220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6217474063
MESH:D001943 Breast Neoplasms Genistein 5.6216541309 17200150 16873071
MESH:D001943 Breast Neoplasms Quercetin 5.6218628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6220435547
MESH:D001943 Breast Neoplasms Tretinoin 5.6216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002105 Cadmium Poisoning Quercetin 5.3316962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.2416192424 16227642 15700767 15673190 15721981 18705752 3786805 10355542 16011737 16124888 16097048 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.2416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.323084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.3212907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.3218788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 16.3217982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.3218971187 17978847 19701751 16807293 19919837 17138121 18665156 11831363 18056438 17428255 10737359 18506893 3084413 20512989 16681979 20935162 19418558 16830150 18788625 19383236 20214788 19822196 16328049 19107877 20727157 19171122 10672840 19539802 20432363 16288022 16502159 16698587 18210153 18978308 16935385 20101231 17055752 19519916 19052882 16779866 18393292 19394651 20514400 19335982 16569478 3581430 18691550 21159647 16878318 20084675 17761372 17173139 19208518 18785209 16540662 18494052 17162532 20524982 20007298
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.3216924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.3212508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.321917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7817123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9616685392 12023789
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7517234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2020419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.2017066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2016096774 16051514
MESH:D006332 Cardiomegaly Quercetin 6.4219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1616332659
MESH:D002375 Catalepsy Haloperidol 4.701977408 15215559
MESH:D002386 Cataract Acetaminophen 6.8210977129
MESH:D002386 Cataract Tretinoin 6.8217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.1321159647 2727394 17174075 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Cyclosporine 12.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4516105132 11677210 15861022 17333356 16919318 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 12.4519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4716354765 15668235 12621046 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003072 Cognition Disorders Clozapine 4.7617123785
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D003110 Colonic Neoplasms Genistein 5.7817182828
MESH:D003110 Colonic Neoplasms oxaliplatin 5.7816024531 16510598 16004971
MESH:D003110 Colonic Neoplasms Quercetin 5.7817191121 15741050 16640504 19056647 19440933 11134977 17148506
MESH:D015179 Colorectal Neoplasms Cisplatin 3.5615273666
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.5617695437 17594712 17401013 17255274 18509181 18448328
MESH:D015179 Colorectal Neoplasms Quercetin 3.5618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.638800419 9211117 9125849 9142499 10589399 16925845 17551590 9224671 9664655 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6319769572
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.6520210726
MESH:D003704 Dementia Haloperidol 4.3911575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5619496084
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 9.8316402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.8320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.8316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.8317107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3415331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4211421492 14725611 12958197 12540782 11834606 18713872 12594235 16485898 17906064 19923254 16177239 19739265 18071297 17562736 19420014 19416960 19085960 12392966 11287661 11461765 15968718 11529661 12705907 16781746 10915739 11743745 16081117 14550746 19164858 19370779 15619225 2444490 17522070 12153990 16227642 10663392 14986274 11739529 16109766 16393943 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.424309450 7120509 19085960 19336974 7440962 3732212 10915739 3786805 6884620 10092053 16227642 9327722 21278145 11566570 17522070 15998439 16177239 15968718 2869522 6623471 7179309 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.4219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Cisplatin 7.6715033597 12231392 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6711462148
MESH:D050171 Dyslipidemias Clozapine 8.3716402076
MESH:D050171 Dyslipidemias Dietary Fats 8.3718367378
MESH:C538011 Eales disease Vitamin E 4.499068938
MESH:D004487 Edema pirinixic acid 5.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9912538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.3816402032
MESH:D016889 Endometrial Neoplasms Genistein 7.1011473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4216530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.4215173087 15464296 16785472 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.2515959796 12631006 16045604 12795759 17595544 19224547 16239168 61145
MESH:D005234 Fatty Liver Cyclosporine 28.2519224547
MESH:D005234 Fatty Liver Dietary Fats 28.2518296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 28.2520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.2515345470
MESH:D005234 Fatty Liver pirinixic acid 28.2520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis Carbon Tetrachloride 31.8118705752
MESH:D005355 Fibrosis Cyclosporine 31.8112639820 12168785
MESH:D005355 Fibrosis Dietary Fats 31.8118296743
MESH:D005355 Fibrosis Quercetin 31.8119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.8120067830
MESH:D005355 Fibrosis Tretinoin 31.8117994277
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Genistein 11.1516598420
MESH:D005909 Glioblastoma Quercetin 11.1519804834
MESH:D005909 Glioblastoma Tretinoin 11.1517312396
MESH:D005910 Glioma Quercetin 2.9717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.4515102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4516096774
MESH:D034381 Hearing Loss Cisplatin 4.1219898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.0620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.0611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 15.0614991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 15.0616080930
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.5719772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5712621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6316863852 16490937
MESH:D006689 Hodgkin Disease Cisplatin 3.4216200630 16170182
MESH:D019584 Hot Flashes Vitamin E 3.7614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 12.2016870215
MESH:D006930 Hyperalgesia oxaliplatin 12.2017418472
MESH:D006930 Hyperalgesia Tretinoin 12.2016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 8.6320558911
MESH:D006943 Hyperglycemia Quercetin 8.6318262572 11834736
MESH:D006948 Hyperkinesis Clozapine 4.7016046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006973 Hypertension Cyclosporine 8.1110903974
MESH:D006973 Hypertension Quercetin 8.1118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3517937319
MESH:D007249 Inflammation Dietary Fats 7.6520412841
MESH:D007249 Inflammation Diethylnitrosamine 7.6518785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6512878042 12200463
MESH:D007251 Influenza, Human Quercetin 10.3616624496
MESH:D007251 Influenza, Human Vitamin E 10.3616624496
MESH:D007333 Insulin Resistance bisphenol A 11.5516393666
MESH:D007333 Insulin Resistance Dietary Fats 11.5518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.5516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4010783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3017551590 15992940
MESH:D007627 Keloid Quercetin 4.7517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9315464296
MESH:D007674 Kidney Diseases Acetaminophen 22.3215629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 22.3215369732
MESH:D007674 Kidney Diseases Cisplatin 22.3218289764 12231392 12649298 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 22.328314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 22.3216962696
MESH:D007674 Kidney Diseases Vitamin E 22.3212488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5712371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5811231351
MESH:D007938 Leukemia Genistein 9.9418980019 17468513
MESH:D007938 Leukemia Quercetin 9.9417468513
MESH:D007938 Leukemia Tretinoin 9.9417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5119285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.4716766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4716331271 17506722 19642359 12679006 19035177 17217047 16788101 17361223 9834237 19225113 17294898 17368321 16766008 17301526 16823087 16891316 15748426 16935935 17649720 19075265 17339181 16140955 17712046 19029980 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Clozapine 3.8117567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3511408273 17157831 16943688 21278145 11903743 17174718 17334410 16239168 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3518522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5112632514 10355542 17766677 12649538 18054572 15052691 18210741 12586293 13678700 17900296 17698563 14716833 16192424 12741479 15931870 17721639 18187930 18395095 14512876 15996030 17640975 20821823 15673190 15959796 17708605 11481614 12445418 18279442 17631135 12609069 17823541 15650968 18412020 15893842 14620537 18472332 18395914 16638106 15370692 18420326 12666154 16033810 15925388 17976157 12445421 14724832 12546737 16027843 18006644 16136751 15730626 14748882 15876570 18705752 16015684 15057751 17557913 16116963 17805973 17869086 12389079 12958196 12667390 18472094 12898905 17944888 18376398 18317297 18418968 18277467 14716496 18429990 15818738 16011737 12632512 17565644 17714472 15123356 18251166 15362042 17525996 18339082 15338365 16097048 18156304 17922224 16248980 18481824 17761835 18166357 18205269 17481882 18263696
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.5117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.5112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5116248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.5116169303
MESH:D008107 Liver Diseases Acetaminophen 6.1412587719 19784758 19460945 12969438 19014921 16611625 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1416964402 15720792 17285989 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8014706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.672125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.6720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.6719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.6719426721 19551842 12112319 18754104 15885732 19499222 19850985 18648771 19255062 19090486 19833225 19254457 9163691 21071580 19256749 2422723 19996281 18977376 20137499 15175105 12771043 20118626 20583210 20452335 10737359 20101389 20492335 19294768 19427195 20501860 21167192 19642983 20405173 2862719 19073162 18978307 21278145 19638242 19690152 19812893 21047994 18644402 16942905 20434301
MESH:D008113 Liver Neoplasms pirinixic acid 20.6720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 20.6718980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.6716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.278603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.2715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.272563599 17854601 18544905 19519916 19539802 18282651 18775883 21159647 19009564 18093689 19004024 16842330 18079962 18308698 17174075 17942915 9362446 19126423 16267830 18164116 3124819 18253720
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.2719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.2712151625
MESH:D008171 Lung Diseases Vitamin E 3.0416863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.2914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.2920464547 17053015 18520028 20064080 18569708 20869020 6695378 18816296 20135361
MESH:D008175 Lung Neoplasms Cisplatin 10.2917225452 11798837 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.2920970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Quercetin 10.2916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.2919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 10.2911062179
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.8112929590 14578162
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Cisplatin 3.3812393984 12374674 12883367 15577323 18505091 16248763 18176117 17023156 11135225 16809738 18332650 17761969 16432458
MESH:D008545 Melanoma Tretinoin 3.3816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D001523 Mental Disorders Clozapine 7.6716856516
MESH:D001523 Mental Disorders Haloperidol 7.6716856516
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.2419142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D009203 Myocardial Infarction Genistein 8.9817141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.9819151258
MESH:D009203 Myocardial Infarction Quercetin 8.9819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.3217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.3216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.3219207477
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.489029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 14.6311141357
MESH:D009369 Neoplasms Cisplatin 14.6316773208
MESH:D009369 Neoplasms pirinixic acid 14.6317405874
MESH:D009369 Neoplasms Quercetin 14.6315185748
MESH:D009369 Neoplasms Tretinoin 14.6316946489 16594593
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2815464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.7911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.7916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.7914600291
MESH:D009421 Nervous System Malformations Tretinoin 21.799125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D009447 Neuroblastoma Cisplatin 3.348761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.498761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.1717929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009765 Obesity Clozapine 7.1518515891 19142110
MESH:D009765 Obesity Dietary Fats 7.1516723640 18674790 18457598 11836018 17217161 20132043 21332399 19632207 20518802
MESH:D009765 Obesity pirinixic acid 7.1520558911
MESH:D010024 Osteoporosis Genistein 3.1319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.4916169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.4919495926
MESH:D010049 Ovarian Diseases bisphenol A 4.7811985600
MESH:D010051 Ovarian Neoplasms Cisplatin 10.796897625 17225452 15464296 19769630
MESH:D010051 Ovarian Neoplasms Genistein 10.7919005980
MESH:D010051 Ovarian Neoplasms Quercetin 10.7919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.7916936753
MESH:D010146 Pain Acetaminophen 6.0316870215
MESH:D010146 Pain Tretinoin 6.0316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.7419003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7416540662
MESH:D010190 Pancreatic Neoplasms Quercetin 11.7416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.3012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.302563599
MESH:D011230 Precancerous Conditions Quercetin 14.3019056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8110548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8111118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8816925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Quercetin 1.8817292933 14715546
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.7511575062
MESH:D011618 Psychotic Disorders Clozapine 8.6615331141
MESH:D011618 Psychotic Disorders Haloperidol 8.6611575062
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5710548101
MESH:D051437 Renal Insufficiency Cisplatin 4.2015464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2314601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.3316862918
MESH:D012559 Schizophrenia Clozapine 3.9920580759 20521326 18806925 20452607 17667964 18855531 20168265 11763009 19369910 16141801 20521320 11151749 20107430 17123785 17726453
MESH:D012559 Schizophrenia Haloperidol 3.9920107430 1830565 18513383 19369910
MESH:D012640 Seizures Picrotoxin 3.868954991 8635557
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.7319755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.738532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7316192470
MESH:D012878 Skin Neoplasms Tretinoin 12.7316467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.552093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.5517522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5518456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.5517261132
MESH:D020521 Stroke Vitamin E 3.3616517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.7716684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.5120210726
MESH:D013736 Testicular Neoplasms Cisplatin 4.4317225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.657505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9417053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 7.9412973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.9416720314
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.9616803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9616129372
MESH:D014591 Uterine Diseases bisphenol A 4.8014652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4015577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Clozapine 9.2420107430 16402076 20564506 17502770 16141801 20521320
MESH:D015430 Weight Gain Dietary Fats 9.2416723640
MESH:D015431 Weight Loss Clozapine 4.8717933447
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
KEGG:00052 Galactose metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00030 Pentose phosphate pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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