AutismKB 2.0

Annotation Detail for PGK2


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Basic Information Top
Gene Symbol:PGK2 ( PGKB,PGKPS,dJ417L20.2 )
Gene Full Name: phosphoglycerate kinase 2
Band: 6p12.3
Quick LinksEntrez ID:5232; OMIM: 172270; Uniprot ID:PGK2_HUMAN; ENSEMBL ID: ENSG00000170950; HGNC ID: 8898
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCOLYSISglycolysis I
PWY-5484glycolysis II
GLUCONEO-PWYgluconeogenesis I
ANAGLYCOLYSIS-PWYglycolysis III
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of PGK2 mRNAincreases expression 19774075
C031280 pyrazole pyrazole results in increased expression of PGK2 mRNAincreases expression 17945193
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.3120041841 18057881 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.2718651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.4519483382
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.9718974383
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.7618218290 15265979
MESH:D056486 Drug-Induced Liver Injury pyrazole 4.7612499123
MESH:D005234 Fatty Liver Amiodarone 4.0714986274
MESH:D006529 Hepatomegaly Amiodarone 4.5115265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.429751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 5.2817991464 18020914
MESH:D008064 Lipidoses Amiodarone 3.8517567588 15342952
MESH:D008133 Long QT Syndrome Amiodarone 3.9617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.6812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.5518516814
MESH:D009181 Mycoses Amiodarone 5.9717974566 12754197
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9911597910 12490602 12832656
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.9718724381
MESH:D013276 Stomach Ulcer Amiodarone 3.8618087811
MESH:D013610 Tachycardia Amiodarone 4.9611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.8619225199
MESH:D013733 Testicular Diseases pyrazole 5.706499806
MESH:D013959 Thyroid Diseases Amiodarone 5.8319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.6218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 5.0817467628 11989578
Pathway ID Pathway Name
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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