AutismKB 2.0

Annotation Detail for PHB


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Basic Information Top
Gene Symbol:PHB ( PHB1 )
Gene Full Name: prohibitin
Band: 17q21.33
Quick LinksEntrez ID:5245; OMIM: 176705; Uniprot ID:PHB_HUMAN; ENSEMBL ID: ENSG00000167085; HGNC ID: 8912
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Diastolic blood pressure
CARDIOVASCULAR
No data
Desease Name
Breast cancer, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PHB mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PHB mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PHB mRNAdecreases expression 12419474
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen promotes the reaction [PHB protein binds to HIC1 promoter]affects binding|increases reaction 19819984
D000082 Acetaminophen Acetaminophen affects the expression of PHB mRNAaffects expression 17562736
D013196 Dihydrotestosterone [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]affects binding|affects cotreatment|increases reaction 18487222
D013196 Dihydrotestosterone PHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]decreases reaction|increases expression|increases reaction 18487222
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PHB mRNAaffects expression 16483693
C053541 bicalutamide AR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]]affects binding|increases reaction 18487222
C053541 bicalutamide bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]affects binding|increases reaction 18487222
C053541 bicalutamide [Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]affects binding|affects cotreatment|increases reaction 18487222
C053541 bicalutamide PHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]decreases reaction|increases expression|increases reaction 18487222
C053541 bicalutamide PHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]]affects binding|increases reaction 18487222
D002713 Chlorine Chlorine results in increased expression of PHB mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of PHB mRNAaffects cotreatment|increases expression 18636392
D003474 Curcumin Curcumin results in decreased expression of PHB proteindecreases expression 19137819
D016572 Cyclosporine Cyclosporine results in decreased expression of PHB mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PHB proteinincreases expression 20935162
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of PHB proteinaffects cotreatment|increases expression 20935162
D002117 Calcitriol Calcitriol results in decreased expression of PHB mRNAdecreases expression 12875902
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PHB mRNAincreases expression 17555576
17942748
16174780
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PHB mRNAincreases expression 16174780
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PHB mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of PHB mRNAdecreases expression 12419474
D015741 Metribolone Metribolone results in decreased expression of PHB proteindecreases expression 17152098
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of PHB mRNAaffects cotreatment|increases expression 18636392
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of PHB proteinaffects cotreatment|increases expression 20935162
C006253 pirinixic acid pirinixic acid results in increased expression of PHB mRNAincreases expression 18301758
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PHB mRNA]increases expression|increases reaction 20059764
D013629 Tamoxifen Tamoxifen affects the expression of PHB mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PHB mRNAincreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PHB proteinincreases expression 12361703
D014212 Tretinoin Tretinoin results in decreased expression of PHB mRNAdecreases expression 12875902
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PHB mRNAaffects expression 21346803
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PHB mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of PHB mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 18.626195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 18.6211752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 18.627525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 18.628875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury Chlorine 8.5020601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.5018653653
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.273712494
MESH:D000236 Adenoma Diethylnitrosamine 6.2710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.1218056438 17162532 17620307 16434500 19052882 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.1217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.1216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.1216835633
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8717887948
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease Curcumin 4.2415590663
MESH:D000544 Alzheimer Disease Ozone 4.2415513908
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9710965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4117497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 7.1616807698
MESH:D001172 Arthritis, Rheumatoid Ozone 7.1615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.1616292516
MESH:D001249 Asthma Ozone 4.7317854713 16373670
MESH:D001249 Asthma Tretinoin 4.7316456186
MESH:D050197 Atherosclerosis Curcumin 3.2018704882
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18396377 18775368 18316065 20603192 17688650 16609825 19460635 18985861 18177632 18558336 17157402 18940202 17507914 19232924
MESH:D001327 Autoimmune Diseases Curcumin 4.2819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8111289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.9717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.588888407
MESH:D002545 Brain Ischemia Curcumin 4.1216770732
MESH:D001932 Brain Neoplasms Curcumin 3.7617596214
MESH:D001943 Breast Neoplasms marker/mechanism
MESH:D001943 Breast Neoplasms Calcitriol 2.8611237771
MESH:D001943 Breast Neoplasms Curcumin 2.8618462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8617474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.8619221464 16273361 15668708 19103187 18351453 20390343 21152245 19410462 18629630 18425577 19155303 17242785 20859285 20005174 15565566 19059307 19011961 18997820 20544844 16202921 19084267 18984771 19200415 17049068 17893378 19066611 18815881 17440819 19189212 18821012 11161223 16818667 17261762 19289846 19288272 19487384 20135344 19244106 19189210 20065188 19115204 21138602 16873071 19142967 18855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8616166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5114754758 18315731 19059883 15516495 16777450 18417511 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002100 Cachexia Ozone 4.5316183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7216050911
MESH:D002277 Carcinoma Curcumin 7.7418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.5516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.553084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.5520101231 18393292 16935385 20524982 16540662 19539802 17162532 19519916 20512989 19171122 19418558 18506893 19822196 10672840 10737359 19052882 18665156 3084413 11831363 17138121 18971187 19208518 16698587 17428255 16779866 20935162 20727157 17761372 21159647 19919837 18691550 20514400 16681979 16878318 18056438 17978847 16502159 18788625 16328049 19394651 18494052 19701751 20432363 16807293 19335982 16288022 20214788 18785209 20007298 17055752 3581430 17173139 19383236 20084675 19107877 18210153 18978308 16830150 16569478
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.556705139 1701930 20935162 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.551917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9118414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.587296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.2711237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.2718462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2716051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3716936243
MESH:D002386 Cataract Acetaminophen 11.7010977129
MESH:D002386 Cataract Tretinoin 11.7017460283
MESH:D002386 Cataract Trinitrotoluene 11.7015817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.327505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.327505956 21159647 17174075 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.9519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9517110522 16919318 17333356 17681005 15861022 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 17.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4715340226 8697196 16354765 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Curcumin 8.9516804969 18200517 16782535
MESH:D003092 Colitis Tretinoin 8.9517035595
MESH:D003103 Coloboma Curcumin 4.3618809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4719359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.6914669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.6915095906
MESH:D016510 Corneal Neovascularization Curcumin 4.6918497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.2016925845 8800419 9211117 9664655 9224671 9125849 9142499 14991402 17551590 10589399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.2016575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.2019769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5418551238
MESH:D003490 Cyanosis Trinitrotoluene 10.5418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6118759878 8156756 12868966 14531868 11298694 8970840 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.303621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.8218403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8217107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.4718204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.7018289764 9022650 18648102 7440962 18692083 11289319 9653073 9328219 8291058 1440618 6679447 6482804 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.7016393943 11834606 19923254 14986274 12594235 16227642 19164858 14725611 11421492 16781746 15619225 16109766 11739529 10663392 10774834 11461765 17562736 18071297 16485898 12540782 15968718 19416960 18713872 11287661 11529661 16081117 11743745 14550746 19420014 17906064 19370779 10915739 2444490 19085960 12392966 12705907 17522070 12153990 12958197 16177239 19739265
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.7019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.7020420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 17.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 17.701733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8517351913
MESH:D004417 Dyspnea Chlorine 4.4120016425
MESH:D004421 Dystonia Phenobarbital 9.781851702
MESH:D004421 Dystonia Valproic Acid 9.781851702
MESH:C538011 Eales disease Vitamin E 4.499068938
MESH:D004487 Edema pirinixic acid 5.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.1715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.1712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.1719031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 11.8019148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.8016202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 11.8016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.103659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.1017275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.2711558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.2716628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.3120417680
MESH:D004827 Epilepsy Valproic Acid 6.3120417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.286401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.286426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.617750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.783659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.783659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.063581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver Curcumin 34.0719297423
MESH:D005234 Fatty Liver Cyclosporine 34.0719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 34.0720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.0715345470
MESH:D005234 Fatty Liver pirinixic acid 34.0720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 34.0714986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 34.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.938888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Curcumin 19.4518705752
MESH:D005355 Fibrosis Cyclosporine 19.4512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.4520067830
MESH:D005355 Fibrosis Tretinoin 19.4517994277
MESH:D005739 Gas Poisoning Chlorine 4.8020016425
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4918462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Curcumin 6.8417596214
MESH:D005909 Glioblastoma Tretinoin 6.8417312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.4318462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.5014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 10.5016080930
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.316705139
MESH:D006529 Hepatomegaly Phenobarbital 18.9916109766
MESH:D006529 Hepatomegaly pirinixic acid 18.9918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.9916120746 15340226 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 18.9915817613
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8317701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.7614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8315340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.0816870215
MESH:D006930 Hyperalgesia Tretinoin 7.0816870215
MESH:D006937 Hypercholesterolemia Curcumin 3.8618704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7315034207
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4216612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4317937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.4312150543
MESH:D007249 Inflammation Curcumin 11.0716956363 18403477 17151092
MESH:D007249 Inflammation Diethylnitrosamine 11.0718785209
MESH:D007249 Inflammation Tamoxifen 11.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0712200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1318200517 18596194
MESH:D007251 Influenza, Human Vitamin E 4.0016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0410783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.819022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 9.3115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.3118776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 9.3112488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.3416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.346582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.3412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 16.3418625569
MESH:D007889 Leiomyoma Curcumin 4.3818555241
MESH:D007938 Leukemia Curcumin 6.1518462866
MESH:D007938 Leukemia Tretinoin 6.1517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0216106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5119285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7517596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7517596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0219075265 19029980 17294898 17217047 17361223 17301526 12679006 16935935 16823087 15748426 19035177 16140955 17649720 19642359 17506722 17339181 16788101 17368321 9834237 17107899 16891316 16331271 17712046 16766008 19225113
MESH:D015458 Leukemia, T-Cell Curcumin 4.5616106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2620032147 18407596 18522880 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.079327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.3818006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3818397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.3816169303
MESH:D008107 Liver Diseases Acetaminophen 8.9319784758 12587719 12969438 16610002 19014921 11587558 19460945 16611625
MESH:D008107 Liver Diseases Curcumin 8.9316956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9317034775
MESH:D008107 Liver Diseases Phenobarbital 8.9319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0516871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.3718754104 20501860 12112319 19090486 20492335 19551842 19690152 18648771 21278145 18977376 19499222 21071580 12771043 19833225 15175105 19073162 20452335 19850985 9163691 2862719 19254457 20434301 19256749 20101389 18644402 19642983 19426721 2422723 20405173 21167192 19638242 19255062 20137499 19427195 10737359 19996281 19812893 20583210 15885732 16942905 19294768 20118626 21047994 18978307
MESH:D008113 Liver Neoplasms Phenobarbital 13.3715975961 8742319 19812893 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 13.3720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 13.3716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.3716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.04598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.043124819 19539802 2563599 18164116 18308698 17942915 17854601 18079962 16842330 16267830 18093689 19009564 9362446 18775883 18282651 18544905 19004024 18253720 19126423 19519916 17174075 21159647
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.0418308698 1399818 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.0412151625
MESH:D008171 Lung Diseases Ozone 7.0519066396 8266340
MESH:D008171 Lung Diseases Vitamin E 7.0516863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0517228818
MESH:D055370 Lung Injury Ozone 3.6420417186
MESH:D008175 Lung Neoplasms Curcumin 8.2118462866 19359593 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2121163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Ozone 8.217614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 8.2118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2111884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 8.2111062179
MESH:D008223 Lymphoma Curcumin 3.4418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4916173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.4911731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.3419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Curcumin 4.9217885582 18462866
MESH:D008545 Melanoma Tamoxifen 4.9212393984 19393235
MESH:D008545 Melanoma Tretinoin 4.9216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008569 Memory Disorders Curcumin 3.9517263510
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008679 Metaplasia Ozone 4.8910496685
MESH:D008881 Migraine Disorders Valproic Acid 3.0418803445 18765137
MESH:D009101 Multiple Myeloma Curcumin 3.3719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.0017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9818551238
MESH:D009336 Necrosis Trinitrotoluene 9.9818551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1718495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.973581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.979029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms pirinixic acid 4.5717405874
MESH:D009369 Neoplasms Tretinoin 4.5716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.1312497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.1319189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8414600291
MESH:D009421 Nervous System Malformations Tretinoin 8.849125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.4218462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.346679447
MESH:D009436 Neural Tube Defects Tretinoin 11.349142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.3416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009765 Obesity Curcumin 4.4219297423
MESH:D009765 Obesity pirinixic acid 4.4220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.1316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.136482804 4026338
MESH:D009784 Occupational Diseases Trinitrotoluene 14.1312819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010024 Osteoporosis Curcumin 3.3418719352
MESH:D010051 Ovarian Neoplasms Curcumin 4.8019020741 18462866
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8016936753
MESH:D010146 Pain Acetaminophen 6.0316870215
MESH:D010146 Pain Tretinoin 6.0316870215
MESH:D010190 Pancreatic Neoplasms Curcumin 11.7217440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7216540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.637296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.6312065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010538 Peritonitis Ozone 3.9216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 12.286228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 12.2811550810
MESH:D011014 Pneumonia Ozone 4.1818007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7611222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.7620603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5715572423
MESH:D011471 Prostatic Neoplasms bicalutamide 1.9017914592 19011039 19240160 15638997 18487222
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9015754350 12479363 16289102 16644109 18247401
MESH:D011471 Prostatic Neoplasms Curcumin 1.9018156803 11398177 10851300 15129424 18226269 12497104 18769126
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9015084515
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 11.4812752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.4812752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.3419168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012120 Respiration Disorders Chlorine 5.0018579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8318379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.223692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.2116283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.2119155313
MESH:D012509 Sarcoma Curcumin 3.9318462866
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 12.9618551238
MESH:D012640 Seizures Phenobarbital 12.963137016 11442880 16876388 4039156
MESH:D012640 Seizures Trinitrotoluene 12.9618551238
MESH:D012640 Seizures Valproic Acid 12.9611044598 17978042 14763951 15475178 1511512 3137016 16876388 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D018805 Sepsis Curcumin 3.9018389075
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.9112065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.9116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6219490988
MESH:D013163 Splenomegaly Trinitrotoluene 4.9915817613
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3718456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3717261132
MESH:D013276 Stomach Ulcer Curcumin 3.3116631530 19188055
MESH:D020521 Stroke Vitamin E 3.3616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.793712494 6582329 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.797505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.791399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.7916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.2616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.268074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.2618593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2616712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.0518462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3515869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33251
    • No data
    Releated disease ID Related disease Name
    PA165111675Drug Resistance
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450761paclitaxel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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