AutismKB 2.0

Annotation Detail for SERPINA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SERPINA1 ( A1A,A1AT,AAT,MGC23330,MGC9222,PI,PI1,PRO2275,alpha1AT )
Gene Full Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Band: 14q32.13
Quick LinksEntrez ID:5265; OMIM: 107400; Uniprot ID:A1AT_HUMAN; ENSEMBL ID: ENSG00000197249; HGNC ID: 8941
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200194FOXA1 transcription factor network
Pathway IDPathway Name
P00011Blood coagulation
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
cystic fibrosis
CARDIOVASCULAR
alpha 1-Antitrypsin Deficiency
alphal-antitrypsin deficiency
heart disease, ischemic
lung function
Serum alpha 1-antitrypsin deficiency
chronic obstructive airways disease.
IMMUNE
alpha 1-antitrypsin indicate a single origin for deficiency allele PI Z
cerebrovascular disease, ischemic
psoriasis
HIV
INFECTION
No data
Desease Name
Emphysema-cirrhosis, due to AAT deficiency
Emphysema due to AAT deficiency
Pulmonary disease, chronic obstructive, susceptibility to
Hemorrhagic diathesis due to 'antithrombin' Pittsburgh
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C041594 4-nonylphenol 4-nonylphenol affects the expression of SERPINA1 mRNAaffects expression 15792627
D000082 Acetaminophen Acetaminophen results in increased expression of SERPINA1 proteinincreases expression 16687475
D000638 Amiodarone Amiodarone affects the expression of SERPINA1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SERPINA1 mRNAaffects expression 16483693
D001194 Asbestos SERPINA1 gene polymorphism results in increased susceptibility to Asbestosincreases response to substance 12368052
14748049
D001553 Benzbromarone Benzbromarone affects the expression of SERPINA1 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SERPINA1 mRNAincreases expression 20440473
C095105 bexarotene bexarotene results in decreased expression of SERPINA1 mRNAdecreases expression 16648578
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of SERPINA1 mRNAdecreases expression 12760830
C034172 chromozym PL SERPINA1 protein affects the metabolism of chromozym PLaffects metabolic processing 6333300
D002994 Clofibrate Clofibrate affects the expression of SERPINA1 mRNAaffects expression 19483382
D003561 Cytarabine Cytarabine results in increased expression of SERPINA1 mRNAincreases expression 19194470
C014347 decitabine decitabine results in increased expression of SERPINA1 mRNAincreases expression 19194470
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in increased expression of SERPINA1 mRNA]affects reaction|increases expression 14699072
D004958 Estradiol Estradiol affects the expression of SERPINA1 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SERPINA1 mRNAincreases expression 19619570
16202921
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SERPINA1 mRNAincreases expression 17557909
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of SERPINA1 proteinincreases expression 10928463
D005001 Ethionine Ethionine affects the expression of SERPINA1 mRNAaffects expression 19483382
D019833 Genistein Genistein results in decreased expression of SERPINA1 mRNAdecreases expression 12075121
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of SERPINA1 mRNAincreases expression 16849584
D007213 Indomethacin SERPINA1 protein mutant form results in increased susceptibility to Indomethacinincreases response to substance 17006946
C098607 JP8 aviation fuel JP8 aviation fuel affects the expression of SERPINA1 mRNAaffects expression 12539871
C031721 naphthalene naphthalene metabolite binds to SERPINA1 proteinaffects binding 16453347
C031721 naphthalene naphthalene metabolite binds to SERPINA1 proteinaffects binding 15892573
D009853 Omeprazole Omeprazole affects the expression of SERPINA1 mRNAaffects expression 19483382
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid affects the expression of SERPINA1 mRNAaffects expression 17383973
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of SERPINA1 mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of SERPINA1 mRNA]decreases expression|increases reaction 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of SERPINA1 mRNAaffects expression 17383973
C006253 pirinixic acid pirinixic acid results in decreased expression of SERPINA1 mRNAdecreases expression 18467677
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SERPINA1 mRNA]decreases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid affects the expression of SERPINA1 mRNAaffects expression 19483382
C045950 propiconazole propiconazole affects the expression of SERPINA1 mRNAaffects expression 17383973
D011441 Propylthiouracil Propylthiouracil affects the expression of SERPINA1 mRNAaffects expression 19483382
C009277 sodium arsenate sodium arsenate results in decreased expression of SERPINA1 mRNAdecreases expression 16882884
C017947 sodium arsenite sodium arsenite affects the expression of SERPINA1 mRNAaffects expression 17450228
C016104 sodium bichromate sodium bichromate results in decreased expression of SERPINA1 mRNAdecreases expression 12760830
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SERPINA1 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SERPINA1 mRNAincreases expression 15644576
D013853 Thioacetamide Thioacetamide affects the expression of SERPINA1 mRNAaffects expression 19483382
C032910 triadimefon triadimefon affects the expression of SERPINA1 mRNAaffects expression 17383973
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.5320464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 12.5311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.5314692618
MESH:D000230 Adenocarcinoma Genistein 12.5311473722
MESH:D000230 Adenocarcinoma Indomethacin 12.5316537180
MESH:D000236 Adenoma Benzo(a)pyrene 6.196695378
MESH:D000236 Adenoma Indomethacin 6.1911497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5617306315 16712894
MESH:D019896 alpha 1-Antitrypsin Deficiency marker/mechanism 3485249
MESH:D016301 Alveolar Bone Loss Indomethacin 5.0217225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6315579461 17627676
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.5310231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.6019183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.6010388637
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5118057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D018771 Arthralgia Indomethacin 4.822160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7411248219
MESH:D001195 Asbestosis marker/mechanism 12368052
MESH:D050197 Atherosclerosis Asbestos 4.0218795166
MESH:D001281 Atrial Fibrillation Amiodarone 3.6518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001477 Bartter Syndrome Indomethacin 4.6510684365
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.2819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.2819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.2819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.2819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.2819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.2819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.2819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 52.2812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.2819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D001929 Brain Edema Indomethacin 4.6811481608
MESH:D002545 Brain Ischemia Indomethacin 4.0812524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.5320146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 3.5316818667 16344269
MESH:D001943 Breast Neoplasms decitabine 3.5319208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 3.5312948864 16675129 17289903 19861407 17261762 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Genistein 3.5316873071 16541309 17200150
MESH:D001943 Breast Neoplasms Indomethacin 3.5317401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5320435547
MESH:D001987 Bronchiectasis marker/mechanism 7785020
MESH:D002056 Burns Indomethacin 4.3710459503
MESH:D002100 Cachexia Indomethacin 4.6611239499 16537180 15141370 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5316835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 6258829
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.133084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.131701930
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.1316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.1316924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 13.1316391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.1317306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.1317997003
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.0118791128 14736730 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1116247446
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2117341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.9320419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 9.9319215824
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 9.9312636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1818670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7715710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.0716332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7418974383
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.221399818
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 14.228243401
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.2218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.2219524636 20056578
MESH:D002637 Chest Pain Omeprazole 4.7615447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6016835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.6018291259
MESH:D002764 Cholecystitis Indomethacin 4.8211181007
MESH:D002779 Cholestasis marker/mechanism 4117022
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9115861022 16919318 17110522 11677210 17333356 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 6.9119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6612621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate triadimefon 5.6616781842
MESH:D003110 Colonic Neoplasms decitabine 5.5117616700
MESH:D003110 Colonic Neoplasms Genistein 5.5117182828
MESH:D003110 Colonic Neoplasms Indomethacin 5.5115936596 15963497 15637740 11260862 15625704 15786552
MESH:D015179 Colorectal Neoplasms decitabine 2.6818981723
MESH:D015179 Colorectal Neoplasms Indomethacin 2.6817054584 12606626 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7814669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.3717302372
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.7810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 3.7816875885 15834900
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D017453 Dermatitis, Irritant JP8 aviation fuel 6.7817574719
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.0216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1319279558
MESH:D003967 Diarrhea Indomethacin 3.487907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.8612153990 16781746 19370779 17906064 11834606 12705907 16393943 11739529 19085960 19739265 11529661 10663392 19923254 14725611 10774834 11421492 12392966 17522070 19164858 11287661 16227642 16081117 19420014 11461765 12540782 15968718 16177239 11743745 14550746 18713872 12594235 19416960 14986274 18071297 2444490 10915739 16485898 16109766 12958197 17562736 15619225
MESH:D056486 Drug-Induced Liver Injury Amiodarone 10.8618218290 15265979
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 10.8618186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.8620420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 10.8612963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.8116133044 16326151 12774134 18446180 18043480 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 8.4516699067 17045617 17351913 17329845 11595431 11535926 17202747 11991626 10671773 11595415 17151854
MESH:D004381 Duodenal Ulcer Omeprazole 8.4516613094 17151854 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.8216707586
MESH:D004487 Edema Indomethacin 13.9916100529 19703484 8985016 7990266 7907874 10653021 8273558
MESH:D004487 Edema perfluorooctanoic acid 13.9917259670 12083418
MESH:D004487 Edema pirinixic acid 13.9912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7719294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.2516402032
MESH:D016889 Endometrial Neoplasms Estradiol 6.7719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 6.7711473722
MESH:D004715 Endometriosis Indomethacin 8.0915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.099294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.1618509659
MESH:D004751 Enteritis Indomethacin 4.4010567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6517980183
MESH:D004802 Eosinophilia Indomethacin 3.7211298111
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3016530937
MESH:D004938 Esophageal Neoplasms Indomethacin 4.3011005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3716456712
MESH:D005234 Fatty Liver Amiodarone 16.3114986274
MESH:D005234 Fatty Liver Clofibrate 16.3119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.3115345470
MESH:D005234 Fatty Liver pirinixic acid 16.3119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D005334 Fever Indomethacin 3.8317627676 10431976 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.5510962813
MESH:D005355 Fibrosis Indomethacin 7.7217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7220067830
MESH:D005499 Folliculitis Indomethacin 4.8211298111
MESH:D005756 Gastritis Acetaminophen 9.9916983495
MESH:D005756 Gastritis Indomethacin 9.9915046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005909 Glioblastoma Genistein 10.8416598420
MESH:D005909 Glioblastoma Indomethacin 10.8412870263
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 10.8417162496
MESH:D005910 Glioma Indomethacin 3.0916487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0211849393
MESH:D018149 Glucose Intolerance sodium arsenate 4.7719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006073 Gout Indomethacin 5.0111248219
MESH:D006258 Head and Neck Neoplasms decitabine 7.2719215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.2715482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3320558911
MESH:D006470 Hemorrhage marker/mechanism 412531
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 9.9315633222
MESH:D006501 Hepatic Encephalopathy Thioacetamide 9.9318665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 3.8916456712
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3615135802
MESH:D006529 Hepatomegaly Amiodarone 29.4515265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 29.453609246
MESH:D006529 Hepatomegaly pirinixic acid 29.4519772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly propiconazole 29.4517178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 29.4515340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 29.4517178688 17178689
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D015658 HIV Infections therapeutic 17448989
MESH:D006689 Hodgkin Disease Cytarabine 6.9216200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.9212676792
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 11.6216870215
MESH:D006930 Hyperalgesia Indomethacin 11.6212727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.6212083418
MESH:D034321 Hyperamylasemia Indomethacin 5.3717883296
MESH:D006937 Hypercholesterolemia Amiodarone 3.579751232 8137927
MESH:D006940 Hyperemia Indomethacin 4.6612524144
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006949 Hyperlipidemias Indomethacin 3.8517546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.5017991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.5018031379 8137927
MESH:D007077 Ileal Diseases Indomethacin 4.6810574470 18306037
MESH:D007079 Ileitis Indomethacin 5.0116133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.0216133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male decitabine 9.9117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.9117937319
MESH:D007248 Infertility, Male sodium arsenite 9.9115346721 12646999
MESH:D007249 Inflammation Indomethacin 7.393291741 12568917 7812673
MESH:D007249 Inflammation perfluorooctanoic acid 7.3912083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.3912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.4616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.4616306350
MESH:D007410 Intestinal Diseases Indomethacin 3.9917994277 11855677 17329856 18236018 15831440 11686837 15610444 10210152 11713966
MESH:D019586 Intracranial Hypertension Indomethacin 5.0215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3116580747
MESH:D007569 Jaw Abnormalities triadimefon 9.3115834900 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.6818306037 16133968 10574470
MESH:D007674 Kidney Diseases Acetaminophen 16.9712587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 16.9716962696
MESH:D007674 Kidney Diseases Estradiol 16.9715618244
MESH:D007674 Kidney Diseases Indomethacin 16.9717190690
MESH:D007674 Kidney Diseases sodium arsenite 16.9720008137
MESH:D007680 Kidney Neoplasms Estradiol 2.7115610895
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 7.8311703811 12228301 10320625
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 7.8319248655
MESH:D007938 Leukemia decitabine 5.9518980019 19235587
MESH:D007938 Leukemia Genistein 5.9517468513 18980019
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6810785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid decitabine 3.7018454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9418704418 18206229 19387464 19010910 17679729 18460780
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.9418360721
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1218055864
MESH:D007964 Leukocytosis Indomethacin 5.0216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3717980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.898812269
MESH:D008064 Lipidoses Amiodarone 3.2715342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3711479899
MESH:D008103 Liver Cirrhosis marker/mechanism 3485248
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.1117823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.1118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.1115158331 11172339 15362042 18395095 12679928 15474484 18458672 17629604 18606216 18416461 15288472 18295389 16248980 15075984 17127702 18032466 12557150 17355460 15716488 17050028 12891558 12531686 16511523 18380797 15288473 15316131 12085344 11481614 16097051 17292413 16098781 15095483 18615449 15078482 18263696 16126171 10677585 11682029 15334695 15465738 16489207 14739098 18031379 12175628 16343077
MESH:D008107 Liver Diseases marker/mechanism 5095241 17006946 3485248 6600583 4117996
MESH:D008107 Liver Diseases Acetaminophen 8.7012969438 19784758 16611625 19014921 12587719 11587558 19460945 16610002
MESH:D008107 Liver Diseases propiconazole 8.7019363144
MESH:D008107 Liver Diseases Thioacetamide 8.7015158337 18374380 16337175
MESH:D008107 Liver Diseases triadimefon 8.7019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6617185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.6617276928 15313186 15633222 12479984
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.8121137059 20195826
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.8114757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 19.8115890375 16377806 20007298
MESH:D008113 Liver Neoplasms propiconazole 19.8119028983
MESH:D008113 Liver Neoplasms sodium arsenite 19.8115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.8116984957
MESH:D008113 Liver Neoplasms triadimefon 19.8119028983
MESH:D008114 Liver Neoplasms, Experimental propiconazole 8.8617178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.8612151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 8.8617178689
MESH:D008133 Long QT Syndrome Amiodarone 3.3217391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 6.7612587719
MESH:D008171 Lung Diseases sodium arsenite 6.7619095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1318516814
MESH:D055370 Lung Injury naphthalene 4.696834280
MESH:D008175 Lung Neoplasms marker/mechanism 17902193
MESH:D008175 Lung Neoplasms Asbestos 7.9512111688
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.9520464547 20135361 18520028 6695378 17053015 18816296 20869020 18569708 20064080
MESH:D008175 Lung Neoplasms bexarotene 7.9517849452
MESH:D008175 Lung Neoplasms Indomethacin 7.9511053908 11497255 16537180
MESH:D008175 Lung Neoplasms sodium arsenite 7.9517077188 19931552 15276417 16712894 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9519555203 11884234
MESH:D008223 Lymphoma decitabine 3.1819470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8111161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.8215591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.8214578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.1419453300
MESH:D008545 Melanoma decitabine 3.2416505122 17785578
MESH:D008545 Melanoma sodium arsenite 3.2419082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008654 Mesothelioma Asbestos 3.9518709470 16564556 16919927 16319530 18310086
MESH:D008881 Migraine Disorders Indomethacin 3.4411903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8016381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.8012636206
MESH:D009101 Multiple Myeloma decitabine 3.1118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5518186108
MESH:D009181 Mycoses Amiodarone 4.5612754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 3.1916882708 19010910 18608210 19157545
MESH:D009203 Myocardial Infarction Genistein 5.1917141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.6716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.6717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.6716411023
MESH:D009362 Neoplasm Metastasis Indomethacin 3.0311239499 11053908 16537180
MESH:D009369 Neoplasms Benzo(a)pyrene 10.4311141357
MESH:D009369 Neoplasms decitabine 10.4319116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 10.4317405874
MESH:D009369 Neoplasms sodium arsenite 10.4311559025
MESH:D009374 Neoplasms, Experimental Indomethacin 8.1710663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.1720056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.4419196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009421 Nervous System Malformations Estradiol 14.4911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 14.4916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.4914600291
MESH:D009436 Neural Tube Defects sodium arsenate 6.9111749123 18186108 10525206 19446573
MESH:D009436 Neural Tube Defects sodium arsenite 6.9112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.4912349958
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.959802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.959802331
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.826374098
MESH:D010003 Osteoarthritis Indomethacin 3.467009135
MESH:D010024 Osteoporosis Genistein 3.0419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7716169203
MESH:D010051 Ovarian Neoplasms decitabine 10.3619259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 10.3619401270
MESH:D010051 Ovarian Neoplasms Genistein 10.3619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.3615276417 17306315
MESH:D010146 Pain Acetaminophen 5.9016870215
MESH:D010146 Pain Indomethacin 5.9013679232 17440234 3291741 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.3318702446 12538197
MESH:D010190 Pancreatic Neoplasms decitabine 2.6419294695
MESH:D010195 Pancreatitis Indomethacin 3.6115028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010201 Panniculitis, Nodular Nonsuppurative marker/mechanism 6982619 3259592
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.8312349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010437 Peptic Ulcer Indomethacin 4.8111148446
MESH:D010518 Periodontitis Indomethacin 4.5717225004
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.3017105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.2521297632
MESH:D047928 Premature Birth Indomethacin 4.7917000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.5417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5411222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.3917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1415378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011507 Proteinuria Indomethacin 3.8511849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.9816919318 15861022
MESH:D029424 Pulmonary Disease, Chronic Obstructive marker/mechanism 16278826
MESH:D011656 Pulmonary Emphysema marker/mechanism 3485249
MESH:D011658 Pulmonary Fibrosis marker/mechanism 72955
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7212490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.0919155313
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7418724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.4410029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 8.4418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.4416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6016709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013272 Stomach Diseases Indomethacin 9.3418545984 18209964 17638125 17160473 16280098 10215738 16113693 10486359 16184426 15038085 15472012 17207306 10192188
MESH:D013272 Stomach Diseases Omeprazole 9.3418545984
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2520155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.2519037991
MESH:D013274 Stomach Neoplasms Indomethacin 3.2515609394
MESH:D013276 Stomach Ulcer Amiodarone 10.4718087811
MESH:D013276 Stomach Ulcer Indomethacin 10.4711595415 11729361 18181030 17135157 16934674 12077510 17657623 17895592 15255614 11145282 10423059 18087811 11523592 14567935 16631530 18543354 10878458 17918041 18193104 15138204 12500499 18299717 16252198 18431645 17977527 10750652 11906479 16150113 11595431 18237397 16169175 12467913 18209962 16755016 12787963 12498302 1323529 15104355 18726076 17627676 17654042 16397915
MESH:D013276 Stomach Ulcer Omeprazole 10.4710750652 16755016 11906479 18237397 17977527 15991576
MESH:D013610 Tachycardia Amiodarone 3.9711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 10.0711994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 10.0711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9012697716
MESH:D013964 Thyroid Neoplasms decitabine 15.1217967635
MESH:D013964 Thyroid Neoplasms Indomethacin 15.1211352223 18791128 14736730
MESH:D013964 Thyroid Neoplasms Propylthiouracil 15.1215710170
MESH:D013964 Thyroid Neoplasms triadimefon 15.1217178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.5319584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8517467628 11989578
MESH:D014456 Ulcer Indomethacin 4.5517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.5417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.5419087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.5411723127 16712894 17306315 16452187
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9814692618
MESH:D014604 Uveal Neoplasms decitabine 4.5717785578
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D014657 Vasculitis marker/mechanism 1684994
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 9.8214671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 9.8215869587
MESH:D014839 Vomiting Indomethacin 4.4011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01998 - 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol
DB03345 - 2-Sulfhydryl-Ethanol
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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