AutismKB 2.0

Annotation Detail for SERPINA4


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Basic Information Top
Gene Symbol:SERPINA4 ( KAL,KLST,KST,PI4,kallistatin )
Gene Full Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
Band: 14q32.13
Quick LinksEntrez ID:5267; OMIM: 147935; Uniprot ID:KAIN_HUMAN; ENSEMBL ID: ENSG00000100665; HGNC ID: 8948
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SERPINA4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SERPINA4 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SERPINA4 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of SERPINA4 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SERPINA4 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of SERPINA4 mRNAaffects expression 19483382
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of SERPINA4 mRNAdecreases expression 19737606
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA4 mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SERPINA4 mRNAdecreases expression 20106945
D002994 Clofibrate Clofibrate affects the expression of SERPINA4 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of SERPINA4 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA4 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of SERPINA4 mRNAdecreases expression 19638242
D005001 Ethionine Ethionine affects the expression of SERPINA4 mRNAaffects expression 19483382
D007657 Ketone Bodies Ketone Bodies results in decreased expression of SERPINA4 mRNAdecreases expression 16807920
D009853 Omeprazole Omeprazole affects the expression of SERPINA4 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of SERPINA4 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in decreased expression of SERPINA4 mRNAdecreases expression 16940010
D011441 Propylthiouracil Propylthiouracil affects the expression of SERPINA4 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SERPINA4 mRNAdecreases expression 20106945
D013853 Thioacetamide Thioacetamide affects the expression of SERPINA4 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9720464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 11.066695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.0619389873
MESH:D000236 Adenoma Diethylnitrosamine 11.066695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.0819052882 18056438 17162532 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7618218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.8718651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 57.8419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 57.8419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 57.8419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 57.8419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 57.8419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 57.8419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 57.8419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 57.8412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 57.8419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.3216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.3216705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.3212907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 11.321701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.3220084675 18056438 18788625 18691550 17173139 16681979 16807293 3581430 19519916 21159647 17978847 10672840 16288022 20512989 17761372 16328049 19052882 20727157 3084413 18978308 18506893 16779866 17428255 18971187 20524982 16830150 19701751 11831363 17138121 18665156 18210153 16540662 16878318 16935385 19171122 19418558 19394651 19822196 19919837 19208518 20935162 17162532 18785209 20214788 19539802 16698587 18393292 20101231 20007298 16569478 19107877 19383236 17055752 16502159 18494052 20432363 19335982 10737359 20514400
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.3217997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0420419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0518974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.806135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 15.801399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.8012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.807505956 2727394 17174075 21159647
MESH:D002637 Chest Pain Omeprazole 5.0815447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.9019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.9016835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 15.9018291259
MESH:D002779 Cholestasis Cyclosporine 7.6519486331
MESH:D002779 Cholestasis pirinixic acid 7.6519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 8697196 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.1121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.1115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.1119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.1120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 15.1112963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.2916613094 15991576 21218061 17151854
MESH:D050171 Dyslipidemias Clofibrate 4.0316707586
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005218 Fat Necrosis Thioacetamide 5.6916456712
MESH:D005234 Fatty Liver Amiodarone 24.2414986274
MESH:D005234 Fatty Liver Clofibrate 24.2419224547
MESH:D005234 Fatty Liver Cyclosporine 24.2419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2421071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 24.2419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Cyclosporine 8.3512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5317276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 4.1716456712
MESH:D006529 Hepatomegaly Amiodarone 14.1915265979
MESH:D006529 Hepatomegaly pirinixic acid 14.1918467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1916120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 15340226 16959395 18606429 8697196
MESH:D006937 Hypercholesterolemia Amiodarone 3.839751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 11.4818020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.4818031379 8137927
MESH:D007249 Inflammation Diethylnitrosamine 4.8218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.3118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1512371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0619248655
MESH:D008064 Lipidoses Amiodarone 3.4817567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8018665156 18522880 18407596 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4418263696 18458672 17292413 15078482 15158331 16126171 18615449 15316131 12085344 11682029 17127702 15095483 12557150 18295389 16511523 18032466 18606216 14739098 15716488 15288473 18395095 15334695 16343077 11172339 15075984 16248980 18031379 15474484 18380797 17629604 18416461 12679928 11481614 16098781 17050028 12891558 15465738 16097051 15288472 16489207 12175628 10677585 17355460 12531686 15362042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2617034775
MESH:D008107 Liver Diseases Thioacetamide 4.2618374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2715633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.677678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.6718177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.6721137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.6721295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.6720452335 15885732 19638242 19642983 18644402 19254457 20137499 20583210 20492335 2422723 12771043 19090486 9163691 19073162 12112319 20101389 19812893 19850985 21278145 20434301 19690152 18648771 19499222 19996281 19426721 19255062 20405173 19551842 19256749 19294768 18754104 15175105 10737359 2862719 16942905 21071580 20501860 19427195 18978307 18977376 20118626 21167192 21047994 19833225
MESH:D008113 Liver Neoplasms pirinixic acid 21.6720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.362876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.368603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.3618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.3619004024 18775883 18282651 19009564 18093689 18164116 17854601 18079962 16842330 17942915 9362446 16267830 19519916 19539802 18308698 18253720 19126423 18544905 2563599 21159647 3124819 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.3612151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5411989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.3412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7820064080 18520028 18816296 17053015 18569708 20135361 6695378 20869020 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7820970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7811884234 19555203
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009181 Mycoses Amiodarone 4.8712754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.2318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.553581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7511141357
MESH:D009369 Neoplasms pirinixic acid 4.7517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.909802331
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.7512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.7516049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.8212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.822563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9917292933
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8412490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7718551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0518724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4016192470
MESH:D013272 Stomach Diseases Omeprazole 4.5818545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.322093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3218456281
MESH:D013276 Stomach Ulcer Amiodarone 7.4418087811
MESH:D013276 Stomach Ulcer Omeprazole 7.4418237397 16755016 10750652 11906479 15991576 17977527
MESH:D013610 Tachycardia Amiodarone 4.2511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1519225199
MESH:D013959 Thyroid Diseases Amiodarone 11.9619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.9612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.307505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.3015710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.1517467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.1716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.1716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.8710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.8710091137
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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