AutismKB 2.0

Annotation Detail for ATP6V0C


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Basic Information Top
Gene Symbol:ATP6V0C ( ATP6C,ATP6L,ATPL,VATL,VPPC,Vma3 )
Gene Full Name: ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Band: 16p13.3
Quick LinksEntrez ID:527; OMIM: 108745; Uniprot ID:VATL_HUMAN; ENSEMBL ID: ENSG00000185883; HGNC ID: 855
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa04145Phagosome
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04966Collecting duct acid secretion
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Signaling by Insulin receptor
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ATP6V0C mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ATP6V0C mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP6V0C mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of ATP6V0C mRNAincreases expression 16648578
D002330 Carmustine Carmustine results in decreased expression of ATP6V0C mRNAdecreases expression 15980968
C099555 CD 437 CD 437 results in decreased expression of ATP6V0C mRNAdecreases expression 12958071
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of ATP6V0C mRNAaffects cotreatment|decreases expression 18636392
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATP6V0C mRNAincreases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in increased expression of ATP6V0C mRNAincreases expression 16221962
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of ATP6V0C mRNAaffects cotreatment|decreases expression 18636392
D010665 Phenylpropanolamine Phenylpropanolamine results in decreased expression of ATP6V0C mRNAdecreases expression 16465460
C488333 Ro 65-7199 Ro 65-7199 results in decreased expression of ATP6V0C mRNAdecreases expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of ATP6V0C mRNAaffects expression 14610520
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury Chlorine 4.4120601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D000855 Anorexia Phenylpropanolamine 5.8017684035
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6617854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001932 Brain Neoplasms Carmustine 4.4616187019
MESH:D001943 Breast Neoplasms bexarotene 2.9916818667 16344269
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7418315731 19059883 18417511 17626835 15516495 16777450 14754758
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.8516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.853084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2516247446
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9317110522 15861022 17333356 16919318 17681005 11677210 16105132
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4312540782 19085960 11529661 16081117 11743745 12705907 18713872 12958197 12153990 16781746 10663392 14725611 2444490 16227642 19739265 11421492 12594235 11834606 10915739 17522070 15619225 16109766 11739529 19416960 14550746 16177239 11287661 18071297 19923254 11461765 17906064 14986274 10774834 16393943 17562736 12392966 19420014 19370779 16485898 15968718 19164858
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 6.4316221962
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004417 Dyspnea Chlorine 4.7620016425
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8915345470
MESH:D005739 Gas Poisoning Chlorine 5.1420016425
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005909 Glioblastoma Carmustine 3.9816187019
MESH:D006529 Hepatomegaly fumonisin B1 4.3716221962
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0416705839
MESH:D008107 Liver Diseases Acetaminophen 1.6512587719 19460945 19784758 12969438 11587558 19014921 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008171 Lung Diseases Ozone 3.4319066396 8266340
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms bexarotene 2.8717849452
MESH:D008175 Lung Neoplasms Ozone 2.878597069 7614698
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.2511161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.4619196723 19196722 15591091
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.9219196722
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5016049721 12819281
MESH:D010051 Ovarian Neoplasms CD 437 3.3417474084
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D011014 Pneumonia Ozone 4.5118007984 18381685 18929643
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D012120 Respiration Disorders Chlorine 5.3518579056
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5116049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.5116720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
Pathway ID Pathway Name
KEGG:04966 Collecting duct acid secretion
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04142 Lysosome
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
REACT:498 Signaling by Insulin receptor
REACT:15518 Transmembrane transport of small molecules
KEGG:05152 Tuberculosis
KEGG:05110 Vibrio cholerae infection
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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