AutismKB 2.0

Annotation Detail for SERPINE2


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Basic Information Top
Gene Symbol:SERPINE2 ( DKFZp686A13110,GDN,PI-7,PI7,PN-1,PN1,PNI )
Gene Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Band: 2q36.1
Quick LinksEntrez ID:5270; OMIM: 177010; Uniprot ID:GDN_HUMAN; ENSEMBL ID: ENSG00000135919; HGNC ID: 8951
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
chronic obstructive pulmonary disease/COPD
chronic obstructive pulmonary disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SERPINE2 proteinaffects expression 20106945
D019386 Alendronate Alendronate affects the expression of SERPINE2 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SERPINE2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of SERPINE2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of SERPINE2 mRNA]affects reaction|decreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SERPINE2 mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SERPINE2 mRNAincreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of SERPINE2 mRNAincreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of SERPINE2 mRNAincreases expression 17547211
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SERPINE2 mRNAaffects expression 17484886
D003024 Clozapine Clozapine results in increased expression of SERPINE2 mRNAincreases expression 15354176
D003024 Clozapine Clozapine results in increased expression of SERPINE2 proteinincreases expression 15354176
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]decreases reaction|increases expression 18200517
D003513 Cycloheximide Cycloheximide results in increased expression of SERPINE2 mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SERPINE2 mRNAaffects cotreatment|increases expression 19684285
D016572 Cyclosporine Cyclosporine results in increased expression of SERPINE2 mRNAincreases expression 20106945
D002945 Cisplatin SERPINE2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D002117 Calcitriol Calcitriol results in increased expression of SERPINE2 mRNAincreases expression 16002434
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of SERPINE2 mRNAincreases expression 17547211
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINE2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SERPINE2 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SERPINE2 mRNAaffects expression 16079270
D005472 Fluorouracil SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
D002955 Leucovorin SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
C051890 irinotecan SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
D001556 Lindane Lindane results in decreased expression of SERPINE2 mRNAdecreases expression 17785943
C008493 methylselenic acid methylselenic acid results in increased expression of SERPINE2 mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas results in increased expression of SERPINE2 mRNAincreases expression 18955075
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SERPINE2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of SERPINE2 mRNAdecreases expression 19270015
19482888
D020849 Raloxifene Raloxifene affects the expression of SERPINE2 mRNAaffects expression 14699072
D020849 Raloxifene Raloxifene affects the expression of SERPINE2 mRNAaffects expression 16079270
D012402 Rotenone Rotenone results in increased expression of SERPINE2 mRNAincreases expression 19013527
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINE2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SERPINE2 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SERPINE2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SERPINE2 mRNAincreases expression 19684285
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNAincreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4214514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.7217670903 12690470 15814532
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.2120127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 16.2111798837 17638652
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 16.2116033868
MESH:D000230 Adenocarcinoma Estradiol 16.2111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 16.2114692618
MESH:D000230 Adenocarcinoma Fluorouracil 16.2117638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.396695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.3919555203
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.2017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2016835633
MESH:D000380 Agranulocytosis Clozapine 4.8014617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1112661182
MESH:D000419 Albuminuria Raloxifene 4.3417451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8117887948
MESH:D000544 Alzheimer Disease Curcumin 4.2315590663
MESH:D000544 Alzheimer Disease Raloxifene 4.2315800139
MESH:D000740 Anemia Fluorouracil 7.9317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6716807698
MESH:D001249 Asthma Mustard Gas 2.6310378619
MESH:D050197 Atherosclerosis Cadmium 6.5415687053
MESH:D050197 Atherosclerosis Curcumin 6.5418704882
MESH:D001327 Autoimmune Diseases Curcumin 4.2319761891
MESH:D001768 Blister Mustard Gas 4.9019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6214601052
MESH:D001930 Brain Injuries Raloxifene 4.2216580743
MESH:D002545 Brain Ischemia Curcumin 4.0716770732
MESH:D001932 Brain Neoplasms Curcumin 3.7117596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5620146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 5.5611237771
MESH:D001943 Breast Neoplasms Cisplatin 5.5619526202 18382427
MESH:D001943 Breast Neoplasms Curcumin 5.5616243823 19250217 18593918 18462866
MESH:D001943 Breast Neoplasms Estradiol 5.5619861407 17289903 14630087 12948864 17261762 17018787 16675129 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 5.5615136595 16595493 19217205 16110121 18357371 18608205 16557594
MESH:D001943 Breast Neoplasms Lindane 5.5614688026
MESH:D001943 Breast Neoplasms Raloxifene 5.5617952589 15572757 15775269 17893378 17595753 16912660 17049068 17440819 17242785 16837676 17261762 15758505
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5620435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7110378619 17687719
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5216124888 15673190 10355542 16192424 3786805 16227642 16097048 15700767 16011737 16050911 18705752 15721981
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4016051944
MESH:D002277 Carcinoma Curcumin 18.2718593918
MESH:D002277 Carcinoma Dimethylnitrosamine 18.2719555203
MESH:D002277 Carcinoma Fluorouracil 18.2717121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 18.2716835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.8012619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.8018788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.8017982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 10.8017971768 16332177 17088986 17045692 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.8017173139 6705139 20007298 1701930 20935162
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.4716685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.4718414057
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 17.0520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 17.0511237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 17.056189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell Curcumin 17.0518462866
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 17.0516033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 17.0516280240 18986760 16757204 17066447
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2715775269
MESH:D002471 Cell Transformation, Neoplastic Cadmium 10.2317332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.2318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Cyclosporine 7.1419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1416919318 15861022 16105132 11677210 17681005 17110522 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9916354765 12621046 15340226 15668235 8697196
MESH:D003072 Cognition Disorders Clozapine 10.8217123785
MESH:D003072 Cognition Disorders Raloxifene 10.8215800139
MESH:D003092 Colitis Curcumin 9.0916804969 16782535 18200517
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.0916804969 16867261 16474422 18023891 11698051 17936198 17991707 16782535 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3517276891
MESH:D003103 Coloboma Curcumin 4.3118809619
MESH:D003110 Colonic Neoplasms arsenite 7.9315037631
MESH:D003110 Colonic Neoplasms Curcumin 7.9319359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 7.9317725105 16340194 18772588 16510598 17169374 15001691 17016597 17018589 17287894 17172411
MESH:D003110 Colonic Neoplasms irinotecan 7.9317287894 17725105
MESH:D015179 Colorectal Neoplasms Cisplatin 4.7015273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.7018448328 17401013 17094418 18509181 15289873 20501625 16282729 14970324 18949393 16303861 17695437 16331619 18288408 18802399 17255274 18383874 17016601 17454858 17594712 15148649 16391804 16524972
MESH:D015179 Colorectal Neoplasms irinotecan 4.7016391804 18259882 17454858 17159606 16303861 15273666 18509181
MESH:D015179 Colorectal Neoplasms Leucovorin 4.7017255274 16303861 17454858 17401013 20501625 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.6418497527
MESH:D019465 Craniofacial Abnormalities Leucovorin 3.0016925845
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.0020055451 10048152 15322242
MESH:D007644 Darier Disease Fluorouracil 4.5316733453
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.8416402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.8418403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8417107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.8218204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.8219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.8215920148 17451421 17308373
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2915331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.8116227642 3732212 6623471 7179309 7440962 10092053 21278145 15027814 17522070 6884620 4309450 10915739 19336974 7120509 15968718 2869522 16177239 15998439 9327722 19085960 11566570 3786805
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 5.818172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8120420201
MESH:D004362 Drug Toxicity Cisplatin 7.5415033597 12649298 12231392 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5411462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8017351913
MESH:D050171 Dyslipidemias Clozapine 4.0016402076
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:D004487 Edema Mustard Gas 10.1911402378 11428631 9260866 11428647
MESH:D004487 Edema Raloxifene 10.1915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.1911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 13.9515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.9515845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.8119148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.809294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004890 Erythema Mustard Gas 4.909357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.8616530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.8615173087 16481741 17638652 16785472 15464296
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.8617016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.8616481741 16337965 16785472 17638652 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver arsenite 27.6618296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.6616239168 16045604 15959796 61145 12631006 19224547 17595544 12795759
MESH:D005234 Fatty Liver Curcumin 27.6619297423
MESH:D005234 Fatty Liver Cyclosporine 27.6619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.6615345470
MESH:D005234 Fatty Liver Raloxifene 27.6617473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005355 Fibrosis arsenite 31.1618296743
MESH:D005355 Fibrosis Carbon Tetrachloride 31.1618705752
MESH:D005355 Fibrosis Curcumin 31.1618705752
MESH:D005355 Fibrosis Cyclosporine 31.1612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.1620067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 31.1617994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4418462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Curcumin 3.3117596214
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.0515102660 15464296
MESH:D006258 Head and Neck Neoplasms Curcumin 12.0518829502 18462866
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.0518337622 15102660 15162350
MESH:D034381 Hearing Loss Cisplatin 4.0819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2115464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9911294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 7.5916109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5912621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7817701891
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006689 Hodgkin Disease Cisplatin 3.3816200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.788697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Alendronate 4.5116769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006937 Hypercholesterolemia Curcumin 3.8218704882
MESH:D006948 Hyperkinesis Clozapine 4.6516046005
MESH:D006973 Hypertension Cyclosporine 7.9910903974
MESH:D006973 Hypertension Raloxifene 7.9915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3217937319
MESH:D007249 Inflammation Curcumin 7.6016956363 17151092 18403477
MESH:D007249 Inflammation Mustard Gas 7.6011428631 16001271 9260866 17524151 11428620 11428647 9357497 8975870 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6012878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.3418200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.3418200517
MESH:D007333 Insulin Resistance Estradiol 2.8016627594 16393666
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3517994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8715464296
MESH:D007674 Kidney Diseases Cadmium 17.4916322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 17.4916962696
MESH:D007674 Kidney Diseases Cisplatin 17.4918289764 12231392 12649298 15190930 19839026
MESH:D007674 Kidney Diseases Cyclosporine 17.4910903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 17.4915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1912371664
MESH:D007680 Kidney Neoplasms Estradiol 11.1915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.1916985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5311231351
MESH:D007889 Leiomyoma Curcumin 10.3518555241
MESH:D007889 Leiomyoma Raloxifene 10.3516973256
MESH:D007938 Leukemia Curcumin 3.1118462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9716106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.5116106398
MESH:D008064 Lipidoses Clozapine 3.7717567588
MESH:D008103 Liver Cirrhosis arsenite 10.2618296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2621278145 16239168 17174718 11903743 17334410 16943688 16221502 17157831 11408273
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2621047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3817823541 17721639 18705752 15893842 12609069 17805973 18166357 12958196 16015684 14724832 18006644 15996030 14748882 15338365 15370692 18376398 17944888 15730626 17708605 17525996 14512876 12667390 18395095 17976157 18472332 18263696 18472094 17714472 14620537 18156304 16136751 18205269 16033810 16027843 17481882 15876570 12445418 15959796 12649538 18429990 14716496 12586293 18277467 12445421 16638106 15673190 15925388 18412020 15818738 13678700 15931870 12898905 12666154 12546737 18054572 18251166 17869086 18210741 17900296 11481614 15057751 12741479 16097048 20821823 17761835 16011737 17922224 18395914 17698563 12632514 12389079 16248980 14716833 15123356 18420326 18317297 18481824 16116963 17640975 18418968 17766677 15362042 18339082 18187930 17565644 17557913 18279442 16192424 12632512 10355542 15052691 17631135 15650968
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.3817355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.3817198567 17203207 15723089 15339415 15744066 17196135 18567088 15366600 18364076 18210741 15793283 15138612 18239293 17881167 15081153 17640959 15571005 17348192 16627068 15298665 17724770 18672772 16042886 18237412 18095165 15161499 16169303 15733078 16009107 15067225 15942678 15086199 14726149 16603200 14568256 15591649 17036385 16270385 15763062 12918455 17201889 12925901 17534399 15842777 16570917 16544323 15383259 14709902 15798949 15864749 17465448 18371158 15492853 14659978 15577212 17666798 18637143 18629640 17432682 15099470 15504291 14643895 17719030 15369754 15479170
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8716964402 15720792 16246199 17285989 15830285
MESH:D008107 Liver Diseases Curcumin 8.8716956363
MESH:D008107 Liver Diseases Lindane 8.871715830
MESH:D008107 Liver Diseases Phenobarbital 8.8719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0814706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.0817457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.3415890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.3420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.3419294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 20.343113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 20.3415113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 20.3421047994 19482888 19812893 8742319 19073162 15975961
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.928603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.9215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 16.9215603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.9218308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.9212151625
MESH:D008171 Lung Diseases Mustard Gas 3.2818161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.7414755239
MESH:D008175 Lung Neoplasms arsenite 14.7416809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.7418816296 17053015 20464547 20064080 20135361 18520028 6695378 18569708 20869020
MESH:D008175 Lung Neoplasms Cisplatin 14.7417225452 11798837 6189445
MESH:D008175 Lung Neoplasms Curcumin 14.7419359593 16243823 18462866
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 14.7419555203 11884234 16061637
MESH:D008175 Lung Neoplasms Fluorouracil 14.7415246190
MESH:D008175 Lung Neoplasms Mustard Gas 14.743148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.7411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5315086387
MESH:D008223 Lymphoma Curcumin 3.4018462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4416173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4016891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D008545 Melanoma Cisplatin 3.5216248763 12393984 18332650 15577323 11135225 18176117 17761969 16432458 12883367 17023156 12374674 16809738 18505091
MESH:D008545 Melanoma Curcumin 3.5218462866 17885582
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5115990972
MESH:D008569 Memory Disorders Curcumin 3.9017263510
MESH:D001523 Mental Disorders Clozapine 3.6916856516
MESH:D008654 Mesothelioma Cisplatin 3.1417638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.2019142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8716757204 18986760
MESH:D052016 Mucositis irinotecan 4.7417159606
MESH:D009101 Multiple Myeloma Curcumin 6.9519372569
MESH:D009101 Multiple Myeloma Raloxifene 6.9516497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6517962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0816810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1218495463
MESH:D009362 Neoplasm Metastasis irinotecan 3.0718259882
MESH:D009369 Neoplasms Benzo(a)pyrene 10.8611141357
MESH:D009369 Neoplasms Cisplatin 10.8616773208
MESH:D009369 Neoplasms Fluorouracil 10.8616928823 18600527 18239605
MESH:D009369 Neoplasms Lindane 10.8616818664 12807735
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2712497104
MESH:D009389 Neovascularization, Pathologic arsenite 9.2715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.2717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2315464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.6817356569 18619942 15790535
MESH:D009421 Nervous System Malformations Estradiol 8.6311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3618462866
MESH:D009447 Neuroblastoma Cisplatin 6.778761367
MESH:D009447 Neuroblastoma irinotecan 6.778761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.598761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.598761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2616436463
MESH:D009503 Neutropenia Mustard Gas 3.737688884 16761898
MESH:D009765 Obesity Clozapine 4.8218515891 19142110
MESH:D009765 Obesity Curcumin 4.8219297423
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D010024 Osteoporosis Alendronate 11.2017882678
MESH:D010024 Osteoporosis Curcumin 11.2018719352
MESH:D010024 Osteoporosis Raloxifene 11.2017882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9815758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Cisplatin 7.5019769630 15464296 6897625 17225452
MESH:D010051 Ovarian Neoplasms Curcumin 7.5018462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 7.5019401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.5919003803
MESH:D010190 Pancreatic Neoplasms Curcumin 11.5919196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.5919003803 15113037 16929163 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.5916965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9617698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010300 Parkinson Disease Rotenone 2.8811445065 18191903 16412576 16140633 11535288 19114014 15451049 19232380 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 3.8515927086 15795934 18197244 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0615464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1215687053
MESH:D010997 Pleural Neoplasms Cisplatin 5.0817638057
MESH:D011041 Poisoning Mustard Gas 3.5615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2412371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.242563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9311118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8617292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.8617075824
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8618247401 15754350 16289102 12479363 16644109
MESH:D011471 Prostatic Neoplasms Curcumin 2.8611398177 12497104 18769126 15129424 18156803 18226269 10851300
MESH:D011471 Prostatic Neoplasms Estradiol 2.8616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.8618626508 19082440
MESH:D011471 Prostatic Neoplasms Lindane 2.8612661182 14688026
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.8616205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8616220300 16536755 15731164
MESH:D011537 Pruritus Ethinyl Estradiol 8.6515861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.6518058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011618 Psychotic Disorders Clozapine 4.0015331141
MESH:D011656 Pulmonary Emphysema Curcumin 4.3019168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317620002 10334151 17266442 17894541 17720292
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7916160472 18722050 15538739 18286688
MESH:D051437 Renal Insufficiency Cisplatin 4.1515464296
MESH:D015427 Reperfusion Injury Leucovorin 4.4617295595
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012509 Sarcoma Curcumin 3.8918462866
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.1814601052
MESH:D012559 Schizophrenia Clozapine 2.7020521320 18855531 11151749 20580759 19369910 17667964 16141801 17726453 17123785 20452607 11763009 20521326 18806925 20168265 20107430
MESH:D012640 Seizures Lindane 5.7412842176 15475178 7539098
MESH:D012640 Seizures Phenobarbital 5.7411442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D018805 Sepsis Curcumin 3.8618389075
MESH:D012871 Skin Diseases Mustard Gas 2.6515451306 16961503 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.6719755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.678532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6716192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0815464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0012587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.1220155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 6.1218396642 15958060 17522103
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.1216033868
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1217522103 19084572 16424979 18567086 15786421 18396642 17172411 17498489 19015929 16951190
MESH:D013274 Stomach Neoplasms irinotecan 6.1215723263
MESH:D013276 Stomach Ulcer Curcumin 3.2716631530 19188055
MESH:D020521 Stroke Raloxifene 3.6216837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.3915464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.861399818
MESH:D013978 Tibial Fractures Estradiol 12.8219048282
MESH:D013978 Tibial Fractures Raloxifene 12.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7616280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.1212973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.1218593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.1217572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.0018462866
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.8916803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.8916803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D014839 Vomiting Cisplatin 4.4511897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015430 Weight Gain Clozapine 4.2517502770 20107430 16402076 16141801 20521320 20564506
MESH:D015431 Weight Loss Clozapine 4.8117933447
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA269
    • No data
    Releated disease ID Related disease Name
    PA447178Pulmonary Disease, Chronic Obstructive
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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