AutismKB 2.0

Annotation Detail for PIK3C2A


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Basic Information Top
Gene Symbol:PIK3C2A ( CPK,DKFZp686L193,MGC142218,PI3-K-C2(ALPHA),PI3-K-C2A )
Gene Full Name: phosphoinositide-3-kinase, class 2, alpha polypeptide
Band: 11p15.1
Quick LinksEntrez ID:5286; OMIM: 603601; Uniprot ID:P3C2A_HUMAN; ENSEMBL ID: ENSG00000011405; HGNC ID: 8971
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Membrane Trafficking
Pathway IDPathway Name
200109Integrins in angiogenesis
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P04398p53 pathway feedback loops 2
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00018EGF receptor signaling pathway
P00005Angiogenesis
P00030Hypoxia response via HIF activation
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PIK3C2A mRNAaffects expression 17562736
D001241 Aspirin Aspirin results in decreased expression of PIK3C2A mRNAdecreases expression 11906190
D001280 Atrazine Atrazine results in increased expression of PIK3C2A mRNAincreases expression 18585445
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PIK3C2A mRNAdecreases expression 20018196
19150397
D003010 Clorgyline Clorgyline results in increased expression of PIK3C2A mRNAincreases expression 19691856
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PIK3C2A mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIK3C2A mRNAaffects cotreatment|increases expression 17942748
D007529 Isoflavones Isoflavones results in increased expression of PIK3C2A mRNAincreases expression 17374662
D017239 Paclitaxel PIK3C2A protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIK3C2A mRNAaffects cotreatment|increases expression 17942748
D013752 Tetracycline Tetracycline results in increased expression of PIK3C2A mRNAincreases expression 16917069
C025643 vinclozolin vinclozolin affects the expression of PIK3C2A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4211874814
MESH:D000505 Alopecia Isoflavones 4.8317569567
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8112372130 20485159
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.7215867366
MESH:D001932 Brain Neoplasms Aspirin 4.5515481559
MESH:D001943 Breast Neoplasms Aspirin 2.0515161893
MESH:D001943 Breast Neoplasms Paclitaxel 2.0516273361 18223236 16244791 18234424 16115903 15136595 18323546 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.163084413
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 3.1616313753
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Isoflavones 4.2417689850
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 16105132 17110522 16919318 11677210 17681005 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 15668235 15340226 12621046 16354765
MESH:D003110 Colonic Neoplasms Aspirin 3.0012411196
MESH:D015179 Colorectal Neoplasms Aspirin 3.8217047198
MESH:D015179 Colorectal Neoplasms Isoflavones 3.8217116718
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.8218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4614986274 16485898 16081117 2444490 16227642 15968718 10915739 14550746 14725611 17522070 12705907 12153990 19739265 11739529 11461765 10663392 18071297 18713872 11287661 11529661 16177239 12392966 16781746 19164858 19085960 15619225 12958197 11421492 19416960 19923254 11834606 12594235 16109766 19420014 17906064 11743745 16393943 10774834 19370779 12540782 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 6.4617522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Aspirin 7.5217259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7820426865
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.7816481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4915345470
MESH:D005234 Fatty Liver Tetracycline 8.4916917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005909 Glioblastoma Aspirin 4.0412870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006261 Headache Aspirin 5.1815240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D019584 Hot Flashes Isoflavones 5.2017290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 15340226 16959395 8697196 16354765
MESH:D012001 Hyperacusis Aspirin 5.9815240983
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Atrazine 11.8412948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.8417937319
MESH:D007248 Infertility, Male vinclozolin 11.8416467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008080 Liposarcoma Paclitaxel 4.9717353645
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16610002 19014921 16611625 12587719 11587558 19460945 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2114749477
MESH:D008545 Melanoma Paclitaxel 2.6012040289 12025231 16342250
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Atrazine 3.571916698
MESH:D008881 Migraine Disorders Aspirin 4.1615240983
MESH:D009101 Multiple Myeloma Paclitaxel 3.7814749477
MESH:D009203 Myocardial Infarction Aspirin 3.6012692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009325 Nausea Aspirin 5.4315240983
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3015867366
MESH:D009395 Nephritis, Interstitial Tetracycline 5.009884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D010003 Osteoarthritis Aspirin 4.147009135
MESH:D010014 Osteolysis Paclitaxel 5.1715867366
MESH:D010024 Osteoporosis Isoflavones 4.1816562857
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0311161223
MESH:D010146 Pain Acetaminophen 7.3316870215
MESH:D010146 Pain Aspirin 7.336363464 6995502
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010300 Parkinson Disease Atrazine 3.3217218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6511026799
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.7311156591
MESH:D020795 Photophobia Aspirin 5.9815240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1411118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.1418042343 19015723 18220299
MESH:D017096 Prion Diseases Tetracycline 5.6110903871
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms Clorgyline 2.9219691856
MESH:D011471 Prostatic Neoplasms Isoflavones 2.9217571952 17374662 16365062 17219775
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.9216356831 17172428 17136230 16729912
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D012135 Respiratory Sounds Atrazine 4.6911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012220 Rhinitis Aspirin 4.5012372130
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.4412269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418396642 18506536
MESH:D020521 Stroke Aspirin 4.4916403987
MESH:D024801 Tauopathies Paclitaxel 5.0116930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Aspirin 9.6217672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.6215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014581 Urticaria Acetaminophen 9.4110982225
MESH:D014581 Urticaria Aspirin 9.4120485159 10982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
REACT:11123 Membrane Trafficking
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33304
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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