AutismKB 2.0

Annotation Detail for PIK3C2G


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Basic Information Top
Gene Symbol:PIK3C2G ( MGC163149,PI3K-C2GAMMA )
Gene Full Name: phosphoinositide-3-kinase, class 2, gamma polypeptide
Band: 12p12.3
Quick LinksEntrez ID:5288; OMIM: 609001; Uniprot ID:P3C2G_HUMAN; ENSEMBL ID: ENSG00000139144; HGNC ID: 8973
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
No data
Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PIK3C2G mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PIK3C2G proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PIK3C2G mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of PIK3C2G mRNAdecreases expression 20106945
D000431 Ethanol Ethanol results in increased expression of PIK3C2G mRNAincreases expression 15353170
D011345 Fenofibrate Fenofibrate results in decreased expression of PIK3C2G mRNAdecreases expression 16707586
D009151 Mustard Gas Mustard Gas results in decreased expression of PIK3C2G mRNAdecreases expression 18955075
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PIK3C2G mRNAincreases expression 16221955
C006253 pirinixic acid pirinixic acid results in decreased expression of PIK3C2G mRNAdecreases expression 16707586
C025299 polyphenols polyphenols results in decreased expression of PIK3C2G mRNAdecreases expression 16293270
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PIK3C2G mRNAdecreases expression 18796159
D013752 Tetracycline Tetracycline results in increased expression of PIK3C2G mRNAincreases expression 16917069
C402769 tipifarnib tipifarnib results in increased expression of PIK3C2G mRNAincreases expression 16403772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.8617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.8718287403
MESH:D000138 Acidosis Ethanol 10.8711192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4515451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D000853 Anophthalmos Ethanol 4.9215513904
MESH:D001008 Anxiety Disorders Ethanol 4.0711141031
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1110378619 17687719
MESH:D002056 Burns Ethanol 4.7616374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6921507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.6915289165 18788625 15763234
MESH:D006332 Cardiomegaly Ethanol 6.9919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D002971 Cleft Lip Ethanol 3.6215513904
MESH:D002972 Cleft Palate Ethanol 6.0615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0615668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms polyphenols 2.6816293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6519302082 11873399 15451039 10194807 11198716 15513904 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6515322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2917906064 16485898 11461765 14986274 11421492 16109766 18071297 16393943 15968718 12392966 19416960 16227642 17522070 19420014 12705907 17562736 16177239 16081117 11739529 12153990 10915739 12958197 14725611 19370779 11287661 11529661 19085960 14550746 11743745 15619225 19739265 10663392 16781746 2444490 18713872 11834606 19164858 12594235 12540782 10774834 19923254
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.2911566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 12.2919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2920420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.2917522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Fenofibrate 4.4816707586
MESH:D004487 Edema Mustard Gas 17.1611428631 9260866 11402378 11428647
MESH:D004487 Edema perfluorooctanoic acid 17.1612083418 17259670
MESH:D004487 Edema pirinixic acid 17.1612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.1611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms Ethanol 2.7716704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.5219224547
MESH:D005234 Fatty Liver Ethanol 19.5218620774 19236843 16409862
MESH:D005234 Fatty Liver pirinixic acid 19.5219236843 20131406
MESH:D005234 Fatty Liver Tetracycline 19.5216917069 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4216946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005756 Gastritis Acetaminophen 11.5816983495
MESH:D005756 Gastritis Ethanol 11.5815046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 15.103609246
MESH:D006529 Hepatomegaly pirinixic acid 15.1016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.1015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 13.5416870215
MESH:D006930 Hyperalgesia Ethanol 13.5418783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 13.5412083418
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D007249 Inflammation Mustard Gas 12.379260866 11428647 11428631 8975870 11428620 17524151 16001271 9357497 11402378
MESH:D007249 Inflammation perfluorooctanoic acid 12.3712083418
MESH:D007249 Inflammation polyphenols 12.3716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.3712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Ethanol 10.3915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D007859 Learning Disorders Ethanol 4.3115451040
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.358812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8717676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2118295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.0718166357
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 5.0715474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0712878042
MESH:D008107 Liver Diseases Acetaminophen 4.2219014921 12969438 19784758 16611625 19460945 16610002 11587558 12587719
MESH:D008107 Liver Diseases polyphenols 4.2216698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7617207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.582125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Fenofibrate 14.5818978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 14.5814757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 14.5816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.248603461
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 10.2418253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2412151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0114755239
MESH:D008175 Lung Neoplasms Mustard Gas 5.018781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0119555203 11884234
MESH:D008175 Lung Neoplasms tipifarnib 5.0116885199
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 4.3816648579
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008569 Memory Disorders Ethanol 4.2815451040 18411066
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.929884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.069802331
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9912384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.5711026799
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 10.0717132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0711222880 11118676 11399792 11896295
MESH:D017096 Prion Diseases Tetracycline 5.5310903871
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517620002 17894541 17266442 10334151 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures Ethanol 3.229754883
MESH:D012871 Skin Diseases Mustard Gas 2.7315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.6116755016 11906479 9211565 17918041 9562338 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.339754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3917997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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