AutismKB 2.0

Annotation Detail for PIK3CA


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Basic Information Top
Gene Symbol:PIK3CA ( MGC142161,MGC142163,PI3K,p110-alpha )
Gene Full Name: phosphoinositide-3-kinase, catalytic, alpha polypeptide
Band: 3q26.32
Quick LinksEntrez ID:5290; OMIM: 171834; Uniprot ID:PK3CA_HUMAN; ENSEMBL ID: ENSG00000121879; HGNC ID: 8975
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04670Leukocyte transendothelial migration
hsa00562Inositol phosphate metabolism
hsa05160Hepatitis C
hsa04973Carbohydrate digestion and absorption
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04150mTOR signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05142Chagas disease
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa05211Renal cell carcinoma
hsa05100Bacterial invasion of epithelial cells
hsa05223Non-small cell lung cancer
hsa05222Small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Hemostasis
Signaling by EGFR
Signaling by Insulin receptor
Signaling by PDGF
Signaling by FGFR
Signaling in Immune system
Pathway IDPathway Name
200181S1P2 pathway
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200185EPHA2 forward signaling
200003Fc-epsilon receptor I signaling in mast cells
200005BCR signaling pathway
200128Neurotrophic factor-mediated Trk receptor signaling
200131IL23-mediated signaling events
200151VEGFR1 specific signals
200017Atypical NF-kappaB pathway
200015GMCSF-mediated signaling events
200158IL2 signaling events mediated by STAT5
200125E-cadherin signaling in keratinocytes
200124IL6-mediated signaling events
200082IL2-mediated signaling events
200145Nongenotropic Androgen signaling
200099IL2 signaling events mediated by PI3K
200075IL1-mediated signaling events
200018IL4-mediated signaling events
200162a6b1 and a6b4 Integrin signaling
200161Signaling events mediated by VEGFR1 and VEGFR2
200042Osteopontin-mediated events
200103p75(NTR)-mediated signaling
200029Plasma membrane estrogen receptor signaling
200051Reelin signaling pathway
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P04398p53 pathway feedback loops 2
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00018EGF receptor signaling pathway
P00005Angiogenesis
P00010B cell activation
P00048PI3 kinase pathway
P00030Hypoxia response via HIF activation
P00047PDGF signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00059p53 pathway
P00036Interleukin signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
Pathway IDPathway Name
500514Gab1 signalosome
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00027Ovarian cancer
Cancers of the breast and female genital organs
No data
Desease Name
colorectal cancer
CANCER
Colonic Neoplasms
breast cancer
No data
Desease Name
Nevus, epidermal
Hepatocellular carcinoma, somatic
Breast cancer, somatic
Ovarian cancer, somatic
Colorectal cancer, somatic
Keratosis, seborrheic, somatic
Nonsmall cell lung cancer, somatic
Gastric cancer, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CA proteindecreases activity 16179367
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PIK3CA mRNAincreases expression 18648102
D000255 Adenosine Triphosphate Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]affects binding|decreases activity|decreases reaction 17550345
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PIK3CA mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PIK3CA mRNAdecreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PIK3CA mRNAdecreases expression 20018196
C107676 deguelin deguelin metabolite results in decreased expression of PIK3CA proteindecreases expression 19139008
C107676 deguelin deguelin results in decreased expression of PIK3CA proteindecreases expression 19139008
D002117 Calcitriol Calcitriol results in increased expression of PIK3CA mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of PIK3CA mRNAincreases expression 16029874
D006820 Hyaluronic Acid Hyaluronic Acid results in increased phosphorylation of PIK3CA proteinincreases phosphorylation 16864594
D018021 Lithium Chloride PIK3CA protein affects the reaction [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein]affects reaction|decreases activity|increases phosphorylation 19196980
D018021 Lithium Chloride PIK3CA protein affects the susceptibility to Lithium Chlorideaffects response to substance 19196980
D018021 Lithium Chloride PIK3CA protein mutant form results in increased susceptibility to Lithium Chlorideincreases response to substance 19196980
D008713 Methimazole Methimazole results in increased expression of PIK3CA mRNAincreases expression 17399805
C494474 perchlorate perchlorate results in increased expression of PIK3CA mRNAincreases expression 17399805
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of PIK3CA mRNAdecreases expression 16221955
D011441 Propylthiouracil Propylthiouracil results in increased expression of PIK3CA mRNAincreases expression 17399805
C059514 resveratrol Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]affects binding|decreases activity|decreases reaction 17550345
C059514 resveratrol resveratrol inhibits the reaction [PIK3CA protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 17550345
C059514 resveratrol resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]affects binding|decreases activity 17550345
C417521 SB 216763 PIK3CA protein affects the reaction [SB 216763 results in increased phosphorylation of and results in decreased activity of GSK3B protein]affects reaction|decreases activity|increases phosphorylation 19196980
C017947 sodium arsenite sodium arsenite results in increased expression of PIK3CA mRNAincreases expression 12016162
D014284 Triiodothyronine Triiodothyronine results in increased expression of PIK3CA mRNAincreases expression 17403546
D013974 Thyroxine Thyroxine results in decreased expression of PIK3CA mRNAdecreases expression 17403546
D013629 Tamoxifen PIK3CA gene mutant form affects the susceptibility to Tamoxifenaffects response to substance 20479250
D013752 Tetracycline Tetracycline results in increased expression of PIK3CA mRNAincreases expression 16917069
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of PIK3CA mRNAincreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D058186 Acute Kidney Injury resveratrol 3.7116538975
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2611798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.2611473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.3815814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.553712494
MESH:D000236 Adenoma resveratrol 6.5515688382
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7516712894 17306315
MESH:D000544 Alzheimer Disease resveratrol 2.5416183991 16162502
MESH:D001169 Arthritis, Experimental resveratrol 3.4117115116
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1519898480
MESH:D050197 Atherosclerosis resveratrol 3.1817967414 16873680
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.871440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9516206674
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 8.9519483382
MESH:D002545 Brain Ischemia resveratrol 4.1317600658
MESH:D001943 Breast Neoplasms marker/mechanism 19685490 20479250 19196980
MESH:D001943 Breast Neoplasms Calcitriol 2.3311237771
MESH:D001943 Breast Neoplasms deguelin 2.3318593368 17035597
MESH:D001943 Breast Neoplasms Estradiol 2.3312948864 16675129 17289903 14630087 18497071 17261762 19861407 17018787
MESH:D001943 Breast Neoplasms resveratrol 2.3316393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 2.3319189210 18821012 19103187 20005174 19410462 15565566 21138602 20544844 21152245 18351453 19059307 20065188 20390343 18855134 20859285 15668708 18815881 19155303 17242785 18629630 17261762 19142967 19011961 11161223 19288272 16818667 19200415 18984771 19084267 19115204 19244106 19066611 17893378 19289846 19487384 16202921 19189212 18997820 17049068 18425577 19221464 20135344 17440819 16873071 16273361
OMIM:604370 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.723581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.7214691202 16217749 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular deguelin 13.7218575727
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.7216924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.7219321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.7215276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.7216924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4416675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3711212258
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7219014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9812490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.5111237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.5116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.5118572023
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 10.5111212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4817572228
MESH:D006332 Cardiomegaly Thyroxine 4.0218093424
MESH:D002318 Cardiovascular Diseases resveratrol 3.3715458977
MESH:D002386 Cataract Adenosine Triphosphate 4.5215003327
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.177505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.1718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.1720056578 19524636
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.0419486331 9022650
MESH:D003092 Colitis resveratrol 3.9816474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4316338953
MESH:D015179 Colorectal Neoplasms marker/mechanism
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5920501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.5916550006
MESH:D003327 Coronary Disease resveratrol 3.6616507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8710525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.668156756 18759878 2524372 8970840 12868966 11298694 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.352952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6416873680
MESH:D003928 Diabetic Nephropathies Estradiol 14.2819279558
MESH:D003928 Diabetic Nephropathies resveratrol 14.2816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.2819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.066482804 18289764 1440618 9328219 6679447 7440962 9653073 8291058 11289319 18648102 18692083 9022650 16192314
MESH:D056486 Drug-Induced Liver Injury Tetracycline 4.0617522070
MESH:D004487 Edema perfluorooctanoic acid 6.8512083418 17259670
MESH:D004487 Edema resveratrol 6.858985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.6015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.6017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.6019031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.0618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.0616202921 19155303 17893378 20544844
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7017923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.993581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9912903497
MESH:D005234 Fatty Liver arsenic trioxide 12.4815073043
MESH:D005234 Fatty Liver Tamoxifen 12.4814986274 19224547
MESH:D005234 Fatty Liver Tetracycline 12.4819224547 16917069
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1416709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.876705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0319069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1116904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 11.007505956
MESH:D006042 Goiter perchlorate 11.0018801409
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.376705139
MESH:D006529 Hepatomegaly perfluorooctanoic acid 3.953609246
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006561 Herpes Simplex resveratrol 4.0316876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Lithium Chloride 5.8719797860
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.7312083418
MESH:D006937 Hypercholesterolemia resveratrol 3.8717188708
MESH:D006949 Hyperlipidemias resveratrol 3.8916873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7915034207
MESH:D006980 Hyperthyroidism Methimazole 5.4714678291
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1717488730
MESH:D007037 Hypothyroidism Methimazole 11.4518031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.4518031379 8137927
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5017600658
MESH:D007248 Infertility, Male sodium arsenite 2.8915346721 12646999
MESH:D007249 Inflammation perfluorooctanoic acid 11.4312083418
MESH:D007249 Inflammation resveratrol 11.4316366677
MESH:D007249 Inflammation Tamoxifen 11.4319457130
MESH:D007249 Inflammation Tobacco Smoke Pollution 11.4318590791
MESH:D007251 Influenza, Human resveratrol 4.3916624496
MESH:D007333 Insulin Resistance Estradiol 2.8716627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.878074119 9022650
MESH:D017492 Keratosis, Seborrheic marker/mechanism
MESH:D007674 Kidney Diseases Estradiol 5.8215618244
MESH:D007674 Kidney Diseases sodium arsenite 5.8220008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.696582329
MESH:D007680 Kidney Neoplasms Estradiol 11.6915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.6918625569
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.4712970779
MESH:D007938 Leukemia arsenic trioxide 6.4715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6617077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1119850784 16467208 20471514 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4619642359 15336539 11468182 17869043 9834237 12679006 16330433 16823087 17107899 11161223 16112521 17217047 19035177 15213294 19075265 16966277 12712474 15622746 17712046 12018890 19225113 15748426 17649720 16331271 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.4616087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2016882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.088812269
MESH:D008064 Lipidoses Tamoxifen 3.0515342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.109327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4018564211
MESH:D008113 Liver Neoplasms arsenic trioxide 13.6614682389
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.6618709148 14757943
MESH:D008113 Liver Neoplasms resveratrol 13.6620405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 13.6615276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 13.6616684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.653712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.6520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2315213294
MESH:D008171 Lung Diseases sodium arsenite 3.0719095001
MESH:D008175 Lung Neoplasms marker/mechanism
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4419825857 11798837
MESH:D008175 Lung Neoplasms deguelin 6.4416288123 19336726
MESH:D008175 Lung Neoplasms sodium arsenite 6.4416712894 17077188 17306315 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 6.4418625569
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 6.4412111688 3440675 16288123 11091918
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.4915688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.4919428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4416891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.448985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4414580682 16827153 19196722 19196723 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.1419453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.1419453300
MESH:D008545 Melanoma resveratrol 4.9917992120
MESH:D008545 Melanoma sodium arsenite 4.9919082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.9912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0315990972
MESH:D008659 Metabolic Diseases resveratrol 4.2417112576
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.2315006635
MESH:D009101 Multiple Myeloma arsenic trioxide 7.0611468182 14977855 19417148 19549372 15949261
MESH:D009101 Multiple Myeloma resveratrol 7.0616490592 17935668 16267019 17049120 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7217962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0616882451 16105982
MESH:D009203 Myocardial Infarction resveratrol 6.4716525036 17125593 17188708 16456233 17015251 16317513
MESH:D009203 Myocardial Infarction SB 216763 6.4716288908
MESH:D017202 Myocardial Ischemia resveratrol 3.8917015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1616810080
MESH:D009205 Myocarditis resveratrol 4.6117322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8116624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.493581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms deguelin 5.4517764071
MESH:D009369 Neoplasms sodium arsenite 5.4511559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.738985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.7320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.639884423
MESH:D009421 Nervous System Malformations Estradiol 3.5016427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.576679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.5710525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.5712854658
MESH:D019636 Neurodegenerative Diseases resveratrol 3.6817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2617929310
OMIM:162900 NEVUS, EPIDERMAL marker/mechanism
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.809802331
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.296482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.873988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1117513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10.9516211241
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.9516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.9519401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.9517306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4715580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.337296757
MESH:D010235 Paraganglioma arsenic trioxide 4.0219927285
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.2811026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.326228378
MESH:D011141 Polyuria Lithium Chloride 5.8519692487
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.5317132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.5316679765
MESH:D017096 Prion Diseases Tetracycline 5.2610903871
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0819131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0815754350 16644109 18247401 16289102 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 2.0816864594
MESH:D011471 Prostatic Neoplasms resveratrol 2.0817718901 17804756 15767336 17675339 17636462 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4316325855
MESH:D015427 Reperfusion Injury resveratrol 3.2017520802 15827377 16314181 16317513 17058453
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.4718410779
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.263692021
MESH:D012509 Sarcoma marker/mechanism 20601955
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8116646077
MESH:D012878 Skin Neoplasms deguelin 13.1516041863
MESH:D012878 Skin Neoplasms resveratrol 13.1515837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 13.1519524636 18572023
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 13.1518590791
MESH:D013088 Spermatocele Tamoxifen 4.1416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013274 Stomach Neoplasms marker/mechanism
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3516321402
MESH:D013959 Thyroid Diseases Thyroxine 5.4919910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.386582329 7505956 1399818 3712494 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.3819014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.3815710170
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms resveratrol 4.0816227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8115213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.198074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.1912973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.1917306315 11723127 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.198653321 17572228 16712894
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 15.1912846360
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.1217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1211813266
MESH:D014594 Uterine Neoplasms resveratrol 3.9917044934
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1517488730
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:05146 Amoebiasis
KEGG:04210 Apoptosis
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04662 B cell receptor signaling pathway
KEGG:04973 Carbohydrate digestion and absorption
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
KEGG:05214 Glioma
REACT:604 Hemostasis
KEGG:05160 Hepatitis C
KEGG:00562 Inositol phosphate metabolism
KEGG:04910 Insulin signaling pathway
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04630 Jak-STAT signaling pathway
KEGG:04670 Leukocyte transendothelial migration
KEGG:05162 Measles
KEGG:05218 Melanoma
KEGG:04150 mTOR signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:04380 Osteoclast differentiation
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:04070 Phosphatidylinositol signaling system
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:9417 Signaling by EGFR
REACT:9470 Signaling by FGFR
REACT:14797 Signaling by GPCR
REACT:498 Signaling by Insulin receptor
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:05222 Small cell lung cancer
KEGG:04660 T cell receptor signaling pathway
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:04930 Type II diabetes mellitus
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33308
    • Releated gene ID Related gene Name
    PA33312PIK3R1
    PA33313PIK3R2
    PA33314PIK3R3
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    PA445062Neoplasms
    PA444283Glioblastoma
    PA444818Lung Neoplasms
    PA443756Colonic Neoplasms
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449383docetaxel
    PA164743471adenosine triphosphate
    PA451365sirolimus
    PA448976choline
    PA152241909PP2
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA449167cyclosporine
    PA451578tacrolimus
    PA450191lecithin
    PA10804imatinib
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB08059 - (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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