AutismKB 2.0

Annotation Detail for PIK3CG


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Basic Information Top
Gene Symbol:PIK3CG ( PI3CG,PI3K,PI3Kgamma,PIK3 )
Gene Full Name: phosphoinositide-3-kinase, catalytic, gamma polypeptide
Band: 7q22.3
Quick LinksEntrez ID:5294; OMIM: 601232; Uniprot ID:PK3CG_HUMAN; ENSEMBL ID: ENSG00000105851; HGNC ID: 8978
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04670Leukocyte transendothelial migration
hsa00562Inositol phosphate metabolism
hsa05160Hepatitis C
hsa04973Carbohydrate digestion and absorption
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04150mTOR signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05142Chagas disease
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa05211Renal cell carcinoma
hsa05100Bacterial invasion of epithelial cells
hsa05223Non-small cell lung cancer
hsa05222Small cell lung cancer
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
No data
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P04398p53 pathway feedback loops 2
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00018EGF receptor signaling pathway
P00005Angiogenesis
P00010B cell activation
P00030Hypoxia response via HIF activation
P00047PDGF signaling pathway
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00059p53 pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1870Drug abuse
1904Diabetes mellitus
1929Pertussis
1934Cancer
2074Asthma
Desease Name
HEMATOLOGICAL
mean platelet volume
Desease Name
Mean platelet volume
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CG proteindecreases activity 16794257
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]decreases reaction|increases activity 15178407
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CG proteindecreases activity 16179367
C505145 5-(2,2-difluorobenzo(1,3)dioxol-5-ylmethylene)thiazolidine-2,4-dione 5-(2,2-difluorobenzo(1,3)dioxol-5-ylmethylene)thiazolidine-2,4-dione results in decreased activity of PIK3CG proteindecreases activity 16179367
C014949 acetylhydrazine acetylhydrazine results in decreased expression of PIK3CG mRNAdecreases expression 15282401
C015001 arsenite arsenite results in decreased expression of PIK3CG mRNAdecreases expression 18191166
D002087 Butyrates Butyrates results in decreased expression of PIK3CG mRNAdecreases expression 16042588
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNA]decreases expression|decreases reaction 11007951
C014347 decitabine decitabine results in increased expression of PIK3CG mRNAincreases expression 17785578
C029424 hydrazine hydrazine results in decreased expression of PIK3CG mRNAdecreases expression 15282401
D007545 Isoproterenol 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]decreases reaction|increases activity 15178407
D007545 Isoproterenol Isoproterenol results in increased activity of PIK3CG proteinincreases activity 15178407
D007545 Isoproterenol wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]decreases reaction|increases activity 15178407
D009151 Mustard Gas Mustard Gas results in increased expression of PIK3CG mRNAincreases expression 18955075
D011794 Quercetin Quercetin results in decreased activity of PIK3CG proteindecreases activity 16794257
C059514 resveratrol resveratrol results in decreased activity of PIK3CG proteindecreases activity 17550345
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNAdecreases expression 11007951
D014212 Tretinoin Tretinoin results in increased expression of PIK3CG mRNAincreases expression 16054129
C009687 wortmannin wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]decreases reaction|increases activity 15178407
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 11752688 14514962
MESH:D058186 Acute Kidney Injury resveratrol 3.8816538975
MESH:D000236 Adenoma resveratrol 3.3315688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000544 Alzheimer Disease resveratrol 2.5716162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2717084956
MESH:D001169 Arthritis, Experimental resveratrol 7.5717115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.5716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Mustard Gas 5.0110378619
MESH:D001249 Asthma Tretinoin 5.0116456186
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0315336622
MESH:D050197 Atherosclerosis resveratrol 3.2917967414 16873680
MESH:D001321 Autistic Disorder marker/mechanism 14627686
MESH:D001327 Autoimmune Diseases Quercetin 4.4519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001768 Blister Mustard Gas 5.2119167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.0316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001919 Bradycardia Isoproterenol 5.236740701
MESH:D002545 Brain Ischemia resveratrol 4.3317600658
MESH:D001943 Breast Neoplasms decitabine 2.3619208741 18320071
MESH:D001943 Breast Neoplasms Quercetin 2.3618628248
MESH:D001943 Breast Neoplasms resveratrol 2.3616393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3616166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002105 Cadmium Poisoning Quercetin 5.6116962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7419519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.7419321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.741917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6416675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0017234771
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.6819215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.6816227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.6816096774 16051514
MESH:D006332 Cardiomegaly Isoproterenol 11.6511179087 7544033
MESH:D006332 Cardiomegaly Quercetin 11.6519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.6518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.4915458977
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8012621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.809407595
MESH:D003092 Colitis resveratrol 9.7716474422
MESH:D003092 Colitis Tretinoin 9.7717035595
MESH:D003110 Colonic Neoplasms arsenite 11.2115037631
MESH:D003110 Colonic Neoplasms Butyrates 11.2115936596
MESH:D003110 Colonic Neoplasms decitabine 11.2117616700
MESH:D003110 Colonic Neoplasms Quercetin 11.2111134977 19056647 16640504 15741050 19440933 17148506 17191121
MESH:D003110 Colonic Neoplasms resveratrol 11.2116338953
MESH:D015179 Colorectal Neoplasms decitabine 3.5618981723
MESH:D015179 Colorectal Neoplasms Quercetin 3.5618852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 3.5616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7716507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4514991402 9211117 8800419 10589399 9142499 17551590 9664655 9224671 9125849 16925845
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.6319496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.6316873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.9916286809
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema Mustard Gas 11.729260866 11428631 11428647 11402378
MESH:D004487 Edema resveratrol 11.728985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.1616714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.1618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.0617872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1819294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8917923197
MESH:D004890 Erythema Mustard Gas 5.219357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9016938888 9664655
MESH:D005234 Fatty Liver arsenite 3.8118296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis arsenite 21.5818296743
MESH:D005355 Fibrosis Quercetin 21.5819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.5820067830
MESH:D005355 Fibrosis Tretinoin 21.5817994277
MESH:D005909 Glioblastoma Quercetin 7.3219804834
MESH:D005909 Glioblastoma Tretinoin 7.3217312396
MESH:D005910 Glioma Quercetin 3.0617643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.8919215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.8916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5814991402 9664655
MESH:D006333 Heart Failure Isoproterenol 4.2518097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.2316876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006943 Hyperglycemia Quercetin 4.0618262572 11834736
MESH:D006949 Hyperlipidemias resveratrol 4.0616873680
MESH:D006973 Hypertension Quercetin 5.2618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2618850075 18670907
MESH:D006984 Hypertrophy Isoproterenol 5.2212791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3317488730
MESH:D007022 Hypotension Isoproterenol 4.836740701
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6917600658
MESH:D007248 Infertility, Male decitabine 3.2217581917
MESH:D007249 Inflammation Mustard Gas 8.4711428631 8975870 9357497 11428620 11428647 16001271 11402378 9260866 17524151
MESH:D007249 Inflammation resveratrol 8.4716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4712878042 12200463
MESH:D007251 Influenza, Human Quercetin 11.4116624496
MESH:D007251 Influenza, Human resveratrol 11.4116624496
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.0316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.0315992940 17551590
MESH:D007627 Keloid Quercetin 5.0017086741
MESH:D007674 Kidney Diseases Quercetin 3.1116962696
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15.1412970779
MESH:D007938 Leukemia decitabine 15.1418980019 19235587
MESH:D007938 Leukemia Quercetin 15.1417468513
MESH:D007938 Leukemia Tretinoin 15.1417143497
MESH:D007951 Leukemia, Myeloid decitabine 9.6619117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 9.6619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9919387464 18206229 18704418 19010910 18460780 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9916294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5218055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.8316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.839834237 19029980 16788101 17217047 17107899 17301526 17361223 17368321 19075265 16140955 19035177 16331271 17294898 19642359 17339181 15748426 16891316 17506722 16823087 16935935 17649720 17712046 19225113 12679006 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008103 Liver Cirrhosis arsenite 3.4318296743
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5312741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5318397230 16248980
MESH:D008113 Liver Neoplasms Quercetin 7.5718980244
MESH:D008113 Liver Neoplasms resveratrol 7.5719073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.9819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008171 Lung Diseases Mustard Gas 3.4718702808 18161513
MESH:D008175 Lung Neoplasms arsenite 4.9316809336
MESH:D008175 Lung Neoplasms Mustard Gas 4.933148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 4.9316280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9319555203 11884234
MESH:D008223 Lymphoma decitabine 3.4419470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3015688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.1311606380 8985016
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma decitabine 5.2216505122 17785578
MESH:D008545 Melanoma resveratrol 5.2217992120
MESH:D008545 Melanoma Tretinoin 5.2216752155
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008659 Metabolic Diseases resveratrol 4.4117112576
MESH:D009101 Multiple Myeloma decitabine 7.5818172295
MESH:D009101 Multiple Myeloma resveratrol 7.5814749477 16490592 17935668 17049120 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9217962980
MESH:D009190 Myelodysplastic Syndromes decitabine 7.5318608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5317596541
MESH:D009203 Myocardial Infarction Isoproterenol 9.8117052832 19595682 16538859 16584858 19172585 15740881 16697266
MESH:D009203 Myocardial Infarction Quercetin 9.8119595682
MESH:D009203 Myocardial Infarction resveratrol 9.8117125593 17188708 16317513 17015251 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 9.0817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0812213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.8119207477
MESH:D009205 Myocarditis resveratrol 4.8117322642
MESH:D009369 Neoplasms decitabine 8.4619470736 17925555 19116145
MESH:D009369 Neoplasms Quercetin 8.4615185748
MESH:D009369 Neoplasms Tretinoin 8.4616946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 4.048985016
MESH:D009389 Neovascularization, Pathologic arsenite 4.4615738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.639125849
MESH:D009436 Neural Tube Defects Tretinoin 3.079142499
MESH:D019636 Neurodegenerative Diseases resveratrol 3.8317652729
MESH:D020078 Neurogenic Inflammation Quercetin 10.8017929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.8017929310
MESH:D009503 Neutropenia Mustard Gas 4.0016761898 7688884
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.3119495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.3117513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 11.4516211241
MESH:D010051 Ovarian Neoplasms decitabine 11.4519331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 11.4519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 11.4516936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.7619294695
MESH:D010190 Pancreatic Neoplasms Quercetin 8.7616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D011041 Poisoning Mustard Gas 3.8315727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Quercetin 4.0019056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.7616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7611222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.7717616702
MESH:D011471 Prostatic Neoplasms Quercetin 3.5414715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 3.5417718901 17675339 16731767 17636462 15767336 17804756
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011537 Pruritus Mustard Gas 4.1418058305
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D011654 Pulmonary Edema Isoproterenol 5.3110903255
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417266442 17720292 17620002 10334151 17894541
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6516325855
MESH:D015427 Reperfusion Injury resveratrol 3.2817058453 17520802 16317513 16314181 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.0619155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.0616116481 16283617
MESH:D012554 Schistosomiasis japonica Quercetin 5.6116862918
MESH:D012871 Skin Diseases Mustard Gas 2.7216961503 12880345 15451306
MESH:D012878 Skin Neoplasms resveratrol 9.558985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5516192470
MESH:D012878 Skin Neoplasms Tretinoin 9.5516467112
MESH:D013274 Stomach Neoplasms decitabine 2.5519037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5517261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5116321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Butyrates 12.2917967635
MESH:D013964 Thyroid Neoplasms decitabine 12.2917967635
MESH:D013964 Thyroid Neoplasms Tretinoin 12.2916026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 10.0016227395
MESH:D014062 Tongue Neoplasms Tretinoin 10.0016051514
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.3916720314
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.6217473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6216129372
MESH:D014594 Uterine Neoplasms resveratrol 4.1717044934
MESH:D014604 Uveal Neoplasms decitabine 13.0417785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.0416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 10.8118097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.8117488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.7418097624
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:05146 Amoebiasis
KEGG:04210 Apoptosis
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04662 B cell receptor signaling pathway
KEGG:04973 Carbohydrate digestion and absorption
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04062 Chemokine signaling pathway
KEGG:05220 Chronic myeloid leukemia
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
KEGG:05214 Glioma
REACT:604 Hemostasis
KEGG:05160 Hepatitis C
KEGG:00562 Inositol phosphate metabolism
KEGG:04910 Insulin signaling pathway
KEGG:04630 Jak-STAT signaling pathway
KEGG:04670 Leukocyte transendothelial migration
KEGG:05162 Measles
KEGG:05218 Melanoma
KEGG:04150 mTOR signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:04380 Osteoclast differentiation
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:04070 Phosphatidylinositol signaling system
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:14797 Signaling by GPCR
KEGG:05222 Small cell lung cancer
KEGG:04660 T cell receptor signaling pathway
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:04930 Type II diabetes mellitus
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33311
    • No data
    Releated disease ID Related disease Name
    PA443425Arteriosclerosis
    Releated drug ID Related drug Name
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02010 - Staurosporine Enzyme Inhibitors
    DB02375 - Myricetin
    DB02656 - 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One Enzyme Inhibitors
    DB04216 - Quercetin Antioxidants
    DB04769 - 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE
    DB06831 - 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
    DB06836 - N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE
    DB07073 - 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one
    DB07335 - 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
    DB07503 - (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE
    DB08059 - (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
    DB08300 - 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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