AutismKB 2.0

Annotation Detail for PI4KA


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Basic Information Top
Gene Symbol:PI4KA ( FLJ16556,PI4K-ALPHA,PIK4CA,pi4K230 )
Gene Full Name: phosphatidylinositol 4-kinase, catalytic, alpha
Band: 22q11.21
Quick LinksEntrez ID:5297; OMIM: 600286; Uniprot ID:PI4KA_HUMAN; ENSEMBL ID: ENSG00000100038,ENSG00000241973; HGNC ID: 8983
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
Pathway IDPathway Name
200109Integrins in angiogenesis
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PI4KA mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PI4KA mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PI4KA mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PI4KA mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PI4KA mRNAdecreases expression 12852829
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PI4KA mRNAdecreases expression 15336504
D002713 Chlorine Chlorine results in decreased expression of PI4KA mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of PI4KA mRNAaffects cotreatment|affects expression 18636392
D003513 Cycloheximide Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PI4KA mRNA]decreases expression|increases reaction 11007951
D006533 Heptachlor Heptachlor results in decreased activity of PI4KA proteindecreases activity 14994277
D006533 Heptachlor Heptachlor results in increased activity of PI4KA proteinincreases activity 14994277
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PI4KA mRNAdecreases expression 15469884
C016340 o,p'-DDT o,p'-DDT results in increased activity of PI4KA proteinincreases activity 14994277
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of PI4KA mRNAaffects cotreatment|affects expression 18636392
D011794 Quercetin Quercetin results in increased expression of PI4KA mRNAincreases expression 15309432
C116926 rofecoxib rofecoxib results in decreased expression of PI4KA mRNAdecreases expression 17070997
C017947 sodium arsenite sodium arsenite results in decreased expression of PI4KA mRNAdecreases expression 12760830
D013749 Tetrachlorodibenzodioxin Cycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PI4KA mRNA]decreases expression|increases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PI4KA mRNAdecreases expression 11007951
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury Chlorine 4.3320601635
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2919825857 11798837
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9316712894 17306315
MESH:D000382 Agricultural Workers' Diseases Heptachlor 5.1912661182
MESH:D000544 Alzheimer Disease Ozone 2.4415513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2417084956
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001169 Arthritis, Experimental rofecoxib 4.3516690336
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Ozone 2.6417854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0015336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Quercetin 4.4219761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001943 Breast Neoplasms Heptachlor 2.138738476
MESH:D001943 Breast Neoplasms Quercetin 2.1318628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1320435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6816777450 15516495 18315731 17626835 18417511 14754758 19059883
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002105 Cadmium Poisoning Quercetin 5.5816962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.4116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.4116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.413084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.4115553829 16217749 15073043 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Quercetin 11.4119519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.4117306315 16507464 15276417
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3818572023
MESH:D006332 Cardiomegaly Quercetin 6.8119794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.756135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7520056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 12621046 8697196 15340226 15668235
MESH:D003110 Colonic Neoplasms Quercetin 4.2919056647 15741050 11134977 17148506 16640504 17191121 19440933
MESH:D003110 Colonic Neoplasms rofecoxib 4.2912902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6120501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6118095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4710048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7319496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9517522070 11739529 16227642 19739265 11421492 14550746 19416960 12153990 12392966 12540782 18071297 12594235 10774834 15619225 11834606 19164858 16781746 16485898 16177239 19370779 19420014 17562736 16109766 10915739 12705907 10663392 14725611 11287661 14986274 2444490 16081117 11529661 19085960 18713872 17906064 19923254 12958197 16393943 15968718 11743745 11461765
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004417 Dyspnea Chlorine 4.6520016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 15322242 18230668
MESH:D004715 Endometriosis rofecoxib 9.3415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.349294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3112903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver arsenic trioxide 3.2915073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Quercetin 8.8119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005739 Gas Poisoning Chlorine 5.0420016425
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005909 Glioblastoma Quercetin 3.3919804834
MESH:D005910 Glioma Quercetin 3.0517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 15340226 16354765 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia Quercetin 4.0318262572 11834736
MESH:D006973 Hypertension Quercetin 5.2318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2318850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 2.9912646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.5416624496
MESH:D007410 Intestinal Diseases rofecoxib 5.0515831440
MESH:D007417 Intestinal Polyps rofecoxib 5.3711245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007627 Keloid Quercetin 4.9717086741
MESH:D007674 Kidney Diseases Acetaminophen 10.1215629191 12587719
MESH:D007674 Kidney Diseases Quercetin 10.1216962696
MESH:D007674 Kidney Diseases sodium arsenite 10.1220008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3716705839
MESH:D007938 Leukemia arsenic trioxide 6.4915070760
MESH:D007938 Leukemia Quercetin 6.4917468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1420471514 16467208 19850784 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2217107899 15213294 17712046 15748426 9834237 17869043 16112521 15622746 16330433 16331271 19075265 11161223 11468182 16823087 19642359 19225113 12712474 15336539 19035177 17217047 16891316 12679006 16966277 17649720 12018890
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6812741479
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.6817565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319014921 12587719 12969438 11587558 19784758 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.037678174
MESH:D008113 Liver Neoplasms arsenic trioxide 18.0314682389
MESH:D008113 Liver Neoplasms Heptachlor 18.032422723 9544696
MESH:D008113 Liver Neoplasms Quercetin 18.0318980244
MESH:D008113 Liver Neoplasms sodium arsenite 18.0315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.156135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.1520377131
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.1519519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008171 Lung Diseases Ozone 7.5219066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.5219095001
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6011798837 19825857
MESH:D008175 Lung Neoplasms Ozone 6.607614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 6.6016280456
MESH:D008175 Lung Neoplasms sodium arsenite 6.6016712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6011884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0319082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1119417148 11468182 15949261 19549372 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1416105982 16882451
MESH:D009203 Myocardial Infarction Quercetin 2.9919595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7919207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4118551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009369 Neoplasms Quercetin 5.2615185748
MESH:D009369 Neoplasms sodium arsenite 5.2611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.3410525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.3412854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.3717929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9016049721
MESH:D010003 Osteoarthritis rofecoxib 4.3816690336
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.2219495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.9616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Quercetin 7.9619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.9615276417 17306315
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010149 Pain, Postoperative rofecoxib 5.4216678543 18165598
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4315580305
MESH:D010190 Pancreatic Neoplasms Quercetin 5.4316965848
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D011014 Pneumonia Ozone 4.4118007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Quercetin 3.9819056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1819131511
MESH:D011471 Prostatic Neoplasms Heptachlor 2.1812661182
MESH:D011471 Prostatic Neoplasms Quercetin 2.1814715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1816039940
MESH:D012120 Respiration Disorders Chlorine 5.2418579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.5816862918
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012878 Skin Neoplasms sodium arsenite 9.4518572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.458532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4516192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.8316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.8316049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.8320435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.8316720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.8316712894 17306315 11723127 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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