AutismKB 2.0

Annotation Detail for ACP2


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Basic Information Top
Gene Symbol:ACP2 ( - )
Gene Full Name: acid phosphatase 2, lysosomal
Band: 11p11.2
Quick LinksEntrez ID:53; OMIM: 171650; Uniprot ID:PPAL_HUMAN; ENSEMBL ID: ENSG00000134575; HGNC ID: 123
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
hsa00740Riboflavin metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
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No data
Desease Name
Lysosomal acid phosphatase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ACP2 mRNAdecreases expression 17547211
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACP2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ACP2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ACP2 mRNAaffects expression 17562736
D000181 Acrylonitrile Acrylonitrile affects the activity of ACP2 proteinaffects activity 1964927
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACP2 mRNAaffects expression 16483693
D000965 Antimony Antimony results in decreased expression of ACP2 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of ACP2 mRNAdecreases expression 17547211
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of ACP2 mRNAincreases expression 18178546
D002857 Chromium Chromium results in decreased expression of ACP2 mRNAdecreases expression 17547211
D016572 Cyclosporine Cyclosporine results in decreased expression of ACP2 mRNAdecreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of ACP2 mRNAdecreases expression 17547211
D008628 Mercury Mercury results in decreased expression of ACP2 mRNAdecreases expression 17547211
C006253 pirinixic acid pirinixic acid results in increased expression of ACP2 mRNAincreases expression 18301758
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of ACP2 mRNAdecreases expression 17547211
D013467 Sulindac Sulindac results in increased expression of ACP2 mRNAincreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACP2 mRNAincreases expression 18796159
16054898
18178546
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.5014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D058186 Acute Kidney Injury Sulindac 4.297897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.9716033868
MESH:D000230 Adenocarcinoma Sulindac 4.9711910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.313712494
MESH:D000236 Adenoma Dimethylnitrosamine 11.3119555203
MESH:D000236 Adenoma Sulindac 11.3110223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.5817611924 11874996 12394442 16460482 11535846 19003578 15623613
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.8616634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001913 Bowen's Disease Sulindac 5.3511207687
MESH:D001932 Brain Neoplasms Acrylonitrile 5.4712562636
MESH:D001943 Breast Neoplasms Chromium 2.1215986119
MESH:D001943 Breast Neoplasms Sulindac 2.1216642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D001991 Bronchitis Antimony 6.138768112
MESH:D002277 Carcinoma Dimethylnitrosamine 8.3019555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3016835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.4916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.493581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.493084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9416033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Antimony 6.5210334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.5210334427
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.066135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.067505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.299022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.2919486331
MESH:D002779 Cholestasis pirinixic acid 13.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 15340226 16354765 15668235 8697196
MESH:D003110 Colonic Neoplasms Sulindac 2.9212458338 12902858
MESH:D015179 Colorectal Neoplasms Sulindac 2.6810666051 11076880 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 11.748970840 14531868 11298694 2524372 18759878 11906362 8156756 12868966
MESH:D017449 Dermatitis, Allergic Contact Mercury 11.7416823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 11.7416823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.473621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.1612861449 17621415
MESH:D004283 Dog Diseases Antimony 5.6512019027
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.209022650 18289764 6679447 16192314 9653073 7440962 11289319 1440618 6482804 18692083 9328219 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2011834606 12392966 16227642 17562736 17906064 19164858 16177239 12594235 12958197 11421492 16081117 16485898 14725611 19923254 15968718 2444490 19085960 16393943 11287661 19420014 19739265 15619225 16109766 17522070 10915739 19370779 14986274 11461765 11529661 18713872 10774834 11743745 14550746 12705907 18071297 12540782 12153990 10663392 11739529 19416960 16781746
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 15.2017851650
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 15.208172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D004715 Endometriosis Sulindac 9.1315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.139294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.423581430
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.4217016578
MESH:D004938 Esophageal Neoplasms Sulindac 7.4212235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 7.5019224547
MESH:D005234 Fatty Liver pirinixic acid 7.5020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.4714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.1219069698
MESH:D005355 Fibrosis Cyclosporine 8.4412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.9911910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly pirinixic acid 8.2219772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2212621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218670907 18850075
MESH:D007249 Inflammation Sulindac 5.203291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2012200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.6212663524 12351151 12584176 12628509 10223192 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.9711245490 12394442
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 18.9812587719 15629191
MESH:D007674 Kidney Diseases Chromium 18.9817934191
MESH:D007674 Kidney Diseases Cyclosporine 18.988314463 18776723 10903974
MESH:D007674 Kidney Diseases Mercury 18.9817934191
MESH:D007674 Kidney Diseases Potassium Dichromate 18.9819665454
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.266582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2612371664
MESH:D007896 Leishmaniasis Antimony 4.7912019027 10953559 21063981 21182181 15220340
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.6511475954 8889330 19141829
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.4810881086 11370249 9643325 10651420 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony 8.6811105143 7875148 7854095 20495762 8142506 1899875 7554475
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.6812707265
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.509834237
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 8.4615034207 9327722
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 8.4612468960
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.4718637143 15099470 15086199 17198567 17534399 17196135 12918455 15492853 16270385 15479170 18237412 16544323 18210741 18364076 18371158 15138612 15733078 16042886 15798949 15942678 14659978 18239293 15366600 16169303 15842777 18672772 17640959 15577212 12925901 17432682 18567088 15864749 15339415 16627068 17881167 18095165 17201889 15763062 15383259 15081153 16009107 17719030 17724770 17036385 14568256 17465448 15161499 17348192 16603200 14709902 18629640 17666798 15571005 15067225 15504291 15298665 15591649 15793283 15723089 15744066 17203207 15369754 14643895 14726149 16570917
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Acetaminophen 4.2319784758 16611625 12969438 12587719 11587558 19460945 19014921 16610002
MESH:D008107 Liver Diseases Sulindac 4.2314986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6117185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.6117457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.647678174
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 10.6415890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 10.6420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.032876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.031399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 14.036150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0312151625
MESH:D008175 Lung Neoplasms Acrylonitrile 4.9917372256
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.9911884234 16061637 19555203
MESH:D008175 Lung Neoplasms Sulindac 4.9915713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Acrylonitrile 5.8412562636
MESH:D008545 Melanoma Sulindac 2.8316642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.463581430
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.906679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4618514411
MESH:D019636 Neurodegenerative Diseases Sulindac 8.4617266991 16850258
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.824026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010146 Pain Acetaminophen 6.8516870215
MESH:D010146 Pain Sulindac 6.853291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.3411504793 16820089
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010409 Penile Diseases Antimony 5.719643325
MESH:D010493 Pericarditis Antimony 6.1020465667
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811896295 11118676 11399792 11222880
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6118551238
MESH:D012640 Seizures Acrylonitrile 6.6120127315
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2712587719
MESH:D013274 Stomach Neoplasms Acrylonitrile 3.4212562636
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.4216033868
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.876587162 1399818 6582329 7505956 3712494
MESH:D014352 Trypanosomiasis Antimony 5.9315220340
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.988074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms Sulindac 4.5818645019
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:00740 Riboflavin metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24447
  • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018