AutismKB 2.0

Annotation Detail for PIP


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Basic Information Top
Gene Symbol:PIP ( GCDFP-15,GCDFP15,GPIP4 )
Gene Full Name: prolactin-induced protein
Band: 7q34
Quick LinksEntrez ID:5304; OMIM: 176720; Uniprot ID:PIP_HUMAN; ENSEMBL ID: ENSG00000159763; HGNC ID: 8993
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
Desease Name
prostate cancer
CANCER
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PIP mRNAaffects expression 17562736
D013196 Dihydrotestosterone AR protein promotes the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]increases expression|increases reaction 10402478
D013196 Dihydrotestosterone bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]decreases reaction|increases expression 10402478
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of PIP mRNAincreases expression 10402478
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of PIP proteinincreases expression 10402478
D013196 Dihydrotestosterone hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]decreases reaction|increases expression 10402478
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PIP mRNAaffects expression 16483693
C053541 bicalutamide bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]decreases reaction|increases expression 10402478
C053541 bicalutamide bicalutamide results in decreased expression of PIP mRNAdecreases expression 10402478
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PIP mRNAaffects cotreatment|increases expression 17183730
C014290 hydroxyflutamide hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of PIP mRNA]decreases reaction|increases expression 10402478
C014290 hydroxyflutamide hydroxyflutamide results in decreased expression of PIP mRNAdecreases expression 10402478
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of PIP mRNAincreases expression 15103026
C006253 pirinixic acid pirinixic acid results in increased expression of PIP mRNAincreases expression 12832660
C025299 polyphenols polyphenols results in decreased expression of PIP mRNAdecreases expression 16293270
C035988 procymidone procymidone results in decreased expression of PIP mRNAdecreases expression 15686871
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PIP mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin results in decreased expression of PIP mRNAdecreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 9.5612805644 15959878 1761407 3652986 1761404
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.568875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 9.1517497229
MESH:D001008 Anxiety Disorders vinclozolin 9.1519015723
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 17688650 18558336 17157402 18316065 18177632 18985861 19232924 15238991 16609825 20603192 18775368 19460635 18396377 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4819085960 19370779 11461765 11739529 15968718 17562736 11834606 12392966 16081117 10774834 10915739 16393943 12958197 18713872 16109766 18071297 15619225 17906064 14986274 12153990 19416960 12705907 19923254 10663392 17522070 16485898 16781746 11743745 11421492 12540782 14725611 11529661 2444490 14550746 19420014 19164858 16227642 19739265 16177239 11287661 12594235
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.4819370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.481733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.687562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D005234 Fatty Liver pirinixic acid 8.0919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.0919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.853652986
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1318467677 19176532 19772884 16221962
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation polyphenols 3.1116366677
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 4.8212805644 15959878
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.2411587558 19014921 12587719 16611625 16610002 12969438 19784758 19460945
MESH:D008107 Liver Diseases polyphenols 4.2416698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8516377806 20007298 15890375
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.208888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2419015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms bicalutamide 4.2619240160 18487222 17914592 19011039 15638997
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7112752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8111738929 1511512 17978042 3137016 15475178 14763951 16876388 11044598
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013576 Syndactyly methoxyacetic acid 5.761761407 1761404
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4317997062
MESH:D013733 Testicular Diseases methoxyacetic acid 5.4818486176 6499806
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014581 Urticaria Acetaminophen 3.0910982225
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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