AutismKB 2.0

Annotation Detail for PITPNA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PITPNA ( MGC99649,PI-TPalpha,PITPN,VIB1A )
Gene Full Name: phosphatidylinositol transfer protein, alpha
Band: 17p13.3
Quick LinksEntrez ID:5306; OMIM: 600174; Uniprot ID:PIPNA_HUMAN; ENSEMBL ID: ENSG00000174238; HGNC ID: 9001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200074Netrin-mediated signaling
No data
Pathway IDPathway Name
500091Role of second messengers in netrin-1 signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PITPNA mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PITPNA mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PITPNA mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in increased expression of PITPNA mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PITPNA mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PITPNA mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PITPNA mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PITPNA mRNAincreases expression 12655037
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PITPNA mRNAincreases expression 17616710
C041786 palm oil palm oil results in increased expression of PITPNA mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of PITPNA mRNAincreases expression 16940010
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of PITPNA mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of PITPNA mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of PITPNA mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PITPNA mRNAaffects cotreatment|increases expression 17942748
D013752 Tetracycline Tetracycline results in increased expression of PITPNA mRNAincreases expression 16917069
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of PITPNA mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of PITPNA mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.853084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9415861022 17681005 17333356 16919318 17110522 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 16354765 12621046 8697196 15340226
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2711529661 16227642 16393943 14725611 11421492 15968718 12392966 18071297 17522070 19085960 16485898 17906064 14986274 12153990 11743745 11461765 19164858 11287661 10663392 16081117 15619225 19739265 2444490 12705907 12594235 16109766 14550746 18713872 10774834 11834606 12540782 10915739 11739529 19416960 19420014 16781746 17562736 16177239 19370779 19923254 12958197
MESH:D056486 Drug-Induced Liver Injury Selenium 12.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2720420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.2717522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7915878914 16704527 16510608 15150132 16805852 15547721 15264214 15623463 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Dietary Fats 19.5019004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.5015345470
MESH:D005234 Fatty Liver pirinixic acid 19.5019236843 20131406
MESH:D005234 Fatty Liver Tetracycline 19.5019224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Dietary Fats 8.9718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Dietary Fats 5.0520412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0512878042 12200463
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance Dietary Fats 7.4211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1112587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.1112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0416705839
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4516169303
MESH:D008107 Liver Diseases Acetaminophen 1.6516610002 12969438 12587719 16611625 19784758 11587558 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.497678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.4916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.906135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 2.3311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.929884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Dietary Fats 4.4916723640 21332399 18457598 17217161 19632207 20132043 18674790 11836018 20518802
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.5711026799
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11118676 11399792 11896295
MESH:D017096 Prion Diseases Tetracycline 5.5310903871
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3217575124 12958204
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02144 - 1,2-Diacyl-Sn-Glycero-3-Phosphoinositol
DB03690 - (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved