AutismKB 2.0

Annotation Detail for PITX1


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Basic Information Top
Gene Symbol:PITX1 ( BFT,CCF,POTX,PTX1 )
Gene Full Name: paired-like homeodomain 1
Band: 5q31.1
Quick LinksEntrez ID:5307; OMIM: 602149; Uniprot ID:PITX1_HUMAN; ENSEMBL ID: ENSG00000069011; HGNC ID: 9004
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1841Stomach cancer
2124Autistic disorder
2164Barrett's esophagus
2231Arthritis
Desease Name
height
DEVELOPMENTAL
Desease Name
Height
Desease Name
Clubfoot, congenital
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PITX1 mRNAaffects expression 16483693
D001241 Aspirin Aspirin results in increased expression of PITX1 mRNAincreases expression 11906190
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PITX1 mRNAaffects cotreatment|increases expression 18164116
C121718 dicyclanil dicyclanil results in increased expression of PITX1 mRNAincreases expression 15664270
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PITX1 mRNAaffects cotreatment|increases expression 18164116
D004317 Doxorubicin Doxorubicin results in increased expression of PITX1 mRNAincreases expression 16404146
D004958 Estradiol Estradiol affects the expression of PITX1 mRNAaffects expression 14699072
C025299 polyphenols polyphenols results in decreased expression of PITX1 mRNAdecreases expression 16293270
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of PITX1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of PITX1 mRNAincreases expression 19244175
D013974 Thyroxine Thyroxine results in decreased expression of PITX1 mRNAdecreases expression 17403546
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of PITX1 mRNAaffects cotreatment|increases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Doxorubicin 4.6017418594
MESH:D000230 Adenocarcinoma Estradiol 4.6011473722
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.146695378 10737359
MESH:D018248 Adenoma, Liver Cell dicyclanil 11.3417162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.3417620307 16434500 19061943 18056438 17162532 19052882
MESH:D000419 Albuminuria Doxorubicin 4.7021441931
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8120485159 12372130
MESH:D001321 Autistic Disorder marker/mechanism 18053270
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9214601052
MESH:D001932 Brain Neoplasms Aspirin 9.5815481559
MESH:D001932 Brain Neoplasms Doxorubicin 9.5817150277
MESH:D001943 Breast Neoplasms Aspirin 2.0415161893
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0417474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.0416264153 19526202 18382427 15668708 18628466 15567936 15939500 16595493 18695136 18234424 15136595 16935488 16096432 17369602 15993339 17983394 15994142 15692762 16826403 15634643 16322301 16115903 11325840 17426702
MESH:D001943 Breast Neoplasms Estradiol 2.0417289903 19861407 12948864 18497071 16675129 14630087 17261762 17018787
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002276 Carcinoid Tumor Doxorubicin 5.0316051944
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 6.8217162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8219822196 16779866 18971187 19208518 17428255 19919837 20084675 17173139 19519916 17761372 16807293 16288022 18691550 20524982 18056438 20007298 17162532 18393292 10737359 17138121 20432363 17978847 18494052 16328049 19335982 16569478 18978308 16502159 19418558 17055752 19394651 21159647 16878318 18210153 20512989 19701751 16540662 20214788 20727157 19052882 20935162 16935385 18788625 19539802 20514400 11831363 16681979 18506893 16830150 3084413 16698587 19171122 19383236 10672840 18785209 3581430 20101231 18665156 19107877
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.8216234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8216924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2216201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.676189445
MESH:D006332 Cardiomegaly Thyroxine 4.1718093424
MESH:D009202 Cardiomyopathies Doxorubicin 3.6216731534 17131338 15792986 17329180 16269455 16612575 17351982 16455267 17308081 16952015 16651473 16278810 17519947 17974986 16364871 17928571 15505089 17007740 15811867 17924179 17382496 16242529 16109756 18627295 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9816243910 17334414
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.012727394 21159647 7505956 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.0118566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D003025 Clubfoot marker/mechanism
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms Aspirin 4.3512411196
MESH:D003110 Colonic Neoplasms polyphenols 4.3516293270
MESH:D015179 Colorectal Neoplasms Aspirin 2.9517047198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9518259882 18802399
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3719107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.3717416283
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.3719370779
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3715131321
MESH:D004362 Drug Toxicity Doxorubicin 3.7718602426
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Aspirin 4.0317259670
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8317359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.8318566989 11473722 19148513
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3718037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3221071580 20387270
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7819069698
MESH:D005909 Glioblastoma Aspirin 7.8812870263
MESH:D005909 Glioblastoma Doxorubicin 7.8817150277
MESH:D006261 Headache Aspirin 5.1815240983
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6215692506
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006331 Heart Diseases Doxorubicin 3.5818006777 16707910 16495754 17888722 16244372 18674790 17875725 16244371 16330681 16144979 16879835 14766674 12587719
MESH:D006333 Heart Failure Doxorubicin 7.5217481944
MESH:D006333 Heart Failure Selenium 7.5217162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0415692506
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.5318501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 10.7917088409
MESH:D019584 Hot Flashes Vitamin E 10.7914716179
MESH:D012001 Hyperacusis Aspirin 5.9815240983
MESH:D007249 Inflammation Diethylnitrosamine 5.5618785209
MESH:D007249 Inflammation polyphenols 5.5616366677
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007674 Kidney Diseases Doxorubicin 10.6015369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 10.6015618244
MESH:D007674 Kidney Diseases Vitamin E 10.6012488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.4616707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.4616518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3716085563
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8919638242 20032147 18665156 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.6516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6516169303
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4317034775
MESH:D008107 Liver Diseases polyphenols 4.4316698588
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.9721295105 19389873
MESH:D008113 Liver Neoplasms dicyclanil 7.9720118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9718644402 19551842 18648771 21071580 20137499 21167192 19690152 20492335 19812893 2422723 15175105 10737359 20452335 19294768 18977376 9163691 16942905 2862719 12771043 21047994 19427195 20501860 19426721 19996281 20101389 19850985 19499222 20434301 12112319 19642983 19073162 19255062 19638242 18978307 18754104 19090486 19254457 19833225 21278145 20405173 15885732 20583210 20118626 19256749
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.4818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4816842330 18164116 16267830 18544905 9362446 18253720 18308698 18079962 21159647 18775883 19004024 19126423 19539802 19009564 2563599 17174075 18282651 17854601 18093689 19519916 3124819 17942915
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.4816842330 17085340
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5920512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 3.5917418594 6189445
MESH:D008175 Lung Neoplasms Vitamin E 3.5911062179
MESH:D008223 Lymphoma Doxorubicin 3.5616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.5315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.5316891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.5315318939
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008654 Mesothelioma Doxorubicin 6.4517638057
MESH:D008654 Mesothelioma Selenium 6.4515107826
MESH:D008881 Migraine Disorders Aspirin 4.1615240983
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6415792986
MESH:D052016 Mucositis Doxorubicin 4.9817415656
MESH:D009203 Myocardial Infarction Aspirin 6.4012692751
MESH:D009203 Myocardial Infarction Doxorubicin 6.4015857846 19429709
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009325 Nausea Aspirin 5.4315240983
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.053581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.0518259882
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009401 Nephrosis Doxorubicin 4.9416899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1215640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 3.8116427766 11399458
MESH:D009447 Neuroblastoma Doxorubicin 3.3315555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D010003 Osteoarthritis Aspirin 4.147009135
MESH:D012516 Osteosarcoma Doxorubicin 4.2315930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Aspirin 3.976995502 6363464
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.7311156591
MESH:D020795 Photophobia Aspirin 5.9815240983
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3717983394
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3717638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.5815749863 16729912 16888761 18437689 16868541 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.5816740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5815084515
MESH:D051437 Renal Insufficiency Doxorubicin 4.4017922066
MESH:D012220 Rhinitis Aspirin 4.5012372130
MESH:D012509 Sarcoma Doxorubicin 4.1216767912 17203757 15675481 18313854 15625365 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9817846226
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.4412269725
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Doxorubicin 3.0115692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7416767912 17203757 15625365
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Aspirin 9.2916403987
MESH:D020521 Stroke Vitamin E 9.2916517955
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4717997062
MESH:D013927 Thrombosis Aspirin 4.6417672075
MESH:D013959 Thyroid Diseases Thyroxine 5.8619910387
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.657505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.6516010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8117653716
MESH:D014581 Urticaria Aspirin 4.5920485159 10982225
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4017334414 17638931 17678736 16364871
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33338
    • No data
    Releated disease ID Related disease Name
    PA443741Clubfoot
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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