AutismKB 2.0

Annotation Detail for PLA2G4A


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Basic Information Top
Gene Symbol:PLA2G4A ( MGC126350,PLA2G4,cPLA2-alpha )
Gene Full Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Band: 1q31.1
Quick LinksEntrez ID:5321; OMIM: 600522; Uniprot ID:PA24A_HUMAN; ENSEMBL ID: ENSG00000116711; HGNC ID: 9035
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LIPASYN-PWYphospholipases
Pathway IDPathway Name
hsa00565Ether lipid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa00590Arachidonic acid metabolism
hsa05145Toxoplasmosis
hsa04730Long-term depression
hsa04972Pancreatic secretion
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
hsa04370VEGF signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Hemostasis
Opioid Signalling
Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
200004Endothelins
200154Signaling mediated by p38-alpha and p38-beta
Pathway IDPathway Name
P00046Oxidative stress response
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00005Angiogenesis
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500292ADP signalling through P2Y purinoceptor 1
500838phospho-PLA2 pathway
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1876Gouts
1904Diabetes mellitus
2025Polyarthritis
2022Liver cancer
2051Leukemia
2053Colon cancer
2069Schizophrenia
2087Bacterial infection
Desease Name
PSYCH
knee osteoarthritis
schizophrenia
METABOLIC
No data
Desease Name
Phospholipase A2, group IV A, deficiency of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PLA2G4A mRNAincreases expression 19933214
C447028 2,2',4,6-tetrachlorobiphenyl PLA2G4A protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]increases reaction|increases secretion 16120751
C009407 2,5,2',5'-tetrachlorobiphenyl 2,5,2',5'-tetrachlorobiphenyl affects the localization of and results in increased phosphorylation of PLA2G4A proteinaffects localization|increases phosphorylation 16290172
C109986 2-aminoethoxydiphenyl borate [Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]affects cotreatment|decreases reaction|increases expression 18938131
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of PLA2G4A mRNAincreases expression 19643169
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 16603213
D020106 Acrylamide Acrylamide analog results in decreased activity of PLA2G4A proteindecreases activity 18287786
D000255 Adenosine Triphosphate Adenosine Triphosphate results in increased activity of PLA2G4A proteinincreases activity 10535451
D000535 Aluminum Aluminum affects the activity of PLA2G4A proteinaffects activity 17279785
C041524 aluminum sulfate aluminum sulfate results in increased expression of PLA2G4A mRNAincreases expression 15961160
D016718 Arachidonic Acid AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]]affects reaction|increases reaction|increases secretion 19162293
D016718 Arachidonic Acid PLA2G4A protein promotes the reaction [2,2',4,6-tetrachlorobiphenyl results in increased secretion of Arachidonic Acid]increases reaction|increases secretion 16120751
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
19162293
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PLA2G4A protein]decreases reaction|increases activity 19063610
D001241 Aspirin Aspirin results in decreased expression of PLA2G4A mRNAdecreases expression 10706128
D001554 Benzene Benzene affects the expression of PLA2G4A mRNAaffects expression 15878777
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PLA2G4A mRNAincreases expression 20064835
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of PLA2G4A proteinincreases expression 16443645
D020122 tert-Butylhydroperoxide 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D020122 tert-Butylhydroperoxide arachidonyltrifluoromethane inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D020122 tert-Butylhydroperoxide calphostin C inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D020122 tert-Butylhydroperoxide Go 6976 inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D020122 tert-Butylhydroperoxide Pertussis Toxin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased activity of PLA2G4A proteinincreases activity 16291515
D020122 tert-Butylhydroperoxide Vitamin E inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PLA2G4A mRNAincreases expression 15336504
C058819 calphostin C calphostin C inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
C459604 candoxin candoxin results in decreased expression of PLA2G4A mRNAdecreases expression 16309724
D002220 Carbamazepine Carbamazepine results in decreased expression of PLA2G4A mRNAdecreases expression 15312812
D002220 Carbamazepine Carbamazepine results in decreased expression of PLA2G4A proteindecreases expression 15312812
D002220 Carbamazepine Carbamazepine results in increased expression of PLA2G4A mRNAincreases expression 17594078
D002220 Carbamazepine Carbamazepine results in increased expression of PLA2G4A proteinincreases expression 17594078
D002220 Carbamazepine Carbamazepine inhibits the reaction [TCFAP2A protein binds to PLA2G4A gene]affects binding|decreases reaction 16806101
D002220 Carbamazepine Carbamazepine inhibits the reaction [TCFAP2B protein binds to PLA2G4A gene]affects binding|decreases reaction 16806101
D002220 Carbamazepine Carbamazepine inhibits the reaction [TCFAP2C protein binds to PLA2G4A gene]affects binding|decreases reaction 16806101
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLA2G4A mRNAaffects expression 17484886
C105934 celecoxib [celecoxib co-treated with docetaxel] results in decreased expression of PLA2G4A proteinaffects cotreatment|decreases expression 16052515
C105934 celecoxib celecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]decreases expression|decreases reaction 15816863
D003513 Cycloheximide Cycloheximide inhibits the reaction [Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]]decreases reaction|increases activity 10874129
D016572 Cyclosporine Cyclosporine results in decreased expression of PLA2G4A mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 9609743
D003907 Dexamethasone Cycloheximide inhibits the reaction [Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]]decreases reaction|increases activity 10874129
D003907 Dexamethasone Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 10874129
D003907 Dexamethasone Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]decreases reaction|increases activity 10874129
D003907 Dexamethasone Dexamethasone results in decreased activity of PLA2G4A proteindecreases activity 10874129
D003907 Dexamethasone Dexamethasone results in decreased expression of PLA2G4A mRNAdecreases expression 10874129
D003907 Dexamethasone Dexamethasone results in decreased expression of PLA2G4A proteindecreases expression 10874129
D002945 Cisplatin Cisplatin results in increased expression of PLA2G4A mRNAincreases expression 15471895
15464296
D004155 Diphenhydramine Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 9609743
D004050 Ditiocarb Acetylcysteine inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 16603213
D004050 Ditiocarb Ditiocarb results in increased expression of PLA2G4A mRNAincreases expression 16603213
D004050 Ditiocarb Ditiocarb results in increased expression of PLA2G4A proteinincreases expression 16603213
D004050 Ditiocarb Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]affects reaction|increases expression 16603213
D004050 Ditiocarb Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein]affects reaction|increases expression 16603213
D004050 Ditiocarb U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 16603213
D004050 Ditiocarb U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A protein]decreases reaction|increases expression 16603213
C067311 docetaxel [celecoxib co-treated with docetaxel] results in decreased expression of PLA2G4A proteinaffects cotreatment|decreases expression 16052515
C046770 EGTA acetoxymethyl ester EGTA acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 19162293
D015777 Eicosanoids PLA2G4A protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]increases metabolic processing|increases reaction 17369491
D015777 Eicosanoids PLA2G5 protein promotes the reaction [Zymosan promotes the reaction [PLA2G4A protein results in increased metabolism of Eicosanoids]]increases metabolic processing|increases reaction 16407308
D004958 Estradiol Estradiol results in decreased expression of PLA2G4A mRNAdecreases expression 14664709
D018690 Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists results in increased expression of and results in increased phosphorylation of and results in increased activity of PLA2G4A proteinincreases activity|increases expression|increases phosphorylation 17550430
D018690 Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists results in increased expression of PLA2G4A mRNAincreases expression 17550430
D005472 Fluorouracil PLA2G4A protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005473 Fluoxetine Fluoxetine results in increased expression of and results in increased phosphorylation of and results in increased activity of PLA2G4A proteinincreases activity|increases expression|increases phosphorylation 16636684
D005473 Fluoxetine Fluoxetine results in increased stability of and results in increased expression of PLA2G4A mRNAincreases expression|increases stability 16636684
C065382 fluticasone fluticasone affects the localization of PLA2G4A proteinaffects localization 15753895
D009240 N-Formylmethionine Leucyl-Phenylalanine PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4]increases metabolic processing|increases reaction 11741884
C081021 Go 6976 Go 6976 inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
D007975 Leukotriene B4 PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4]increases metabolic processing|increases reaction 11741884
D007975 Leukotriene B4 PLA2G4A protein promotes the reaction [Zymosan analog results in increased metabolism of Leukotriene B4]increases metabolic processing|increases reaction 11741884
D006632 Histamine Dexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 9609743
D006632 Histamine Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 9609743
D006632 Histamine Histamine results in increased expression of PLA2G4A mRNAincreases expression 9609743
D006632 Histamine L 663536 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 9609743
C060893 L 663536 L 663536 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 9609743
D008070 Lipopolysaccharides Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 10874129
D008070 Lipopolysaccharides PLA2G4A protein affects the susceptibility to [Lipopolysaccharides co-treated with Zymosan]affects cotreatment|affects response to substance 10881173
D008070 Lipopolysaccharides PLA2G4A protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]affects cotreatment|increases metabolic processing|increases reaction 16787386
D008094 Lithium Lithium results in increased expression of PLA2G4A mRNAincreases expression 17594078
D008094 Lithium Lithium results in increased expression of PLA2G4A proteinincreases expression 17594078
D016651 Lithium Carbonate Lithium Carbonate results in increased expression of PLA2G4A mRNAincreases expression 17594078
D016651 Lithium Carbonate Lithium Carbonate results in increased expression of PLA2G4A proteinincreases expression 17594078
C104810 methyl arachidonylfluorophosphonate methyl arachidonylfluorophosphonate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
C005219 methyl cellosolve methyl cellosolve results in increased expression of PLA2G4A mRNAincreases expression 19643169
C008493 methylselenic acid methylselenic acid results in increased expression of PLA2G4A mRNAincreases expression 18548127
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
D009543 Nifedipine [Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]affects cotreatment|decreases reaction|increases expression 18938131
D009543 Nifedipine Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 19162293
D009569 Nitric Oxide Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]affects reaction|increases expression 16603213
D009569 Nitric Oxide Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein]affects reaction|increases expression 16603213
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PLA2G4A mRNAincreases expression 17616710
D010126 Ozone Ozone results in increased expression of PLA2G4A proteinincreases expression 12855403
D010126 Ozone SOD1 protein inhibits the reaction [Ozone results in increased expression of PLA2G4A protein]decreases reaction|increases expression 12855403
C508075 Pam(3)CSK(4) peptide PLA2G4A protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]increases metabolic processing|increases reaction 17369491
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D011374 Progesterone Progesterone results in increased expression of PLA2G4A mRNAincreases expression 18070364
D011453 Prostaglandins PLA2G4A protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]affects cotreatment|increases metabolic processing|increases reaction 16787386
C116926 rofecoxib rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]decreases expression|decreases reaction 15816863
D012906 Smoke Smoke results in increased expression of PLA2G4A mRNAincreases expression 17255567
D013467 Sulindac Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]decreases expression|decreases reaction 15816863
D013467 Sulindac Sulindac results in decreased expression of PLA2G4A mRNAdecreases expression 10706128
D013629 Tamoxifen PLA2G4A mRNA results in decreased susceptibility to Tamoxifendecreases response to substance 21119660
C011363 terephthalic acid terephthalic acid results in increased expression of PLA2G4A mRNAincreases expression 16621493
D013749 Tetrachlorodibenzodioxin 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
D013749 Tetrachlorodibenzodioxin AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]]affects reaction|increases reaction|increases secretion 19162293
D013749 Tetrachlorodibenzodioxin arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
19162293
D013749 Tetrachlorodibenzodioxin EGTA acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 19162293
D013749 Tetrachlorodibenzodioxin methyl arachidonylfluorophosphonate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
D013749 Tetrachlorodibenzodioxin N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 18938131
D013749 Tetrachlorodibenzodioxin [Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]affects cotreatment|decreases reaction|increases expression 18938131
D013749 Tetrachlorodibenzodioxin Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 19162293
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNAincreases expression 18938131
19162293
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of PLA2G4A proteinincreases activity|increases phosphorylation 19162293
D013749 Tetrachlorodibenzodioxin arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PLA2G4A protein]decreases reaction|increases activity 19063610
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PLA2G4A promoter]affects binding|increases reaction 19282623
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNAincreases expression 19933214
17942748
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of PLA2G4A proteinincreases phosphorylation 10874129
C113580 U 0126 U 0126 results in decreased phosphorylation of PLA2G4A proteindecreases phosphorylation 17369491
C113580 U 0126 U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]decreases reaction|increases expression 16603213
C113580 U 0126 U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A protein]decreases reaction|increases expression 16603213
D014635 Valproic Acid Valproic Acid results in increased expression of PLA2G4A mRNAincreases expression 17594078
D014635 Valproic Acid Valproic Acid results in increased expression of PLA2G4A proteinincreases expression 17594078
D014810 Vitamin E Vitamin E inhibits the reaction [tert-Butylhydroperoxide results in increased activity of PLA2G4A protein]decreases reaction|increases activity 16291515
D015032 Zinc Zinc results in increased expression of PLA2G4A mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of PLA2G4A mRNAincreases expression 17074742
D015054 Zymosan PLA2G4A protein promotes the reaction [Zymosan analog affects the localization of NCF1 protein]affects localization|increases reaction 12101222
D015054 Zymosan PLA2G4A protein promotes the reaction [Zymosan analog affects the localization of NCF2 protein]affects localization|increases reaction 12101222
D015054 Zymosan PLA2G4A protein promotes the reaction [Zymosan analog results in increased metabolism of Leukotriene B4]increases metabolic processing|increases reaction 11741884
D015054 Zymosan Cycloheximide inhibits the reaction [Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]]decreases reaction|increases activity 10874129
D015054 Zymosan Dexamethasone inhibits the reaction [Zymosan results in increased activity of PLA2G4A protein]decreases reaction|increases activity 10874129
D015054 Zymosan PLA2G4A protein affects the susceptibility to [Lipopolysaccharides co-treated with Zymosan]affects cotreatment|affects response to substance 10881173
D015054 Zymosan PLA2G4A protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]affects cotreatment|increases metabolic processing|increases reaction 16787386
D015054 Zymosan Zymosan results in increased phosphorylation of PLA2G4A proteinincreases phosphorylation 10874129
D015054 Zymosan PLA2G5 protein promotes the reaction [Zymosan promotes the reaction [PLA2G4A protein results in increased metabolism of Eicosanoids]]increases metabolic processing|increases reaction 16407308
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 10.6514745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 10.6514745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 19.396499820 7151721 6499812 6499823 6499796
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 19.398986270
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 19.396474471 6499812 3652986
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.3915322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 19.398875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.3019490988
MESH:D000138 Acidosis Zinc Sulfate 4.217265320
MESH:D000168 Acrocephalosyndactylia U 0126 4.8017694057
MESH:D000169 Acrodermatitis Zinc 4.7016889938 17202136 17190629
MESH:D058186 Acute Kidney Injury Cisplatin 6.9712690470 17670903 15814532
MESH:D058186 Acute Kidney Injury Sulindac 6.977897758
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.3911850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.9720127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 10.9711798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 10.9711473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.9717638652
MESH:D000230 Adenocarcinoma Sulindac 10.9711910360
MESH:D000236 Adenoma Benzo(a)pyrene 5.486695378
MESH:D000236 Adenoma Sulindac 5.4810223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.6816835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 13.0119003578 16215675
MESH:D011125 Adenomatous Polyposis Coli Leukotriene B4 13.0117942926
MESH:D011125 Adenomatous Polyposis Coli Sulindac 13.0112394442 11874996 19003578 11535846 16460482 15623613 17611924
MESH:D000544 Alzheimer Disease Aluminum 10.2110721010 17662457
MESH:D000544 Alzheimer Disease Lithium 10.2119621015
MESH:D000544 Alzheimer Disease Nitric Oxide 10.2117556102
MESH:D000544 Alzheimer Disease Ozone 10.2115513908
MESH:D000544 Alzheimer Disease Zinc 10.2116325427 16410023 17119284 16580781
MESH:D000550 Amblyopia Valproic Acid 4.5217688650
MESH:D000690 Amyotrophic Lateral Sclerosis marker/mechanism 15816863
MESH:D000740 Anemia Fluorouracil 11.3715504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 11.3711748828
MESH:D000740 Anemia Zymosan 11.3718664788
MESH:D000741 Anemia, Aplastic Benzene 3.8114761424 11369114 17661222
MESH:D000748 Anemia, Macrocytic methyl cellosolve 5.633699323
MESH:D000755 Anemia, Sickle Cell Zinc 4.2316916123
MESH:D000860 Anoxia Zinc Sulfate 4.327265320
MESH:D001008 Anxiety Disorders Fluoxetine 7.4318083778
MESH:D001008 Anxiety Disorders Valproic Acid 7.4317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.3919183758
MESH:D001168 Arthritis Leukotriene B4 5.4711006272
MESH:D001169 Arthritis, Experimental Dexamethasone 9.9017659584
MESH:D001169 Arthritis, Experimental rofecoxib 9.9016690336
MESH:D001169 Arthritis, Experimental Zymosan 9.9017659584 15142272 16872482 15188379 15944321
MESH:D001172 Arthritis, Rheumatoid Ozone 2.3615570426
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 10.286499823 6499807 10689203
MESH:D053627 Asthenozoospermia methyl cellosolve 10.283987992
MESH:D001249 Asthma fluticasone 12.0511596838 11991558 11101185
MESH:D001249 Asthma Histamine 12.0516387687
MESH:D001249 Asthma Leukotriene B4 12.0511006272 19667530
MESH:D001249 Asthma Ozone 12.0516373670 17854713
MESH:D001249 Asthma Zinc 12.0517085522
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.1120485159 12372130
MESH:D001250 Asthma, Exercise-Induced Leukotriene B4 5.2119667531
MESH:D001259 Ataxia 2-ethoxyethanol 4.807151721
MESH:D001284 Atrophy 2-ethoxyethanol 9.2015850284 6499799
MESH:D001284 Atrophy methyl cellosolve 9.203699323 6705890 2626667
MESH:D001321 Autistic Disorder marker/mechanism 15301788
MESH:D001321 Autistic Disorder Arachidonic Acid 2.3418582451
MESH:D001321 Autistic Disorder Fluoxetine 2.3418775368 19232924
MESH:D001321 Autistic Disorder Valproic Acid 2.3416609825 18396377 17507914 17157402 18940202 19460635 20603192 19232924 18177632 17688650 18775368 18316065 18558336 18985861 15238991
MESH:D053713 Azoospermia 2-ethoxyethanol 4.896492198 6499807
MESH:D001714 Bipolar Disorder Carbamazepine 13.8320046352 17594078
MESH:D001714 Bipolar Disorder Lithium 13.8320338123 17594078 19153942 20046352
MESH:D001714 Bipolar Disorder Lithium Carbonate 13.8319448189 17594078 19330793
MESH:D001714 Bipolar Disorder Valproic Acid 13.8317594078 20046352
MESH:D001724 Birth Weight 2-ethoxyethanol 5.806499823 2884743
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.4212125929
MESH:D001791 Blood Platelet Disorders marker/mechanism
MESH:D001836 Body Weight Changes 2-ethoxyethanol 9.666499796 7151721
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 9.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.4015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.408888407
MESH:D001855 Bone Marrow Diseases Benzene 4.5216183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.1714601052
MESH:D001913 Bowen's Disease Sulindac 4.6411207687
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.6217868700
MESH:D001930 Brain Injuries Progesterone 8.7815845082 15665606 15380490
MESH:D001930 Brain Injuries Zinc 8.7817109824
MESH:D001932 Brain Neoplasms Aspirin 3.8115481559
MESH:D001943 Breast Neoplasms marker/mechanism 21119660
MESH:D001943 Breast Neoplasms Acrylamide 9.4316253758 18183576
MESH:D001943 Breast Neoplasms Aspirin 9.4315161893
MESH:D001943 Breast Neoplasms Benzene 9.4317162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.4320146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 9.4318382427 19526202
MESH:D001943 Breast Neoplasms docetaxel 9.4318628466 16495393 19526202 15692762 17369602 16264153 15567936
MESH:D001943 Breast Neoplasms Estradiol 9.4316675129 17018787 12948864 19861407 17289903 18497071 14630087 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 9.4316557594 18357371 15136595 16110121 18608205 16595493 19217205
MESH:D001943 Breast Neoplasms Nitric Oxide 9.4315631943
MESH:D001943 Breast Neoplasms Progesterone 9.4315562024 16175315 17614352
MESH:D001943 Breast Neoplasms Sulindac 9.4316642371
MESH:D001943 Breast Neoplasms Tamoxifen 9.4319244106 19189212 18629630 19011961 16818667 16873071 18821012 19142967 16273361 21152245 17242785 19115204 19289846 18855134 19059307 15668708 19288272 15565566 19066611 19200415 20859285 16202921 19410462 18351453 20390343 17893378 20135344 20544844 17261762 17440819 20005174 19189210 18997820 19221464 17049068 11161223 18984771 19084267 18425577 18815881 21138602 19487384 20065188 19155303 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.4320435547
MESH:D016535 Bronchial Hyperreactivity Leukotriene B4 7.2412654629 12794006
MESH:D016535 Bronchial Hyperreactivity Ozone 7.2415516495 17626835 18417511 19059883 18315731 16777450 14754758
MESH:D001986 Bronchial Spasm Histamine 5.1118298128
MESH:D029481 Bronchitis, Chronic fluticasone 6.0017687719
MESH:D002100 Cachexia Ozone 4.0416183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 7.6716011737 15721981 16124888 15700767 16097048 16192424 10355542 16050911 18705752 16227642 15673190 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 7.6716050911
MESH:D002276 Carcinoid Tumor Fluorouracil 3.9616051944
MESH:D002277 Carcinoma Fluorouracil 6.3017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.3016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8219066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 7.1218788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 7.1217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 7.1216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 7.1217088986 17045692 16799960 16332177 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 7.1216924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.1716685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung docetaxel 5.1711894018
MESH:D002292 Carcinoma, Renal Cell celecoxib 5.7716369983
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.7718695887
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 14.5617015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.5620419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 14.5617066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.5616757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 14.5618922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 14.5616543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.9418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.1616936243
MESH:D002386 Cataract Adenosine Triphosphate 4.1615003327
MESH:D002418 Cattle Diseases Acrylamide 4.7412510666
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 8.3318226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.3312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.3318566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 11.286499794
MESH:D002764 Cholecystitis methyl cellosolve 11.286499794
MESH:D002779 Cholestasis Cyclosporine 6.5619486331
MESH:D002779 Cholestasis Nitric Oxide 6.5616919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.7715340226 15668235 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms Aspirin 11.5912411196
MESH:D003110 Colonic Neoplasms celecoxib 11.5916004971
MESH:D003110 Colonic Neoplasms Dexamethasone 11.5915824018
MESH:D003110 Colonic Neoplasms Fluorouracil 11.5916340194 15001691 17169374 17725105 17172411 17016597 17287894 17018589 18772588 16510598
MESH:D003110 Colonic Neoplasms rofecoxib 11.5912902858
MESH:D003110 Colonic Neoplasms Sulindac 11.5912902858 12458338
MESH:D015179 Colorectal Neoplasms Aspirin 5.4217047198
MESH:D015179 Colorectal Neoplasms celecoxib 5.4211197048 18349538
MESH:D015179 Colorectal Neoplasms Cisplatin 5.4215273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.4216524972 18802399 18949393 18509181 18288408 16303861 16391804 18383874 17594712 20501625 15289873 17094418 18448328 17255274 16282729 15148649 17016601 17401013 14970324 16331619 17454858 17695437
MESH:D015179 Colorectal Neoplasms Sulindac 5.4210666051 18059344 11076880 11197048
MESH:D000013 Congenital Abnormalities methyl cellosolve 7.436499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 9.9215643154
MESH:D019465 Craniofacial Abnormalities Carbamazepine 9.929014606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 9.9217728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.9210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 9.9216575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 9.9219769572
MESH:D019465 Craniofacial Abnormalities Zinc 9.9219302082
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.7719747007
MESH:D007644 Darier Disease Fluorouracil 10.8916733453
MESH:D007644 Darier Disease Lithium 10.8920338123
MESH:D003643 Death 2-ethoxyethanol 5.256499796
MESH:D015140 Dementia, Vascular Nitric Oxide 5.2617556102
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6819031437
MESH:D003866 Depressive Disorder Fluoxetine 4.0815014590
MESH:D003872 Dermatitis marker/mechanism 18287786
MESH:D003872 Dermatitis Benzene 4.0815902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.7712438553
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.0619244398
MESH:D003920 Diabetes Mellitus Zinc 3.6116479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.4617107852
MESH:D003928 Diabetic Nephropathies Estradiol 6.8519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 6.8519279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.8117187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.5112861449 17621415
MESH:D003967 Diarrhea Dexamethasone 3.067237001
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.7611748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.9416538175 20216337 16538176 15057820
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 9.1411287661
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 9.1417465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.1419336974 15968718 7179309 16177239 15027814 4309450 6623471 16227642 3786805 19085960 15998439 9327722 10915739 7440962 6884620 11566570 21278145 17522070 10092053 2869522 3732212 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.141733752 19641884
MESH:D004362 Drug Toxicity Carbamazepine 10.7520216337
MESH:D004362 Drug Toxicity Cisplatin 10.7512649298 15033597 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 10.7511462148
MESH:D004421 Dystonia Valproic Acid 3.401851702
MESH:C538011 Eales disease Vitamin E 3.999068938
MESH:D004485 Eczema Dexamethasone 3.7912438553
MESH:D004487 Edema Arachidonic Acid 27.369599246 11698051 9831321 16716910 7990266 15177302
MESH:D004487 Edema Aspirin 27.3617259670
MESH:D004487 Edema Dexamethasone 27.3619703484
MESH:D004487 Edema Fluoxetine 27.3612798668
MESH:D004487 Edema L 663536 27.367990266
MESH:D004487 Edema Tetrachlorodibenzodioxin 27.3612711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 27.3611698051 16716910 8113982 15177302 9599246 8273558 7812673
MESH:D004487 Edema Zymosan 27.367907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.1915322242 18230668 16714409
MESH:D020964 Embryo Loss 2-ethoxyethanol 5.806499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 11.7017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 11.7017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.7019031437
MESH:D016889 Endometrial Neoplasms Estradiol 5.7519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.7516202921 20544844 17893378 19155303
MESH:D004715 Endometriosis celecoxib 22.1615652904
MESH:D004715 Endometriosis Progesterone 22.1616134523
MESH:D004715 Endometriosis rofecoxib 22.1615652904
MESH:D004715 Endometriosis Sulindac 22.1615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 22.1610568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.7017637181 15821434 15328337
MESH:D004802 Eosinophilia Histamine 4.3812689652
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.5916538176 19915237 20485159 18855540 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 8.9317275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.9317275665 3659116
MESH:D004828 Epilepsies, Partial Carbamazepine 8.0215008574 16628512 17116037
MESH:D004828 Epilepsies, Partial Valproic Acid 8.0216628512 3922381
MESH:D004827 Epilepsy Carbamazepine 5.7017178248 19700373 18234410 17465707 7988514 20417680 821787 19620853 19439326 9014606
MESH:D004827 Epilepsy Valproic Acid 5.7020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 2.997562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 9.447750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 8.5715276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.573659116
MESH:D004916 Erythromelalgia Carbamazepine 5.0219549232
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 17.4816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 17.4815464296 16481741 15173087 16785472 17638652
MESH:D004938 Esophageal Neoplasms docetaxel 17.4816337965
MESH:D004938 Esophageal Neoplasms Fluorouracil 17.4816337965 17638652 16481741 16785472 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 17.4815623463 16805852 15547721 15547733 15150132 15878914 15264214 16510608 16704527
MESH:D004938 Esophageal Neoplasms Sulindac 17.4812235107
MESH:D004938 Esophageal Neoplasms Zinc 17.4816543248
MESH:D005076 Exanthema Carbamazepine 4.7720485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.4711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.6412631006 12795759 15959796 17595544 16239168 61145 19224547 16045604
MESH:D005234 Fatty Liver Cyclosporine 13.6419224547
MESH:D005234 Fatty Liver Tamoxifen 13.6414986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 13.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.7716709447
MESH:D005313 Fetal Death 2-ethoxyethanol 8.572884743 7151721 6499823 7198755 6499820
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.5711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.1716575769
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 8.996499796
MESH:D005317 Fetal Growth Retardation Valproic Acid 8.9918558336 8888407
MESH:D005327 Fetal Resorption 2-ethoxyethanol 10.306499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 10.306499812 6474471 3987992 6499821
MESH:D020567 Fetal Weight 2-ethoxyethanol 11.286499820 2884743 7151721
MESH:D020567 Fetal Weight methyl cellosolve 11.286499821 6474471 6499812
MESH:D005334 Fever Arachidonic Acid 7.5111852909
MESH:D005334 Fever Lipopolysaccharides 7.5111852909 9205823
MESH:D018221 Fibromatosis, Abdominal Sulindac 10.6314745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 10.6314745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 9.3219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.3219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 10.7918705752
MESH:D005355 Fibrosis Cyclosporine 10.7912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.7920067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 4.813652986
MESH:D005756 Gastritis Zinc 4.0917241300
MESH:D005764 Gastroesophageal Reflux Sulindac 4.3411910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.528708960
MESH:D005909 Glioblastoma Aspirin 3.4712870263
MESH:D005910 Glioma Fluorouracil 2.5416145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8810696789
MESH:D006130 Growth Disorders Zinc 3.4817217573
MESH:D006261 Headache Aspirin 8.9315240983
MESH:D006261 Headache Nitric Oxide 8.9311554966 11284996
MESH:D006258 Head and Neck Neoplasms Cisplatin 6.3115102660 15464296
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.3115162350 15102660 18337622
MESH:D034381 Hearing Loss Cisplatin 3.7019898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.8315464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 12.5720471113
MESH:D006330 Heart Defects, Congenital Lithium 12.5719638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 12.5710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 12.5716080930
MESH:D006333 Heart Failure Zinc 3.1517162251
MESH:D006335 Heart Injuries Zinc 5.0517074742
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.086499821
MESH:D016481 Helicobacter Infections Zinc 3.8817241300
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 9.1720172899 10514026
MESH:D006402 Hematologic Diseases Benzene 9.1716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7215720958
MESH:D006461 Hemolysis 2-ethoxyethanol 9.9819051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 9.9817874071
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 7.4619110552 19900420
MESH:D006505 Hepatitis Zymosan 7.4619110552
MESH:D006527 Hepatolenticular Degeneration Zinc 9.0517276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 9.0517063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.2216120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 4.957520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 4.9516863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.3215709030
MESH:D006689 Hodgkin Disease Cisplatin 3.0216200630 16170182
MESH:D019584 Hot Flashes Estradiol 13.1117088409
MESH:D019584 Hot Flashes Fluoxetine 13.1114716179
MESH:D019584 Hot Flashes Vitamin E 13.1114716179
MESH:D006849 Hydrocephalus Valproic Acid 4.1717688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.338697196 16959395 15340226 16354765 18606429
MESH:D012001 Hyperacusis Aspirin 5.0515240983
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8316899240
MESH:D006940 Hyperemia Nitric Oxide 4.9111156591
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.1310459572
MESH:D006965 Hyperplasia Carbamazepine 4.5318773962
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 3.9017604070
MESH:D006973 Hypertension Benzene 12.9217940673
MESH:D006973 Hypertension Cyclosporine 12.9210903974
MESH:D006973 Hypertension Dexamethasone 12.9217042910
MESH:D006973 Hypertension Nifedipine 12.9220102058
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.9218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4015338365
MESH:D006976 Hypertension, Pulmonary L 663536 7.3214726295
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 7.3215838368
MESH:D007022 Hypotension Zinc Sulfate 3.837265320
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.7215869954
MESH:D007247 Infertility, Female 2-ethoxyethanol 8.886499823
MESH:D007247 Infertility, Female Acrylamide 8.8811020651
MESH:D007248 Infertility, Male 2-ethoxyethanol 8.866499823
MESH:D007248 Infertility, Male Acrylamide 8.8615355880 12507653 11020651 15749267
MESH:D007248 Infertility, Male methyl cellosolve 8.863987992
MESH:D007249 Inflammation Aluminum 32.4716052892
MESH:D007249 Inflammation Arachidonic Acid 32.4715177302 9831321 17371808
MESH:D007249 Inflammation Dexamethasone 32.4711099482 8960868
MESH:D007249 Inflammation Fluoxetine 32.4712798668
MESH:D007249 Inflammation Lipopolysaccharides 32.479205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation Progesterone 32.4715869954
MESH:D007249 Inflammation Sulindac 32.473291741
MESH:D007249 Inflammation Tamoxifen 32.4719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 32.4712200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 32.478273558 15177302 7812673 7562506 11698051
MESH:D007249 Inflammation Zymosan 32.4711289658 8014878
MESH:D015212 Inflammatory Bowel Diseases Leukotriene B4 4.1411006272
MESH:D007251 Influenza, Human Vitamin E 3.5016624496
MESH:D007333 Insulin Resistance Estradiol 2.4816627594 16393666
MESH:D007410 Intestinal Diseases Nitric Oxide 8.3110210152 11713966 11574821
MESH:D007410 Intestinal Diseases rofecoxib 8.3115831440
MESH:D007414 Intestinal Neoplasms Sulindac 4.0212351151 12663524 10213222 12628509 12584176 10223192
MESH:D007417 Intestinal Polyps rofecoxib 9.4711245490
MESH:D007417 Intestinal Polyps Sulindac 9.4712394442 11245490
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.9817255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.1417553498
MESH:D007511 Ischemia Zinc 3.9516584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.7016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7315604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.4315464296
MESH:D007674 Kidney Diseases Cisplatin 14.3218289764 12649298 15190930 12231392 19839026
MESH:D007674 Kidney Diseases Cyclosporine 14.3218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 14.3215618244
MESH:D007674 Kidney Diseases Vitamin E 14.3212488133
MESH:D007674 Kidney Diseases Zinc 14.3216960431
MESH:D007676 Kidney Failure, Chronic Zinc 3.7916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0112371664
MESH:D007680 Kidney Neoplasms Estradiol 13.0115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.0116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.0118625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.0811231351
MESH:D007896 Leishmaniasis Nitric Oxide 4.0617218153
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.6915237267
MESH:D007938 Leukemia Benzene 3.0017119257 14694614 15935818 18335105
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.6116972261
MESH:D007951 Leukemia, Myeloid Benzene 3.6917506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.5219478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.5217596541 16294345
MESH:D007970 Leukopenia Lipopolysaccharides 4.0015821434
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 3.976499821
MESH:D008064 Lipidoses Fluoxetine 6.5817567588 15342952
MESH:D008064 Lipidoses Tamoxifen 6.5815342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.3917157831 16239168 17174718 21278145 11903743 11408273 16221502 17334410 16943688
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.7512468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.8717698563 17805973 18395095 13678700 18054572 17525996 12649538 15650968 16011737 18156304 14748882 15338365 16136751 18481824 18472094 17631135 14716833 18205269 17714472 15893842 17557913 15123356 16015684 15362042 15931870 11481614 17922224 18418968 17869086 14724832 18263696 18187930 17900296 12586293 12445418 15673190 16097048 18210741 18251166 17640975 18472332 18279442 18376398 15730626 12609069 18166357 18395914 16192424 14512876 18317297 15370692 17708605 15959796 12445421 12666154 16248980 17823541 17565644 16033810 15052691 14716496 16116963 12546737 17721639 18277467 15057751 15818738 12632514 16638106 20821823 17976157 15876570 17481882 18429990 15925388 10355542 14620537 17761835 18420326 17766677 18006644 17944888 12898905 12741479 12389079 18705752 18412020 12958196 18339082 12667390 15996030 12632512 16027843
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.8716718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.8714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.8712878042
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 10.8717565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.8718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.8712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.8716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.6317285989 15720792 16964402 16246199 15830285
MESH:D008107 Liver Diseases Sulindac 3.6316867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.4815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.0714706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.7120195826 21137059
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 13.7118177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.7119294768
MESH:D008113 Liver Neoplasms Fluorouracil 13.7115113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms Tamoxifen 13.7116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7116984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 7.1412562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 7.1412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 7.1412151625
MESH:D008171 Lung Diseases Acetylcysteine 13.5812815614
MESH:D008171 Lung Diseases Aluminum 13.5816052892
MESH:D008171 Lung Diseases Ozone 13.5819066396 8266340
MESH:D008171 Lung Diseases Vitamin E 13.5816863852
MESH:D017563 Lung Diseases, Interstitial Benzene 9.0214698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.0217228818
MESH:D055370 Lung Injury Lipopolysaccharides 11.4221114838
MESH:D055370 Lung Injury Nitric Oxide 11.4211395602
MESH:D055370 Lung Injury Ozone 11.4220417186
MESH:D008175 Lung Neoplasms Benzene 24.7612562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 24.7620464547 20869020 20064080 17053015 6695378 18520028 20135361 18569708 18816296
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 24.7619359593 18597497 11246140 15390079 11696405 19925653 16337739
MESH:D008175 Lung Neoplasms Cisplatin 24.7617225452 11798837 6189445
MESH:D008175 Lung Neoplasms Dexamethasone 24.7615824018 11195469
MESH:D008175 Lung Neoplasms Fluorouracil 24.7615246190
MESH:D008175 Lung Neoplasms L 663536 24.7615899809
MESH:D008175 Lung Neoplasms Ozone 24.768597069 7614698
MESH:D008175 Lung Neoplasms Smoke 24.7611091918
MESH:D008175 Lung Neoplasms Sulindac 24.7619359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 24.7618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 24.7619555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 24.7611807781
MESH:D008175 Lung Neoplasms Vitamin E 24.7611062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.0915086387
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.3216628512
MESH:D008223 Lymphoma Benzene 6.4017584886 17119257
MESH:D008223 Lymphoma Nitric Oxide 6.4016166326
MESH:D008231 Lymphopenia methyl cellosolve 5.083699323
MESH:D015674 Mammary Neoplasms, Animal Benzene 7.7612562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.7619428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 25.0411921183
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 25.041500032
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 25.0412104042 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 25.0411807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 25.0417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 25.0419196722 14580682 16827153 11731420 19196723
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 25.048985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 25.0412773700
MESH:D020149 Manganese Poisoning Estradiol 10.2819453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.2819453300
MESH:D008545 Melanoma Cisplatin 7.9212393984 15577323 16248763 17023156 18332650 17761969 12883367 18505091 12374674 16432458 18176117 16809738 11135225
MESH:D008545 Melanoma docetaxel 7.9212417787
MESH:D008545 Melanoma Histamine 7.9217709802
MESH:D008545 Melanoma Sulindac 7.9216642371
MESH:D008545 Melanoma Tamoxifen 7.9212393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 9.1915990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 9.1915990972
MESH:D001523 Mental Disorders Fluoxetine 3.9716856516
MESH:D008607 Mental Retardation Carbamazepine 3.449014606
MESH:D008654 Mesothelioma Cisplatin 2.9217638057
MESH:D008661 Metabolism, Inborn Errors marker/mechanism
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0716801185
MESH:D008679 Metaplasia Ozone 4.3910496685
MESH:D008881 Migraine Disorders Aspirin 9.7515240983
MESH:D008881 Migraine Disorders Nitric Oxide 9.7511701602
MESH:D008881 Migraine Disorders Valproic Acid 9.7518765137 18803445
MESH:D020326 Migraine without Aura Nitric Oxide 4.4514659530 11304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 6.6816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 6.6816757204 18986760
MESH:D009101 Multiple Myeloma Benzene 9.3617119195
MESH:D009101 Multiple Myeloma celecoxib 9.3616123214
MESH:D009101 Multiple Myeloma Dexamethasone 9.3615867202 16118317 15744524
MESH:D009102 Multiple Organ Failure Zymosan 4.5618160304 12879239 15213630 10890648 12130978 15834315 10479408 17724436 15259001 15241586
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 5.6617086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 5.6617086897
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.398888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.089809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.0817596541
MESH:D009203 Myocardial Infarction Aspirin 5.4212692751
MESH:D009203 Myocardial Infarction Lithium 5.4216288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7316810080
MESH:D009207 Myoclonus Fluoxetine 5.188041377
MESH:D009224 Myotonia Congenita Carbamazepine 4.7720399394
MESH:D009325 Nausea Aspirin 4.5015240983
MESH:D009336 Necrosis 2-ethoxyethanol 4.6520172899
MESH:D009362 Neoplasm Metastasis Acetylcysteine 4.9714720322
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 6.0511141357
MESH:D009369 Neoplasms Cisplatin 6.0516773208
MESH:D009369 Neoplasms Fluorouracil 6.0516928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 8.8119196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.8119189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.0417289903
MESH:D009395 Nephritis, Interstitial Cisplatin 3.7815464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6918481113 19348381
MESH:D009410 Nerve Degeneration Acrylamide 4.1411264303 12387366 12387367
MESH:D009422 Nervous System Diseases Acrylamide 4.3912164553 12507653
MESH:D009421 Nervous System Malformations Carbamazepine 12.6416990009
MESH:D009421 Nervous System Malformations Estradiol 12.6411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.6414600291
MESH:D009436 Neural Tube Defects Acetylcysteine 9.5019446573
MESH:D009436 Neural Tube Defects Benzene 9.5015643154
MESH:D009436 Neural Tube Defects Valproic Acid 9.5016359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 3.048761367
MESH:D019636 Neurodegenerative Diseases Sulindac 3.6916850258 17266991
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.008761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 2.9416436463
MESH:D009503 Neutropenia Leukotriene B4 4.698305713
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.8120418887
MESH:D009784 Occupational Diseases Benzene 3.5715576619 15913788 17119257 15727169 17479406 17178637 15612468 15935809 16737584
MESH:D009845 Oligospermia 2-ethoxyethanol 9.0620172899
MESH:D009845 Oligospermia methyl cellosolve 9.063987992
MESH:D010003 Osteoarthritis Aspirin 6.737009135
MESH:D010003 Osteoarthritis rofecoxib 6.7316690336
MESH:D010018 Osteomalacia Carbamazepine 4.7717016548
MESH:D010051 Ovarian Neoplasms Benzene 11.9612562636
MESH:D010051 Ovarian Neoplasms Cisplatin 11.9615464296 19769630 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 11.9619401270
MESH:D010051 Ovarian Neoplasms Progesterone 11.9616525653 17393432
MESH:D010051 Ovarian Neoplasms U 0126 11.9616211241
MESH:D010146 Pain Aspirin 11.616363464 6995502
MESH:D010146 Pain Carbamazepine 11.6115215642
MESH:D010146 Pain Fluoxetine 11.6112798668
MESH:D010146 Pain Sulindac 11.613291741
MESH:D010149 Pain, Postoperative rofecoxib 4.6816678543 18165598
MESH:D010190 Pancreatic Neoplasms Cisplatin 13.0219003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 13.0216929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms L 663536 13.0212384795
MESH:D010190 Pancreatic Neoplasms Sulindac 13.0211504793 16820089
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 13.0215976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.6218404319 18922899 8330346 12065085
MESH:D010267 Parapsoriasis Carbamazepine 5.0116538176
MESH:D010300 Parkinson Disease Ditiocarb 4.0211445065
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.2217679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5312520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 4.8411156591
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 8.2011510240
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 8.2015464296
MESH:D010538 Peritonitis Ozone 8.1516369182
MESH:D010538 Peritonitis Zymosan 8.1514761945 18557954 18760300 17371808 18977430 19088179 17826846 19641140 15979727 15259001 11985352
MESH:D020795 Photophobia Aspirin 5.0515240983
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.318041377
MESH:D010997 Pleural Neoplasms Cisplatin 4.6317638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 14.6411893704
MESH:D011014 Pneumonia Lipopolysaccharides 14.6411605937 12224865
MESH:D011014 Pneumonia Ozone 14.6418929643 18007984 18381685
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.6418573544
MESH:D011041 Poisoning Diphenhydramine 5.2712460839
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.6312371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.1121297632
MESH:D011225 Pre-Eclampsia Zinc 3.6217114810
MESH:D011248 Pregnancy Complications Carbamazepine 4.479014606
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 23.162884743 7198755 6499817
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 23.169014606
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 23.166499817 12530607 7974496
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 23.1611118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 23.1620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.2520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms celecoxib 2.5715570007 17908994
MESH:D011471 Prostatic Neoplasms docetaxel 2.5716644109 18824434 16520278 19103299
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5718626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.5716205645
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011471 Prostatic Neoplasms Zinc 2.5716606632 12429649 16700911 16517595
MESH:D011537 Pruritus L 663536 4.9617827870
MESH:D019310 Pseudolymphoma Carbamazepine 10.239591791 12752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.2312752131 11422049
MESH:D011565 Psoriasis Cyclosporine 5.2216882103
MESH:D011565 Psoriasis Leukotriene B4 5.2211006272
MESH:D012004 Rectal Neoplasms Fluorouracil 3.4115538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Cisplatin 3.7315464296
MESH:D012128 Respiratory Distress Syndrome, Adult marker/mechanism 10881173
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 7.3512210543
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.3518379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.2410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1718990726
MESH:D012162 Retinal Degeneration Zinc 3.5816584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.5219155313
MESH:D012220 Rhinitis Aspirin 7.4112372130
MESH:D012220 Rhinitis Histamine 7.4112689652
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5618045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 3.7614601052
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 4.789673227
MESH:D012559 Schizophrenia Valproic Acid 1.9615737665 19110320
MESH:D012640 Seizures Carbamazepine 7.279844417 9046859 16876388 15946322 19414003 16938433 16180713
MESH:D012640 Seizures Lithium 7.2719660546
MESH:D012640 Seizures Valproic Acid 7.2717978042 1511512 11738929 14763951 3137016 11044598 15475178 16876388
MESH:D018805 Sepsis Zymosan 4.0611441115
MESH:D020230 Serotonin Syndrome Fluoxetine 5.188704074
MESH:D012772 Shock, Septic Diphenhydramine 5.7718063050
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.5812269725
MESH:D012871 Skin Diseases Vitamin E 2.2218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.3910029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.3916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 10.398330346 12065085 18404319 8985016 11807781
MESH:D012893 Sleep Disorders Carbamazepine 4.4319414003
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.6315464296
MESH:D013088 Spermatocele Tamoxifen 3.5816709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.5516503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.5519457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.2219490988
MESH:D013226 Status Epilepticus Lithium 10.3019951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 10.3012833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.5319694795 15057820 19915237 16415921 16538176 18855540 20485159
MESH:D013272 Stomach Diseases Dexamethasone 3.6315472012
MESH:D013274 Stomach Neoplasms Benzene 8.6712562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.6720155912 2093021
MESH:D013274 Stomach Neoplasms celecoxib 8.6715609394
MESH:D013274 Stomach Neoplasms Cisplatin 8.6715958060 17522103 18396642
MESH:D013274 Stomach Neoplasms docetaxel 8.6716557585
MESH:D013274 Stomach Neoplasms Fluorouracil 8.6718567086 17522103 16951190 16424979 19015929 17498489 19084572 18396642 17172411 15786421
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 8.6717575124 12958204
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 16.036499799
MESH:D013276 Stomach Ulcer Acetylcysteine 16.0317918041
MESH:D013276 Stomach Ulcer Dexamethasone 16.0315138204
MESH:D013276 Stomach Ulcer Nifedipine 16.0314653237
MESH:D013276 Stomach Ulcer Nitric Oxide 16.0315138204
MESH:D020521 Stroke Aspirin 7.0216403987
MESH:D020521 Stroke Vitamin E 7.0216517955
MESH:D013733 Testicular Diseases 2-ethoxyethanol 13.6510514026 6499806 10048760
MESH:D013733 Testicular Diseases Acrylamide 13.6515864552
MESH:D013733 Testicular Diseases methyl cellosolve 13.656499806
MESH:D013736 Testicular Neoplasms Cisplatin 3.9815464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5515821434
MESH:D013927 Thrombosis Aspirin 3.9217672075
MESH:D013953 Thymus Neoplasms Benzene 4.2610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.1912697716
MESH:D013978 Tibial Fractures Estradiol 3.9719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.0116280240
MESH:D014062 Tongue Neoplasms Zinc 8.0116543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.5217262798
MESH:D014456 Ulcer marker/mechanism
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.823119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.2717053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 9.2717225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 9.2717572228 16712894 8653321
MESH:D001749 Urinary Bladder Neoplasms terephthalic acid 9.2716621493 16896691
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.968888407
MESH:D014581 Urticaria Aspirin 7.5210982225 20485159
MESH:D014581 Urticaria Histamine 7.5218298128
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 7.6016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 7.6016803524
MESH:D014594 Uterine Neoplasms Benzene 12.5812562636
MESH:D014594 Uterine Neoplasms celecoxib 12.5818645019
MESH:D014594 Uterine Neoplasms Sulindac 12.5818645019
MESH:D014605 Uveitis Cyclosporine 16.191336536
MESH:D014605 Uveitis Dexamethasone 16.191336536
MESH:D014605 Uveitis Zymosan 16.1911006244
MESH:D014625 Vaginal Neoplasms Cisplatin 3.9315577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8812125929
MESH:D014839 Vomiting Cisplatin 4.0111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5315886252
MESH:D014985 Xerophthalmia Cyclosporine 3.7317120751
Pathway ID Pathway Name
KEGG:00592 alpha-Linolenic acid metabolism
KEGG:00590 Arachidonic acid metabolism
KEGG:00565 Ether lipid metabolism
KEGG:04975 Fat digestion and absorption
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04724 Glutamatergic synapse
KEGG:00564 Glycerophospholipid metabolism
KEGG:04912 GnRH signaling pathway
REACT:604 Hemostasis
KEGG:00591 Linoleic acid metabolism
KEGG:04730 Long-term depression
KEGG:04010 MAPK signaling pathway
KEGG:01100 Metabolic pathways
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:05145 Toxoplasmosis
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA271
    • No data
    Releated disease ID Related disease Name
    PA445174Osteoarthritis
    PA447021Osteoarthritis, Knee
    Releated drug ID Related drug Name
    PA448497aspirin
    PA448871celecoxib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00588 antagonist Fluticasone Propionate Anti-inflammatory Agents;Adrenergic Agents;Dermatologic Agents;Bronchodilator Agents;Anti-Allergic Agents
    DB01103 antagonist Quinacrine Antineoplastic Agents;Enzyme Inhibitors;Antiprotozoals;Antimalarials;Anticestodal Agents;Antinematodal Agents;Antihelmintics
    Drugbank ID Action Drug Name Description
    DB00591 inhibitor Synotic Otic Solution Anti-inflammatory Agents;Antipruritics;Glucocorticoids
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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