AutismKB 2.0

Annotation Detail for PLAUR


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Basic Information Top
Gene Symbol:PLAUR ( CD87,UPAR,URKR )
Gene Full Name: plasminogen activator, urokinase receptor
Band: 19q13
Quick LinksEntrez ID:5329; OMIM: 173391; Uniprot ID:UPAR_HUMAN; ENSEMBL ID: ENSG00000011422; HGNC ID: 9053
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Metabolism of proteins
Hemostasis
Pathway IDPathway Name
200189FGF signaling pathway
200079Arf6 downstream pathway
200044Validated transcriptional targets of AP1 family members Fra1 and Fra2
200108amb2 Integrin signaling
Pathway IDPathway Name
P00050Plasminogen activating cascade
P00011Blood coagulation
Pathway IDPathway Name
500304Dissolution of Fibrin Clot
500547Attachment of GPI anchor to uPAR
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
1918Atherosclerosis
1934Cancer
2018Rheumatic fever
2102Polycystic ovary syndrome
2220Dermatitis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PLAUR mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PLAUR mRNAaffects expression 17562736
D000584 Amiloride Amiloride inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]decreases reaction|increases expression 12070711
D000584 Amiloride Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]decreases reaction|increases expression 12070711
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLAUR mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of PLAUR mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PLAUR mRNAdecreases expression 15761015
19128835
19642359
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PLAUR proteindecreases expression 19642359
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PLAUR mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PLAUR mRNAaffects expression 20382639
C095105 bexarotene bexarotene results in decreased expression of PLAUR mRNAdecreases expression 17178900
C004541 biochanin A biochanin A results in decreased expression of PLAUR proteindecreases expression 16598420
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PLAUR mRNAincreases expression 15336504
D002087 Butyrates Butyrates inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]decreases reaction|increases expression 12070711
D002087 Butyrates Butyrates inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]decreases reaction|increases expression 12070711
D002251 Carbon Tetrachloride PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]affects reaction|increases expression 18279442
D002251 Carbon Tetrachloride PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]affects reaction|increases expression 18279442
D002251 Carbon Tetrachloride PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]affects reaction|increases expression 18279442
D002794 Choline Choline affects the expression of PLAUR mRNAaffects expression 17616785
D003474 Curcumin Curcumin results in increased expression of PLAUR mRNAincreases expression 15713895
D003513 Cycloheximide [Cycloheximide co-treated with IFNA2 protein] results in increased expression of PLAUR mRNAaffects cotreatment|increases expression 12070711
D003513 Cycloheximide [Cycloheximide co-treated with IFNG protein] results in increased expression of PLAUR mRNAaffects cotreatment|increases expression 12070711
D003513 Cycloheximide Cycloheximide results in increased expression of PLAUR mRNAincreases expression 12070711
D003907 Dexamethasone Dexamethasone results in decreased expression of PLAUR mRNAdecreases expression 12732289
D004391 Dust Dust results in increased expression of PLAUR mRNAincreases expression 17805423
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAUR mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol inhibits the reaction [EGF protein results in increased expression of PLAUR protein]decreases reaction|increases expression 19395996
D004958 Estradiol Estradiol results in increased expression of PLAUR mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PLAUR mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLAUR mRNAaffects cotreatment|increases expression 17942748
D005492 Folic Acid Folic Acid affects the expression of PLAUR mRNAaffects expression 16361273
C070081 fulvestrant fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein]decreases reaction|increases expression 19395996
C424943 glutamyl-Se-methylselenocysteine glutamyl-Se-methylselenocysteine results in decreased expression of PLAUR mRNAdecreases expression 11306469
D006820 Hyaluronic Acid [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR mRNAaffects binding|increases activity|increases expression 12402308
D006820 Hyaluronic Acid [Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR proteinaffects binding|increases activity|increases expression 12402308
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLAUR mRNAincreases expression 11739494
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLAUR mRNAincreases expression 11779202
D009151 Mustard Gas Mustard Gas results in increased expression of PLAUR mRNAincreases expression 18988085
C029938 nickel sulfate nickel sulfate results in decreased expression of PLAUR mRNAdecreases expression 16780908
D005996 Nitroglycerin Nitroglycerin results in increased expression of PLAUR mRNAincreases expression 12102619
D010126 Ozone Ozone results in increased expression of PLAUR mRNAincreases expression 16716893
16330353
D010672 Phenytoin Phenytoin results in decreased expression of PLAUR mRNAdecreases expression 14741686
D011374 Progesterone Progesterone results in increased expression of PLAUR mRNAincreases expression 17170212
D011374 Progesterone Progesterone results in increased expression of PLAUR proteinincreases expression 17170212
D020849 Raloxifene Raloxifene results in decreased expression of PLAUR proteindecreases expression 16277677
C016104 sodium bichromate sodium bichromate results in decreased expression of PLAUR mRNAdecreases expression 12760830
D012965 Sodium Chloride Sodium Chloride results in increased expression of PLAUR mRNAincreases expression 16115654
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAUR mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLAUR mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLAUR mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLAUR mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLAUR mRNAdecreases expression 19684285
19933214
D013792 Thalidomide Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]decreases reaction|increases expression 16288038
D013792 Thalidomide Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]decreases reaction|increases expression 16288038
D013792 Thalidomide Thalidomide results in decreased expression of PLAUR proteindecreases expression 16288038
D014212 Tretinoin Tretinoin results in decreased expression of PLAUR mRNAdecreases expression 19642359
D014212 Tretinoin Tretinoin results in decreased expression of PLAUR proteindecreases expression 19642359
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]decreases reaction|increases expression 19225232
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of PLAUR mRNAincreases expression 16330358
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of PLAUR mRNAincreases expression 19465080
D015054 Zymosan Zymosan results in increased expression of PLAUR mRNAincreases expression 11739494
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 12.006195326 8986270 9677735 3425630 9118846 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.0015322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 12.008333272
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D058186 Acute Kidney Injury Folic Acid 3.9517003819 16316344 16595132
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.1618653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 8.1611954676 19131640 12718980 16100012
MESH:D000230 Adenocarcinoma arsenic trioxide 6.3011798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.3011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.3014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.153712494
MESH:D000236 Adenoma Folic Acid 6.1516963246
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.9516835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.7717306315
MESH:D000419 Albuminuria Raloxifene 4.1917308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6417887948
MESH:D000505 Alopecia Tretinoin 3.2715955085
MESH:D000544 Alzheimer Disease Curcumin 8.5415590663
MESH:D000544 Alzheimer Disease Folic Acid 8.5417116317
MESH:D000544 Alzheimer Disease Ozone 8.5415513908
MESH:D000544 Alzheimer Disease Raloxifene 8.5415800139
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.0816510725
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7511748828
MESH:D000740 Anemia Zymosan 7.7518664788
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D020261 Arsenic Poisoning Arsenic 2.7412569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 20.1617659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 20.1615885639
MESH:D001169 Arthritis, Experimental Thalidomide 20.169598899
MESH:D001169 Arthritis, Experimental Tretinoin 20.1616412693
MESH:D001169 Arthritis, Experimental Zymosan 20.1615142272 15188379 15944321 17659584 16872482
MESH:D001172 Arthritis, Rheumatoid Curcumin 6.7616807698
MESH:D001172 Arthritis, Rheumatoid Ozone 6.7615570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.7616292516
MESH:D001249 Asthma Mustard Gas 7.0810378619
MESH:D001249 Asthma Ozone 7.0817854713 16373670
MESH:D001249 Asthma Tretinoin 7.0816456186
MESH:D050197 Atherosclerosis Arsenic 9.6612928151 19371607
MESH:D050197 Atherosclerosis Curcumin 9.6618704882
MESH:D050197 Atherosclerosis Phenytoin 9.6615136057
MESH:D001284 Atrophy fulvestrant 4.4411514358
MESH:D001321 Autistic Disorder marker/mechanism 21328570 19360663
MESH:D001321 Autistic Disorder Acetaminophen 2.3118445737
MESH:D001321 Autistic Disorder Choline 2.3116818868
MESH:D001321 Autistic Disorder Folic Acid 2.3121388746
MESH:D001327 Autoimmune Diseases Curcumin 4.0719761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.581440618 11289319
MESH:D001768 Blister Mustard Gas 4.7319167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.1116206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 9.5715665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.5716580743
MESH:D002545 Brain Ischemia Curcumin 3.9016770732
MESH:D001932 Brain Neoplasms Curcumin 3.5717596214
MESH:D001943 Breast Neoplasms bexarotene 6.4416344269 16818667
MESH:D001943 Breast Neoplasms Curcumin 6.4418462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Estradiol 6.4412948864 16675129 17261762 19861407 17289903 18497071 14630087 17018787
MESH:D001943 Breast Neoplasms Folic Acid 6.4416777985
MESH:D001943 Breast Neoplasms fulvestrant 6.4418984771
MESH:D001943 Breast Neoplasms glutamyl-Se-methylselenocysteine 6.4411306469
MESH:D001943 Breast Neoplasms Progesterone 6.4417614352 16175315 15562024
MESH:D001943 Breast Neoplasms Raloxifene 6.4417261762 17440819 17893378 16837676 16912660 17049068 15572757 15775269 15758505 17595753 17952589 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.4420435547
MESH:D001943 Breast Neoplasms Tretinoin 6.4416873071 16166294 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3419059883 17626835 14754758 15516495 16777450 18315731 18417511
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1616813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9311589617
MESH:D002100 Cachexia Ozone 4.3116183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3616192424 15700767 3786805 16097048 18705752 16124888 16050911 15721981 10355542 15673190 16227642 16011737
MESH:D002277 Carcinoma marker/mechanism 15302576
MESH:D002277 Carcinoma Curcumin 7.1618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3415504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7216168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 15.433581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.433084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 15.4316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.4316217749 15073043 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.4318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.4316924424
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 15.4316313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.431917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.3016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.3018414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4319014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.467296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7412490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 6.8118922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.8118462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.8116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Amiloride 13.9614644129
MESH:D002295 Carcinoma, Transitional Cell Arsenic 13.9618640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 13.9617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2918670907 18850075 16120746
MESH:D006332 Cardiomegaly valsartan 6.2919597038
MESH:D009202 Cardiomyopathies valsartan 4.1516247790
MESH:D002318 Cardiovascular Diseases Arsenic 14.9617938729 19152805 15738583
MESH:D002318 Cardiovascular Diseases Folic Acid 14.9616755160
MESH:D002318 Cardiovascular Diseases Raloxifene 14.9615775269
MESH:D002318 Cardiovascular Diseases valsartan 14.9611230374
MESH:D002340 Carotid Artery Diseases Arsenic 3.9518022660 16973168
MESH:D002386 Cataract Acetaminophen 6.3610977129
MESH:D002386 Cataract Tretinoin 6.3617460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.437505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.4320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.4318566989
MESH:D002493 Central Nervous System Diseases Phenytoin 4.884080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D018281 Cholangiocarcinoma Thalidomide 8.5618291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.8019486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 6.8016919318 17333356 15861022 16105132 11677210 17681005 17110522
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.4411748493
MESH:D002822 Choriocarcinoma Tretinoin 4.7216461808
MESH:D002971 Cleft Lip Folic Acid 7.3121254359
MESH:D002971 Cleft Lip Phenytoin 7.312227380
MESH:D002972 Cleft Palate Folic Acid 12.558946559 21254359
MESH:D002972 Cleft Palate Phenytoin 12.556856622 10789828 6862529 1687470 2227380 3877104
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.558697196 16354765 15340226 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 12.559407595
MESH:D003072 Cognition Disorders Raloxifene 4.2015800139
MESH:D003092 Colitis Amiloride 19.5012065299
MESH:D003092 Colitis Curcumin 19.5016782535 16804969 18200517
MESH:D003092 Colitis Thalidomide 19.5016680017
MESH:D003092 Colitis Tretinoin 19.5017035595
MESH:D003103 Coloboma Curcumin 10.0518809619
MESH:D003103 Coloboma Phenytoin 10.059212184
MESH:D003110 Colonic Neoplasms Butyrates 5.4815936596
MESH:D003110 Colonic Neoplasms Curcumin 5.4819359593 16340194
MESH:D003110 Colonic Neoplasms Dexamethasone 5.4815824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6820501625
MESH:D015179 Colorectal Neoplasms Folic Acid 2.6817087956 16985020 17245555 17116713 16963246
MESH:D000013 Congenital Abnormalities Phenytoin 8.1810627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.1817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 11.2018497527
MESH:D016510 Corneal Neovascularization Thalidomide 11.209301478
MESH:D003324 Coronary Artery Disease valsartan 3.7317719468
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7812609071
MESH:D003384 Coxsackievirus Infections valsartan 5.4120392896
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.879200351
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 8.7110525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 8.7117728286
MESH:D019465 Craniofacial Abnormalities Phenytoin 8.7119952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.7115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Thalidomide 8.719200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.7114991402 10589399 9664655 17551590 9125849 16925845 9224671 9211117 9142499 8800419
MESH:D003424 Crohn Disease Thalidomide 3.9516078585
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7015213294
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8017474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 9.2812868966 8970840 8156756 14531868 11906362 11298694 2524372 18759878
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 9.2812438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 9.2816823706 11298694 16780908
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.102952479 3621924
MESH:D002658 Developmental Disabilities Choline 4.3816818868
MESH:D003921 Diabetes Mellitus, Experimental valsartan 7.9311508273
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 7.9316684804
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.5318403477
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.5316886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5317107852
MESH:D003928 Diabetic Nephropathies Curcumin 18.5318204486
MESH:D003928 Diabetic Nephropathies Estradiol 18.5319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 18.5317308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies valsartan 18.5318630688 11427623
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D003967 Diarrhea Dexamethasone 3.307237001
OMIM:607208 DRAVET SYNDROME Phenytoin 4.9711748493
MESH:D003875 Drug Eruptions Phenytoin 5.0815024534
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 7.7318692083 8291058 1440618 16192314 9328219 11289319 18648102 7440962 9022650 9653073 6482804 6679447 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.7319420014 10774834 11287661 19739265 11743745 14986274 19370779 18071297 17906064 17562736 19923254 16227642 2444490 16393943 12705907 11834606 15619225 16781746 10663392 11461765 11739529 14725611 19164858 16109766 14550746 11421492 12540782 17522070 11529661 16177239 10915739 16081117 12153990 12392966 18713872 15968718 12594235 19416960 16485898 19085960 12958197
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 7.736884620 17522070 6623471 21278145 15027814 10915739 19336974 2869522 16177239 4309450 7179309 15968718 10092053 7440962 3786805 9327722 3732212 15998439 7120509 16227642 11566570 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.7320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4411462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6417351913
MESH:D004485 Eczema Dexamethasone 4.0512438553
MESH:D004487 Edema Dexamethasone 17.6319703484
MESH:D004487 Edema Mustard Gas 17.639260866 11402378 11428631 11428647
MESH:D004487 Edema Raloxifene 17.6315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.6312711302 11000095
MESH:D004487 Edema Zymosan 17.637907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4815322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.4818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.6312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 18.6317654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.6317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.6315845917
MESH:D016889 Endometrial Neoplasms Estradiol 10.8911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 10.8917301261
MESH:D016889 Endometrial Neoplasms Tretinoin 10.8916569247
MESH:D004715 Endometriosis Progesterone 7.6916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.6910568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9715328337 15821434 17637181
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.7920235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.791399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 4.4811558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.71821787 11434505 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.887750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.643659116
MESH:D004890 Erythema Mustard Gas 4.739357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.473581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.4712903497
MESH:D017889 Exfoliation Syndrome Folic Acid 5.0616504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.769664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 20.5915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5912795759 16239168 12631006 17595544 15959796 61145 16045604 19224547
MESH:D005234 Fatty Liver Curcumin 20.5919297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5915345470
MESH:D005234 Fatty Liver Raloxifene 20.5917473493
MESH:D005313 Fetal Death Phenytoin 9.3410627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.3411858732
MESH:D005334 Fever Lipopolysaccharides 3.6411852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.586705139
MESH:D005355 Fibrosis Carbon Tetrachloride 23.3018705752
MESH:D005355 Fibrosis Curcumin 23.3018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.3020067830
MESH:D005355 Fibrosis Tretinoin 23.3017994277
MESH:D005355 Fibrosis valsartan 23.3016893502
MESH:D005534 Foot Diseases Arsenic 5.126392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8516904648
MESH:D005756 Gastritis Acetaminophen 9.8116983495
MESH:D005756 Gastritis Folic Acid 9.8117171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2718462866
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.8712701121
MESH:D005885 Gingival Hyperplasia Phenytoin 5.239029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.7914659971 16390469
MESH:D005901 Glaucoma Folic Acid 4.6816504073
MESH:D005909 Glioblastoma biochanin A 10.4516598420
MESH:D005909 Glioblastoma Curcumin 10.4517596214
MESH:D005909 Glioblastoma Tretinoin 10.4517312396
MESH:D005910 Glioma Thalidomide 3.6316327979
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.1316928621
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.647505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006130 Growth Disorders Amiloride 4.4719703807
MESH:D006261 Headache Nitroglycerin 4.7511554966 11284996
MESH:D006258 Head and Neck Neoplasms Curcumin 6.9118829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7216084493
MESH:D006330 Heart Defects, Congenital Folic Acid 9.8617286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.8610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.8614991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.2411110106
MESH:D006333 Heart Failure valsartan 3.9819027736
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 13.426705139
MESH:D006505 Hepatitis Carbon Tetrachloride 13.4219900420 19110552
MESH:D006505 Hepatitis Zymosan 13.4219110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.4812621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6217701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.917520565
MESH:D006558 Herpes Genitalis Estradiol 4.5915709030
MESH:D006679 HIV Seropositivity Folic Acid 5.0617209195
MESH:D019584 Hot Flashes Estradiol 3.3217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.618697196 16354765 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 6.5016870215
MESH:D006930 Hyperalgesia Tretinoin 6.5016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1016899240
MESH:D006937 Hypercholesterolemia Curcumin 3.6718704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1516778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 8.6216433478 16395265 16755160 16865747 16397167
MESH:D020138 Hyperhomocysteinemia Phenytoin 8.6210459572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.0817050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5215034207
MESH:D006973 Hypertension Amiloride 22.2419344079 15174897 18524855
MESH:D006973 Hypertension Arsenic 22.2411953799 16076760 9931084
MESH:D006973 Hypertension Dexamethasone 22.2417042910
MESH:D006973 Hypertension Raloxifene 22.2415787275 17577099
MESH:D006973 Hypertension Sodium Chloride 22.2411507004
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 22.2418850075 18670907
MESH:D006973 Hypertension valsartan 22.2410903974 18390891 20102058 16475468 18344623 11427623 12692753 12850387
MESH:D006974 Hypertension, Malignant valsartan 5.9711560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6715338365
MESH:D006987 Hypesthesia Arsenic 5.1216093927
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.4219822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9517937319
MESH:D007248 Infertility, Male fulvestrant 5.9511514358
MESH:D007249 Inflammation Amiloride 28.5317237260
MESH:D007249 Inflammation Curcumin 28.5316956363 18403477 17151092
MESH:D007249 Inflammation Dexamethasone 28.538960868 11099482
MESH:D007249 Inflammation Lipopolysaccharides 28.5317963957 12878042 9205823 17237260 17255318
MESH:D007249 Inflammation Mustard Gas 28.5311428620 16001271 8975870 11428647 9260866 9357497 17524151 11402378 11428631
MESH:D007249 Inflammation Progesterone 28.5315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 28.5312200463 12878042
MESH:D007249 Inflammation Thalidomide 28.5316134734
MESH:D007249 Inflammation Zymosan 28.538014878 11289658
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0318596194 18200517
MESH:D007333 Insulin Resistance Estradiol 2.6816627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.3517994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.8510783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2317255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.4117553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.588074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.6517551590 15992940
MESH:D007642 Keratosis Arsenic 4.5616930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 8.7015629191 12587719
MESH:D007674 Kidney Diseases Estradiol 8.7015618244
MESH:D007674 Kidney Diseases valsartan 8.7012164870 10903974 16893502
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.216582329
MESH:D007680 Kidney Neoplasms Estradiol 6.2115610895
MESH:D007889 Leiomyoma Curcumin 9.8318555241
MESH:D007889 Leiomyoma Raloxifene 9.8316973256
MESH:D016773 Leishmaniasis, Cutaneous Sodium Chloride 4.589499605
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.0116514283
MESH:D007938 Leukemia arsenic trioxide 9.2115070760
MESH:D007938 Leukemia Curcumin 9.2118462866
MESH:D007938 Leukemia Tretinoin 9.2117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.4812560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.4816106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.2019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.2019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.7016467208 17050201 16968895 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 5.7018720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.7019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 11.1117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.1117107899 19225113 16330433 16966277 16331271 12018890 15213294 17869043 19035177 15622746 15748426 17217047 19642359 17649720 9834237 16823087 16891316 15336539 19075265 12679006 11468182 11161223 16112521 17712046 12712474
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.1117368321 16140955 16766008 19642359 15748426 17339181 16331271 19035177 19029980 17361223 19225113 16891316 16788101 17712046 16823087 9834237 17649720 17217047 12679006 17107899 17506722 19075265 17301526 17294898 16935935
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.3516882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.3516106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.2715821434
MESH:D056929 Liddle Syndrome Amiloride 5.5519344079
MESH:D017880 Limb Deformities, Congenital Thalidomide 7.5210473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.529224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2217157831 17174718 16943688 16239168 21278145 17334410 11903743 11408273 16221502
MESH:D008103 Liver Cirrhosis Thalidomide 6.2217174718 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.3818054572 14748882 15052691 15673190 18317297 17481882 14724832 15730626 18166357 12898905 17766677 17708605 15959796 16638106 16116963 18412020 14716833 12649538 18263696 15123356 17976157 17557913 15057751 18205269 16027843 10355542 18705752 17869086 16015684 17714472 17565644 18472332 17640975 18277467 12609069 17761835 18395095 18251166 12958196 15925388 12445421 12586293 17944888 15996030 18420326 17698563 15370692 15931870 15650968 18376398 15893842 18279442 20821823 18339082 15876570 16136751 17823541 12389079 18418968 15338365 12667390 15818738 13678700 17721639 18006644 12546737 17525996 18395914 14620537 18210741 16033810 17805973 18481824 15362042 18187930 17922224 12445418 18472094 12666154 12632514 14716496 12741479 16192424 16248980 11481614 12632512 14512876 17900296 17631135 16097048 18156304 16011737 18429990
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 14.3817355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.3816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 14.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 14.3815465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.3818397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 14.3815619341 15504291 16872305
MESH:D008107 Liver Diseases Acetaminophen 14.1912969438 11587558 19460945 12587719 19014921 19784758 16610002 16611625
MESH:D008107 Liver Diseases Arsenic 14.1911134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 14.1915830285 16246199 15720792 17285989 16964402
MESH:D008107 Liver Diseases Curcumin 14.1916956363
MESH:D008107 Liver Diseases Folic Acid 14.1916877991
MESH:D008107 Liver Diseases Phenytoin 14.1914986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.1716899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 9.2316368122
MESH:D008113 Liver Neoplasms arsenic trioxide 9.2314682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.2319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.2316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.846587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.8420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.8412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.8412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0215213294
MESH:D008171 Lung Diseases Mustard Gas 6.6418161513 18702808
MESH:D008171 Lung Diseases Ozone 6.6419066396 8266340
MESH:D055370 Lung Injury Asbestos, Crocidolite 12.8217365036
MESH:D055370 Lung Injury Lipopolysaccharides 12.8221114838
MESH:D055370 Lung Injury Ozone 12.8220417186
MESH:D008175 Lung Neoplasms Arsenic 14.1117306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 14.1111798837 19825857
MESH:D008175 Lung Neoplasms bexarotene 14.1117849452
MESH:D008175 Lung Neoplasms Curcumin 14.1119359593 16243823 18462866
MESH:D008175 Lung Neoplasms Dexamethasone 14.1115824018 11195469
MESH:D008175 Lung Neoplasms Mustard Gas 14.113148597 8781369
MESH:D008175 Lung Neoplasms Ozone 14.118597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.1119555203 11884234
MESH:D008175 Lung Neoplasms Vehicle Emissions 14.119255578
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2117718048
MESH:D008223 Lymphoma Curcumin 3.2818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2716173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.4415591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.4411408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.4417203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.0419453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.2616832597
MESH:D008527 Medulloblastoma Tretinoin 2.6017453147
MESH:D008545 Melanoma Curcumin 4.7817885582 18462866
MESH:D008545 Melanoma Thalidomide 4.7816098027 12829675 17089043
MESH:D008545 Melanoma Tretinoin 4.7816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008569 Memory Disorders Curcumin 3.7517263510
MESH:D008591 Meningomyelocele Tretinoin 4.0016940565
MESH:D008607 Mental Retardation Phenytoin 3.519212184
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0018303189 16966607 16166281
MESH:D008679 Metaplasia Ozone 4.6710496685
MESH:D008708 Methemoglobinemia Nitroglycerin 4.343537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.7214659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1115863610
MESH:D009101 Multiple Myeloma arsenic trioxide 19.4019549372 15949261 11468182 19417148 14977855
MESH:D009101 Multiple Myeloma Curcumin 19.4019372569
MESH:D009101 Multiple Myeloma Dexamethasone 19.4016118317 15744524 15867202
MESH:D009101 Multiple Myeloma Raloxifene 19.4016497877
MESH:D009101 Multiple Myeloma Thalidomide 19.4019112201 15939924 19112817 15741222 16445831 15920492 15867202 19372569 17168659 15744524
MESH:D009102 Multiple Organ Failure Zymosan 4.8112130978 15213630 10479408 18160304 15241586 12879239 10890648 17724436 15834315 15259001
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4917962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 15.5416882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 15.549809623
MESH:D009190 Myelodysplastic Syndromes Thalidomide 15.5418720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 15.5417596541
MESH:D009203 Myocardial Infarction Nitroglycerin 3.6014729435
MESH:D017202 Myocardial Ischemia Arsenic 7.8715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9516810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.0917484760
MESH:D009224 Myotonia Congenita Phenytoin 4.981896199
MESH:D009232 Myxoma Raloxifene 5.1116343187
MESH:D009361 Neoplasm Invasiveness Amiloride 15.0514644129
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 15.0516624393
MESH:D009361 Neoplasm Invasiveness Curcumin 15.0518495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.293581430
MESH:D009369 Neoplasms Tretinoin 2.2016594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.6719196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.6712497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3017289903
MESH:D009421 Nervous System Malformations Estradiol 20.1216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.1214600291
MESH:D009421 Nervous System Malformations Thalidomide 20.1216859833
MESH:D009421 Nervous System Malformations Tretinoin 20.129125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.1918462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 24.686679447
MESH:D009436 Neural Tube Defects Arsenic 24.6816620997
MESH:D009436 Neural Tube Defects arsenic trioxide 24.6810525206
MESH:D009436 Neural Tube Defects Folic Acid 24.6817438019
MESH:D009436 Neural Tube Defects Phenytoin 24.689118846
MESH:D009436 Neural Tube Defects Tretinoin 24.689142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5218514411
MESH:D020078 Neurogenic Inflammation Arsenic 3.9817056641
MESH:D009503 Neutropenia Folic Acid 8.2816322990
MESH:D009503 Neutropenia Mustard Gas 8.2816761898 7688884
MESH:D009765 Obesity Curcumin 2.6319297423
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.054026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.583988306
MESH:D010018 Osteomalacia Phenytoin 4.9817016548
MESH:D010024 Osteoporosis Curcumin 6.5118719352
MESH:D010024 Osteoporosis Raloxifene 6.5119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8315758505 15579764 17893378 17823083
MESH:D010051 Ovarian Neoplasms Arsenic 20.5917306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 20.5912452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 20.5919020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 20.5919401270
MESH:D010051 Ovarian Neoplasms Progesterone 20.5916525653 17393432
MESH:D010051 Ovarian Neoplasms Thalidomide 20.5916288038
MESH:D010051 Ovarian Neoplasms Tretinoin 20.5916936753
MESH:D010146 Pain Acetaminophen 9.3416870215
MESH:D010146 Pain Phenytoin 9.3415215642
MESH:D010146 Pain Tretinoin 9.3416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.6815580305
MESH:D010190 Pancreatic Neoplasms Curcumin 7.6819401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.6815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.077296757
MESH:D010235 Paraganglioma arsenic trioxide 3.7619927285
MESH:D010291 Paresis Thalidomide 5.879200351
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.7716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.566392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 9.0216369182
MESH:D010538 Peritonitis Zymosan 9.0219088179 15979727 17826846 11985352 18557954 18760300 15259001 14761945 19641140 18977430 17371808
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.036228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.4710923243
MESH:D011014 Pneumonia Lipopolysaccharides 9.6712224865 11605937
MESH:D011014 Pneumonia Ozone 9.6718007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.4115727166
MESH:D017689 Polydactyly Phenytoin 4.689212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.1421297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 7.1417031469
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7611896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5020887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 15302576
MESH:D011471 Prostatic Neoplasms Arsenic 2.3416140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3419131511
MESH:D011471 Prostatic Neoplasms biochanin A 2.3412111696
MESH:D011471 Prostatic Neoplasms Curcumin 2.3418226269 18156803 11398177 15129424 10851300 12497104 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 2.3416740699
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 2.3416864594
MESH:D011471 Prostatic Neoplasms Raloxifene 2.3415731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Thalidomide 2.3416729912
MESH:D011507 Proteinuria Arsenic 13.3121343184
MESH:D011507 Proteinuria Tretinoin 13.3116636307
MESH:D011507 Proteinuria valsartan 13.3117664856 18344623 12164870
MESH:D011536 Prurigo Thalidomide 5.8712755975
MESH:D011537 Pruritus Ethinyl Estradiol 8.1016919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.1018058305
MESH:D019310 Pseudolymphoma Phenytoin 5.101419762 8603615 12752131
MESH:D011625 Pterygium Tretinoin 4.3616723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.1519168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.4317365031 15814490 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.4317894541 10334151 17266442 17620002 17720292
MESH:D011658 Pulmonary Fibrosis valsartan 8.4317241526
MESH:D011693 Purpura Raloxifene 5.1115770314
MESH:D051437 Renal Insufficiency Folic Acid 4.3615728788
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.9910666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.9911700416 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4410835634
MESH:D012135 Respiratory Sounds Vehicle Emissions 4.8018950799
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.053692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7016116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012509 Sarcoma Curcumin 3.7418462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.5516646077
MESH:D012559 Schizophrenia Folic Acid 2.8416641680
MESH:D019873 Schnitzler Syndrome Thalidomide 5.5116096327
MESH:D012640 Seizures Phenytoin 3.463691417 15946322 9844417 10029267 16876388 11044598 19919933 3137016
MESH:D018805 Sepsis Curcumin 8.5218389075
MESH:D018805 Sepsis Zymosan 8.5211441115
MESH:D012871 Skin Diseases Arsenic 7.3619834688 18709164 16353154 17050553 17453740 6392382 16702368 17548696 16759981 15952646 17938729
MESH:D012871 Skin Diseases Folic Acid 7.3618709164
MESH:D012871 Skin Diseases Mustard Gas 7.3616961503 15451306 12880345
MESH:D012878 Skin Neoplasms Arsenic 11.7916251483 17029826 15504454 17050553 17976673 19538983
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 11.798532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.7916192470
MESH:D012878 Skin Neoplasms Tretinoin 11.7916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5016709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.0616361298
MESH:D013119 Spinal Cord Injuries Progesterone 3.8515862959 16503802
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.7320235791
MESH:D013272 Stomach Diseases Dexamethasone 3.8915472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4217007042
MESH:D013274 Stomach Neoplasms Folic Acid 4.4217171786
MESH:D013274 Stomach Neoplasms Sodium Chloride 4.4216646055
MESH:D013274 Stomach Neoplasms Tretinoin 4.4217261132
MESH:D013276 Stomach Ulcer Curcumin 10.0716631530 19188055
MESH:D013276 Stomach Ulcer Dexamethasone 10.0715138204
MESH:D013276 Stomach Ulcer Thalidomide 10.0715138204
MESH:D020521 Stroke Folic Acid 7.8816517955
MESH:D020521 Stroke Raloxifene 7.8816837676
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 14.466582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.4619014326
MESH:D013964 Thyroid Neoplasms Butyrates 14.4617967635
MESH:D013964 Thyroid Neoplasms Tretinoin 14.4616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.2519048282
MESH:D013978 Tibial Fractures Raloxifene 12.2519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4116051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5315213294
MESH:D014376 Tuberculosis Tretinoin 2.9516040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 17.508074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 17.5019322015 19429237 17976673 18640142 11144890 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 17.5011780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Curcumin 17.5018593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 17.5017572228
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 17.5011144890
MESH:D014565 Urogenital Neoplasms Curcumin 4.8318462866
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.3016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1716752155
MESH:D014605 Uveitis Dexamethasone 10.831336536
MESH:D014605 Uveitis Zymosan 10.8311006244
MESH:D014652 Vascular Diseases Arsenic 10.8017056641
MESH:D014652 Vascular Diseases Thalidomide 10.8015741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D020257 Ventricular Remodeling valsartan 5.2719027736
MESH:D014820 Vitiligo Tretinoin 3.6516761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D009396 Wilms Tumor Tretinoin 3.6016287080
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33383
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00009 - Alteplase Thrombolytic Agents
    DB00013 - Urokinase Thrombolytic Agents
    DB00015 - Reteplase Thrombolytic Agents
    DB00029 - Anistreplase Thrombolytic Agents
    DB00031 - Tenecteplase Thrombolytic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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