AutismKB 2.0

Annotation Detail for PLCD1


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Basic Information Top
Gene Symbol:PLCD1 ( - )
Gene Full Name: phospholipase C, delta 1
Band: 3p22.2
Quick LinksEntrez ID:5333; OMIM: 602142; Uniprot ID:PLCD1_HUMAN; ENSEMBL ID: ENSG00000187091; HGNC ID: 9060
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6367D-myo-inositol-5-phosphate metabolism
LIPASYN-PWYphospholipases
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
No data
Pathway IDPathway Name
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
1993Esophagus cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PLCD1 mRNAaffects expression 17562736
D000535 Aluminum Aluminum results in increased expression of PLCD1 proteinincreases expression 10814511
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]decreases reaction|increases expression 19225867
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLCD1 mRNAaffects cotreatment|increases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PLCD1 mRNAincreases expression 15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLCD1 mRNAaffects expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLCD1 mRNAaffects cotreatment|increases expression 18164116
D005419 Flavonoids Flavonoids results in decreased expression of PLCD1 mRNAdecreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PLCD1 mRNAdecreases expression 15469884
D009638 Norepinephrine anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]decreases reaction|increases expression 19225867
D009638 Norepinephrine Norepinephrine results in increased expression of and results in increased activity of PLCD1 proteinincreases activity|increases expression 19225867
D009638 Norepinephrine Norepinephrine results in increased expression of PLCD1 mRNAincreases expression 19225867
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]decreases reaction|increases activity|increases expression 19225867
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]decreases reaction|increases expression 19225867
D010126 Ozone Ozone results in decreased expression of PLCD1 mRNAdecreases expression 16330353
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]decreases reaction|increases activity|increases expression 19225867
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]decreases reaction|increases expression 19225867
D014635 Valproic Acid Valproic Acid results in increased expression of PLCD1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.608875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0217620307 18056438 19061943 19052882 17162532 16434500
MESH:D000544 Alzheimer Disease Aluminum 4.8617662457 10721010
MESH:D000544 Alzheimer Disease Ozone 4.8615513908
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6616373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 2.3018445737
MESH:D001321 Autistic Disorder Norepinephrine 2.308570775
MESH:D001321 Autistic Disorder Valproic Acid 2.3017507914 17688650 19232924 17157402 18316065 18775368 18558336 16609825 18396377 18940202 20603192 18177632 19460635 15238991 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.458888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7418417511 18315731 15516495 14754758 16777450 17626835 19059883
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816227642 16097048 15673190 16192424 15721981 16011737 10355542 18705752 15700767 3786805 16050911 16124888
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 6.7119418558
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7119335982 17173139 19383236 20524982 20084675 19052882 18971187 19822196 16540662 17138121 18691550 10672840 18978308 3084413 20432363 18210153 16807293 19919837 18056438 11831363 19107877 16779866 20514400 18506893 16698587 19171122 18788625 19701751 18665156 16288022 20512989 17978847 17162532 17055752 16681979 18393292 16328049 21159647 18785209 19208518 20935162 17761372 16878318 20214788 19394651 16569478 19519916 19539802 20007298 16935385 17428255 20727157 18494052 3581430 16830150 20101231 19418558 16502159 10737359
MESH:D006332 Cardiomegaly Norepinephrine 4.4111179087
MESH:D002375 Catalepsy Norepinephrine 5.658216760
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.912727394 21159647 17174075 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3010915739 16393943 16177239 10774834 17906064 12594235 19085960 19923254 18071297 12958197 15968718 18713872 17522070 11834606 16081117 19164858 11743745 14550746 19416960 12540782 11421492 10663392 16781746 16227642 11461765 2444490 19739265 17562736 11287661 15619225 16109766 19420014 11529661 19370779 14725611 16485898 11739529 14986274 12705907 12392966 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.309327722 3786805 2869522 15027814 3732212 10915739 16227642 7120509 7440962 10092053 4309450 21278145 15968718 6623471 16177239 7179309 17522070 6884620 19085960 11566570 19336974 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.3019107877
MESH:D056486 Drug-Induced Liver Injury Prazosin 12.3018071297
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.3019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0516628512 3922381
MESH:D004827 Epilepsy Norepinephrine 7.31821787
MESH:D004827 Epilepsy Valproic Acid 7.3120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.6512795759 12631006 16045604 16239168 61145 15959796 19224547 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 13.6521071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 13.6519224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006930 Hyperalgesia Acetaminophen 8.4516870215
MESH:D006930 Hyperalgesia Prazosin 8.4512727271
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007022 Hypotension Norepinephrine 5.086740701
MESH:D007249 Inflammation Aluminum 8.8316052892
MESH:D007249 Inflammation Diethylnitrosamine 8.8318785209
MESH:D007249 Inflammation Flavonoids 8.8317296493
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 5.4916972261
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7511408273 17334410 16943688 16221502 17174718 11903743 17157831 21278145 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7520032147 18407596 18522880 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7510355542 16248980 16192424 17714472 18705752 14716496 15876570 14716833 18166357 15052691 12741479 18376398 12586293 18472332 18156304 17481882 18279442 17922224 12632512 18251166 17766677 18210741 17557913 12445418 18205269 17805973 12546737 18420326 15123356 15730626 16097048 15338365 18395914 18263696 12898905 16015684 18412020 18054572 18187930 18277467 11481614 18395095 17721639 16033810 17640975 17869086 18339082 17761835 17944888 17976157 18429990 15959796 14724832 18006644 13678700 12632514 16116963 14620537 17900296 12609069 18418968 17708605 15893842 15925388 17525996 14748882 17565644 18472094 12445421 17698563 18481824 15931870 12958196 12389079 15650968 16136751 15818738 16638106 18317297 12649538 16027843 14512876 12667390 15370692 15057751 12666154 20821823 17823541 15996030 16011737 17631135 15673190 15362042
MESH:D008107 Liver Diseases Acetaminophen 6.5916610002 19460945 11587558 19784758 16611625 19014921 12587719 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5916246199 16964402 15720792 15830285 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6714706259 16899240
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.6921295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6919690152 19294768 18644402 2862719 20137499 21047994 12112319 15885732 19073162 19996281 12771043 20118626 18754104 21167192 19499222 16942905 20101389 19642983 18977376 20492335 18648771 20434301 19638242 19551842 15175105 2422723 20452335 19850985 19254457 18978307 19426721 20501860 21278145 19833225 19812893 20405173 19427195 19090486 21071580 20583210 19255062 10737359 19256749 9163691
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.2218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.2212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2216842330 18775883 17174075 18164116 17942915 18079962 19539802 18253720 3124819 18544905 9362446 19519916 18093689 19004024 18282651 17854601 16267830 19126423 21159647 18308698 19009564 2563599
MESH:D008171 Lung Diseases Aluminum 8.2416052892
MESH:D008171 Lung Diseases Ozone 8.248266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5920970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Ozone 2.597614698 8597069
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.5117086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.5117086897
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 4.9115642760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009436 Neural Tube Defects Valproic Acid 3.188888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D011014 Pneumonia Ozone 4.5118007984 18381685 18929643
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9520603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.6712752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.791511512 15475178 3137016 11738929 14763951 16876388 11044598 17978042
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013610 Tachycardia Norepinephrine 5.533261545
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014581 Urticaria Acetaminophen 3.0610982225
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33388
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03401 - D-Myo-Inositol-1,4,5-Triphosphate
    DB03956 - D-Myo-Inositol-2,4,5-Trisphosphate
    DB04184 - Acetate Ion Indicators and Reagents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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