AutismKB 2.0

Annotation Detail for PLCG1


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Basic Information Top
Gene Symbol:PLCG1 ( NCKAP3,PLC-II,PLC1,PLC148,PLCgamma1 )
Gene Full Name: phospholipase C, gamma 1
Band: 20q12
Quick LinksEntrez ID:5335; OMIM: 172420; Uniprot ID:PLCG1_HUMAN; ENSEMBL ID: ENSG00000124181; HGNC ID: 9065
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6367D-myo-inositol-5-phosphate metabolism
LIPASYN-PWYphospholipases
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa00562Inositol phosphate metabolism
hsa04012ErbB signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04722Neurotrophin signaling pathway
hsa05223Non-small cell lung cancer
hsa01100Metabolic pathways
hsa05214Glioma
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Signalling by NGF
Axon guidance
Hemostasis
Signaling by EGFR
Signaling by PDGF
Signaling by FGFR
Signaling in Immune system
Pathway IDPathway Name
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200189FGF signaling pathway
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200003Fc-epsilon receptor I signaling in mast cells
200128Neurotrophic factor-mediated Trk receptor signaling
200132Nephrin/Neph1 signaling in the kidney podocyte
200157EPO signaling pathway
200151VEGFR1 specific signals
200121EPHA forward signaling
200127PDGFR-beta signaling pathway
200125E-cadherin signaling in keratinocytes
200085EGF receptor (ErbB1) signaling pathway
200140PDGFR-alpha signaling pathway
200062TCR signaling in naive CD8+ T cells
200098Class I PI3K signaling events
200071S1P1 pathway
200074Netrin-mediated signaling
200180N-cadherin signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200011LPA receptor mediated events
200043S1P4 pathway
200022TCR signaling in naive CD4+ T cells
200192Signaling events mediated by focal adhesion kinase
200059Regulation of CDC42 activity
Pathway IDPathway Name
P00009Axon guidance mediated by netrin
P00053T cell activation
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00056VEGF signaling pathway
P00018EGF receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P00005Angiogenesis
P043745HT2 type receptor mediated signaling pathway
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500511EGFR interacts with phospholipase C-gamma
500307PECAM1 interactions
500091Role of second messengers in netrin-1 signaling
500481Generation of second messenger molecules
500632PLC-gamma1 signalling
500249Phospholipase C-mediated cascade
500509Down-stream signal transduction
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2053Colon cancer
2109Turner's syndrome
Desease Name
bipolar disorder
PSYCH
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PLCG1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PLCG1 mRNAdecreases expression 18648102
D000079 Acetaldehyde PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein]]affects localization|affects reaction|decreases reaction 17991733
D000079 Acetaldehyde PLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]affects localization|affects reaction|decreases reaction 17991733
D000082 Acetaminophen Acetaminophen affects the expression of PLCG1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLCG1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of PLCG1 proteindecreases expression 16483693
C030233 benzo(a)pyrene-1,6-quinone benzo(a)pyrene-1,6-quinone results in increased phosphorylation of PLCG1 proteinincreases phosphorylation 19166869
C018003 benzo(a)pyrene-3,6-quinone benzo(a)pyrene-3,6-quinone results in increased phosphorylation of PLCG1 proteinincreases phosphorylation 19166869
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLCG1 mRNAaffects cotreatment|decreases expression 20360939
C043561 chrysin BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]decreases reaction|increases degradation 16215670
C043561 chrysin chrysin results in increased degradation of PLCG1 proteinincreases degradation 16215670
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLCG1 mRNAaffects cotreatment|decreases expression 20360939
D000431 Ethanol [Ethanol co-treated with sodium arsenite] results in increased localization of PLCG1 proteinaffects cotreatment|increases localization 18182400
D005472 Fluorouracil PLCG1 protein results in decreased susceptibility to Fluorouracildecreases response to substance 17531112
D006534 Heptachlor Epoxide Heptachlor Epoxide results in increased expression of PLCG1 proteinincreases expression 11246134
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PLCG1 mRNAaffects cotreatment|increases expression 17183730
C506002 ircinin-1 ircinin-1 results in increased cleavage of PLCG1 proteinincreases cleavage 16163705
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLCG1 mRNAincreases expression 12057914
C064769 N-acetylsphingosine BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]decreases reaction|increases degradation 16215670
C064769 N-acetylsphingosine N-acetylsphingosine results in increased degradation of PLCG1 proteinincreases degradation 16215670
D009638 Norepinephrine Norepinephrine results in increased expression of and results in increased activity of PLCG1 proteinincreases activity|increases expression 19225867
D009638 Norepinephrine Norepinephrine results in increased expression of PLCG1 mRNAincreases expression 19225867
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]decreases reaction|increases activity|increases expression 19225867
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]decreases reaction|increases expression 19225867
D010100 Oxygen Oxygen deficiency results in increased expression of PLCG1 mRNAincreases expression 17914565
D010126 Ozone Ozone results in decreased expression of PLCG1 mRNAdecreases expression 16330353
D010269 Paraquat Paraquat results in decreased expression of PLCG1 mRNAdecreases expression 17077588
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]decreases reaction|increases activity|increases expression 19225867
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]decreases reaction|increases expression 19225867
C059514 resveratrol resveratrol results in decreased expression of PLCG1 mRNAdecreases expression 12569576
C017947 sodium arsenite [Ethanol co-treated with sodium arsenite] results in increased localization of PLCG1 proteinaffects cotreatment|increases localization 18182400
C017947 sodium arsenite sodium arsenite results in decreased expression of PLCG1 mRNAdecreases expression 12760830
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PLCG1 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLCG1 mRNAincreases expression 18796159
D013752 Tetracycline Tetracycline results in increased expression of PLCG1 mRNAincreases expression 16917069
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PLCG1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.9317676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.9315322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.938875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D000138 Acidosis Ammonium Chloride 9.7118287403
MESH:D000138 Acidosis Ethanol 9.7111192467
MESH:D058186 Acute Kidney Injury resveratrol 3.6516538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.8618653653 11850527
MESH:D055371 Acute Lung Injury Oxygen 8.8616759491
MESH:D000230 Adenocarcinoma Fluorouracil 2.3717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.463712494
MESH:D000236 Adenoma Diethylnitrosamine 10.4610737359 6695378
MESH:D000236 Adenoma resveratrol 10.4615688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.2917620307 16434500 19052882 18056438 19061943 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5411874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0915451040 15451039
MESH:D000544 Alzheimer Disease Ozone 4.2015513908
MESH:D000544 Alzheimer Disease resveratrol 4.2016162502 16183991
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Fluorouracil 8.0217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0211748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D000853 Anophthalmos Ethanol 4.5915513904
MESH:D000860 Anoxia Oxygen 4.8320872349
MESH:D001008 Anxiety Disorders Ethanol 8.3911141031
MESH:D001008 Anxiety Disorders Valproic Acid 8.3917497229
MESH:D001169 Arthritis, Experimental resveratrol 3.3617115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Acetaldehyde 5.209600491
MESH:D001249 Asthma Ozone 5.2017854713 16373670
MESH:D050197 Atherosclerosis Oxygen 6.6516391483
MESH:D050197 Atherosclerosis resveratrol 6.6516873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.2518445737
MESH:D001321 Autistic Disorder Norepinephrine 2.258570775
MESH:D001321 Autistic Disorder Valproic Acid 2.2518316065 18775368 18985861 18177632 17157402 19460635 17507914 15238991 17688650 19232924 20603192 18940202 18558336 16609825 18396377
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.9617594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D002545 Brain Ischemia resveratrol 4.0617600658
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8717474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.8715136595 16557594 18357371 16595493 16110121 19217205 18608205
MESH:D001943 Breast Neoplasms Heptachlor Epoxide 2.878738476 15770527
MESH:D001943 Breast Neoplasms Oxygen 2.8717263869
MESH:D001943 Breast Neoplasms resveratrol 2.8717651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5015516495 17626835 18417511 19059883 18315731 16777450 14754758
MESH:D002056 Burns Ethanol 4.4316374292
MESH:D002100 Cachexia Ozone 4.5116183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4416051944
MESH:D002277 Carcinoma Fluorouracil 7.5917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.2616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.263581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.263084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.2620101231 20214788 17428255 20514400 16698587 17978847 20007298 17138121 3581430 10737359 16540662 18971187 19335982 19171122 19383236 18665156 20524982 16935385 19107877 20727157 18393292 18506893 19519916 19919837 18056438 19539802 20432363 19208518 18210153 17055752 16807293 3084413 18494052 16878318 16830150 16288022 17761372 19701751 18691550 17173139 16681979 16569478 18785209 16502159 21159647 19418558 19052882 16328049 18978308 18788625 11831363 10672840 16779866 20512989 17162532 20084675 20935162 19822196 19394651
MESH:D006528 Carcinoma, Hepatocellular Ethanol 16.2618788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.2617045692 16799960 17088986 16332177 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.2616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.2617306315 16507464 15276417
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3616675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.147296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2318986760 16280240 17066447 16757204
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.2316227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2318572023
MESH:D006332 Cardiomegaly Ethanol 10.8819332462
MESH:D006332 Cardiomegaly Norepinephrine 10.8811179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.8816120746 18670907 18850075
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.2510525098
MESH:D002318 Cardiovascular Diseases resveratrol 3.3215458977
MESH:D002375 Catalepsy Norepinephrine 5.318216760
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.756135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.757505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.757505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7519524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.989022650 19486331
MESH:D002971 Cleft Lip Ethanol 3.4715513904
MESH:D002972 Cleft Palate Ethanol 5.6315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6315668235 15340226 8697196 12621046 16354765
MESH:D003092 Colitis resveratrol 3.9116474422
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7717725105 17169374 16510598 17287894 18772588 16340194 15001691 17016597 17018589 17172411
MESH:D003110 Colonic Neoplasms resveratrol 3.7716338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6217454858 15148649 18288408 18802399 17016601 16391804 17094418 16282729 18383874 20501625 15289873 16524972 18949393 16331619 16303861 17401013 17594712 17695437 18448328 14970324 17255274 18509181
MESH:D015179 Colorectal Neoplasms resveratrol 2.6216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.6116507316
MESH:D019465 Craniofacial Abnormalities Ethanol 3.6810194807 15513904 11198716 15451040 15451039 11873399 19302082
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6816575769 17688650 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7918551238
MESH:D007644 Darier Disease Fluorouracil 4.5616733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5911298694 18759878 2524372 11906362 8970840 8156756 14531868 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.283621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5916873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7716286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 24.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 24.5818692083 9653073 6679447 11289319 7440962 16192314 9328219 18289764 6482804 1440618 8291058 9022650 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.5819164858 16485898 2444490 16177239 19739265 16109766 19416960 19370779 14725611 12958197 12540782 17522070 11743745 11421492 10663392 17562736 18713872 12705907 11529661 17906064 19420014 15968718 12594235 10774834 11739529 19085960 15619225 11287661 11461765 16081117 14550746 16393943 12153990 12392966 19923254 14986274 10915739 18071297 16781746 11834606 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 24.5819107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 24.5811566570
MESH:D056486 Drug-Induced Liver Injury Prazosin 24.5818071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.5820420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 24.5817522070
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 24.581733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004417 Dyspnea Oxygen 4.6020016425
MESH:D004421 Dystonia Valproic Acid 3.841851702
MESH:D004487 Edema resveratrol 6.198985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.8117872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1715821434 15328337 17637181
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6217923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.933659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6916628512 3922381
MESH:D004827 Epilepsy Norepinephrine 6.80821787
MESH:D004827 Epilepsy Valproic Acid 6.8018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.406426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.077750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.843659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.983581430
MESH:D004938 Esophageal Neoplasms Ethanol 6.9816704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9816785472 15173087 17638652 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 17.1821071580 20387270
MESH:D005234 Fatty Liver Ethanol 17.1816409862 19236843 18620774
MESH:D005234 Fatty Liver Tetracycline 17.1816917069 19224547
MESH:D005234 Fatty Liver Valproic Acid 17.1814986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0716946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9118558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.829205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7320067830
MESH:D005739 Gas Poisoning Oxygen 4.9920016425
MESH:D005756 Gastritis Acetaminophen 10.3616983495
MESH:D005756 Gastritis Ethanol 10.3615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005910 Glioma Fluorouracil 2.7816145905
MESH:D005911 Gliosis Paraquat 4.9311124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2315162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2111294989 10048152
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6716120746 12621046 15340226
MESH:D006561 Herpes Simplex resveratrol 3.9516876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8115340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 12.2616870215
MESH:D006930 Hyperalgesia Ethanol 12.2618783367
MESH:D006930 Hyperalgesia Prazosin 12.2612727271
MESH:D006937 Hypercholesterolemia resveratrol 3.8017188708
MESH:D006949 Hyperlipidemias resveratrol 3.8216873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4016612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1017488730
MESH:D007022 Hypotension Norepinephrine 4.786740701
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4217600658
MESH:D007248 Infertility, Male Paraquat 6.424850670
MESH:D007248 Infertility, Male sodium arsenite 6.4215346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 11.0118785209
MESH:D007249 Inflammation Lipopolysaccharides 11.0117255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation resveratrol 11.0116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0112878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.3116624496
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.3910783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4217255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.4415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 9.4112587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 9.4115369732
MESH:D007674 Kidney Diseases sodium arsenite 9.4120008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.3716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.376582329
MESH:D007680 Kidney Neoplasms Fluorouracil 11.3716985049
MESH:D007859 Learning Disorders Ethanol 3.9915451040
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1116294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.5916766008
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5916087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.4715821434
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6517676605
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4018522880 18407596 18665156 20032147 19638242
MESH:D008103 Liver Cirrhosis Ethanol 6.4015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8718295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.069327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.4318166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008107 Liver Diseases Acetaminophen 3.7019784758 12587719 12969438 19014921 19460945 16610002 16611625 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7017034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4317207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.577678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.5718754104 2862719 21047994 18648771 20118626 19090486 19427195 21071580 19833225 21278145 18978307 19642983 16942905 19254457 20405173 19551842 9163691 20101389 19812893 2422723 10737359 18644402 20452335 19690152 19996281 19426721 15885732 12112319 19256749 19499222 20434301 12771043 19850985 19294768 19255062 18977376 20492335 20137499 19073162 19638242 20583210 15175105 20501860 21167192
MESH:D008113 Liver Neoplasms Fluorouracil 20.5717045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Heptachlor Epoxide 20.5711246134
MESH:D008113 Liver Neoplasms resveratrol 20.5719073162 20405173 19812893 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 20.5716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.5716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.932876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.936587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.9318308698 16267830 17174075 2563599 18164116 19519916 21159647 19009564 19126423 19539802 18544905 9362446 18253720 18775883 17942915 18282651 19004024 17854601 18079962 16842330 18093689 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9312151625
MESH:D008171 Lung Diseases Ozone 7.0119066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.0119095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D055370 Lung Injury Lipopolysaccharides 14.0121114838
MESH:D055370 Lung Injury Oxygen 14.0118339021
MESH:D055370 Lung Injury Ozone 14.0120417186
MESH:D008175 Lung Neoplasms Acetaldehyde 8.1817372256
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1820512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 8.1815246190
MESH:D008175 Lung Neoplasms Ozone 8.187614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 8.1819931552 17077188 16712894 15276417 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5615086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0215688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 2.9711606380 8985016
MESH:D008545 Melanoma resveratrol 3.3617992120
MESH:D008545 Melanoma sodium arsenite 3.3616487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008569 Memory Disorders Ethanol 3.9718411066 15451040
MESH:D008659 Metabolic Diseases resveratrol 4.1717112576
MESH:D008679 Metaplasia Ozone 4.8710496685
MESH:D008881 Migraine Disorders Valproic Acid 3.0318803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4618986760 16757204
MESH:D009101 Multiple Myeloma resveratrol 3.3117935668 16267019 14749477 17164350 17049120 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6417962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0317596541
MESH:D009203 Myocardial Infarction resveratrol 2.9416317513 17125593 16525036 16456233 17188708 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.4117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4112213967
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 4.6715642760
MESH:D009205 Myocarditis resveratrol 4.5317322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.637678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.403581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.403581430 9029167
MESH:D009369 Neoplasms Fluorouracil 4.8116928823 18600527 18239605
MESH:D009369 Neoplasms sodium arsenite 4.8111559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.488985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4820056578
MESH:D009395 Nephritis, Interstitial Tetracycline 4.559884423
MESH:D009410 Nerve Degeneration Paraquat 3.5416893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.296679447
MESH:D009436 Neural Tube Defects sodium arsenite 11.2912854658
MESH:D009436 Neural Tube Defects Valproic Acid 11.298888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.9818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.9820387270
MESH:D019636 Neurodegenerative Diseases resveratrol 12.9817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1917929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2916436463
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.2216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.226482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0417513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3717306315 15276417
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.2216540662
MESH:D010190 Pancreatic Neoplasms Ethanol 8.2212384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.2216929163 16500647 15113037 19003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010300 Parkinson Disease Paraquat 2.7312911755 11181820 16140633 16510128 15824117 11445065 15451049 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2116190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.2011026799
MESH:D010538 Peritonitis Ozone 3.9116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D011014 Pneumonia Lipopolysaccharides 17.2512224865 11605937
MESH:D011014 Pneumonia Ozone 17.2518007984 18381685 18929643
MESH:D011014 Pneumonia Paraquat 17.2512504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.362563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 14.9516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9511896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.9520603192
MESH:D017096 Prion Diseases Tetracycline 5.1810903871
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7218626508 19082440
MESH:D011471 Prostatic Neoplasms resveratrol 2.7215767336 17675339 17804756 17636462 16731767 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7216039940
MESH:D019310 Pseudolymphoma Valproic Acid 4.3111422049 12752131
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8317997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8215538739 18286688 18722050 16160472
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3516325855
MESH:D015427 Reperfusion Injury resveratrol 3.1616314181 17058453 17520802 15827377 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.7418339021 17627322
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.7411700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5810835634
MESH:D012135 Respiratory Sounds Paraquat 3.8311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.353692021
MESH:D012162 Retinal Degeneration Paraquat 8.3516458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9619155313
MESH:D012220 Rhinitis Acetaldehyde 4.5517050345
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 9.0118551238
MESH:D012640 Seizures Ethanol 9.019754883
MESH:D012640 Seizures Valproic Acid 9.0115475178 14763951 1511512 16876388 11738929 17978042 11044598 3137016
MESH:D012878 Skin Neoplasms resveratrol 8.8615837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 8.8619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8616192470
MESH:D016135 Spinal Dysraphism sodium arsenite 8.9712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.9719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3318456281
MESH:D013274 Stomach Neoplasms Ethanol 3.3318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3316424979 18567086 18396642 17498489 15786421 19015929 17172411 17522103 19084572 16951190
MESH:D013276 Stomach Ulcer Ethanol 3.3311906479 17189318 17918041 9211565 16755016 9562338
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2816321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.069754883
MESH:D013398 Sudden Infant Death Oxygen 5.3112563064
MESH:D013610 Tachycardia Norepinephrine 5.223261545
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.551399818 6587162 6582329 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.557505956
MESH:D014062 Tongue Neoplasms Fluorouracil 9.3316280240
MESH:D014062 Tongue Neoplasms resveratrol 9.3316227395
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.7816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.788074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7816452187 11723127 17306315 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.7716803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.7717473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.7711813266
MESH:D014594 Uterine Neoplasms resveratrol 3.9217044934
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0817488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04020 Calcium signaling pathway
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:05214 Glioma
REACT:604 Hemostasis
KEGG:00562 Inositol phosphate metabolism
KEGG:04670 Leukocyte transendothelial migration
KEGG:01100 Metabolic pathways
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
KEGG:04070 Phosphatidylinositol signaling system
REACT:22291 Phosphorylation of PLCgamma by Netrin-1
REACT:9417 Signaling by EGFR
REACT:9470 Signaling by FGFR
REACT:16888 Signaling by PDGF
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
KEGG:04370 VEGF signaling pathway
KEGG:05110 Vibrio cholerae infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33392
    • Releated gene ID Related gene Name
    PA43AGTR1
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA448948chloroquine
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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