AutismKB 2.0

Annotation Detail for PLD1


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Basic Information Top
Gene Symbol:PLD1 ( - )
Gene Full Name: phospholipase D1, phosphatidylcholine-specific
Band: 3q26.31
Quick LinksEntrez ID:5337; OMIM: 602382; Uniprot ID:PLD1_HUMAN; ENSEMBL ID: ENSG00000075651; HGNC ID: 9067
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LIPASYN-PWYphospholipases
PWY-3561choline biosynthesis III
Pathway IDPathway Name
hsa00565Ether lipid metabolism
hsa00564Glycerophospholipid metabolism
hsa04912GnRH signaling pathway
hsa04144Endocytosis
hsa01100Metabolic pathways
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
hsa04666Fc gamma R-mediated phagocytosis
No data
Pathway IDPathway Name
200187Alpha-synuclein signaling
200113ErbB1 downstream signaling
200057CDC42 signaling events
Pathway IDPathway Name
P00005Angiogenesis
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1860Brain tumor
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid 20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased activity of PLD1 proteinincreases activity 15964316
C494667 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid results in increased activity of PLD1 proteinincreases activity 15964316
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PLD1 mRNAincreases expression 19933214
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of PLD1 proteinincreases activity 17427178
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PLD1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PLD1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PLD1 mRNAincreases expression 18648102
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLD1 mRNAaffects expression 16483693
C028617 aroclor 1248 aroclor 1248 results in increased activity of PLD1 proteinincreases activity 17427178
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of PLD1 mRNAaffects expression 17331233
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNAaffects cotreatment|increases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PLD1 mRNAincreases expression 17879257
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]decreases reaction|increases activity 11243883
C006780 bisphenol A bisphenol A results in decreased expression of PLD1 mRNAdecreases expression 20678512
D015124 8-Bromo Cyclic Adenosine Monophosphate 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of and results in increased activity of PLD1 proteinincreases activity|increases expression 17065600
D015124 8-Bromo Cyclic Adenosine Monophosphate PLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]affects reaction|increases expression 17065600
D015124 8-Bromo Cyclic Adenosine Monophosphate PLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]affects reaction|increases expression 17065600
D020001 1-Butanol 1-Butanol results in decreased activity of PLD1 proteindecreases activity 16449385
D020001 1-Butanol [1-Butanol results in decreased activity of PLD1 protein] which affects the localization of APP proteinaffects localization|decreases activity 16449385
D020001 1-Butanol 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]affects reaction|decreases reaction|increases phosphorylation 11243883
D020001 1-Butanol 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]affects reaction|decreases reaction|increases phosphorylation 11243883
D020001 1-Butanol [1-Butanol inhibits the reaction [PRKCA protein binds to PLD1 protein]] which results in decreased activity of PLD1 proteinaffects binding|decreases activity|decreases reaction 15652502
D020001 1-Butanol 1-Butanol results in decreased activity of PLD1 proteindecreases activity 18344600
15652502
D020001 1-Butanol 1-Butanol results in decreased activity of PLD1 proteindecreases activity 16178010
C018021 cobaltous chloride Acetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
C018021 cobaltous chloride cobaltous chloride results in increased activity of PLD1 proteinincreases activity 17640750
C018021 cobaltous chloride N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
C018021 cobaltous chloride PD 169316 inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
C018021 cobaltous chloride PLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone]increases abundance|increases reaction 17640750
C018021 cobaltous chloride PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]increases expression|increases reaction 17640750
C018021 cobaltous chloride Reactive Oxygen Species affects the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]affects reaction|increases expression|increases reaction 17640750
C018021 cobaltous chloride rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
D016572 Cyclosporine Cyclosporine results in decreased expression of PLD1 mRNAdecreases expression 20106945
D003609 Dactinomycin PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]decreases reaction|increases cleavage 14640974
D003609 Dactinomycin PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]decreases reaction|increases cleavage 14640974
D003609 Dactinomycin PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]increases activity|increases phosphorylation|increases reaction 14640974
D003609 Dactinomycin PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]increases activity|increases phosphorylation|increases reaction 14640974
D003609 Dactinomycin PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]increases activity|increases phosphorylation|increases reaction 14640974
D003609 Dactinomycin PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]increases activity|increases phosphorylation|increases reaction 14640974
C117975 DDMS DDMS results in increased activity of PLD1 proteinincreases activity 15964316
C017180 decamethrin decamethrin results in decreased expression of PLD1 mRNAdecreases expression 19017407
C014347 decitabine decitabine affects the expression of PLD1 mRNAaffects expression 17145863
D019794 2,3-Diphosphoglycerate 2,3-Diphosphoglycerate results in decreased activity of PLD1 proteindecreases activity 16857255
C045651 epigallocatechin gallate PLD1 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]increases expression|increases reaction 15210717
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLD1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PLD1 mRNAincreases expression 19619570
D011345 Fenofibrate Fenofibrate inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]decreases reaction|increases activity 15964316
D011345 Fenofibrate Fenofibrate results in decreased activity of PLD1 proteindecreases activity 15964316
D009240 N-Formylmethionine Leucyl-Phenylalanine PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 11427526
D009240 N-Formylmethionine Leucyl-Phenylalanine PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 11427526
D009240 N-Formylmethionine Leucyl-Phenylalanine PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]affects reaction|increases abundance 17560994
D019833 Genistein Genistein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]decreases reaction|increases activity|increases phosphorylation 15150437
C081021 Go 6976 Go 6976 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]decreases reaction|increases activity|increases phosphorylation 15150437
D006861 Hydrogen Peroxide Genistein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]decreases reaction|increases activity|increases phosphorylation 15150437
D006861 Hydrogen Peroxide Go 6976 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]decreases reaction|increases activity|increases phosphorylation 15150437
D006861 Hydrogen Peroxide [Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of PLD1 proteinaffects cotreatment|increases phosphorylation 15150437
D006861 Hydrogen Peroxide [Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein]affects binding|affects cotreatment|increases phosphorylation 15150437
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 proteinincreases activity|increases phosphorylation 15150437
D012701 Serotonin HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]affects reaction|increases activity 18621911
D012701 Serotonin Ketanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]affects reaction|decreases reaction|increases activity 18621911
D012701 Serotonin PLD1 protein affects the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 18621911
D012701 Serotonin Serotonin results in increased activity of PLD1 proteinincreases activity 18621911
D007650 Ketanserin Ketanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]affects reaction|decreases reaction|increases activity 18621911
C032881 lysophosphatidic acid 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]affects reaction|decreases reaction|increases phosphorylation 11243883
C032881 lysophosphatidic acid 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]affects reaction|decreases reaction|increases phosphorylation 11243883
C032881 lysophosphatidic acid bisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]decreases reaction|increases activity 11243883
C032881 lysophosphatidic acid lysophosphatidic acid results in increased activity of PLD1 proteinincreases activity 11243883
C032881 lysophosphatidic acid Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]decreases reaction|increases activity 11243883
C032881 lysophosphatidic acid PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 11243883
C032881 lysophosphatidic acid PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 11243883
C032881 lysophosphatidic acid toxB protein, Clostridium difficile inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PLD1 protein]decreases reaction|increases phosphorylation 14769825
D008543 Melanins [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melaninsdecreases abundance|decreases activity|decreases expression 14615486
D009074 Melanocyte-Stimulating Hormones Melanocyte-Stimulating Hormones results in decreased expression of and results in decreased activity of PLD1 proteindecreases activity|decreases expression 14615486
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNAaffects cotreatment|increases expression 17905399
D015735 Mifepristone Mifepristone results in increased expression of PLD1 mRNAincreases expression 17584828
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of PLD1 mRNAincreases expression 16809437
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
C433446 N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine results in increased activity of PLD1 proteinincreases activity 15964316
D009638 Norepinephrine Fenofibrate inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]decreases reaction|increases activity 15964316
D009638 Norepinephrine Norepinephrine results in increased activity of PLD1 proteinincreases activity 15964316
D009638 Norepinephrine pirinixic acid inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]decreases reaction|increases activity 15964316
C408604 PD 169316 PD 169316 inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]decreases reaction|increases activity 11243883
D010712 Phosphatidic Acids Phosphatidic Acids results in increased activity of PLD1 proteinincreases activity 16857255
D010712 Phosphatidic Acids PLD1 protein results in increased chemical synthesis of Phosphatidic Acidsincreases chemical synthesis 16178010
C068564 phosphatidylbutanol PLD1 protein results in increased chemical synthesis of phosphatidylbutanolincreases chemical synthesis 14640974
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLD1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]decreases reaction|increases activity 15964316
C006253 pirinixic acid pirinixic acid results in decreased activity of PLD1 proteindecreases activity 15964316
D015232 Dinoprostone PLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone]increases abundance|increases reaction 17640750
D017382 Reactive Oxygen Species Reactive Oxygen Species affects the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]affects reaction|increases expression|increases reaction 17640750
D017382 Reactive Oxygen Species PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]affects reaction|increases abundance 17560994
C085746 rottlerin rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]decreases reaction|increases expression|increases reaction 17640750
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLD1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLD1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLD1 mRNAincreases expression 19619570
D013752 Tetracycline Tetracycline results in increased expression of PLD1 mRNAincreases expression 16917069
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of PLD1 proteinincreases activity 15067002
D013755 Tetradecanoylphorbol Acetate toxB protein, Clostridium difficile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PLD1 protein]decreases reaction|increases phosphorylation 14769825
C052342 topiramate topiramate results in increased expression of PLD1 mRNAincreases expression 16979414
C031815 toxB protein, Clostridium difficile toxB protein, Clostridium difficile inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PLD1 protein]decreases reaction|increases phosphorylation 14769825
C031815 toxB protein, Clostridium difficile toxB protein, Clostridium difficile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PLD1 protein]decreases reaction|increases phosphorylation 14769825
D014212 Tretinoin Tretinoin results in increased expression of PLD1 mRNAincreases expression 16249480
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNAaffects cotreatment|increases expression 17905399
D014638 Vanadates [Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of PLD1 proteinaffects cotreatment|increases phosphorylation 15150437
D014638 Vanadates [Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein]affects binding|affects cotreatment|increases phosphorylation 15150437
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.2611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 2.9618287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.5718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 5.9520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 5.9511473722
MESH:D000230 Adenocarcinoma Genistein 5.9511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.343712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.346695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 7.9116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.9116835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.5017942926
MESH:D000437 Alcoholism topiramate 4.5518552399 17925516 19331489
MESH:D000505 Alopecia Tretinoin 3.1315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4311748828
MESH:D000741 Anemia, Aplastic Benzene 3.9011369114 17661222 14761424
MESH:D001014 Aortic Aneurysm Dinoprostone 5.0310231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.0419183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 10.0410388637
MESH:D001169 Arthritis, Experimental Tretinoin 2.6916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1016292516
MESH:D001249 Asthma epigallocatechin gallate 4.4816516891
MESH:D001249 Asthma Tretinoin 4.4816456186
MESH:D001259 Ataxia 1-Butanol 5.037820390
MESH:D001321 Autistic Disorder Norepinephrine 3.128570775
MESH:D001321 Autistic Disorder Serotonin 3.1218405062 8570775 18361446 15132762 19221690 18062943 17157402
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.4819761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8316935849
MESH:D001477 Bartter Syndrome Dinoprostone 5.1515976003
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.4111289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.1519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.1512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.1516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3615746008
MESH:D001855 Bone Marrow Diseases Benzene 4.6216183116
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 4.9314601052
MESH:D001862 Bone Resorption bisphenol A 3.3311985600
MESH:D001919 Bradycardia Serotonin 4.888112388
MESH:D001943 Breast Neoplasms Benzene 5.0011921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.0020146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 5.0017123778
MESH:D001943 Breast Neoplasms decitabine 5.0018320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 5.0016675129 17261762 18497071 17289903 19861407 12948864 17018787 14630087
MESH:D001943 Breast Neoplasms Genistein 5.0016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 5.0016443354 16873071 16166294
MESH:D001943 Breast Neoplasms Trichloroethylene 5.0015986119
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.6516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.653581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.6516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.6516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.651917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.3917123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.367296757
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 12.0017015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.0020419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 12.0019215824
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 12.0018922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.0016051514 16096774
MESH:D006332 Cardiomegaly marker/mechanism 15988127
MESH:D006332 Cardiomegaly Norepinephrine 5.9811179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9818670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 6.0916332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.0916936243
MESH:D002375 Catalepsy Norepinephrine 4.948216760
MESH:D002386 Cataract Tretinoin 2.7217460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.796135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.797505956
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 20.7918226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.7912371664
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 20.7916192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.7918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9916129372
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.0921254450
MESH:D002659 Child Development Disorders, Pervasive topiramate 6.0915650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.7319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 10.7319486331
MESH:D002779 Cholestasis pirinixic acid 10.7319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5516461808
MESH:D021081 Chronobiology Disorders Serotonin 6.0817157402
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.8012621046 15340226 16354765 15668235 8697196
MESH:D002972 Cleft Palate Tretinoin 4.809407595
MESH:D003092 Colitis Tretinoin 3.1217035595
MESH:D003110 Colonic Neoplasms decitabine 3.4017616700
MESH:D003110 Colonic Neoplasms Genistein 3.4017182828
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5517141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 6.3715643154
MESH:D019465 Craniofacial Abnormalities decamethrin 6.3719861644
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 6.3715736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.3720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.379224671 9664655 9142499 14991402 9211117 17551590 9125849 10589399 16925845 8800419
MESH:D003490 Cyanosis 2,4-dinitrotoluene 8.9518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 8.9518551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.8619747007
MESH:D003872 Dermatitis Benzene 4.1815902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.3914531868 8970840 8156756 11298694 18759878 11906362 12868966 2524372
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 5.3916823706 11298694 15059100
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.942952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 8.7616988119
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 8.7616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 8.7617107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 8.7616979414
MESH:D003928 Diabetic Nephropathies Estradiol 2.9019279558
MESH:D003967 Diarrhea Dinoprostone 7.0811488427 7237001 10446763
MESH:D003967 Diarrhea Serotonin 7.0810446763 11488427 8112388
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.239653073 18289764 18692083 9328219 9022650 1440618 16192314 8291058 7440962 11289319 18648102 6482804 6679447
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 15.2311287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2320420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 15.2317522070
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 15.237120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3111462148
MESH:D050171 Dyslipidemias Fenofibrate 3.9816707586
MESH:D004487 Edema bisindolylmaleimide I 16.068273558
MESH:D004487 Edema pirinixic acid 16.0612083418
MESH:D004487 Edema Serotonin 16.0618841975
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.0611000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 16.0611698051 8273558 16716910 9599246 8113982 15177302 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.9116714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.9118230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5019294695
MESH:D004714 Endometrial Hyperplasia Genistein 3.9916402032
MESH:D016889 Endometrial Neoplasms Estradiol 14.4311473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 14.4316569247
MESH:D016889 Endometrial Neoplasms Genistein 14.4311473722
MESH:D016889 Endometrial Neoplasms Tretinoin 14.4316569247
MESH:D004715 Endometriosis Mifepristone 7.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.419294722 10568697
MESH:D004827 Epilepsy Norepinephrine 6.55821787
MESH:D004827 Epilepsy topiramate 6.5519148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.6616499746
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 3.713581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.7116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.3011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.3016938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 10.0719224547
MESH:D005234 Fatty Liver pirinixic acid 10.0719236843 20131406
MESH:D005234 Fatty Liver Tetracycline 10.0716917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8711858732
MESH:D005334 Fever Dinoprostone 4.3516997862 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.416705139
MESH:D005355 Fibrosis Cyclosporine 11.3512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.3520067830
MESH:D005355 Fibrosis Tretinoin 11.3517994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.628708960
MESH:D005909 Glioblastoma Genistein 5.8416598420
MESH:D005909 Glioblastoma Tretinoin 5.8417312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.487505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9810696789
MESH:D006258 Head and Neck Neoplasms decitabine 6.4219215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.4216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.0620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.0611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.069664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.1520558911
MESH:D018883 Heat Stroke Ketanserin 6.5616205318
MESH:D006402 Hematologic Diseases Benzene 4.1016183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.956705139
MESH:D006529 Hepatomegaly pirinixic acid 6.3318467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.3315340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.4215709030
MESH:D019584 Hot Flashes Estradiol 3.1417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4316354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Dinoprostone 6.7016793879
MESH:D006930 Hyperalgesia Tretinoin 6.7016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.6620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.3515034207
MESH:D006973 Hypertension Benzene 7.0417940673
MESH:D006973 Hypertension Cyclosporine 7.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.0418670907 18850075
MESH:D007022 Hypotension Norepinephrine 4.446740701
MESH:D007248 Infertility, Male decitabine 2.7917581917
MESH:D007249 Inflammation bisindolylmaleimide I 6.588273558
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.5812878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 6.588273558 15177302 7562506 11698051 7812673
MESH:D007299 Insect Bites and Stings decamethrin 5.1815189238
MESH:D007333 Insulin Resistance bisphenol A 9.9116393666
MESH:D007333 Insulin Resistance Estradiol 9.9116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 9.9116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1817994277
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.4619381132
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.418074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.1416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.1415992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8315604871
MESH:D007674 Kidney Diseases Cyclosporine 4.708314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 4.7015618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.7316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.1116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.1116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.116582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.1112371664
MESH:D007680 Kidney Neoplasms Estradiol 18.1115610895
MESH:D007938 Leukemia Benzene 12.2418335105 14694614 15935818 17119257
MESH:D007938 Leukemia decitabine 12.2418980019 19235587
MESH:D007938 Leukemia Genistein 12.2418980019 17468513
MESH:D007938 Leukemia Tretinoin 12.2417143497
MESH:D007951 Leukemia, Myeloid Benzene 12.9617506065
MESH:D007951 Leukemia, Myeloid decitabine 12.9617236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 12.9616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.3519478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.3518704418 17679729 18206229 18460780 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.3519850784 17596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.7416331271 17217047 9834237 17294898 16766008 12679006 17368321 19029980 19642359 16140955 16891316 16823087 15748426 16935935 19035177 17301526 17712046 17506722 17107899 16788101 17361223 17649720 19075265 19225113 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.869224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 11.3615816358
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 11.3617481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.3614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 11.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Genistein 11.3617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.3618397230 16248980
MESH:D008107 Liver Diseases Dinoprostone 3.3015816358
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 14.4716835634 18644402
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.477678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4721137059 20195826
MESH:D008113 Liver Neoplasms Fenofibrate 14.4718978307
MESH:D008113 Liver Neoplasms pirinixic acid 14.4716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.216135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.216587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Benzene 18.2112562636
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 18.2118775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.2112151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 18.217955063
MESH:D008171 Lung Diseases Acetylcysteine 3.6312815614
MESH:D017563 Lung Diseases, Interstitial Benzene 4.2014698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.4517365036
MESH:D008175 Lung Neoplasms Benzene 4.1012562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.1020869020 18520028 18569708 20464547 20135361 18816296 20064080 17053015 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.1019555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.1011807781
MESH:D008223 Lymphoma Benzene 6.3517584886 17119257
MESH:D008223 Lymphoma decitabine 6.3519470736
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.8512562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 10.9911921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.9911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.9914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 10.998985016
MESH:D020149 Manganese Poisoning Estradiol 3.8719453300
MESH:D008527 Medulloblastoma Tretinoin 2.5117453147
MESH:D008545 Melanoma decitabine 6.2217785578 16505122
MESH:D008545 Melanoma epigallocatechin gallate 6.2217992120 11746506
MESH:D008545 Melanoma Reactive Oxygen Species 6.2217992120
MESH:D008545 Melanoma Tretinoin 6.2216752155
MESH:D008591 Meningomyelocele Tretinoin 3.8416940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 2.9118303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1716801185
MESH:D008881 Migraine Disorders topiramate 4.1418759728 16942474 18803445 18765137
MESH:D020326 Migraine without Aura Dinoprostone 4.6911304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7216381670
MESH:D009101 Multiple Myeloma Benzene 6.1117119195
MESH:D009101 Multiple Myeloma decitabine 6.1118172295
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 4.8917962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 6.2319010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.2317596541
MESH:D009203 Myocardial Infarction Genistein 4.7217141266
MESH:D009203 Myocardial Infarction pirinixic acid 4.7219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.4916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.4917141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 16.4915642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.4916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.3618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.3618551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.143581430
MESH:D009362 Neoplasm Metastasis Acetylcysteine 5.1414720322
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 15.488820588
MESH:D009369 Neoplasms Benzo(a)pyrene 15.4811141357
MESH:D009369 Neoplasms decitabine 15.4819470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 15.4817405874
MESH:D009369 Neoplasms Tretinoin 15.4816594593 16946489
MESH:D009369 Neoplasms Trichloroethylene 15.4811911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1417289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.189884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 24.7111399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 24.7111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 24.7116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 24.719125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 14.006679447
MESH:D009436 Neural Tube Defects Acetylcysteine 14.0019446573
MESH:D009436 Neural Tube Defects Benzene 14.0015643154
MESH:D009436 Neural Tube Defects Tretinoin 14.009142499
MESH:D009765 Obesity pirinixic acid 1.6420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.3016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.3016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.304026338 6482804
MESH:D009784 Occupational Diseases Benzene 17.3017119257 15612468 17479406 15935809 15576619 15913788 16737584 15727169 17178637
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.413988306
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.8618500342
MESH:D010024 Osteoporosis Genistein 2.8619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.5316169203
MESH:D010049 Ovarian Diseases bisphenol A 4.3911985600
MESH:D010051 Ovarian Neoplasms Benzene 15.8312562636
MESH:D010051 Ovarian Neoplasms decitabine 15.8319331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 15.8319401270
MESH:D010051 Ovarian Neoplasms Genistein 15.8319005980
MESH:D010051 Ovarian Neoplasms Mifepristone 15.8316525653
MESH:D010051 Ovarian Neoplasms Tretinoin 15.8316936753
MESH:D010146 Pain Tretinoin 2.4316870215
MESH:D010190 Pancreatic Neoplasms decitabine 10.2919294695
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 10.2915580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 10.2915976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.2915976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 12.257296757
MESH:D010212 Papilloma Hydrogen Peroxide 12.2512065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 12.2512065085 18922899 8330346 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6312520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.8211026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.866228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.3110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9918163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.7112371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.5210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.5211222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.1417616702
MESH:D017096 Prion Diseases Tetracycline 4.8110903871
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.7520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.7520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.2416740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.2416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.2416925846 15256057 15378649
MESH:D011507 Proteinuria Tretinoin 3.0516636307
MESH:D011565 Psoriasis Cyclosporine 1.9916882103
MESH:D011625 Pterygium Tretinoin 4.1916723453
MESH:D011629 Puberty, Precocious bisphenol A 4.1810548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.7715814490 17365031 17975199 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.0619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 3.9812210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.923692021
MESH:D012208 Rhabdomyosarcoma decitabine 9.1019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.1016283617 16116481
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.5114601052
MESH:D012640 Seizures 2,4-dinitrotoluene 7.5418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.5418551238
MESH:D012640 Seizures topiramate 7.5416499746
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.5310029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.5312065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.5316192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.5311807781 12065085 8985016 8330346 18404319
MESH:D012878 Skin Neoplasms Tretinoin 14.5316467112
MESH:D013274 Stomach Neoplasms Benzene 4.0712562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.072093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.0719037991
MESH:D013274 Stomach Neoplasms Tretinoin 4.0717261132
MESH:D013276 Stomach Ulcer Acetylcysteine 3.4817918041
MESH:D019966 Substance-Related Disorders bisphenol A 3.3916684133 16045194
MESH:D013610 Tachycardia Norepinephrine 4.863261545
MESH:D013953 Thymus Neoplasms Benzene 4.3610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 9.307505956 6582329 3712494 1399818 6587162
MESH:D013964 Thyroid Neoplasms decitabine 9.3017967635
MESH:D013964 Thyroid Neoplasms Tretinoin 9.3017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.0719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.2616051514
MESH:D014376 Tuberculosis Tretinoin 2.8316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.8416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.8416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.848074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.8417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.8419087683 17616700
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 9.9910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 9.9910091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.1516129372
MESH:D014591 Uterine Diseases bisphenol A 4.3914652134
MESH:D014594 Uterine Neoplasms Benzene 3.7712562636
MESH:D014604 Uveal Neoplasms decitabine 10.7917785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.7916752155
MESH:D014605 Uveitis Cyclosporine 3.371336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9812125929
MESH:D014820 Vitiligo Tretinoin 3.4916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6315886252
MESH:D009396 Wilms Tumor Tretinoin 3.4516287080
MESH:D014947 Wounds and Injuries lysophosphatidic acid 4.8115541073
MESH:D014985 Xerophthalmia Cyclosporine 3.8317120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
KEGG:00565 Ether lipid metabolism
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04724 Glutamatergic synapse
KEGG:00564 Glycerophospholipid metabolism
KEGG:04912 GnRH signaling pathway
KEGG:01100 Metabolic pathways
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164742228
    • No data
    No data
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA450191lecithin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00122 - Choline Dietary supplement;Micronutrient;Nootropic Agents;Lipotropic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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