AutismKB 2.0

Annotation Detail for TPCN1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TPCN1 ( FLJ20612,KIAA1169,TPC1 )
Gene Full Name: two pore segment channel 1
Band: 12q24.13
Quick LinksEntrez ID:53373; OMIM: 609666; Uniprot ID:TPC1_HUMAN; ENSEMBL ID: ENSG00000186815; HGNC ID: 18182
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TPCN1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of TPCN1 mRNAaffects expression 17562736
C011890 kojic acid kojic acid results in increased expression of TPCN1 mRNAincreases expression 16595896
D008345 Manganese Manganese results in increased expression of TPCN1 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of TPCN1 mRNAincreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000756 Anemia, Sideroblastic Manganese 12.3016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 12.3016910769
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.419022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288970840 8156756 11298694 12868966 2524372 18759878 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9911289319 7440962 9022650 16192314 18648102 18692083 6482804 18289764 8291058 9328219 9653073 1440618 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9916109766 18071297 14986274 11743745 19085960 11739529 17522070 19420014 15968718 18713872 15619225 19416960 16227642 16485898 12705907 14725611 16177239 17906064 16081117 16781746 10774834 10663392 11421492 19370779 11834606 12594235 12958197 12153990 12392966 11461765 2444490 14550746 19923254 16393943 17562736 11529661 19739265 11287661 12540782 19164858 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005909 Glioblastoma Manganese 4.1317043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 16610002 19014921 19784758 16611625 19460945 11587558 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.876587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.8718544905
MESH:D020149 Manganese Poisoning Manganese 6.1319453300 16568477 16551646
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009069 Movement Disorders Manganese 5.4116551646
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009410 Nerve Degeneration Manganese 4.5516551646
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010300 Parkinson Disease Manganese 3.4711181820
MESH:D020734 Parkinsonian Disorders Manganese 4.8216140633
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156587162 6582329 7505956 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved