AutismKB 2.0

Annotation Detail for PLG


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Basic Information Top
Gene Symbol:PLG ( DKFZp779M0222 )
Gene Full Name: plasminogen
Band: 6q26
Quick LinksEntrez ID:5340; OMIM: 173350; Uniprot ID:PLMN_HUMAN; ENSEMBL ID: ENSG00000122194; HGNC ID: 9071
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Diabetes pathways
Hemostasis
Signaling by PDGF
Pathway IDPathway Name
200066Angiopoietin receptor Tie2-mediated signaling
200115Syndecan-4-mediated signaling events
200108amb2 Integrin signaling
200103p75(NTR)-mediated signaling
Pathway IDPathway Name
P00050Plasminogen activating cascade
P00011Blood coagulation
Pathway IDPathway Name
500304Dissolution of Fibrin Clot
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00223Inherited thrombophilia
Desease IDDesease Name
1831Prostate cancer
1832Congenital abnormality
1848Embryoma
1858Hemorrhagic disorder
1896Adrenoleukodystrophy
2066Lung cancer
2106Pancreas cancer
Desease Name
CARDIOVASCULAR
vascular disease
No data
Desease Name
Plasminogen Tochigi disease
Thrombophilia, dysplasminogenemic
Plasminogen deficiency, types I and II
Conjunctivitis, ligneous
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PLG mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of PLG mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PLG mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PLG proteinaffects expression 20106945
D000584 Amiloride Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein]decreases reaction|increases degradation 14644129
D015119 6-Aminocaproic Acid 6-Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 17482686
D015119 6-Aminocaproic Acid 6-Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 17482686
D000638 Amiodarone Amiodarone affects the expression of PLG mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLG mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased activity of PLG proteindecreases activity 19781379
D001553 Benzbromarone Benzbromarone affects the expression of PLG mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PLG mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AMY2 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AURKA mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2A1D mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL6 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNA2 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB2 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CHI3L3 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CTDSP2 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of DBP mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of EGR1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELA1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELA2A mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELOVL6 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of GSTM3 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of KIF22 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LCN2 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LPL mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MARCO mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NNMT mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of OSTA mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PLK1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PMF1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PNLIPRP1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PRSS2 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTTG1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SAA1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of STMN1 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TRY4 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of X99384 mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride PLG protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2L11 protein]affects reaction|increases expression 17482686
D002251 Carbon Tetrachloride PLG protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 17482686
D002251 Carbon Tetrachloride PLG protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 17482686
D002251 Carbon Tetrachloride PLG protein affects the susceptibility to Carbon Tetrachlorideaffects response to substance 16006527
D002251 Carbon Tetrachloride PLG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]decreases reaction|increases expression 14716496
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLG mRNAaffects expression 12734012
D002994 Clofibrate Clofibrate affects the expression of PLG mRNAaffects expression 19483382
D003276 Contraceptives, Oral Contraceptives, Oral results in increased expression of PLGincreases expression 15185533
D016572 Cyclosporine Cyclosporine results in decreased expression of PLG mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of PLG mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG proteinaffects binding|increases expression 14561536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG proteinaffects cotreatment|increases activity 11720199
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG proteinaffects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PLG proteinaffects cotreatment|increases expression 15157790
12618251
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PLG proteinaffects cotreatment|increases expression 12618251
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PLG proteinincreases expression 17374706
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased activity of PLG proteinincreases activity 15318540
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of PLG proteinincreases expression 12618251
D005001 Ethionine Ethionine affects the expression of PLG mRNAaffects expression 19483382
D005227 Fatty Acids Fatty Acids results in decreased activity of PLG proteindecreases activity 14724836
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG proteinaffects cotreatment|increases activity 11720199
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG proteinaffects cotreatment|increases expression 12618251
D007531 Isoflurophate Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 17482686
D007531 Isoflurophate Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 17482686
D009640 Norethindrone [Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG proteinaffects binding|increases expression 14561536
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PLG proteinaffects cotreatment|increases expression 12618251
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PLG proteinaffects cotreatment|increases expression 12618251
15157790
C516519 NuvaRing NuvaRing results in increased expression of PLG proteinincreases expression 15157790
D009853 Omeprazole Omeprazole affects the expression of PLG mRNAaffects expression 19483382
D010100 Oxygen Oxygen deficiency promotes the reaction [PLAU protein results in increased activity of PLG protein]increases activity|increases reaction 12485432
C093973 PD 98059 PD 98059 inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 17482686
C093973 PD 98059 PD 98059 inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 17482686
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLG mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of PLG mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of PLG mRNAaffects expression 19483382
D012406 Roxarsone Roxarsone results in decreased expression of PLG mRNAdecreases expression 18414637
D012645 Selenomethionine Selenomethionine affects the expression of PLG mRNAaffects expression 17222674
C017947 sodium arsenite sodium arsenite affects the expression of PLG mRNAaffects expression 19590694
C017947 sodium arsenite sodium arsenite affects the expression of PLG mRNAaffects expression 17450228
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLG mRNAdecreases expression 20106945
D013752 Tetracycline Tetracycline results in increased expression of PLG mRNAincreases expression 16917069
D013853 Thioacetamide Thioacetamide affects the expression of PLG mRNAaffects expression 19483382
D014260 Triclosan Triclosan inhibits the reaction [TNF protein results in increased metabolism of PLG protein]decreases reaction|increases metabolic processing 19874453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.0317505938
MESH:D000152 Acne Vulgaris norgestimate 11.0317505938
MESH:D055371 Acute Lung Injury Oxygen 8.0616759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.0618653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.2419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.2420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.2411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.2414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.436695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5117306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000860 Anoxia Oxygen 4.6720872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4718218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4315885639
MESH:D050197 Atherosclerosis Oxygen 3.5816391483
MESH:D001281 Atrial Fibrillation Amiodarone 3.6219698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.7119483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 58.7116206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.7119483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.7119483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.7119483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.7119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.7119483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 58.7112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.7119483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.9112948864 16675129 17018787 14630087 19861407 17289903 18497071 17261762
MESH:D001943 Breast Neoplasms Oxygen 1.9117263869
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9811589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.413786805 16011737 15673190 16097048 15700767 18705752 16227642 16050911 15721981 16124888 10355542 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.4716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.4716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.4712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 18.4716217749 15073043 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 18.471701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.4718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.4716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.4715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.4717997003
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.1920419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.1918572023
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.7514644129
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7018974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.306135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.301399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.3012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.3018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.3020056578 19524636
MESH:D002637 Chest Pain Omeprazole 4.7215447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4816835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.4818291259
MESH:D002779 Cholestasis Cyclosporine 16.9919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.9916919318 17110522 16105132 15861022 11677210 17333356 17681005
MESH:D002779 Cholestasis Levonorgestrel 16.9915861022
MESH:D002779 Cholestasis pirinixic acid 16.9919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9415668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis Amiloride 4.7412065299
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8520501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.4917141729 14669216
MESH:D000013 Congenital Abnormalities Triclosan 8.4919283420
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.3410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3410048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.6518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.6518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.7421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 16.7421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 16.7415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.7410092053 17522070 6884620 15998439 7179309 7120509 15027814 16227642 19336974 9327722 11566570 4309450 3732212 7440962 10915739 3786805 16177239 15968718 19085960 2869522 21278145 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.7420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 16.7417522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.7412963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.9715991576 17151854 21218061 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.7916707586
MESH:D004417 Dyspnea Oxygen 4.4520016425
MESH:D004487 Edema pirinixic acid 5.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8312538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.7311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.0712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3316456712
MESH:D005234 Fatty Liver Amiodarone 37.3814986274
MESH:D005234 Fatty Liver arsenic trioxide 37.3815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 37.3817595544 16239168 12795759 61145 15959796 19224547 12631006 16045604
MESH:D005234 Fatty Liver Clofibrate 37.3819224547
MESH:D005234 Fatty Liver Cyclosporine 37.3819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 37.3815345470
MESH:D005234 Fatty Liver pirinixic acid 37.3820131406 19236843
MESH:D005234 Fatty Liver Tetracycline 37.3816917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005355 Fibrosis Carbon Tetrachloride 12.5618705752
MESH:D005355 Fibrosis Cyclosporine 12.5612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.5620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9016904648
MESH:D005739 Gas Poisoning Oxygen 4.8320016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006130 Growth Disorders Amiloride 4.5119703807
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2317276928 15929193 18665440
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2819110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.2816456712
MESH:D006529 Hepatomegaly Amiodarone 12.2715265979
MESH:D006529 Hepatomegaly pirinixic acid 12.2719772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.2716120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8412676792
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6616354765 15340226 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.549751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006973 Hypertension Amiloride 7.8119344079 15174897 18524855
MESH:D006973 Hypertension Cyclosporine 7.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.4719822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4416945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.3717991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.3718031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.9117937319
MESH:D007248 Infertility, Male sodium arsenite 9.9115346721 12646999
MESH:D007248 Infertility, Male Triclosan 9.9120821571
MESH:D007249 Inflammation Amiloride 7.4917237260
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.4912200463 12878042
MESH:D007249 Inflammation Triclosan 7.499584910 20507366
MESH:D007333 Insulin Resistance Estradiol 6.3616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 8.7518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 8.7515618244
MESH:D007674 Kidney Diseases sodium arsenite 8.7520008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.2116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 15.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 15.2112371664
MESH:D007680 Kidney Neoplasms Estradiol 15.2115610895
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7919248655
MESH:D007938 Leukemia arsenic trioxide 2.6415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.4516972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 10.4516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0720471514 19850784 16467208 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9619225113 15336539 15213294 12679006 16891316 17869043 19035177 17217047 17649720 15622746 19642359 16330433 19075265 16112521 17107899 16331271 16823087 15748426 16966277 11468182 17712046 12018890 12712474 9834237 11161223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9916882451
MESH:D056929 Liddle Syndrome Amiloride 5.6019344079
MESH:D008064 Lipidoses Amiodarone 3.2415342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6016239168 17334410 16221502 17157831 11408273 11903743 21278145 16943688 17174718
MESH:D008106 Liver Cirrhosis, Experimental therapeutic 14716496
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1416097048 18279442 20821823 16027843 16015684 15996030 18054572 15959796 16033810 18429990 14512876 15362042 15730626 12632512 17922224 18156304 18166357 17976157 12389079 18263696 17823541 14716833 17900296 18317297 14620537 17761835 12666154 18418968 15673190 16011737 17805973 17708605 12898905 17525996 16638106 17631135 17557913 18187930 18472332 17640975 18277467 12445421 17869086 12741479 15338365 12958196 18472094 12609069 12546737 18339082 12445418 18395095 17481882 18420326 14716496 12667390 18006644 18205269 15370692 13678700 17698563 15818738 14724832 18376398 16136751 16116963 12649538 15052691 14748882 15876570 15931870 15123356 12632514 17565644 18705752 17766677 18210741 18251166 18395914 15650968 18481824 16192424 18412020 10355542 15057751 17714472 15925388 17721639 17944888 15893842 16248980 12586293 11481614
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.1418263696 18295389 12679928 16248980 18615449 16126171 16343077 18031379 12085344 17050028 15288473 18032466 12557150 15474484 18606216 15316131 16511523 12531686 17127702 15078482 12891558 17629604 18395095 15716488 15465738 15095483 16098781 11682029 14739098 11481614 16489207 15288472 15362042 11172339 15334695 15075984 12175628 18458672 16097051 15158331 10677585 18416461 17355460 17292413 18380797
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9315720792 16246199 15830285 17285989 16964402
MESH:D008107 Liver Diseases Thioacetamide 3.9318374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7116899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 8.7115633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 23.227678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.229163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 23.2214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.2221137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 23.2219294768
MESH:D008113 Liver Neoplasms pirinixic acid 23.2216377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 23.2215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.2216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.082876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.088603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.0820377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.0815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0812151625
MESH:D008133 Long QT Syndrome Amiodarone 7.2311989578 15350150 17391786
MESH:D008133 Long QT Syndrome arsenic trioxide 7.2315213294
MESH:D008171 Lung Diseases Amiodarone 6.6612587719
MESH:D008171 Lung Diseases sodium arsenite 6.6619095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0918516814
MESH:D055370 Lung Injury Oxygen 4.1418339021
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.0014755239
MESH:D008175 Lung Neoplasms arsenic trioxide 6.0011798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.0017053015 20869020 20464547 18569708 18520028 18816296 20135361 20064080 6695378
MESH:D008175 Lung Neoplasms sodium arsenite 6.0017306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.0019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7411807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 5.7415358634
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008545 Melanoma sodium arsenite 1.9819082730 16487513
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8419417148 15949261 14977855 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009181 Mycoses Amiodarone 4.5117974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9216882451 16105982
MESH:D009203 Myocardial Infarction Contraceptives, Oral 5.9711752354
MESH:D009203 Myocardial Infarction pirinixic acid 5.9719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.0818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.087678174 18551238
MESH:D009361 Neoplasm Invasiveness Amiloride 9.4614644129
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.4616624393
MESH:D009369 Neoplasms Benzo(a)pyrene 7.0611141357
MESH:D009369 Neoplasms pirinixic acid 7.0617405874
MESH:D009369 Neoplasms sodium arsenite 7.0611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.409884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2614600291
MESH:D009436 Neural Tube Defects arsenic trioxide 6.5010525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.5012854658
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.579802331
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.7912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.7916049721
MESH:D010024 Osteoporosis Levonorgestrel 4.4312665316
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.1219769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 7.1219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.1217306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.3915580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0411026799
OMIM:217090 PLASMINOGEN DEFICIENCY, TYPE I marker/mechanism
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.2617105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8111118676 11222880 11896295 11399792
MESH:D017096 Prion Diseases Tetracycline 5.0310903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1416740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011537 Pruritus Ethinyl Estradiol 8.7416919318 15861022
MESH:D011537 Pruritus Levonorgestrel 8.7415861022
MESH:D011565 Psoriasis Cyclosporine 2.0916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7012490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.1618339021 17627322
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.0118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.0118551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3119755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 8.3118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5516709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5012854658
MESH:D013272 Stomach Diseases Omeprazole 4.2318545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.2617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.262093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 6.4618087811
MESH:D013276 Stomach Ulcer Omeprazole 6.4616755016 17977527 10750652 11906479 18237397 15991576
MESH:D013398 Sudden Infant Death Oxygen 5.1612563064
MESH:D013610 Tachycardia Amiodarone 3.9311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 16.4411994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 16.4411994571
MESH:D019851 Thrombophilia Gestodene 16.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.4915669648
MESH:D013927 Thrombosis Gestodene 8.4915669648
MESH:D013959 Thyroid Diseases Amiodarone 18.9219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 18.9212697716
MESH:D013959 Thyroid Diseases Triclosan 18.9219910387
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.4919014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.4915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4918020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D016171 Torsades de Pointes Amiodarone 8.9917467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 8.9915213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.0916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.0916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.0920435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.0917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.0911723127 16452187 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.7210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.7210091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9414692618
MESH:D014605 Uveitis Cyclosporine 3.601336536
MESH:D014652 Vascular Diseases sodium arsenite 4.0417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 15.9615869587 14671159
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 15.9615869587
MESH:D020246 Venous Thrombosis Levonorgestrel 15.9615869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:15380 Diabetes pathways
REACT:604 Hemostasis
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:16888 Signaling by PDGF
KEGG:05150 Staphylococcus aureus infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33405
    • No data
    Releated disease ID Related disease Name
    PA161845799Aspergillosis Infection
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    PA449470epinephrine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00009 activator Alteplase Thrombolytic Agents
    DB00013 activator Urokinase Thrombolytic Agents
    DB00015 activator Reteplase Thrombolytic Agents
    DB00029 activator Anistreplase Thrombolytic Agents
    DB00031 activator Tenecteplase Thrombolytic Agents
    DB00086 activator Streptokinase Thrombolytic Agents
    DB00302 antagonist Tranexamic Acid Antifibrinolytic Agents
    DB00513 antagonist Aminocaproic Acid Antifibrinolytic Agents
    DB03709 - Bicine
    DB06692 - Tisseel Kit Vh 5.0 Antifibrinolytic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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