AutismKB 2.0

Annotation Detail for CLIC5


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Basic Information Top
Gene Symbol:CLIC5 ( CLIC5B,FLJ90663,MST130,MSTP130,dJ447E21.4 )
Gene Full Name: chloride intracellular channel 5
Band: 6p21.1
Quick LinksEntrez ID:53405; OMIM: 607293; Uniprot ID:CLIC5_HUMAN; ENSEMBL ID: ENSG00000112782; HGNC ID: 13517
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CLIC5 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of CLIC5 mRNAdecreases expression 19654921
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLIC5 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CLIC5 mRNAincreases expression 17484886
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLIC5 mRNAaffects cotreatment|decreases expression 20360939
D018038 Sodium Selenite Sodium Selenite results in increased expression of CLIC5 mRNAincreases expression 18175754
D014415 Tunicamycin Tunicamycin results in increased expression of CLIC5 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3018056438 16434500 17620307 19061943 17162532 19052882
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9312569548 16835338 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.4012928151 19371607
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1415700767 16097048 15673190 16124888 16050911 16011737 16192424 15721981 10355542 3786805 16227642 18705752
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7315504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8516507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.853581430 19394651 18691550 17428255 16681979 20935162 21159647 19052882 16779866 18785209 18971187 3084413 11831363 20524982 18665156 20084675 10737359 16807293 19418558 17761372 19822196 19519916 20512989 18393292 20007298 18210153 17162532 19539802 20101231 16569478 18978308 16935385 19107877 10672840 19383236 19919837 18494052 19171122 20432363 16328049 19335982 16540662 18056438 20727157 16288022 16698587 20514400 18788625 18506893 16878318 17138121 19208518 17055752 20214788 17978847 17173139 19701751 16830150 16502159
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7518922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6319152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.5618022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.042727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6916227642 6623471 7440962 7120509 10915739 3732212 16177239 6884620 19085960 15998439 15968718 17522070 21278145 3786805 2869522 9327722 15027814 19336974 11566570 7179309 10092053 4309450
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6919107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6915131321
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.7861145 12795759 19224547 15959796 16239168 16045604 17595544 12631006
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7821071580 20387270
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 2.9516076760 9931084 11953799
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8510783313
MESH:D007642 Keratosis Arsenic 5.3912749816 16930632
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.6915369732
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.6417339181
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.6416766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0716239168 17157831 16221502 16943688 11408273 11903743 17174718 21278145 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0718522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7512632512 15370692 18279442 18317297 16027843 12666154 15959796 12445418 18156304 12389079 14716833 17823541 18263696 18054572 18429990 17565644 14724832 18006644 18418968 15650968 12667390 15893842 17525996 15052691 12445421 14512876 16011737 16116963 17640975 14716496 17900296 17698563 17944888 15925388 17976157 14620537 15876570 16015684 16097048 18277467 17631135 15730626 16192424 17922224 18395095 15996030 12609069 17557913 16033810 18339082 18420326 18187930 15057751 12741479 18705752 15338365 18205269 17714472 13678700 17761835 20821823 17708605 18166357 15123356 11481614 12958196 18481824 17766677 17721639 15362042 10355542 17481882 18251166 18376398 12649538 17869086 18210741 18472094 18395914 16248980 17805973 16136751 15931870 18412020 12586293 15818738 15673190 12898905 16638106 14748882 18472332 12546737 12632514
MESH:D008107 Liver Diseases Arsenic 6.9511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.9515720792 16246199 15830285 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 6.9517034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 8.0416368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.049163691 15175105 18754104 19996281 19812893 21071580 20405173 21278145 20492335 18648771 20452335 12771043 19256749 19642983 18644402 12112319 10737359 19690152 15885732 20583210 2422723 18977376 19090486 19255062 19073162 20137499 20434301 19426721 19850985 21167192 19551842 19254457 2862719 19294768 19833225 19638242 20501860 20101389 19427195 19499222 18978307 20118626 16942905 21047994
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4918544905 19004024 18164116 18093689 17942915 17854601 18253720 16842330 18079962 2563599 18775883 19126423 19539802 9362446 16267830 21159647 19009564 3124819 18282651 17174075 19519916 18308698
MESH:D008175 Lung Neoplasms Arsenic 2.6717306315 17976673 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6720970405 21163286 6695378 20512841
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.669029167 3581430
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010051 Ovarian Neoplasms Arsenic 2.8117306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3915371236 16905509 6392382
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.4016140617
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4018760546
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D012871 Skin Diseases Arsenic 2.8017453740 16759981 17938729 16702368 17548696 16353154 18709164 6392382 17050553 19834688 15952646
MESH:D012878 Skin Neoplasms Arsenic 3.1217029826 17050553 17976673 16251483 19538983 15504454
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9018640142 15987713 19429237 17306315 11144890 19322015 17976673
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26592
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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