AutismKB 2.0

Annotation Detail for SERPINF2


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Basic Information Top
Gene Symbol:SERPINF2 ( A2AP,AAP,ALPHA-2-PI,API,PLI )
Gene Full Name: serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Band: 17p13.3
Quick LinksEntrez ID:5345; OMIM: 613168; Uniprot ID:A2AP_HUMAN; ENSEMBL ID: ENSG00000167711; HGNC ID: 9075
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
No data
Pathway IDPathway Name
P00050Plasminogen activating cascade
P00011Blood coagulation
Pathway IDPathway Name
500304Dissolution of Fibrin Clot
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1858Hemorrhagic disorder
1976Squamous cell cancer
2012Pulmonary embolism
Desease Name
HEMATOLOGICAL
bleeding tendency
enhanced fibrinolytic potential
No data
Desease Name
Alpha-2-plasmin inhibitor deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SERPINF2 mRNAdecreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SERPINF2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of SERPINF2 mRNAaffects expression 19483382
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of SERPINF2 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of SERPINF2 mRNAaffects cotreatment|increases expression 18585445
D001553 Benzbromarone Benzbromarone affects the expression of SERPINF2 mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of SERPINF2 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of SERPINF2 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of SERPINF2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SERPINF2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SERPINF2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERPINF2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SERPINF2 mRNAdecreases expression 17108234
D005001 Ethionine Ethionine affects the expression of SERPINF2 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of SERPINF2 mRNAaffects expression 19483382
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of SERPINF2 mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of SERPINF2 mRNA]decreases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in decreased expression of SERPINF2 mRNAdecreases expression 16221962
18445702
17950772
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SERPINF2 mRNA]decreases expression|increases reaction 20059764
17950772
C006253 pirinixic acid pirinixic acid affects the expression of SERPINF2 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of SERPINF2 mRNAaffects expression 19483382
D013629 Tamoxifen Tamoxifen affects the expression of SERPINF2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERPINF2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SERPINF2 mRNAincreases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of SERPINF2 mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin results in decreased expression of SERPINF2 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7911752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Estradiol 4.1611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.713712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.1611874814
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:C537777 Alpha-2-plasmin inhibitor deficiency marker/mechanism
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7418218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.8519698954 18651412
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9611289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 65.3319483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 65.3319483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 65.3319483382
MESH:D001778 Blood Coagulation Disorders Ethionine 65.3319483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 65.3319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 65.3319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 65.3319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 65.3312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 65.3319483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 65.3316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001943 Breast Neoplasms Estradiol 1.9218497071 17261762 17289903 19861407 17018787 16675129 14630087 12948864
MESH:D001943 Breast Neoplasms Tamoxifen 1.9220135344 15565566 18351453 18984771 19155303 17440819 16273361 18425577 18629630 20005174 19115204 20390343 19103187 19189212 19059307 19084267 19142967 17049068 18855134 19066611 16202921 19200415 11161223 19487384 17893378 19011961 18815881 20065188 18997820 18821012 19288272 15668708 21138602 19189210 20859285 19289846 19410462 17261762 17242785 16873071 20544844 21152245 19244106 19221464 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.9421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.941701930
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.9416924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.9416924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.9417997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.941917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2716051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8715710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0218974383
MESH:D002386 Cataract Tretinoin 3.0517460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.667505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 15.661399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.6612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.6618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D002637 Chest Pain Omeprazole 5.0515447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3516835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.3518291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.809022650 19486331
MESH:D002779 Cholestasis Cyclosporine 18.8019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.8017333356 15861022 17681005 16105132 17110522 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 18.8019176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6715340226 15668235 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.679407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.439211117 16925845 9224671 9125849 9142499 17551590 10589399 14991402 8800419 9664655
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7412868966 8970840 11906362 11298694 8156756 2524372 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.432952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.6519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.6519279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.8518289764 7440962 9653073 9328219 9022650 18692083 11289319 6679447 1440618 6482804 18648102 16192314 8291058
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.8515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.8512963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.2617151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 4.0216707586
MESH:D004487 Edema perfluorooctanoic acid 11.1112083418 17259670
MESH:D004487 Edema pirinixic acid 11.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7616714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.7312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.7319031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.1719148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.1716202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 12.1716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.679664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.6616456712
MESH:D005234 Fatty Liver Amiodarone 29.9414986274
MESH:D005234 Fatty Liver Clofibrate 29.9419224547
MESH:D005234 Fatty Liver Cyclosporine 29.9419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.9415345470
MESH:D005234 Fatty Liver pirinixic acid 29.9419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 29.9419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Cyclosporine 14.3512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3520067830
MESH:D005355 Fibrosis Tretinoin 14.3517994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Tretinoin 2.9617312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.429664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5118665440 15929193 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.246705139
MESH:D006505 Hepatitis Thioacetamide 9.2416456712
MESH:D006529 Hepatomegaly Amiodarone 20.1915265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 20.193609246
MESH:D006529 Hepatomegaly pirinixic acid 20.1918467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.1912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.8712083418
MESH:D006930 Hyperalgesia Tretinoin 7.8716870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.818137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 11.4017991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.408137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Atrazine 6.7612948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7617937319
MESH:D007249 Inflammation perfluorooctanoic acid 8.1612083418
MESH:D007249 Inflammation Tamoxifen 8.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.0516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.0516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.818314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.8115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.286582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 17.2815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.2818625569
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0419248655
MESH:D007938 Leukemia Tretinoin 2.7417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1116891316 19075265 17339181 19029980 16766008 17294898 19035177 17301526 17107899 16331271 17217047 16823087 17712046 17506722 17649720 17361223 9834237 16935935 17368321 15748426 19642359 16788101 12679006 16140955 19225113
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.178812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008064 Lipidoses Amiodarone 7.7517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.7517567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.6415316131 18458672 16098781 12085344 14739098 15095483 17629604 15716488 18263696 18606216 12531686 17292413 11172339 15158331 18416461 17355460 15075984 16511523 18032466 18615449 12679928 16343077 15288473 11682029 18395095 12175628 16489207 12557150 15334695 15362042 17127702 15288472 11481614 18380797 10677585 12891558 16097051 16126171 18295389 15465738 17050028 15078482 15474484 18031379 16248980
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.6416248980 18397230
MESH:D008107 Liver Diseases Thioacetamide 2.6915158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2515633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.9818177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.9814757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 13.9815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 13.9816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.56598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.568603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5612151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4218516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3414755239
MESH:D008175 Lung Neoplasms Tamoxifen 3.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3419555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8317203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.8319196723 16827153 14580682 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.4619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.4619453300
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Tamoxifen 3.2519393235 12393984
MESH:D008545 Melanoma Tretinoin 3.2516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008654 Mesothelioma Atrazine 3.501916698
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009181 Mycoses Amiodarone 4.8512754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.613581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms pirinixic acid 4.8017405874
MESH:D009369 Neoplasms Tretinoin 4.8016594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.9616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.969125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.086679447
MESH:D009436 Neural Tube Defects Tretinoin 7.089142499
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.859802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 11.859802331
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.364026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010051 Ovarian Neoplasms Estradiol 4.7419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7416936753
MESH:D010146 Pain Tretinoin 2.8516870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010300 Parkinson Disease Atrazine 3.2517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.4717132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4711399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2016740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2015067354
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8312490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012135 Respiratory Sounds Atrazine 4.4511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416283617 16116481
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0218724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.4616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013272 Stomach Diseases Omeprazole 4.5518545984
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Amiodarone 7.3718087811
MESH:D013276 Stomach Ulcer Omeprazole 7.3716755016 11906479 10750652 18237397 15991576 17977527
MESH:D013610 Tachycardia Amiodarone 4.2211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Amiodarone 11.8719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.741399818 7505956 6582329 6587162 3712494
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.7415710170
MESH:D013964 Thyroid Neoplasms Tretinoin 11.7416026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.8019584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D016171 Torsades de Pointes Amiodarone 4.1311989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.958074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.9516712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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