AutismKB 2.0

Annotation Detail for PLOD1


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Basic Information Top
Gene Symbol:PLOD1 ( FLJ42041,LH,LH1,LLH,PLOD )
Gene Full Name: procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
Band: 1p36.22
Quick LinksEntrez ID:5351; OMIM: 153454; Uniprot ID:PLOD1_HUMAN; ENSEMBL ID: ENSG00000083444; HGNC ID: 9081
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
bone density
longer forms of a repetitive sequence
METABOLIC
No data
Desease Name
Nevo syndrome
Ehlers-Danlos syndrome, type VI
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PLOD1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PLOD1 mRNAaffects expression 21346803
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in decreased expression of PLOD1 mRNAdecreases expression 15135645
D000082 Acetaminophen Acetaminophen affects the expression of PLOD1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLOD1 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of PLOD1 mRNAincreases expression 16474171
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] affects the expression of PLOD1 mRNAaffects cotreatment|affects expression 16322899
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PLOD1 mRNAincreases expression 17005392
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] affects the expression of PLOD1 mRNAaffects cotreatment|affects expression 16322899
D004958 Estradiol Estradiol results in increased expression of PLOD1 mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of PLOD1 mRNAincreases expression 16474171
C006253 pirinixic acid pirinixic acid results in increased expression of PLOD1 mRNAincreases expression 18301758
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of PLOD1 mRNAincreases expression 16474171
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLOD1 mRNAdecreases expression 11752688
D002762 Cholecalciferol Cholecalciferol results in increased expression of PLOD1 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Doxorubicin 7.2117418594
MESH:D000230 Adenocarcinoma Estradiol 7.2111473722
MESH:D000230 Adenocarcinoma Genistein 7.2111473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000419 Albuminuria Doxorubicin 4.5821441931
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.6415014928
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.0716142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7614601052
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.8417150277
MESH:D001943 Breast Neoplasms bisphenol A 3.7917123778
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.7911325840 17020986 17388661 12006526 18234424 15136595 15093573 18323546 16978400
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.7915324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 3.7915994142 15939500 16115903 19526202 16595493 18628466 17426702 16096432 15567936 16264153 15668708 18695136 15136595 17983394 18382427 15692762 11325840 18234424 15993339 15634643 16322301 16935488 17369602 16826403
MESH:D001943 Breast Neoplasms Estradiol 3.7912948864 17018787 17289903 16675129 17261762 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms Genistein 3.7916873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8716051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 17.0516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 17.0516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.053084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 17.0519701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 17.0516924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 17.0516234567 16023760 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.0516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 17.0516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.9416152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.9116201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.9116201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.646189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5516952015 16364871 16269455 16651473 17974986 17308081 16278810 16242529 17928571 16731534 18627295 17329180 15505089 17131338 17924179 17519947 17007740 15476868 17351982 16455267 16109756 15792986 15811867 17382496 16612575
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9517334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.736135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9218802399 18259882
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.9215531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5916002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003556 Cystitis Cyclophosphamide 5.0518372110 18710439 10700343 15643279 12388444 18093676 16413132 12913760 16989017 16614059 18295254 10498854 12161096 17979934 16651033 15276878 18483878 18433785 11948286 17010015
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7316140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.0910990075 11751995 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2318772604
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.1021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1019416960 19420014 19370779 14986274 11739529 10915739 17562736 15619225 10663392 16177239 16393943 16081117 2444490 17906064 18713872 11287661 19923254 16227642 12392966 12958197 12594235 19085960 12540782 11834606 12705907 15968718 18071297 19739265 12153990 17522070 11529661 10774834 11743745 11421492 14725611 16109766 11461765 16781746 14550746 19164858 16485898
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.1017416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Doxorubicin 8.1818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:C536198 Ehlers-Danlos syndrome type 6 marker/mechanism 15666309
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.0616402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.0616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 17.9716804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.9717359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.9711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 17.9711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2218037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.2611006010
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver pirinixic acid 2.7919236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6716513791 15751030 16534752 16002989 16611131
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9920067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0016452187
MESH:D005909 Glioblastoma Doxorubicin 7.3917150277
MESH:D005909 Glioblastoma Genistein 7.3916598420
MESH:D018316 Gliosarcoma Cyclophosphamide 5.5611389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.0815172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5515692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.5017888722 17875725 18006777 16244372 16244371 16879835 12587719 14766674 16495754 16144979 16330681 18674790 16707910
MESH:D006333 Heart Failure Doxorubicin 7.1017481944
MESH:D006333 Heart Failure pirinixic acid 7.1020558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9315692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.3311918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.6014986274
MESH:D006529 Hepatomegaly pirinixic acid 8.4016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.7917606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 7.7918501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1115340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4814722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.6216002989
MESH:D007154 Immune System Diseases Cyclophosphamide 5.3916076520
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007248 Infertility, Male Cyclophosphamide 3.647193160 16517039
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 12.4216393666
MESH:D007333 Insulin Resistance Estradiol 12.4216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 10.1615629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 10.1615699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 10.1615618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1816707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.9816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.9816705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.9814681315 16762066 15003126
MESH:D007680 Kidney Neoplasms Estradiol 17.9815610895
MESH:D007738 Kyphosis marker/mechanism 15666309
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1017184923
MESH:D007938 Leukemia Cyclophosphamide 6.7210602166
MESH:D007938 Leukemia Genistein 6.7217468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2216085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5117658394 17802794 17008537 18587576 17296974 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1110373061
MESH:D007970 Leukopenia Cyclophosphamide 5.0210052129 11830472
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.7716595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.7717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6316610002 19014921 11587558 12969438 19460945 19784758 12587719 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.777678174
MESH:D008113 Liver Neoplasms Diethylstilbestrol 10.7716712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 10.7720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.322876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.3217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 14.321423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.3212151625
MESH:D008175 Lung Neoplasms Doxorubicin 2.4017418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4011884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Cyclophosphamide 12.8112854902
MESH:D008223 Lymphoma Diethylstilbestrol 12.8115700306
MESH:D008223 Lymphoma Doxorubicin 12.8116098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.6316675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 9.0711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.0717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6115621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.1415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1417203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.1414578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma Doxorubicin 2.2916827129
MESH:D008546 Melanoma, Experimental Acetaminophen 10.9719513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.9716388313
MESH:D008654 Mesothelioma Doxorubicin 3.0717638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5315792986
MESH:D052016 Mucositis Doxorubicin 4.8417415656
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.5515857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.5517141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.5519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.3016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.3017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.3016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9618259882
MESH:D009369 Neoplasms Cyclophosphamide 8.4518854779
MESH:D009369 Neoplasms Diethylstilbestrol 8.4515313581
MESH:D009369 Neoplasms pirinixic acid 8.4517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009401 Nephrosis Doxorubicin 4.8116899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0216889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 31.1911399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 31.1911399458
MESH:D009421 Nervous System Malformations Estradiol 31.1911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 31.1916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 31.1914600291
MESH:D009447 Neuroblastoma Cyclophosphamide 7.2616115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 7.2615555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.9412837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.368291058
MESH:C536113 Nevo syndrome marker/mechanism 15666309
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D009845 Oligospermia Cyclophosphamide 4.7616517039
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D012516 Osteosarcoma Doxorubicin 4.1315930896
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010146 Pain Acetaminophen 6.9316870215
MESH:D010146 Pain Cyclophosphamide 6.9312161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.1911332152
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4016702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2217983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7116977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2217638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8221297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.6010548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.6017184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.6011222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.6520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.6520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4816740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.4817024972
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.4817136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.4816868541 15897917 16888761 18437689 16729912 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 2.4816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4816925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4815721890
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2916636934
MESH:D051437 Renal Insufficiency Doxorubicin 4.2617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012509 Sarcoma Doxorubicin 4.0115675481 17710206 18313854 15625365 17203757 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8417846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.8516636934
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012878 Skin Neoplasms Doxorubicin 5.7315692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6115625365 17203757 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 4.7716002989 16709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.5616517039
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316684133 16045194
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.1112837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3917909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.9416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.9416049721
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.9414692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.9417306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.9417653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0616175088
MESH:D014591 Uterine Diseases bisphenol A 14.0314652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 14.0314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2617678736 17334414 17638931 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00126 activator Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
DB00139 - Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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