AutismKB 2.0

Annotation Detail for PLP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PLP1 ( HLD1,MMPL,PLP,PLP/DM20,PMD,SPG2 )
Gene Full Name: proteolipid protein 1
Band: Xq22.2
Quick LinksEntrez ID:5354; OMIM: 300401; Uniprot ID:MYPR_HUMAN; ENSEMBL ID: ENSG00000123560; HGNC ID: 9086
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1791Neuropathy
1832Congenital abnormality
1906Cerebral palsy
2069Schizophrenia
Desease Name
connatal Pelizaeus-Merzbacher disease
No data
Desease Name
Pelizaeus-Merzbacher disease
Spastic paraplegia-2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PLP1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLP1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of PLP1 mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PLP1 mRNAdecreases expression 20106945
D003024 Clozapine Clozapine results in decreased expression of PLP1 mRNAdecreases expression 18797397
D003024 Clozapine Clozapine results in increased expression of PLP1 mRNAincreases expression 17266109
D004041 Dietary Fats Dietary Fats results in increased expression of PLP1 mRNAincreases expression 18042831
D005047 Etoposide PLP1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D006220 Haloperidol Haloperidol results in decreased expression of PLP1 mRNAdecreases expression 18797397
17177202
D008466 Mechlorethamine Mechlorethamine results in decreased expression of PLP1 mRNAdecreases expression 17107856
D016685 Mitomycin PLP1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C076029 olanzapine olanzapine results in decreased expression of PLP1 mRNAdecreases expression 18797397
C041786 palm oil palm oil results in increased expression of PLP1 mRNAincreases expression 18042831
D010622 Phencyclidine Phencyclidine results in increased expression of PLP1 mRNAincreases expression 17266109
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLP1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000380 Agranulocytosis Clozapine 5.1314617031 12649775 16160616
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8818414634 16835338 16251483 12569548
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D050197 Atherosclerosis Arsenic 3.2819371607 12928151
MESH:D001321 Autistic Disorder Haloperidol 2.8418080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.8417069543 18685284
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.2614601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Etoposide 1.9716322251
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002057 Burns, Chemical Mechlorethamine 6.339625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6217687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2512619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2516507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7618922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.4819152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.3618022660 16973168
MESH:D002375 Catalepsy Haloperidol 4.991977408 15215559
MESH:D002389 Catatonia olanzapine 6.3516772815 18071103
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 15340226 12621046 15668235 8697196
MESH:D003072 Cognition Disorders Clozapine 5.0417123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9020210726
MESH:D003704 Dementia Haloperidol 4.6311575062
MESH:D002658 Developmental Disabilities olanzapine 4.7317069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5517107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6515331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Clozapine 8.9916402076
MESH:D050171 Dyslipidemias Dietary Fats 8.9918367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Dietary Fats 3.2918296743 17967931 19551842 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Dietary Fats 8.8718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8720067830
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006561 Herpes Simplex Etoposide 4.6410809021
MESH:D006689 Hodgkin Disease Etoposide 3.9216135485 17606976 16200630 18180244 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 8697196 16959395 16354765 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006948 Hyperkinesis Clozapine 4.9916046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006963 Hyperphagia olanzapine 6.3117933447
MESH:D006973 Hypertension Arsenic 5.2911953799 16076760 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007249 Inflammation Dietary Fats 5.0020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0012200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1411836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007642 Keratosis Arsenic 5.0712749816 16930632
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5917339181
MESH:D008064 Lipidoses Clozapine 4.0017567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Arsenic 2.5511134558
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.479163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Arsenic 14.4716368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4720195826 21137059
MESH:D008113 Liver Neoplasms Mitomycin 14.4715113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.918603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D008133 Long QT Syndrome olanzapine 4.7720210726
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8914755239
MESH:D008175 Lung Neoplasms Arsenic 4.8917976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8920869020 18816296 18520028 17053015 6695378 20464547 18569708 20064080 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8911884234 19555203
MESH:D008223 Lymphoma Etoposide 3.9612854902 12556972
MESH:D001523 Mental Disorders Clozapine 13.9516856516
MESH:D001523 Mental Disorders Haloperidol 13.9516856516
MESH:D001523 Mental Disorders olanzapine 13.9516856516
MESH:D008659 Metabolic Diseases olanzapine 5.4419142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.4619142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D017202 Myocardial Ischemia Arsenic 9.1515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.1512213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects Arsenic 3.4916620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D009765 Obesity Clozapine 7.8018515891 19142110
MESH:D009765 Obesity Dietary Fats 7.8019632207 17217161 18457598 11836018 16723640 21332399 18674790 20132043 20518802
MESH:D009765 Obesity olanzapine 7.8018515891
MESH:D010051 Ovarian Neoplasms Arsenic 2.7617306315
MESH:D010190 Pancreatic Neoplasms Etoposide 5.9819003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 5.9815113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D020371 Pelizaeus-Merzbacher Disease marker/mechanism
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.076392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 2.6816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6817292933
MESH:D011471 Prostatic Neoplasms Etoposide 2.6817172428
MESH:D011507 Proteinuria Arsenic 4.0621343184
MESH:D011595 Psychomotor Agitation Haloperidol 12.0611575062
MESH:D011595 Psychomotor Agitation olanzapine 12.0618685284
MESH:D011618 Psychotic Disorders Clozapine 9.2915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.2911575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012512 Sarcoma, Ewing's Etoposide 4.7714601052
MESH:D012559 Schizophrenia Clozapine 5.9520452607 20521320 20580759 17667964 20107430 20168265 11763009 11151749 20521326 16141801 18855531 17123785 17726453 18806925 19369910
MESH:D012559 Schizophrenia Haloperidol 5.9520107430 18513383 1830565 19369910
MESH:D012559 Schizophrenia olanzapine 5.9517726453 20107430 20521326
MESH:D012871 Skin Diseases Arsenic 2.7616353154 19834688 15952646 18709164 17938729 16759981 16702368 17548696 6392382 17453740 17050553
MESH:D012878 Skin Neoplasms Arsenic 9.5816251483 15504454 17050553 19538983 17976673 17029826
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5816192470
MESH:C536857 Spastic paraplegia 2, X-linked marker/mechanism
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D017180 Tachycardia, Ventricular Haloperidol 11.1720210726
MESH:D017180 Tachycardia, Ventricular olanzapine 11.1720210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.2317976673 19322015 19429237 11144890 18640142 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2317053015
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Clozapine 16.7117502770 20521320 16402076 16141801 20564506 20107430
MESH:D015430 Weight Gain Dietary Fats 16.7116723640
MESH:D015430 Weight Gain olanzapine 16.7120107430 17933447 19434072
MESH:D015431 Weight Loss Clozapine 5.1617933447
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved