AutismKB 2.0

Annotation Detail for PLSCR1


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Basic Information Top
Gene Symbol:PLSCR1 ( MMTRA1B )
Gene Full Name: phospholipid scramblase 1
Band: 3q24
Quick LinksEntrez ID:5359; OMIM: 604170; Uniprot ID:PLS1_HUMAN; ENSEMBL ID: ENSG00000188313; HGNC ID: 9092
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PLSCR1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PLSCR1 mRNAincreases expression 11264010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PLSCR1 mRNAaffects expression 16483693
C004984 apocarotenal apocarotenal results in increased expression of PLSCR1 mRNAincreases expression 17034753
C006632 arsenic trioxide arsenic trioxide results in increased expression of PLSCR1 mRNAincreases expression 20458559
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLSCR1 mRNAaffects cotreatment|increases expression 18164116
D019207 beta Carotene beta Carotene results in increased expression of PLSCR1 mRNAincreases expression 17034753
D002118 Calcium Calcium binds to PLSCR1 proteinaffects binding 16260419
C019304 ciprofibrate ciprofibrate results in increased expression of PLSCR1 mRNAincreases expression 12771043
D016572 Cyclosporine Cyclosporine results in increased expression of PLSCR1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PLSCR1 mRNAincreases expression 12771043
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLSCR1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of PLSCR1 mRNAdecreases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PLSCR1 mRNAincreases expression 19638242
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PLSCR1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PLSCR1 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PLSCR1 mRNAdecreases expression 17108234
D005472 Fluorouracil PLSCR1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008070 Lipopolysaccharides IL1B protein promotes the reaction [Lipopolysaccharides results in increased expression of PLSCR1 mRNA]increases expression|increases reaction 17590392
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLSCR1 mRNAincreases expression 17590392
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PLSCR1 proteinincreases expression 17590392
D008070 Lipopolysaccharides TNF protein promotes the reaction [Lipopolysaccharides results in increased expression of PLSCR1 mRNA]increases expression|increases reaction 17590392
D010615 Phenacetin Phenacetin results in increased expression of PLSCR1 mRNAincreases expression 17082564
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLSCR1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PLSCR1 mRNAincreases expression 19482888
C030299 phenylhydrazine phenylhydrazine results in increased expression of PLSCR1 mRNAincreases expression 17082564
C006253 pirinixic acid pirinixic acid results in increased expression of PLSCR1 mRNAincreases expression 17426115
C085746 rottlerin rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA]decreases reaction|increases expression 16260419
C085746 rottlerin rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein]decreases reaction|increases expression 16260419
D013629 Tamoxifen Tamoxifen affects the expression of PLSCR1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PLSCR1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLSCR1 mRNAdecreases expression 19619570
D014212 Tretinoin Tretinoin results in increased expression of PLSCR1increases expression 16260419
D014425 Turpentine Turpentine results in increased expression of PLSCR1 mRNAincreases expression 17590392
D014425 Turpentine Turpentine results in increased expression of PLSCR1 proteinincreases expression 17590392
C025643 vinclozolin vinclozolin affects the expression of PLSCR1 mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNAaffects cotreatment|increases expression 20370541
D015054 Zymosan Zymosan results in increased expression of PLSCR1 mRNAincreases expression 17590392
D015054 Zymosan Zymosan results in increased expression of PLSCR1 proteinincreases expression 17590392
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.629612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.3918653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.3918653653
MESH:D000210 Acute-Phase Reaction Turpentine 5.9616044259
MESH:D000230 Adenocarcinoma arsenic trioxide 9.7211798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 9.7211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7214692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.7217638652
MESH:D000236 Adenoma beta-Naphthoflavone 6.4819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.486695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.1217162532 16434500 18056438 19061943 19052882 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.1217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.1216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.1216835633
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000740 Anemia Fluorouracil 25.8416511603 15504547 17963324
MESH:D000740 Anemia Phenacetin 25.842444515
MESH:D000740 Anemia phenylhydrazine 25.842444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 25.8411748828
MESH:D000740 Anemia Zymosan 25.8418664788
MESH:D000743 Anemia, Hemolytic Phenacetin 10.421949026 17698508 17082564
MESH:D000743 Anemia, Hemolytic phenylhydrazine 10.4217082564 17084956 17698508
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.6215885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.6216412693
MESH:D001169 Arthritis, Experimental Zymosan 11.6216872482 15142272 15944321 15188379 17659584
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.3916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.3919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.3912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.3916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D002545 Brain Ischemia beta Carotene 4.8816157235
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8517474063
MESH:D001943 Breast Neoplasms Estradiol 2.8517261762 16675129 14630087 12948864 17289903 18497071 17018787 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 2.8519217205 16557594 15136595 18608205 18357371 16595493 16110121
MESH:D001943 Breast Neoplasms Tamoxifen 2.8517261762 18855134 20859285 20065188 20390343 19142967 18425577 19189210 19244106 11161223 21152245 18821012 17893378 18997820 19066611 16202921 16873071 16818667 19221464 15668708 17440819 18629630 20005174 20135344 19487384 19084267 21138602 19011961 20544844 16273361 15565566 19155303 19289846 19059307 18815881 18351453 19103187 17242785 18984771 19189212 17049068 19288272 19200415 19115204 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4616051944
MESH:D002277 Carcinoma Fluorouracil 7.6417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.323084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.3215073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.3216878318 20524982 20101231 17138121 16935385 17428255 18393292 16807293 18210153 18785209 16288022 16779866 16698587 10737359 16540662 3581430 17162532 19171122 20727157 19335982 16830150 19394651 19383236 21159647 19052882 20084675 17173139 18978308 16328049 19701751 18788625 20007298 16569478 11831363 18494052 19539802 19919837 16681979 16502159 18971187 3084413 18691550 19208518 18506893 10672840 18665156 20512989 17978847 20214788 19822196 20514400 19418558 17055752 20432363 19107877 20935162 17761372 19519916 18056438
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.3216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.3217045692 17971768 18930000 16332177 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.321701930 17173139 20935162 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.3216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.321917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9218695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5218986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 6.8210977129
MESH:D002386 Cataract Tretinoin 6.8217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3317174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis Cyclosporine 12.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4517681005 17333356 16919318 17110522 16105132 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 12.4519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4715668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2018772588 16510598 17169374 17725105 17016597 15001691 17172411 16340194 17287894 17018589
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.4920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.4916524972 17594712 18509181 17401013 18802399 18949393 16282729 17094418 17695437 18448328 16303861 15148649 17454858 16331619 18383874 15289873 20501625 16391804 17016601 18288408 17255274 14970324
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6315322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.639142499 10589399 8800419 16925845 9125849 17551590 9224671 9664655 9211117 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D007644 Darier Disease Fluorouracil 4.5816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2519279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.7619923254 16485898 16081117 17562736 14725611 12392966 11834606 16393943 12594235 11739529 16781746 18713872 16109766 12705907 17522070 14550746 19164858 10774834 16227642 10663392 2444490 12153990 11461765 17906064 19739265 11529661 11287661 18071297 12958197 19370779 15968718 19420014 19085960 11743745 15619225 12540782 16177239 11421492 10915739 14986274 19416960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.7619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7211462148
MESH:D004362 Drug Toxicity Zidovudine 7.7215040536
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema pirinixic acid 10.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4312711302 11000095
MESH:D004487 Edema Zymosan 10.437907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2819031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.6418566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.6417893378 20544844 19155303 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 11.6416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1917637181 15328337 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6611558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4112903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4116785472 15173087 16481741 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 34.0715073043
MESH:D005234 Fatty Liver Cyclosporine 34.0719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 34.0721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.0715345470
MESH:D005234 Fatty Liver pirinixic acid 34.0719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 34.0714986274 19224547
MESH:D005234 Fatty Liver Zidovudine 34.0718299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005334 Fever Lipopolysaccharides 3.839205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Cyclosporine 13.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5220067830
MESH:D005355 Fibrosis Tretinoin 13.5217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.3315102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1714991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006402 Hematologic Diseases Zidovudine 4.5212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Zymosan 4.5019110552
MESH:D006529 Hepatomegaly Phenobarbital 13.1816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.1816221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.1815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D015658 HIV Infections beta Carotene 6.8016960176
MESH:D015658 HIV Infections Zidovudine 6.8011141242 11698656 17358032 20032539 11363243
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 15340226 16354765 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.0816870215
MESH:D006930 Hyperalgesia Tretinoin 7.0816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2017937319
MESH:D007248 Infertility, Male vinclozolin 6.2016467254
MESH:D007249 Inflammation Diethylnitrosamine 14.7218785209
MESH:D007249 Inflammation Lipopolysaccharides 14.7212878042 17255318 17237260 9205823 17963957
MESH:D007249 Inflammation Tamoxifen 14.7219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.7212200463 12878042
MESH:D007249 Inflammation Zymosan 14.728014878 11289658
MESH:D007333 Insulin Resistance Estradiol 6.7516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.7516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4317255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.6317553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 9.2812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.288314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.2815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 21.5412371664
MESH:D007680 Kidney Neoplasms Estradiol 21.5415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 21.5416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 21.5418625569
MESH:D007680 Kidney Neoplasms Zidovudine 21.5412579204
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8316316344
MESH:D007938 Leukemia arsenic trioxide 6.0015070760
MESH:D007938 Leukemia Tretinoin 6.0017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.2117077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 9.2120370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7516467208 16968895 19850784 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7517596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1815622746 19642359 17869043 12712474 16966277 11468182 17217047 19075265 15748426 16891316 12679006 12018890 17649720 9834237 15336539 15213294 16330433 19035177 16823087 16112521 11161223 17712046 19225113 17107899 16331271
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1817107899 15748426 17712046 17217047 16788101 19225113 16891316 17649720 17361223 17506722 19075265 16140955 17339181 16823087 17368321 16935935 19642359 17294898 9834237 16766008 19035177 19029980 12679006 17301526 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.4915821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2620032147 19638242 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2621047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.3812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.1512969438 11587558 16611625 12587719 19014921 16610002 19460945 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1517034775
MESH:D008107 Liver Diseases Phenobarbital 6.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0516871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 28.6114682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 28.6121295105 19389873
MESH:D008113 Liver Neoplasms ciprofibrate 28.6112771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.6118977376 19833225 19255062 9163691 15885732 21071580 20137499 21167192 12771043 20501860 20583210 21047994 18644402 19073162 20101389 19642983 19812893 2422723 19254457 19427195 20434301 2862719 19294768 20492335 20452335 10737359 15175105 12112319 19850985 19499222 18754104 19551842 18648771 21278145 19996281 19090486 16942905 20405173 19638242 19426721 19256749 20118626 18978307 19690152
MESH:D008113 Liver Neoplasms Fluorouracil 28.6116603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 28.6119812893 8742319 19482888 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 28.6120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 28.6116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.6116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 21.7020377131
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 21.7017113696
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.7018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.7017174075 18544905 9362446 18775883 18308698 19539802 3124819 16267830 18164116 21159647 19126423 18079962 17942915 17854601 2563599 19009564 16842330 18282651 19004024 18093689 18253720 19519916
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.706150874 18308698 1399818 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.7012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D055370 Lung Injury Lipopolysaccharides 3.8021114838
MESH:D008175 Lung Neoplasms arsenic trioxide 10.2911798837 19825857
MESH:D008175 Lung Neoplasms beta Carotene 10.2916401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.2920970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 10.2915246190
MESH:D008175 Lung Neoplasms Tamoxifen 10.2918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.2919555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 10.2918800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5815086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5311807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5319196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Tamoxifen 3.1612393984 19393235
MESH:D008545 Melanoma Tretinoin 3.1616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008708 Methemoglobinemia Phenacetin 4.763537620 4834387 16296465 1949026
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6317358032
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4716757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9619417148 15949261 19549372 11468182 14977855
MESH:D009102 Multiple Organ Failure Zymosan 5.0115834315 18160304 17724436 15241586 12130978 10890648 12879239 15259001 15213630 10479408
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0016105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.453581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms beta Carotene 11.0617051425
MESH:D009369 Neoplasms Fluorouracil 11.0618600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 11.0617405874
MESH:D009369 Neoplasms Tretinoin 11.0616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.1616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.169125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8510525206
MESH:D009436 Neural Tube Defects Tretinoin 6.859142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3016436463
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010024 Osteoporosis Calcium 3.6517882678
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.4819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 7.4819401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4816936753
MESH:D010146 Pain Acetaminophen 6.0316870215
MESH:D010146 Pain Tretinoin 6.0316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.5015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.5016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.5019003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.5016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010538 Peritonitis Zymosan 4.6815979727 15259001 14761945 19088179 18760300 17826846 11985352 18977430 17371808 19641140 18557954
MESH:D011014 Pneumonia Lipopolysaccharides 4.3412224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7911222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.7918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1119131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1119082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1115067354
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8318286688 18722050 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5910835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7616646077
MESH:D012640 Seizures Phenobarbital 2.564039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D018805 Sepsis Zymosan 4.4811441115
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2316192470
MESH:D012878 Skin Neoplasms Tretinoin 5.2316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D013272 Stomach Diseases beta Carotene 4.8817638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.1717007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 6.1715786421 17522103 17172411 16951190 18567086 18396642 19015929 19084572 16424979 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 6.1717261132
MESH:D013274 Stomach Neoplasms Zidovudine 6.1717696246
MESH:D013276 Stomach Ulcer beta Carotene 4.0712500499
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.34978859
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9815821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.8019014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.807505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.801399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.8016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.2216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.2216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.0420435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 8.0411144890
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.0417572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.8416803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.8416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014605 Uveitis Cyclosporine 11.271336536
MESH:D014605 Uveitis Zymosan 11.2711006244
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5512579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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