AutismKB 2.0

Annotation Detail for PLTP


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Basic Information Top
Gene Symbol:PLTP ( HDLCQ9 )
Gene Full Name: phospholipid transfer protein
Band: 20q13.12
Quick LinksEntrez ID:5360; OMIM: 172425; Uniprot ID:PLTP_HUMAN; ENSEMBL ID: ENSG00000100979; HGNC ID: 9093
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500797HDL-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1918Atherosclerosis
2236Cardiovascular disease
Desease Name
HDL cholesterol
METABOLIC
triglycerides
obesity
cholesterol, HDL cholesterol, LDL
Desease Name
HDL cholesterol
Triglycerides
Desease Name
High density lipoprotein cholesterol level QTL 9
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PLTP proteinaffects expression 20106945
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of PLTP mRNAdecreases expression 17023530
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PLTP mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PLTP mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PLTP mRNAaffects expression 20382639
C459604 candoxin candoxin results in decreased expression of PLTP mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLTP mRNAaffects expression 17484886
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of PLTP mRNA]affects reaction|increases expression 17585979
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PLTP mRNAaffects cotreatment|affects expression 17602206
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNAaffects cotreatment|decreases expression 16054899
D003907 Dexamethasone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D004041 Dietary Fats Dietary Fats results in decreased expression of PLTP mRNAdecreases expression 18042831
15238619
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PLTP mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLTP mRNA]decreases reaction|increases expression 17854601
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PLTP mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PLTP mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PLTP mRNAdecreases expression 17942748
D011345 Fenofibrate Fenofibrate results in increased expression of PLTP mRNAincreases expression 11798191
C056933 fumonisin B1 fumonisin B1 results in increased expression of PLTP mRNAincreases expression 16221962
C473027 GW 3965 GW 3965 results in increased expression of PLTP mRNAincreases expression 17449538
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNAaffects cotreatment|decreases expression 16054899
D015056 1-Methyl-3-isobutylxanthine EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C029938 nickel sulfate nickel sulfate results in decreased expression of PLTP mRNAdecreases expression 16100012
D010126 Ozone Ozone results in decreased expression of PLTP mRNAdecreases expression 12763052
C041786 palm oil palm oil results in decreased expression of PLTP mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in decreased expression of PLTP mRNAdecreases expression 17215068
D010269 Paraquat Paraquat affects the expression of PLTP mRNAaffects expression 15493455
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PLTP mRNAincreases expression 17681415
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLTP mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PLTP mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of PLTP mRNAincreases expression 19482888
D010672 Phenytoin Phenytoin results in increased expression of PLTP mRNAincreases expression 15136057
C006253 pirinixic acid pirinixic acid results in increased expression of PLTP mRNAincreases expression 15375163
18301758
11798191
20059764
16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLTP mRNA]increases expression|increases reaction 20059764
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D013629 Tamoxifen Tamoxifen affects the expression of PLTP mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLTP mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C423915 TO-901317 TO-901317 results in increased expression of PLTP mRNAincreases expression 17449538
D014212 Tretinoin Tretinoin results in increased expression of PLTP mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.716195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 12.716195326 8986270 9118846 3425630 9677735 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.7115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D055371 Acute Lung Injury nickel sulfate 8.2911954676 12718980 19131640 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 8.2918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.5919825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5914692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.096695378
MESH:D000236 Adenoma Diethylnitrosamine 6.096695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.5518056438 19052882 17620307 19061943 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.5517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.5516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.5516835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4911874814
MESH:D000505 Alopecia Tretinoin 3.4015955085
MESH:D000544 Alzheimer Disease Ozone 4.2615513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.2619621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.0015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.0011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.2917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.2915885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.2916412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4316292516
MESH:D001249 Asthma Ozone 4.6517854713 16373670
MESH:D001249 Asthma Tretinoin 4.6516456186
MESH:D050197 Atherosclerosis Phenytoin 3.7615136057
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 26.1516206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 26.1519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 26.1519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 26.1512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 26.1516197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8117474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.8120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8117474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.8120390343 18351453 18997820 20544844 19244106 11161223 19410462 19189210 19084267 18425577 20859285 18984771 17440819 18629630 17049068 15565566 16818667 16202921 21138602 19289846 17242785 19189212 19059307 18815881 18821012 17893378 20065188 19142967 16273361 20135344 19066611 15668708 19288272 19115204 19487384 19155303 19103187 19221464 21152245 20005174 16873071 18855134 19200415 19011961 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8116166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4619059883 18417511 16777450 15516495 14754758 18315731 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0711589617
MESH:D002100 Cachexia Ozone 4.4616183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5116011737 15700767 16124888 16227642 16097048 16050911 10355542 3786805 15673190 16192424 18705752 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.3321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.3315073043 16217749 15553829 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.3318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.3320514400 19822196 16288022 19052882 17173139 16779866 16502159 19394651 16878318 11831363 18506893 19335982 16328049 20084675 16935385 21159647 19208518 19418558 18393292 17428255 20214788 19383236 19701751 19107877 17138121 18665156 20432363 3581430 17055752 17162532 19539802 16807293 19171122 16830150 16569478 20101231 18691550 10737359 17978847 20524982 18788625 20512989 10672840 18785209 18056438 18210153 16681979 16540662 19919837 17761372 20727157 20007298 18494052 18978308 3084413 20935162 19519916 16698587 18971187
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.331701930 6705139 17173139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.331917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.2820419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.2816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118670907 16120746 18850075
MESH:D002386 Cataract Tretinoin 2.9317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1820889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.181399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.187505956 2727394 21159647 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 10.764080065
MESH:D002493 Central Nervous System Diseases Phenytoin 10.764080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0616105132 17333356 11677210 17681005 15861022 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 7.0619176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.5911748493
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002971 Cleft Lip Phenytoin 4.012227380
MESH:D002972 Cleft Palate Phenytoin 9.2310789828 6862529 6856622 3877104 2227380 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.2312621046 15668235 15340226 16354765 8697196
MESH:D002972 Cleft Palate Tretinoin 9.239407595
MESH:D003092 Colitis Tretinoin 3.4317035595
MESH:D003103 Coloboma Phenytoin 4.909212184
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4515824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Phenytoin 8.6110627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.6117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.9910525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.9917728286
MESH:D019465 Craniofacial Abnormalities Phenytoin 6.998986270 19952982 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.9914991402 10589399 9142499 17551590 9664655 8800419 9125849 16925845 9224671 9211117
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8415213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.4712438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.4711298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0717446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7320387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.7312642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7317107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2419279558
MESH:D003967 Diarrhea Dexamethasone 3.447237001
OMIM:607208 DRAVET SYNDROME Phenytoin 5.1111748493
MESH:D003875 Drug Eruptions Phenytoin 5.2315024534
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.296884620 7440962 10092053 21278145 17522070 16177239 11566570 2869522 15998439 10915739 7179309 19085960 3786805 16227642 15027814 4309450 3732212 15968718 7120509 9327722 19336974 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.2919107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 8.2916221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D050171 Dyslipidemias marker/mechanism 17952847
MESH:D050171 Dyslipidemias Clofibrate 13.5016707586
MESH:D050171 Dyslipidemias Dietary Fats 13.5018367378
MESH:D050171 Dyslipidemias Fenofibrate 13.5016707586
MESH:D004421 Dystonia Phenobarbital 3.751851702
MESH:D004485 Eczema Dexamethasone 4.1912438553
MESH:D004487 Edema Dexamethasone 19.0219703484
MESH:D004487 Edema perfluorooctanoic acid 19.0212083418 17259670
MESH:D004487 Edema pirinixic acid 19.0212083418
MESH:D004487 Edema rosiglitazone 19.0212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 19.0211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0016714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 13.9017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.9019031437
MESH:D016889 Endometrial Neoplasms Fenofibrate 11.5316569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.5316202921 17893378 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 11.5316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.789294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.9320235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.951399206 6251365
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.833659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.403922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 9.4017116037 11558140
MESH:D004827 Epilepsy Phenobarbital 6.5520417680
MESH:D004827 Epilepsy Phenytoin 6.55821787 11434505 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.316401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.767750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 10.767750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.923659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 9.923659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.7612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1511564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1516938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 45.0115073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 45.0116045604 19224547 12795759 17595544 12631006 16239168 15959796 61145
MESH:D005234 Fatty Liver Clofibrate 45.0119224547
MESH:D005234 Fatty Liver Dietary Fats 45.0117967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 45.0120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 45.0115345470
MESH:D005234 Fatty Liver pirinixic acid 45.0120131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 45.0119196556
MESH:D005234 Fatty Liver Tamoxifen 45.0119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0716709447
MESH:D005313 Fetal Death Phenytoin 9.8310627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.8311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.8918705752
MESH:D005355 Fibrosis Dietary Fats 18.8918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.8920067830
MESH:D005355 Fibrosis Tretinoin 18.8917994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0016904648
MESH:D005885 Gingival Hyperplasia Phenytoin 5.399029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.9514659971 16390469
MESH:D005909 Glioblastoma Tretinoin 2.8317312396
MESH:D005911 Gliosis Paraquat 4.8811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.2314991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 24.2316221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 24.233609246
MESH:D006529 Hepatomegaly Phenobarbital 24.2316109766
MESH:D006529 Hepatomegaly pirinixic acid 24.2319176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 24.2312621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.9912083418
MESH:D006930 Hyperalgesia rosiglitazone 11.9912083418
MESH:D006930 Hyperalgesia Tretinoin 11.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3421332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9420558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.4410459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.3621332399
MESH:D006973 Hypertension Dexamethasone 4.8917042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1317937319
MESH:D007248 Infertility, Male Paraquat 6.134850670
MESH:D007249 Inflammation Dexamethasone 22.018960868 11099482
MESH:D007249 Inflammation Dietary Fats 22.0120412841
MESH:D007249 Inflammation Diethylnitrosamine 22.0118785209
MESH:D007249 Inflammation perfluorooctanoic acid 22.0112083418
MESH:D007249 Inflammation rosiglitazone 22.0112083418
MESH:D007249 Inflammation Tamoxifen 22.0119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.0112200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.3618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.3616306350
MESH:D007333 Insulin Resistance rosiglitazone 11.3616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4917994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1017551590 15992940
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D007680 Kidney Neoplasms Tamoxifen 2.8218625569
MESH:D007938 Leukemia arsenic trioxide 5.8815070760
MESH:D007938 Leukemia Tretinoin 5.8817143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.6419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7016467208 16968895 20471514 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0316966277 17107899 17217047 19642359 15213294 19035177 19075265 12712474 16891316 9834237 17869043 16330433 19225113 11468182 11161223 16112521 15622746 17649720 12679006 16331271 15336539 17712046 12018890 15748426 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0316891316 19035177 16766008 19642359 17301526 16788101 16331271 17107899 19029980 16140955 15748426 17361223 16935935 17712046 17368321 17217047 19225113 17339181 12679006 9834237 17506722 17649720 19075265 16823087 17294898
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0916882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.958812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.119224671
MESH:D008064 Lipidoses Tamoxifen 2.9615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.4911903743 11408273 16239168 16943688 16221502 17157831 21278145 17334410 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 14.4918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.4918665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 14.4921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 12.5918156304 15052691 18472094 15650968 12632514 15959796 17708605 18263696 12898905 14716833 18210741 16027843 17766677 12445418 12958196 12666154 16192424 12445421 17631135 18395095 17714472 12609069 18412020 15123356 18395914 17640975 17805973 15925388 17922224 15996030 18251166 18420326 18472332 14716496 15818738 17944888 13678700 16011737 15730626 15893842 17481882 11481614 15931870 17976157 17869086 16116963 17698563 17823541 18376398 17565644 16248980 14724832 15673190 18054572 17761835 18705752 18277467 18418968 15338365 12741479 17557913 12667390 14748882 18205269 12649538 17525996 12632512 15370692 18187930 16033810 12546737 18339082 12389079 18317297 16638106 17721639 16136751 18481824 10355542 18006644 14512876 18279442 15057751 15362042 17900296 14620537 16097048 16015684 12586293 18166357 15876570 20821823 18429990
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 12.5916718785
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 12.5915474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.5915474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 12.5915980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 12.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 12.5918397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8116964402 15720792 17285989 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8117034775
MESH:D008107 Liver Diseases Phenobarbital 8.8119363144
MESH:D008107 Liver Diseases Phenytoin 8.8114986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 40.672125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 40.6714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 40.6721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 40.6719294768
MESH:D008113 Liver Neoplasms Clofibric Acid 40.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 40.6719090486 21167192 2862719 19427195 20118626 21047994 20101389 20405173 12112319 19073162 19642983 9163691 15175105 20583210 19426721 20434301 19254457 19551842 18978307 2422723 18977376 18644402 21071580 10737359 19690152 18754104 12771043 19255062 19294768 19850985 18648771 19996281 21278145 19812893 20501860 19256749 19499222 19833225 20452335 15885732 20137499 16942905 19638242 20492335
MESH:D008113 Liver Neoplasms Fenofibrate 40.6718978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 40.6714757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 40.6715975961 19812893 19073162 8742319 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 40.6715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 40.6716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 40.6716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.618603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.6120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.6115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.6119519916 18544905 18079962 18253720 16267830 18164116 19009564 21159647 19004024 18282651 17174075 18775883 9362446 18308698 19539802 17942915 16842330 17854601 2563599 19126423 18093689 3124819
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 25.6118775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 25.6118308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.6112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1415213294
MESH:D008171 Lung Diseases Ozone 3.1919066396 8266340
MESH:D055370 Lung Injury Ozone 3.5820417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.3414755239
MESH:D008175 Lung Neoplasms arsenic trioxide 12.3419825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.3420464547 18520028 18569708 20869020 18816296 20135361 20064080 17053015 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 12.3411195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.3420970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Ozone 12.347614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 12.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.3411884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4819428831
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.6916827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.6919196722 19196723 16827153 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.2619453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tamoxifen 3.1219393235 12393984
MESH:D008545 Melanoma Tretinoin 3.1216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D008607 Mental Retardation Phenytoin 3.579212184
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1517261469
MESH:D008679 Metaplasia Ozone 4.8210496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9816381670
MESH:D009101 Multiple Myeloma arsenic trioxide 6.7819417148 15949261 11468182 19549372 14977855
MESH:D009101 Multiple Myeloma Dexamethasone 6.7815744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.4416882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 11.449809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.4417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 11.5617484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 11.5617484760
MESH:D009224 Myotonia Congenita Phenytoin 5.131896199
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6916624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.353581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.3811141357
MESH:D009369 Neoplasms pirinixic acid 7.3817405874
MESH:D009369 Neoplasms Tretinoin 7.3816946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219200415 19189210 19196722
MESH:D009410 Nerve Degeneration Paraquat 3.5116893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 8.639125849
MESH:D009436 Neural Tube Defects arsenic trioxide 11.2410525206
MESH:D009436 Neural Tube Defects Phenytoin 11.249118846
MESH:D009436 Neural Tube Defects Tretinoin 11.249142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.159802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 11.159802331
MESH:D009765 Obesity Dietary Fats 4.1919632207 17217161 11836018 16723640 18457598 21332399 20518802 20132043 18674790
MESH:D009765 Obesity pirinixic acid 4.1920558911
MESH:D010018 Osteomalacia Phenobarbital 11.1417016548
MESH:D010018 Osteomalacia Phenytoin 11.1417016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.5712452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5716936753
MESH:D010146 Pain Phenytoin 6.4315215642
MESH:D010146 Pain Tretinoin 6.4316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.4715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.4716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.4716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.4715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9019927285
MESH:D010300 Parkinson Disease Paraquat 2.7112911755 11124998 16140633 11445065 15451049 16510128 15824117 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1616190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010538 Peritonitis Ozone 3.8616369182
OMIM:172425 PHOSPHOLIPID TRANSFER PROTEIN marker/mechanism
MESH:D011014 Pneumonia Ozone 10.1318381685 18007984 18929643
MESH:D011014 Pneumonia Paraquat 10.1312504350
MESH:D017689 Polydactyly Phenytoin 4.819212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.322563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.322563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3921297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.7417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7411896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6115067354
MESH:D011507 Proteinuria Tretinoin 3.3516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 11.6112752131
MESH:D019310 Pseudolymphoma Phenytoin 11.611419762 8603615 12752131
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8116324872 17997886
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.4111700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.4111700416
MESH:D012135 Respiratory Sounds Paraquat 3.7811874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration Paraquat 3.6616458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8416116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6916646077
MESH:D012640 Seizures Phenobarbital 5.753137016 11442880 4039156 16876388
MESH:D012640 Seizures Phenytoin 5.753137016 15946322 16876388 3691417 9844417 19919933 11044598 10029267
MESH:D003294 Seizures, Febrile Phenobarbital 4.546407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.6119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.6116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013088 Spermatocele Tamoxifen 10.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7619457130
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.8820235791
MESH:D013272 Stomach Diseases Dexamethasone 4.0415472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.462093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4618456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.4617261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.2515138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.3819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.387505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.381399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.3816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6815213294
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.6512845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.6517053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.6516712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3316752155
MESH:D014605 Uveitis Dexamethasone 4.531336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Dietary Fats 3.5016723640
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA273
    • Releated gene ID Related gene Name
    PA273PLTP
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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