AutismKB 2.0

Annotation Detail for PLXNA1


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Basic Information Top
Gene Symbol:PLXNA1 ( DKFZp761P19121,NOV,NOVP,PLEXIN-A1,PLXN1 )
Gene Full Name: plexin A1
Band: 3q21.3
Quick LinksEntrez ID:5361; OMIM: 601055; Uniprot ID:PLXA1_HUMAN; ENSEMBL ID: ENSG00000114554; HGNC ID: 9099
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
No data
No data
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
1841Stomach cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PLXNA1 mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PLXNA1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PLXNA1 mRNAaffects expression 17562736
C061133 Am 80 Am 80 results in increased expression of PLXNA1 mRNAincreases expression 17229644
D018038 Sodium Selenite Sodium Selenite results in increased expression of PLXNA1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001172 Arthritis, Rheumatoid Am 80 3.8116819260
MESH:D050197 Atherosclerosis Am 80 4.5316484594
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 5.2415894690
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.282524372 8156756 14531868 12868966 8970840 18759878 11298694 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1016285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.721440618 18692083 11289319 6679447 9328219 7440962 16192314 9653073 18648102 9022650 6482804 8291058 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7212153990 19370779 11461765 10915739 19923254 12705907 2444490 12958197 12594235 17562736 12540782 11287661 11743745 17522070 14550746 16485898 10774834 11421492 11529661 14725611 18713872 18071297 19164858 16781746 19739265 11834606 10663392 12392966 19416960 16227642 11739529 16177239 19420014 16393943 15619225 16109766 15968718 19085960 17906064 16081117 14986274
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.7215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 5.5316819260
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007333 Insulin Resistance Sodium Selenite 3.4914714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.8616531727 16819260
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 12969438 12587719 19460945 19014921 19784758 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.731399818 6587162 3712494 598648
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4614737004
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009101 Multiple Myeloma Am 80 4.7817229644
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011471 Prostatic Neoplasms Am 80 3.7816289102
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.7818760546
MESH:D011565 Psoriasis Am 80 4.1816819260
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.151399818 7505956 6582329 6587162 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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