AutismKB 2.0

Annotation Detail for ADAM22


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Basic Information Top
Gene Symbol:ADAM22 ( MDC2,MGC149832 )
Gene Full Name: ADAM metallopeptidase domain 22
Band: 7q21.12
Quick LinksEntrez ID:53616; OMIM: 603709; Uniprot ID:ADA22_HUMAN; ENSEMBL ID: ENSG00000008277; HGNC ID: 201
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol Estradiol results in decreased expression of ADAM22 mRNAdecreases expression 19429434
C008493 methylselenic acid methylselenic acid results in increased expression of ADAM22 mRNAincreases expression 18548127
D020849 Raloxifene Raloxifene results in decreased expression of ADAM22 mRNAdecreases expression 19429434
D014284 Triiodothyronine Triiodothyronine results in increased expression of ADAM22 mRNAincreases expression 17403546
D013629 Tamoxifen Tamoxifen results in decreased expression of ADAM22 mRNAdecreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000419 Albuminuria Raloxifene 5.0417308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D001930 Brain Injuries Raloxifene 4.9616580743
MESH:D001943 Breast Neoplasms Estradiol 1.9416675129 17261762 17289903 14630087 12948864 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Raloxifene 1.9415758505 15775269 17893378 17440819 15572757 17049068 17595753 17261762 16837676 17952589 16912660 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 1.9417440819 18997820 18351453 18821012 19189210 20065188 21138602 19066611 18815881 18984771 15565566 18629630 19011961 17242785 18855134 20005174 17049068 19142967 19084267 19155303 19410462 11161223 20544844 16202921 19189212 16818667 19221464 20135344 19487384 17261762 17893378 21152245 15668708 19288272 16873071 20859285 19115204 18425577 19103187 20390343 16273361 19244106 19059307 19289846 19200415
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1116924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.6817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.6817572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6815775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D003072 Cognition Disorders Raloxifene 5.1015800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4917474826
MESH:D003928 Diabetic Nephropathies Estradiol 16.9819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.9815920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.9819279558
MESH:D004487 Edema Raloxifene 3.7015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.7515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.7519031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.1219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.1219155303 16202921 17893378 20544844
MESH:D005234 Fatty Liver Raloxifene 9.2517473493
MESH:D005234 Fatty Liver Tamoxifen 9.2514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D006331 Heart Diseases Raloxifene 3.7711110106
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006973 Hypertension Raloxifene 2.9717577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007333 Insulin Resistance Estradiol 3.1816627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms Estradiol 8.4215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.4218625569
MESH:D007889 Leiomyoma Raloxifene 4.9016973256
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5318564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6919196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.7819453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.7819453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.1715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6816497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009232 Myxoma Raloxifene 6.1716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 4.0911399458 16427766
MESH:D010024 Osteoporosis Raloxifene 3.5915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6317823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0716205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0716536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011693 Purpura Raloxifene 6.1715770314
MESH:D013088 Spermatocele Tamoxifen 4.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D020521 Stroke Raloxifene 4.1116837676
MESH:D013978 Tibial Fractures Estradiol 15.8419048282
MESH:D013978 Tibial Fractures Raloxifene 15.8419048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6116712894 8653321 17572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.8216837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.1716343187
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24518
    • No data
    Releated disease ID Related disease Name
    PA444065Epilepsy
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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