AutismKB 2.0

Annotation Detail for BCMO1


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Basic Information Top
Gene Symbol:BCMO1 ( BCDO,BCDO1,BCMO,BCO,BCO1,FLJ10730 )
Gene Full Name: beta-carotene 15,15'-monooxygenase 1
Band: 16q23.2
Quick LinksEntrez ID:53630; OMIM: 605748; Uniprot ID:BCDO1_HUMAN; ENSEMBL ID: ENSG00000135697; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
protein quantitative trait loci
plasma carotenoid and tocopherol levels
Desease Name
Plasma carotenoid and tocopherol levels
Desease Name
Hypercarotenemia and vitamin A deficiency, autosomal dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BCMO1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BCMO1 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of BCMO1 mRNAdecreases expression 16699835
D000499 Allylamine Allylamine affects the expression of BCMO1 mRNAaffects expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BCMO1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of BCMO1 mRNAdecreases expression 15761015
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]]decreases reaction|increases oxidation 9526112
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BCMO1 mRNAdecreases expression 20127859
D019207 beta Carotene beta Carotene results in increased expression of and results in increased activity of BCMO1 proteinincreases activity|increases expression 16186334
D019207 beta Carotene beta Carotene results in increased expression of BCMO1 mRNAincreases expression 16186334
D019207 beta Carotene Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]]decreases reaction|increases oxidation 9526112
D019207 beta Carotene BCMO1 protein results in increased oxidation of beta Caroteneincreases oxidation 9526112
D019207 beta Carotene Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]decreases reaction|increases oxidation 9526112
D019207 beta Carotene Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]]decreases reaction|increases oxidation 9526112
D019207 beta Carotene BCMO1 protein results in increased cleavage of beta Caroteneincreases cleavage 16711651
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of BCMO1 mRNAdecreases expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of BCMO1 mRNAdecreases expression 18457598
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of BCMO1 mRNAdecreases expression 17606305
D005419 Flavonoids Flavonoids results in increased expression of BCMO1 mRNAincreases expression 18035473
D016877 Oxidants Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]]decreases reaction|increases oxidation 9526112
D016877 Oxidants Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]decreases reaction|increases oxidation 9526112
D016877 Oxidants Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]]decreases reaction|increases oxidation 9526112
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCMO1 mRNAaffects binding|decreases expression|increases activity 19710929
D012172 Retinaldehyde BCMO1 protein results in increased chemical synthesis of Retinaldehydeincreases chemical synthesis 16711651
C084904 Ro 41-5253 Ro 41-5253 results in increased expression of BCMO1 mRNAincreases expression 16186334
C084904 Ro 41-5253 Ro 41-5253 results in increased expression of BCMO1 proteinincreases expression 16186334
D014212 Tretinoin Tretinoin results in decreased expression of BCMO1 mRNAdecreases expression 18230668
D014212 Tretinoin Tretinoin affects the expression of BCMO1 mRNAaffects expression 16186334
D014212 Tretinoin Tretinoin results in decreased expression of BCMO1 mRNAdecreases expression 16699835
D014810 Vitamin E Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCMO1 protein results in increased oxidation of beta Carotene]]decreases reaction|increases oxidation 9526112
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9319825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9314692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4216434500
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.7015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.0016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.0019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.0016206674 16197459
MESH:D002545 Brain Ischemia beta Carotene 5.0316157235
MESH:D001943 Breast Neoplasms alitretinoin 2.3416344269
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.3416443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3417474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.3420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.7216097048 15700767 16124888 10355542 16011737 15721981 18705752 16050911 16227642 3786805 16192424 15673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.7216050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.753084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.7515553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7518788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.751917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5020419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5016096774 16051514
MESH:D002386 Cataract Acetaminophen 7.1010977129
MESH:D002386 Cataract Tretinoin 7.1017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.726135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5817110522 17681005 17333356 16919318 15861022 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 7.5819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tretinoin 2.649407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D003139 Common Cold Ascorbic Acid 5.4217323712
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8110525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.819125849 17551590 9211117 16925845 14991402 10589399 9664655 8800419 9224671 9142499
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8119769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.0816506275
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0718713872 16227642 12594235 11834606 12540782 16781746 11743745 14725611 10663392 18071297 10915739 11461765 2444490 19416960 19420014 14986274 11287661 11421492 11529661 15968718 19739265 17522070 19164858 12705907 17906064 16109766 12153990 16393943 14550746 12392966 11739529 10774834 16485898 19370779 12958197 15619225 16081117 19085960 16177239 17562736 19923254
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.077120509 6884620 3732212 16177239 17522070 2869522 4309450 7440962 3786805 21278145 9327722 19085960 15998439 15968718 16227642 10915739 6623471 7179309 15027814 10092053 19336974 11566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4018367378
MESH:C538011 Eales disease Ascorbic Acid 12.889068938
MESH:C538011 Eales disease Vitamin E 12.889068938
MESH:D004487 Edema pirinixic acid 2.4212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.4118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0616569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3816530937
MESH:D005124 Eye Abnormalities Tretinoin 3.539664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 23.9915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.9916045604 61145 19224547 16239168 15959796 17595544 12631006 12795759
MESH:D005234 Fatty Liver Dietary Fats 23.9917967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.9915345470
MESH:D005234 Fatty Liver pirinixic acid 23.9919236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 14.4718705752
MESH:D005355 Fibrosis Dietary Fats 14.4718296743
MESH:D005355 Fibrosis Tretinoin 14.4717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005909 Glioblastoma Tretinoin 2.9617312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 15.7516080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.7520471113
MESH:D006330 Heart Defects, Congenital Tretinoin 15.7514991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 15.7516080930
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 2.9319772884 18467677 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 6.0516490937 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.0516863852 16490937
MESH:D015658 HIV Infections beta Carotene 4.0116960176
MESH:D019584 Hot Flashes Vitamin E 3.9214716179
MESH:D006930 Hyperalgesia Acetaminophen 7.4416870215
MESH:D006930 Hyperalgesia Tretinoin 7.4416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
OMIM:115300 HYPERCAROTENEMIA AND VITAMIN A DEFICIENCY, AUTOSOMAL DOMINANT marker/mechanism
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4417937319
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Flavonoids 5.0917296493
MESH:D007251 Influenza, Human Vitamin E 4.1616624496
MESH:D007333 Insulin Resistance Dietary Fats 7.1011836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.8415992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.5816144296
MESH:D007674 Kidney Diseases Acetaminophen 5.8415629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 5.8412488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9216705839
MESH:D007938 Leukemia arsenic trioxide 6.2315070760
MESH:D007938 Leukemia Tretinoin 6.2317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8417050201 19850784 20471514 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8419850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4919075265 16966277 19035177 12679006 17712046 17649720 17107899 17869043 12712474 15622746 19642359 16891316 15336539 19225113 12018890 11161223 16330433 15213294 16112521 16823087 16331271 17217047 15748426 11468182 9834237
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4917368321 9834237 19225113 19035177 19029980 17217047 17301526 16140955 16766008 17361223 12679006 17107899 16331271 16823087 16788101 17294898 15748426 17712046 17506722 17339181 19075265 17649720 16935935 19642359 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2916882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.5117334410 17157831 17174718 16943688 11408273 16239168 16221502 11903743 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5118296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6814620537 16248980 16033810 18472332 17900296 17761835 18705752 18277467 14512876 15123356 16015684 17557913 12389079 18376398 11481614 18210741 18481824 17708605 15370692 16136751 15057751 12546737 14716496 18412020 12666154 17805973 18420326 18251166 16097048 18187930 20821823 12898905 18006644 18339082 18166357 17766677 17922224 15673190 17823541 16192424 12445418 17869086 18054572 15362042 16638106 18395914 17698563 12958196 15925388 18472094 17944888 17714472 14724832 17481882 13678700 15730626 18205269 12632512 15876570 15931870 18317297 15338365 12445421 14748882 17640975 12649538 17976157 15996030 12667390 17631135 17525996 12741479 18418968 12586293 16011737 12632514 14716833 15818738 18263696 18156304 18429990 16116963 16027843 15959796 15052691 18279442 17721639 10355542 15893842 15650968 17565644 18395095 12609069
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6815474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 6.6816248980
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6816248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.6816169303
MESH:D008107 Liver Diseases Acetaminophen 3.8416611625 16610002 19014921 19784758 12969438 11587558 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8415720792 17285989 16964402 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2116899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.977678174
MESH:D008113 Liver Neoplasms arsenic trioxide 13.9714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.9721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.9719294768
MESH:D008113 Liver Neoplasms pirinixic acid 13.9715890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.252876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.2520377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 18.2518544905
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 18.2517113696
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.2512014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008171 Lung Diseases Ascorbic Acid 7.5816863852
MESH:D008171 Lung Diseases Vitamin E 7.5816863852
MESH:D008175 Lung Neoplasms alitretinoin 8.4816413115
MESH:D008175 Lung Neoplasms arsenic trioxide 8.4819825857 11798837
MESH:D008175 Lung Neoplasms Ascorbic Acid 8.4816401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.486695378 18816296 17053015 18569708 20064080 20464547 18520028 20135361 20869020
MESH:D008175 Lung Neoplasms beta Carotene 8.4816401635
MESH:D008175 Lung Neoplasms Vitamin E 8.4811062179
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Tretinoin 1.9316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0619549372 15949261 11468182 19417148 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2616882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9016624393
MESH:D009369 Neoplasms alitretinoin 15.4116946489
MESH:D009369 Neoplasms Benzo(a)pyrene 15.4111141357
MESH:D009369 Neoplasms beta Carotene 15.4117051425
MESH:D009369 Neoplasms pirinixic acid 15.4117405874
MESH:D009369 Neoplasms Tretinoin 15.4116594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.719125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1610525206
MESH:D009436 Neural Tube Defects Tretinoin 7.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D009765 Obesity Ascorbic Acid 7.3917217161
MESH:D009765 Obesity Dietary Fats 7.3920518802 11836018 17217161 18457598 21332399 16723640 18674790 19632207 20132043
MESH:D009765 Obesity pirinixic acid 7.3920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3716049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.8119769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8116936753
MESH:D010146 Pain Acetaminophen 6.4016870215
MESH:D010146 Pain Tretinoin 6.4016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2115580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D017499 Porokeratosis alitretinoin 5.9516144296
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2515861022 16919318
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.2814606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2916849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4918551238
MESH:D012871 Skin Diseases Ascorbic Acid 5.1518709164
MESH:D012871 Skin Diseases Vitamin E 5.1518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5810029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 5.5816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013272 Stomach Diseases beta Carotene 5.0317638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.312093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 3.3117261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.7618726076
MESH:D013276 Stomach Ulcer beta Carotene 7.7612500499
MESH:D020521 Stroke Ascorbic Acid 8.7016403987 16517955
MESH:D020521 Stroke Vitamin E 8.7016517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.0419014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.1416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.1412973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2610091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D015430 Weight Gain Dietary Fats 3.6816723640
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00830 Retinol metabolism
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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