AutismKB 2.0

Annotation Detail for PLXNB1


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Basic Information Top
Gene Symbol:PLXNB1 ( KIAA0407,MGC149167,PLEXIN-B1,PLXN5,SEP )
Gene Full Name: plexin B1
Band: 3p21.31
Quick LinksEntrez ID:5364; OMIM: 601053; Uniprot ID:PLXB1_HUMAN; ENSEMBL ID: ENSG00000164050; HGNC ID: 9103
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Signaling by GPCR
Axon guidance
No data
Pathway IDPathway Name
P00007Axon guidance mediated by semaphorins
Pathway IDPathway Name
500073Sema4D mediated inhibition of cell attachment and migration
500074Sema4D induced cell migration and growth-cone collapse
500437G alpha (12/13) signalling events
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
1848Embryoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PLXNB1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PLXNB1 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of PLXNB1 mRNAdecreases expression 20106945
D019833 Genistein Genistein results in decreased expression of PLXNB1 mRNAdecreases expression 16705744
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLXNB1 mRNAaffects binding|decreases expression|increases activity 19710929
C025643 vinclozolin vinclozolin affects the expression of PLXNB1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Genistein 2.5411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Genistein 2.4916873071 16541309 17200150
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.787296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.783084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002318 Cardiovascular Diseases Genistein 3.5116332659
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.759022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.7519486331
MESH:D002779 Cholestasis pirinixic acid 14.7519176532
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2112868966 18759878 14531868 8970840 8156756 11298694 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9618648102 9653073 18289764 8291058 18692083 9328219 6482804 16192314 11289319 1440618 6679447 7440962 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9619923254 11834606 19164858 18713872 16393943 19416960 16109766 14725611 15619225 12153990 12392966 15968718 19370779 11421492 17562736 19739265 14550746 11461765 2444490 16227642 11739529 10663392 16177239 11287661 10774834 17522070 16485898 17906064 11743745 16781746 16081117 18071297 19420014 12705907 11529661 14986274 12540782 12958197 12594235 19085960 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004714 Endometrial Hyperplasia Genistein 5.0516402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5511473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Cyclosporine 8.6619224547
MESH:D005234 Fatty Liver pirinixic acid 8.6620131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005909 Glioblastoma Genistein 3.4516598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 19772884 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.3418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.176582329
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1712371664
MESH:D007938 Leukemia Genistein 3.1618980019 17468513
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.5117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5115474484
MESH:D008107 Liver Diseases Acetaminophen 1.6911587558 16610002 16611625 12969438 12587719 19014921 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.711399818 3712494 598648 6587162
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1212929590 14578162
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction Genistein 6.0417141266
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Genistein 4.4116427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010024 Osteoporosis Genistein 3.4319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4416169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6719005980
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Genistein 3.4116925846 15256057 15378649
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.127505956 3712494 6587162 6582329 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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