AutismKB 2.0

Annotation Detail for PNOC


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Basic Information Top
Gene Symbol:PNOC ( PPNOC )
Gene Full Name: prepronociceptin
Band: 8p21.1
Quick LinksEntrez ID:5368; OMIM: 601459; Uniprot ID:PNOC_HUMAN; ENSEMBL ID: ENSG00000168081; HGNC ID: 9163
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500405Peptide ligand-binding receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1789Movement disorder
1870Drug abuse
2126Encephalopathies
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PNOC mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PNOC mRNAaffects expression 16483693
D001285 Atropine Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]affects binding|decreases reaction|increases activity 12007927
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PNOC mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PNOC mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]affects cotreatment|decreases reaction|increases expression 17640482
D004958 Estradiol PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 17640482
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PNOC mRNAincreases expression 15834898
12655037
17351261
D005419 Flavonoids Flavonoids results in decreased expression of PNOC mRNAdecreases expression 18035473
C029424 hydrazine hydrazine results in decreased expression of PNOC mRNAdecreases expression 15282401
C402921 J 113397 J 113397 inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]affects binding|decreases reaction|increases activity 12007927
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PNOC mRNAincreases expression 12057914
D009151 Mustard Gas Mustard Gas results in decreased expression of PNOC mRNAdecreases expression 15674843
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PNOC mRNAincreases expression 17616710
C439964 nociceptin (1-13) amide nociceptin (1-13) amide affects the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]affects binding|affects reaction|increases activity 12007927
C439964 nociceptin (1-13) amide nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]affects cotreatment|decreases reaction|increases expression 17640482
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PNOC mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]affects cotreatment|decreases reaction|increases expression 17640482
D011374 Progesterone PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 17640482
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PNOC mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PNOC mRNAdecreases expression 15644576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.9818653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.9818653653
MESH:D000230 Adenocarcinoma Estradiol 4.2011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2014692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.8419389873
MESH:D000236 Adenoma Diethylnitrosamine 6.846695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.2417162532 19061943 16434500 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001249 Asthma Mustard Gas 2.7010378619
MESH:D001768 Blister Mustard Gas 5.1519167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415665606 15380490 15845082
MESH:D001943 Breast Neoplasms Atropine 2.3512762645
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3517474063
MESH:D001943 Breast Neoplasms Estradiol 2.3516675129 17261762 17289903 19861407 12948864 18497071 17018787 14630087
MESH:D001943 Breast Neoplasms Progesterone 2.3517614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9817687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9818978308 16328049 18494052 18210153 21159647 16288022 20512989 20007298 18785209 19822196 16830150 18393292 17428255 17761372 19519916 16779866 18788625 20214788 16681979 10672840 19383236 18506893 18665156 19539802 16698587 17978847 18056438 17055752 20514400 16935385 18971187 19208518 19107877 19701751 20432363 17138121 19394651 3084413 20727157 16569478 16540662 17173139 18691550 19919837 19335982 19171122 3581430 19052882 16807293 16502159 20101231 20524982 19418558 11831363 20935162 10737359 17162532 16878318 20084675
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9816924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.6521159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.6518566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6911677210 16919318 17333356 16105132 15861022 17681005 17110522
MESH:D002779 Cholestasis pirinixic acid 7.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915340226 16354765 8697196 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D003967 Diarrhea Atropine 4.9410867622
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.7119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004381 Duodenal Ulcer Atropine 5.2811595415
MESH:D004487 Edema Mustard Gas 11.3211402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 11.3212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.9817692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9711473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 8.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.8710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3915821434 15328337 17637181
MESH:D004890 Erythema Mustard Gas 5.159357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7715264214 16704527 15878914 15150132 15547733 15623463 16510608 15547721 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Diethylnitrosamine 12.9421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.9415345470
MESH:D005234 Fatty Liver pirinixic acid 12.9420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005334 Fever Lipopolysaccharides 3.999205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2216221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2216120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16959395 15340226 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Diethylnitrosamine 19.8518785209
MESH:D007249 Inflammation Flavonoids 19.8517296493
MESH:D007249 Inflammation Lipopolysaccharides 19.859205823 12878042 17255318 17237260 17963957
MESH:D007249 Inflammation Mustard Gas 19.8517524151 16001271 11402378 8975870 11428620 9357497 9260866 11428647 11428631
MESH:D007249 Inflammation Progesterone 19.8515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.8512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.1516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6117255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Estradiol 2.5715618244
MESH:D007680 Kidney Neoplasms Estradiol 2.9615610895
MESH:D007970 Leukopenia Lipopolysaccharides 4.6915821434
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8120032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.9212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9212878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0917034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 10.6319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.6318648771 20583210 12771043 19294768 19426721 20501860 20452335 9163691 19427195 2422723 19812893 19833225 21278145 19642983 19499222 2862719 12112319 21167192 19073162 18978307 19690152 20434301 19254457 19256749 18644402 19551842 20137499 21071580 15175105 21047994 18754104 19090486 19638242 19996281 18977376 10737359 16942905 20405173 20101389 15885732 19850985 20492335 19255062 20118626
MESH:D008113 Liver Neoplasms pirinixic acid 10.6320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6316984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 9.7918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.792563599 18164116 18093689 19126423 19004024 18079962 16842330 18775883 17942915 18253720 19009564 18544905 19539802 17174075 16267830 21159647 17854601 18308698 19519916 3124819 9362446 18282651
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7912151625
MESH:D008171 Lung Diseases Mustard Gas 3.4318702808 18161513
MESH:D055370 Lung Injury Lipopolysaccharides 3.9921114838
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4120970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 3.418781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4111884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0111807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0111408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4819453300
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D009216 Myopia Atropine 4.9812601066
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.563581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009421 Nervous System Malformations Estradiol 9.4116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009503 Neutropenia Mustard Gas 3.9516761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010051 Ovarian Neoplasms Estradiol 4.8519401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.8516525653 17393432
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.5511605937 12224865
MESH:D011041 Poisoning Atropine 9.2517849254 18072136
MESH:D011041 Poisoning Mustard Gas 9.2515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.532563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0916740699
MESH:D011537 Pruritus Ethinyl Estradiol 9.5015861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.5018058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9217266442 17620002 17720292 17894541 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012640 Seizures Atropine 4.3717157343 12660363 11218047
MESH:D012871 Skin Diseases Mustard Gas 2.7116961503 12880345 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2715862959 16503802
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6118456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6112958204 17575124
MESH:D013276 Stomach Ulcer Atropine 4.7211595415
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.977505956
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D014202 Tremor Atropine 5.7317594079
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33485
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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