AutismKB 2.0

Annotation Detail for FXYD5


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Basic Information Top
Gene Symbol:FXYD5 ( DYSAD,IWU1,KCT1,OIT2,PRO6241,RIC )
Gene Full Name: FXYD domain containing ion transport regulator 5
Band: 19q13.12
Quick LinksEntrez ID:53827; OMIM: 606669; Uniprot ID:FXYD5_HUMAN; ENSEMBL ID: ENSG00000089327; HGNC ID: 4029
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of FXYD5 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of FXYD5 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FXYD5 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FXYD5 mRNAdecreases expression 20127859
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of FXYD5 mRNAincreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of FXYD5 mRNAincreases expression 15003993
14729362
D016572 Cyclosporine Cyclosporine results in increased expression of FXYD5 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXYD5 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FXYD5 mRNAincreases expression 17557909
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of FXYD5 mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of FXYD5 mRNAincreases expression 14729362
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of FXYD5 mRNAincreases expression 20713471
D010126 Ozone Ozone results in increased expression of FXYD5 mRNAincreases expression 16716893
D010656 Phenylephrine Phenylephrine results in increased expression of FXYD5 mRNAincreases expression 18158353
D018038 Sodium Selenite Sodium Selenite results in increased expression of FXYD5 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXYD5 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of FXYD5 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2014692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.926695378
MESH:D000236 Adenoma Methylcholanthrene 6.926695378 10545420
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000544 Alzheimer Disease Ozone 2.4415513908
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1417460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Ozone 2.6417854713 16373670
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4711922910
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 18775368 18985861 18396377 18558336 18177632 15238991 19460635 18316065 16609825 17507914 17688650 17157402 19232924 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.088888407
MESH:D001919 Bradycardia Phenylephrine 4.5915306635
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0011921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7018417511 16777450 15516495 17626835 18315731 14754758 19059883
MESH:D002100 Cachexia Ozone 4.7916183385
MESH:D002277 Carcinoma Methylcholanthrene 8.4110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 2.9021507988 12619106 12907637
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Phenylephrine 6.9317124262 17287366 15728586 11179087 16170337 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9316120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5316936243
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9112371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.9116192471
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 7.8419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8416105132 11677210 17681005 17333356 17110522 15861022 16919318
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1112621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4817688650 16575769 8888407
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0312705907 19370779 16081117 12153990 17522070 17562736 11421492 12392966 19085960 19739265 14725611 19420014 11834606 12540782 16781746 19164858 16227642 11739529 17906064 16393943 11461765 18713872 18071297 19923254 19416960 11743745 14986274 10915739 16177239 11529661 16109766 2444490 12958197 10663392 10774834 14550746 15968718 15619225 16485898 12594235 11287661
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.031733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9615322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 13.2519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2515345470
MESH:D005234 Fatty Liver Valproic Acid 13.2519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1718558336 8888407
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9914633661 10962813
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4911294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006973 Hypertension Cyclosporine 8.6710903974
MESH:D006973 Hypertension Phenylephrine 8.6712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6716612254
MESH:D006984 Hypertrophy Phenylephrine 4.5812791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.2914714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.858314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7612371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6319460945 16611625 19784758 16610002 12969438 11587558 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.442125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4420195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.008603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.00598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0012151625
MESH:D008171 Lung Diseases Ozone 3.3919066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D055370 Lung Injury Ozone 3.8920417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.6314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6320464547 20064080 18569708 17053015 18816296 20869020 20135361 6695378 18520028
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.637750092 11893704 1399818 15390079 16271038 10545420 9230183 6695378 16337739 20512841 20970405 21163286 17909032
MESH:D008175 Lung Neoplasms Ozone 6.637614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6319555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.5911921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008679 Metaplasia Ozone 5.1710496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1811141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.1312065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010538 Peritonitis Ozone 4.1716369182
MESH:D011014 Pneumonia Ozone 4.4418007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6311896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.6320603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2218760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.6012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7511738929 16876388 1511512 17978042 3137016 15475178 14763951 11044598
MESH:D012852 Sinusitis Phenylephrine 4.757327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.6810029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.6812065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.688532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.6816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28445
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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