AutismKB 2.0

Annotation Detail for FXYD4


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Basic Information Top
Gene Symbol:FXYD4 ( CHIF )
Gene Full Name: FXYD domain containing ion transport regulator 4
Band: 10q11.21
Quick LinksEntrez ID:53828; OMIM: NA; Uniprot ID:FXYD4_HUMAN; ENSEMBL ID: ENSG00000150201; HGNC ID: 4028
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04960Aldosterone-regulated sodium reabsorption
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of FXYD4 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FXYD4 mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of FXYD4 mRNAincreases expression 17011747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FXYD4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FXYD4 mRNAdecreases expression 16174780
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FXYD4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXYD4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FXYD4 mRNAdecreases expression 16174780
17351261
D006418 Heme Heme results in decreased expression of FXYD4 mRNAdecreases expression 15539406
D013629 Tamoxifen Tamoxifen affects the expression of FXYD4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXYD4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FXYD4 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.8817129689 15324884
MESH:D001943 Breast Neoplasms Tamoxifen 1.8820859285 19011961 18425577 19142967 21152245 20544844 16273361 17893378 19289846 18629630 19288272 18351453 20065188 11161223 19200415 15565566 19103187 16818667 16873071 18855134 17242785 19189210 19059307 15668708 18984771 19244106 20005174 20135344 17440819 16202921 19410462 19189212 17261762 19155303 19115204 18821012 19487384 19221464 17049068 19084267 20390343 18997820 21138602 19066611 18815881
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2715948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2716924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717333356 16105132 17110522 16919318 15861022 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 12621046 8697196 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8912952375 16002989
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.1416804899 15700306
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.1419155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.7216002989 16611131 15751030 16513791 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.7216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 16959395 16354765 18606429 8697196
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7914722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Heme 9.2912649161
MESH:D007249 Inflammation Tamoxifen 9.2919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.2912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.3515003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3518625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.9716712894 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3119555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Diethylstilbestrol 2.8815313581
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.7611399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7614600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.9217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.9211896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2917136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Diethylstilbestrol 22.9216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 22.9216709447
MESH:D013088 Spermatocele Tamoxifen 22.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.5216712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.528653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014947 Wounds and Injuries Heme 5.5212649161
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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