AutismKB 2.0

Annotation Detail for IL20RA


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Basic Information Top
Gene Symbol:IL20RA ( FLJ40993,IL-20R1,ZCYTOR7 )
Gene Full Name: interleukin 20 receptor, alpha
Band: 6q23.3
Quick LinksEntrez ID:53832; OMIM: 605620; Uniprot ID:I20RA_HUMAN; ENSEMBL ID: ENSG00000016402; HGNC ID: 6003
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
No data
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of IL20RA mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of IL20RA mRNAaffects expression 17562736
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of IL20RA mRNAaffects cotreatment|increases expression 17404688
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of IL20RA mRNAincreases expression 17560707
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of IL20RA mRNAincreases expression 17560707
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of IL20RA mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of IL20RA mRNAincreases expression 17404688
C079198 S 1 (combination) IL20RA protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Estradiol 2.1812948864 16675129 17289903 14630087 18497071 17018787 19861407 17261762
MESH:D001943 Breast Neoplasms Progesterone 2.1816175315 15562024 17614352
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.1518347146 18212800
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 3.9115984520
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.286135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2818566989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9416485898 16081117 12153990 16109766 19164858 19085960 11743745 18071297 19923254 19739265 2444490 16781746 18713872 16177239 19370779 16227642 19420014 11421492 12392966 14986274 12594235 15968718 17562736 11461765 15619225 11529661 10663392 12958197 10774834 14725611 16393943 17522070 12540782 17906064 14550746 11834606 11739529 11287661 12705907 10915739 19416960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema perfluorooctanoic acid 3.8617259670 12083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1117692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 4.0316134523
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 6.0919093184
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.4317162496
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 4.9215984520 18607998
MESH:D006529 Hepatomegaly perfluorooctanoic acid 4.453609246
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 8.6116870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.6112083418
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007249 Inflammation perfluorooctanoic acid 5.8512083418
MESH:D007249 Inflammation Progesterone 5.8515869954
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007674 Kidney Diseases Acetaminophen 6.3712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms Estradiol 8.1515610895
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.638812269
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 19460945 11587558 19014921 12587719 19784758 16611625 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 5.117678174
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 5.1114757943 18709148
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.706135515 2876784 2876786
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6216891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.6217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 3.9816427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.319802331
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010051 Ovarian Neoplasms Estradiol 5.1119401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.1116525653 17393432
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.7917132714
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D013119 Spinal Cord Injuries Progesterone 4.6815862959 16503802
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.3616557585 18553229 18506536
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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