AutismKB 2.0

Annotation Detail for FGFRL1


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Basic Information Top
Gene Symbol:FGFRL1 ( FGFR5,FHFR )
Gene Full Name: fibroblast growth factor receptor-like 1
Band: 4p16.3
Quick LinksEntrez ID:53834; OMIM: 605830; Uniprot ID:FGRL1_HUMAN; ENSEMBL ID: ENSG00000127418; HGNC ID: 3693
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of FGFRL1 mRNAaffects expression 18343893
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FGFRL1 mRNAaffects expression 21346803
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FGFRL1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FGFRL1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGFRL1 mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FGFRL1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FGFRL1 mRNAincreases expression 19482888
D013629 Tamoxifen Tamoxifen affects the expression of FGFRL1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of FGFRL1 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGFRL1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGFRL1 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.6717620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9319059307 19084267 19288272 19115204 20390343 19142967 21138602 15668708 19289846 15565566 17242785 16202921 17440819 19189212 19200415 20544844 19244106 19011961 17261762 19189210 19221464 18629630 16873071 19155303 20065188 18855134 17049068 11161223 19487384 20135344 18821012 18984771 16818667 20005174 21152245 18351453 18815881 19103187 18425577 19410462 16273361 19066611 20859285 17893378 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8116705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8117173139 6705139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8116924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017681005 17333356 16919318 11677210 15861022 16105132 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 15668235 8697196 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2420544844 17893378 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005234 Fatty Liver Tamoxifen 8.7914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 7.4711294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Phenobarbital 9.8716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.8716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 15340226 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 5.3719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3712200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2918625569
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.537678174
MESH:D008113 Liver Neoplasms Phenobarbital 11.5319073162 19812893 21047994 8742319 15975961 19482888
MESH:D008113 Liver Neoplasms Tamoxifen 11.5316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.882876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.881399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8812151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8114580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6218551238
MESH:D012640 Seizures Phenobarbital 6.623137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3816049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.388653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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