AutismKB 2.0

Annotation Detail for DUOX1


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Basic Information Top
Gene Symbol:DUOX1 ( LNOX1,MGC138840,MGC138841,NOXEF1,THOX1 )
Gene Full Name: dual oxidase 1
Band: 15q21.1
Quick LinksEntrez ID:53905; OMIM: 606758; Uniprot ID:DUOX1_HUMAN; ENSEMBL ID: ENSG00000137857; HGNC ID: 3062
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DUOX1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DUOX1 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in decreased expression of DUOX1 mRNAdecreases expression 20678512
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUOX1 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of DUOX1 mRNAincreases expression 19244175
D013974 Thyroxine Thyroxine results in decreased expression of DUOX1 proteindecreases expression 17332529
D014212 Tretinoin Tretinoin results in increased expression of DUOX1 mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9319483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.9316197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.2417123778
MESH:D001943 Breast Neoplasms Tretinoin 2.2416443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.971917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516051514 16096774
MESH:D006332 Cardiomegaly Thyroxine 4.2418093424
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Selenium 10.7217936198
MESH:D003092 Colitis Tretinoin 10.7217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839125849 10589399 8800419 16925845 9224671 17551590 9142499 9664655 14991402 9211117
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0115619225 16177239 16081117 17906064 18713872 11421492 19370779 17522070 16109766 15968718 17562736 12705907 12392966 12958197 19164858 19085960 19923254 11287661 12594235 14986274 16485898 18071297 11743745 10915739 11739529 14725611 11529661 16227642 2444490 11834606 19420014 19416960 10774834 11461765 16393943 14550746 19739265 10663392 12153990 12540782 16781746
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 3.0419236843 20131406
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D006333 Heart Failure pirinixic acid 7.4820558911
MESH:D006333 Heart Failure Selenium 7.4817162251
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007333 Insulin Resistance bisphenol A 7.8816393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8816306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3219225113 16891316 17107899 9834237 19029980 17712046 17368321 19642359 16331271 17649720 17339181 16823087 17301526 17294898 16935935 19035177 15748426 16788101 16766008 17506722 17217047 19075265 16140955 12679006 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6819014921 16611625 19784758 16610002 19460945 11587558 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9015890375 16377806 20007298
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms pirinixic acid 5.3117405874
MESH:D009369 Neoplasms Tretinoin 5.3116946489 16594593
MESH:D009421 Nervous System Malformations bisphenol A 10.9116427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 10.919125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3616740699
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013959 Thyroid Diseases Thyroxine 6.0819910387
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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